*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : ZE9275000
CHEMICAL NAME : 2,6-Xylidine
CAS REGISTRY NUMBER : 87-62-7
BEILSTEIN REFERENCE NO. : 0636332
REFERENCE : 4-12-00-02521 (Beilstein Handbook Reference)
LAST UPDATED : 199710
DATA ITEMS CITED : 19
MOLECULAR FORMULA : C8-H11-N
MOLECULAR WEIGHT : 121.20
WISWESSER LINE NOTATION : ZR B1 F1
COMPOUND DESCRIPTOR : Tumorigen
Mutagen
Natural Product
SYNONYMS/TRADE NAMES :
* 1-Amino-2,6-dimethylbenzene
* 2-Amino-1,3-dimethylbenzene
* 2-Amino-m-xylene
* 2-Amino-1,3-xylene
* Aniline, 2,6-dimethyl-
* 2,6-Dimethylaniline
* 2,6-Dimethylbenzenamine
* 2,6-Dimethylphenylamine
* NCI-C56188
* 2,6-Xylylamine
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 840 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - cyanosis
Blood - changes in spleen
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
22,153,1972
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 707 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB214-270
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 3150 mg/kg/20D-C
TOXIC EFFECTS :
Blood - changes in spleen
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year:
3,285,1983
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 6200 mg/kg/2W-I
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-278,1990
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 13300 mg/kg/4W-I
TOXIC EFFECTS :
Liver - other changes
Liver - changes in liver weight
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - phosphatases
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 12,63,1979
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 20150 mg/kg/13W-I
TOXIC EFFECTS :
Brain and Coverings - changes in brain weight
Liver - changes in liver weight
Blood - changes in other cell count (unspecified)
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-278,1990
** TUMORIGENIC DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 107 gm/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Sense Organs and Special Senses (Olfaction) - tumors
Endocrine - tumors
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-278,1990
** MUTATION DATA **
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 50 umol/plate
REFERENCE :
JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc.,
Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC
20037) V.1- 1953- Volume(issue)/page/year: 34,157,1986
TYPE OF TEST : Phage inhibition capacity
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 39 ug/well
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 260,349,1991
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Rodent - hamster Ovary
DOSE/DURATION : 1 gm/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E.
11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year:
10(Suppl 10),1,1987
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Rodent - hamster Ovary
DOSE/DURATION : 301 mg/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E.
11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year:
10(Suppl 10),1,1987
*** REVIEWS ***
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 57,323,1993
IARC Cancer Review:Human Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 57,323,1993
IARC Cancer Review:Group 2B
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 57,323,1993
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X7951
No. of Facilities: 21 (estimated)
No. of Industries: 1
No. of Occupations: 5
No. of Employees: 4354 (estimated)
No. of Female Employees: 729 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
NTP Carcinogenesis Studies (feed);clear evidence:rat
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-278,90
*** END OF RECORD ***
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| ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
| | NAME | CAS |
|
Xylene, tetranitro-
| 24239-79-0 |
|
Xylenol
| 1300-71-6 |
|
2,3-Xylenol
| 526-75-0 |
|
2,4-Xylenol
| 105-67-9 |
|
2,5-Xylenol
| 95-87-4 |
|
Venom, spider, Latrodectus variolus
| 95-87-4 |
|
2,6-Xylenol
| 576-26-1 |
|
3,4-Xylenol
| 95-65-8 |
|
3,5-Xylenol
| 108-68-9 |
|
4,5-Xylenol, 2-amino-
| 6623-41-2 |
|
3,5-Xylenol, 4-amino-
| 3096-70-6 |
|
2,6-Xylenol, alpha(sup 2),alpha(sup6)-bis(diethylamino)-4-(4-quinolinylamino)-
| 3096-70-6 |
|
2,6-Xylenol, 4-bromo-
| 2374-05-2 |
|
2,4-Xylenol, 6-tert-butyl-
| 1879-09-0 |
|
3,4-Xylenol, 6-tert-butyl-
| 1445-23-4 |
|
2,4-Xylenol, 6,6'-butylidenebis-
| 3772-23-4 |
|
Venom, spider, Loxosceles gaucho
| 3772-23-4 |
|
3,5-Xylenol, 4-chloro-
| 88-04-0 |
|
2,4-Xylenol, 6-chloro-alpha(sup 4)-(dimethylamino)-
| 82965-44-4 |
|
2,6-Xylenol, 4-chloro-alpha(sup 2),alpha(sup2)-di(3,4-xylyl)-
| 64038-53-5 |
|
2,6-Xylenol, 4-chloro-alpha(sup 2)-(methylimino)-
| 63238-79-9 |
|
2,6-Xylenol,4-((7-chloro-4-quinolyl)amino)-alpha,alpha'-di-1-pyrrolidinyl-
| 5201-88-7 |
|
3,4-Xylenol, 6-cyclohexyl-alpha(sup 4)-piperidino-
| 106609-32-9 |
|
3,5-Xylenol, 4-(dimethylamino)-
| 6120-10-1 |
|
2,4-Xylenol, alpha-(dimethylamino)-, hydrochloride
| 6120-10-1 |
|
2,5-Xylenol, alpha-(dimethylamino)-, hydrochloride
| 6120-10-1 |
|
2,6-Xylenol, alpha-(dimethylamino)-, hydrochloride
| 1198-86-3 |
|
Venom, spider, Loxosceles reclusa
| 1198-86-3 |
|
2,4-Xylenol, alpha(sup 4)-(dimethylamino)-6-propyl-,hydrochloride
| 96432-75-6 |
|
2,6-Xylenol,alpha-((3-(dimethylamino)propyl)methylamino)-4-iodo-,dihydrochloride
| 96432-75-6 |
|
2,5-Xylenol, 4,6-dinitro-
| 15968-56-6 |
|
2,6-Xylenol, alpha(sup 2),alpha(sup6)-dipiperidino-4-(4-quinolinylamino)-
| 15968-56-6 |
|
2,3-Xylenol, 6-isopropyl-alpha(sup 2)-morpholino-
| 1715-74-8 |
|
2,6-Xylenol, 4-nitro-
| 2423-71-4 |
|
Xylenol, phosphate (31)
| 25155-23-1 |
|
Xylia xylocarpa (roxb.) Taub., fruit extractSUBSTANCE DEFINITION :Plant belonging to the family MimosaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
| 25155-23-1 |
|
Xylia xylocarpa (roxb.) Taub., stem bark extractSUBSTANCE DEFINITION :Plant belonging to the family FabaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
| 25155-23-1 |
|
Xylidine
| 1300-73-8 |
|
Venom, spider, Loxosceles rufipes
| 1300-73-8 |
|
2,3-Xylidine
| 87-59-2 |
|
2,4-Xylidine
| 95-68-1 |
|
2,5-Xylidine
| 95-78-3 |
|
2,6-Xylidine
| 87-62-7 |
|
3,4-Xylidine
| 95-64-7 |
|
3,5-Xylidine
| 108-69-0 |
|
2,4-Xylidine, alpha(sup 4)-(p-aminophenyl)-alpha(sup4)-(4-imino-2,5-cyclohexadien- 1-ylidene)-
| 3248-93-9 |
|
3,4-Xylidine, 6-(beta-carboxypropionyl)-,hydrochloride, hydrate
| 91641-63-3 |
|
2,6-Xylidine, N-(2-(diethylamino)ethyl)-,dihydrochloride
| 78280-29-2 |
|
2,6-Xylidine, N,N-dimethyl-4-(phenylazo)-
| 20557-73-7 |
|
Venom, snake, Trimeresurus flavoviridis, hemorrhagicprinciple 1
| 20557-73-7 |
|
|