* BMY-25282
* 7-N-(Dimethylaminomethylene)mitomycin C
*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : CN0739000
CHEMICAL NAME : Azirino(2',3':3,4)pyrrolo(1,2-a)indole-4,7-dione,
1,1a,2,8,8a,8b-hexahydro-6-
(((dimethylamino)methylene)amino)-8-(hydroxymethyl)-8
a-methoxy-5-methyl-, carbamate (ester)
CAS REGISTRY NUMBER : 88949-01-3
LAST UPDATED : 199309
DATA ITEMS CITED : 4
MOLECULAR FORMULA : C18-H23-N5-O5
MOLECULAR WEIGHT : 389.46
COMPOUND DESCRIPTOR : Drug
SYNONYMS/TRADE NAMES :
* BMY-25282
* 7-N-(Dimethylaminomethylene)mitomycin C
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 250 ug/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - dyspnea
Skin and Appendages - hair
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year:
9,90,1987
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 2100 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
45,6475,1985
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1400 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
45,6475,1985
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 250 ug/kg/5D-I
TOXIC EFFECTS :
Cardiac - cardiomyopathy including infarction
Kidney, Ureter, Bladder - changes in both tubules and glomeruli
Related to Chronic Data - death
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year:
9,90,1987
*** END OF RECORD ***
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