*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : CO4025000
CHEMICAL NAME : Azoxybenzene
CAS REGISTRY NUMBER : 495-48-7
OTHER CAS REGISTRY NOS. : 55599-32-1
BEILSTEIN REFERENCE NO. : 0743984
LAST UPDATED : 199806
DATA ITEMS CITED : 20
MOLECULAR FORMULA : C12-H10-N2-O
MOLECULAR WEIGHT : 198.24
WISWESSER LINE NOTATION : ONR&UNR
COMPOUND DESCRIPTOR : Mutagen
SYNONYMS/TRADE NAMES :
* Azobenzene, oxide
* Azossibenzene
* Azoxybenzeen
* Azoxybenzide
* Azoxybenzol
* Azoxydibenzene
* Benzene, azoxydi-
* Diazene, diphenyl-, 1-oxide
* Diphenyldiazene 1-oxide
* Fenazox
* Ordinary azoxybenzene
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 620 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
Volume(issue)/page/year: 10,61,1954
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 940 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd,
eds., Nottingham, Royal Soc. of Chemistry, 1983-86 Volume(issue)/page/year:
A195,1983
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 515 mg/kg
TOXIC EFFECTS :
Gastrointestinal - other changes
Liver - other changes
REFERENCE :
KYDKAJ Kyoritsu Yakka Daigaku Kenkyu Nenpo. Annual Report of the Kyoritsu
College of Pharmacy. (Kyoritsu Yakka Daigaku, 1-5-30 Shibakoen Minato-ku,
Tokyo, Japan) V.1- 1955- Volume(issue)/page/year: 21,25,1976
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CBCCT* "Summary Tables of Biological Tests," National Research Council
Chemical-Biological Coordination Center. (National Academy of Science
Library, 2101 Constitution Ave., NW, Washington, DC 20418)
Volume(issue)/page/year: 7,389,1955
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 1350 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd,
eds., Nottingham, Royal Soc. of Chemistry, 1983-86 Volume(issue)/page/year:
A195,1983
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 275 mg/kg
TOXIC EFFECTS :
Gastrointestinal - other changes
Kidney, Ureter, Bladder - other changes
REFERENCE :
AEXPBL Archiv fuer Experimentelle Pathologie und Pharmakologie. (Leipzig,
Ger. Dem. Rep.) V.1-109, 1873-1925. For publisher information, see NSAPCC.
Volume(issue)/page/year: 35,401,1895
** MUTATION DATA **
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 10 ug/plate
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc., 52
Vanderbilt Ave., New York, NY 10017) V.1- 1981- Volume(issue)/page/year:
1,271,1981
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 50 ug/plate
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc., 52
Vanderbilt Ave., New York, NY 10017) V.1- 1981- Volume(issue)/page/year:
1,351,1981
TYPE OF TEST : DNA repair
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 500 mg/L
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc., 52
Vanderbilt Ave., New York, NY 10017) V.1- 1981- Volume(issue)/page/year:
1,195,1981
TYPE OF TEST : DNA damage
TEST SYSTEM : Bacteria - Bacillus subtilis
DOSE/DURATION : 1 mg/disc
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc., 52
Vanderbilt Ave., New York, NY 10017) V.1- 1981- Volume(issue)/page/year:
1,175,1981
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Yeast - Saccharomyces cerevisiae
DOSE/DURATION : 250 mg/L
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc., 52
Vanderbilt Ave., New York, NY 10017) V.1- 1981- Volume(issue)/page/year:
1,414,1981
TYPE OF TEST : Gene conversion and mitotic recombination
TEST SYSTEM : Yeast - Saccharomyces cerevisiae
DOSE/DURATION : 196 ppm
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc., 52
Vanderbilt Ave., New York, NY 10017) V.1- 1981- Volume(issue)/page/year:
1,481,1981
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Human Lymphocyte
DOSE/DURATION : 1 umol/L
REFERENCE :
MSCREJ Medical Science Research. (Elsevier Applied Science Pub. Ltd., Crown
House, Linton Rd., Barking, Essex IG11 8JU, UK) V.15- 1987-
Volume(issue)/page/year: 20,373,1992
TYPE OF TEST : Micronucleus test
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 6400 ug/kg
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc., 52
Vanderbilt Ave., New York, NY 10017) V.1- 1981- Volume(issue)/page/year:
1,686,1981
TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 792 ug/kg
REFERENCE :
MSCREJ Medical Science Research. (Elsevier Applied Science Pub. Ltd., Crown
House, Linton Rd., Barking, Essex IG11 8JU, UK) V.15- 1987-
Volume(issue)/page/year: 20,373,1992
TYPE OF TEST : Sperm Morphology
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 792 ug/kg
REFERENCE :
MSCREJ Medical Science Research. (Elsevier Applied Science Pub. Ltd., Crown
House, Linton Rd., Barking, Essex IG11 8JU, UK) V.15- 1987-
Volume(issue)/page/year: 20,373,1992
TYPE OF TEST : Morphological transformation
TEST SYSTEM : Rodent - hamster Kidney
DOSE/DURATION : 33400 ug/L
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc., 52
Vanderbilt Ave., New York, NY 10017) V.1- 1981- Volume(issue)/page/year:
1,626,1981
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: Mammalian micronucleus
EPA GENETOX PROGRAM 1988, Negative: Sperm morphology-mouse
EPA TSCA Section 8(b) CHEMICAL INVENTORY
*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
| NAME | CAS |
8-Azoniabicyclo(3.2.1)octane,8,8'-(1,5-pentanediyl)bis(3-(3-hydroxy-1-oxo-2-phenylpropoxy)- 8-methyl-, diiodide
| 941-14-0 |
3-Azoniabicyclo(3.2.1)octane,1,3,8,8-tetramethyl-3-(3-(trimethylammonio)propyl)-,bis(methyl sulfate)
| 14149-43-0 |
3-Azoniabicyclo(3.2.1)octane,1,3,8,8-tetramethyl-3-(3-(trimethylammonio)propyl)-,dichloride
| 14149-43-0 |
3-Azoniabicyclo(3.2.1)octane,1,3,8,8-tetramethyl-3-(3-(trimethylammonio)propyl)-,diiodide
| 58594-48-2 |
1-Azoniabicyclo(3.2.1)octan-6-ol, 1-methyl-, bromide,diphenylacetate
| 69766-47-8 |
Azirino(2',3'3,4)pyrrolo(1,2-a)indole-4,7-dione,1,1a,2,8,8a,8b-hexahydro-6,8a-dimethoxy-5-methyl-8-methylene-,(1aS-(1a-alpha,8a-alpha,8b-alpha))-
| 74422-30-3 |
17a-Azonia-D-honoandrostane,17a,17a-dimethyl-3-(1-methylpyrrolidinio)-, dibromide
| 70433-02-2 |
1-Azoniaspiro(4.5)decane,1-(3-carbamoyl-3,3-diphenylpropyl)-1-methyl-, bromide
| 70433-02-2 |
1-Azoniaspiro(4.5)decane,1-(3-(dimethylcarbamoyl)-3,3-diphenylpropyl)-1-methyl-, bromide
| 70433-02-2 |
2-Azoniaspiro(4.5)decane, 2-dodecyl-2-methyl-, iodide
| 798-02-7 |
8-Azoniaspiro(4.5)decane,8-(3-(p-fluorobenzoyl)propyl)-8-methyl-, iodide
| 1096-06-6 |
5-Azoniaspiro(4.5)decane,2-hydroxy-2-methyl-1-methylene-, iodide
| 41598-48-5 |
2-Azoniaspiro(4.4)nonane, 2-allyl-2-methyl-, iodide
| 41598-48-5 |
5-Azoniaspiro(4.4)nonane,2-((cyclohexylhydroxyphenylacetyl)oxy)-, bromide
| 76302-53-9 |
5-Azoniaspiro(4.4)nonane,2-((cyclopentylhydroxyphenylacetyl)oxy)-, bromide
| 76302-54-0 |
5-Azoniaspiro(4.4)nonane,2-((hydroxydiphenylacetyl)oxy)-, bromide
| 76302-54-0 |
Azirino(2',3'3,4)pyrrolo(1,2-a)indole-4,7-dione,1,1a,2,8,8a,8b-hexahydro-6-dimethylamino-8-(hydroxymethyl)-8a-methoxy-5-methyl-, carbamate
| 4049-15-4 |
6-Azoniaspiro(5,5)undecane bromide
| 6286-82-4 |
3-Azoniaspiro(5.5)undecane, 3,3,9-trimethyl-, iodide
| 775-73-5 |
1H-Azonine-1-ethanol, octahydro-, benzilate,hydrochloride
| 99901-10-7 |
1H-Azonine-1-ethanol, octahydro-beta-methyl-,benzilate, hydrochloride
| 99901-11-8 |
1H-Azonine, octahydro-1-nitroso-
| 20917-50-4 |
2-Azoninethione, octahydro-, (Z)-
| 20917-50-4 |
Azoninium,octahydro-1-(5-octahydroazonino-2,4-pentadienylidene)-, chloride
| 23996-86-3 |
2H-Azonin-2-one, octahydro-
| 935-30-8 |
2-Azoninone, octahydro-, (Z)-
| 935-30-8 |
m,o'-Azotoluene, 4-nitro-
| 17277-81-5 |
Azirino(2',3'3,4)pyrrolo(1,2-a)indole-4,7-dione,1,1a,2,8,8a,8b-hexahydro-6-(((dimethylamino)methylene)amino)-8-(hydroxymethyl)-8a-methoxy-5-methyl-, carbamate (ester)
| 88949-01-3 |
Azotrex
| 8054-08-8 |
Azoxybenzene
| 495-48-7 |
Azoxybenzene, 3,3'-bis(dichloroarsino)-
| 495-48-7 |
Azoxybenzene, 4,4'-dichloro-
| 614-26-6 |
Azoxybenzene, 5,5'-dichloro-2,2'-dimethyl-
| 66941-45-5 |
Azoxybenzene, 3,3',4,4'-tetrachloro-
| 21232-47-3 |
Azulene
| 275-51-4 |
1-Azulenecarboxaldehyde,4-methyl-7-(1-methylethenyl)-
| 85-33-6 |
1-Azulenecarboxamide,3-acetamido-N-(2-(diethylamino)ethyl)-, hydrochloride
| 54805-31-1 |
1-Azulenecarboxamide, N-(2-(diethylamino)ethyl)-,hydrochloride
| 54805-26-4 |
Azirino(2',3'3,4)pyrrolo(1,2-a)indole-4,7-dione,1,1a,2,8,8a,8b-hexahydro-1,5-dimethyl-6-dimethylamino-8a-hydroxy-8-(hydroxymethyl)-,8-carbamate
| 30823-13-3 |
1-Azulenecarboxamide,N-(2-(diethylamino)ethyl)-3-nitro-, hydrochloride
| 54805-30-0 |
Azulenecarboxamide, 1-(N-methylpiperazinyl)-,hydrochloride
| 54805-27-5 |
Azulenecarboxamide, 1-(N-methylpiperazinyl)-3-nitro-,hydrochloride
| 54805-28-6 |
Azulenecarboxylic acid
| 64059-36-5 |
5,6-Azulenedicarboxaldehyde,1,2,3,3a,8,8a-hexahydro-3a-hydroxy-2,2,8-trimethyl-,(3aS-(3a- alpha,8-alpha,8a-alpha))-
| 96910-73-5 |
Azulene, 1,4-dimethyl-7-ethyl-
| 529-05-5 |
Azulene, 1,4-dimethyl-7-isopropyl-
| 489-84-9 |
1-Azulenemethanol, 4-methyl-7-(1-methylethenyl)-
| 113393-59-2 |
Azulene,1,2,3,4,5,6,7,8-octahydro-1,4-dimethyl-7-(1-methylethylidene)-, monoepoxide
| 68071-23-8 |
1-Azulenesulfonic acid, 3-ethyl-7-(1-methylethyl)-,sodium salt
| 97683-31-3 |
Azirino(2',3'3,4)pyrrolo(1,2-a)indole-4,7-dione,1,1a,2,8,8a,8b-hexahydro-1,5-dimethyl-6-(ethylamino)-8a-alpha-hydroxy-8-(hydroxymethyl)-,8-carbamate
| 21448-81-7 |
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