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MSDS  : Acetic acid, (2,4-dichlorophenoxy)-, isooctyl ester
CAS  : 25168-26-7
SYNONYMS  : * Agroxone 5 * 2,4-Dichlorophenoxyacetic acid, isooctyl ester * 2,4-D isooctyl ester * Isooctyl alcohol, (2,4-dichlorophenoxy)acetate * Isooctyl 2,4-dichlorophenoxyacetate * Isooktylester kyseliny 2,4-dichlorfenoxyoctove * Reed LV 2,4-D * Reed LV 400 2,4-D * Reed LV 600 2,4-D * Silvapron D
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : AG8575000
CHEMICAL NAME : Acetic acid, (2,4-dichlorophenoxy)-, isooctyl ester
CAS REGISTRY NUMBER : 25168-26-7
OTHER CAS REGISTRY NOS. : 1280-20-2
LAST UPDATED : 199603
DATA ITEMS CITED : 15
MOLECULAR FORMULA : C16-H22-Cl2-O3
MOLECULAR WEIGHT : 333.28
WISWESSER LINE NOTATION : GR CG DO1VO5Y1&1
COMPOUND DESCRIPTOR : Agricultural Chemical
Tumorigen
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Agroxone 5
* 2,4-Dichlorophenoxyacetic acid, isooctyl ester
* 2,4-D isooctyl ester
* Isooctyl alcohol, (2,4-dichlorophenoxy)acetate
* Isooctyl 2,4-dichlorophenoxyacetate
* Isooktylester kyseliny 2,4-dichlorfenoxyoctove
* Reed LV 2,4-D
* Reed LV 400 2,4-D
* Reed LV 600 2,4-D
* Silvapron D

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 982 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year:
9,423,1987

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : >2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year:
9,423,1987

** TUMORIGENIC DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 14 gm/kg/78W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Liver - tumors
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB223-159

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 21 mg/kg
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Blood - tumors
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB223-159

** REPRODUCTIVE DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 1370 mg/kg
SEX/DURATION : female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - live birth index (measured after birth)
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB81-191140

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 302 mg/kg
SEX/DURATION : female 9-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 9,801,1971

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 188 mg/kg
SEX/DURATION : female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - homeostasis
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
gain)
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 9,801,1971

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 1131 mg/kg
SEX/DURATION : female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 9,801,1971

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 528 mg/kg
SEX/DURATION : female 8-11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 9,801,1971

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE : 1680 mg/kg
SEX/DURATION : female 7-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
AECTCV Archives of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ
070944) V.1- 1973- Volume(issue)/page/year: 6,33,1977

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE : 438 mg/kg
SEX/DURATION : female 8-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
gain)
REFERENCE :
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc.,
41 E. 11th St., New York, NY 10003) V.1- 1980- Volume(issue)/page/year:
7,7,1987

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE : 1170 mg/kg
SEX/DURATION : female 6-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - extra-embryonic structures
(e.g., placenta, umbilical cord)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - eye/ear
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB223-160

** MUTATION DATA **

TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Human Lymphocyte
DOSE/DURATION : 50 ug/L
REFERENCE :
DBABEF Doga Bilim Dergisi, Seri A2: Biyoloji. Natural Science Journal,
Series A2. (Turkiye Bilimsel ve Teknik Arastirma Kurumu, Ataturk Bul. No.
221, Kavaklidere, Ankara, Turkey) V.8- 1984- Volume(issue)/page/year:
8,105,1984

*** REVIEWS ***

IARC Cancer Review:Animal Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 15,111,1977

*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 82947
No. of Facilities: 100 (estimated)
No. of Industries: 4
No. of Occupations: 5
No. of Employees: 291 (estimated)


*** END OF RECORD ***
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Acetic acid,2,2'-((3,6-dichloro-9-oxo-9H-fluorene-2,7-diyl)bis(oxy))bis-, dipropyl ester 123278-17-1
Acetic acid, (2,4-dichlorophenoxy)- 94-75-7
Acetic acid, (3,4-dichlorophenoxy)- 588-22-7
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Acetic acid, (2,4-dichlorophenoxy)-, compd. with1-amino-2-propanol (1:1) 6365-72-6
Acetic acid, (2,4-dichlorophenoxy)-, ammonium salt 2307-55-3
Acetic acid, 2,4-dichlorophenoxy-, 2-butenyl ester 14600-07-8
Acetic acid, (2,4-dichlorophenoxy)-,3-(2-butoxyethoxy)propyl ester 1928-57-0
Acetic acid, (2,4-dichlorophenoxy)-, butoxyethylester 1929-73-3
Acetic acid, (2,4-dichlorophenoxy)-,2-butoxy-2-oxoethyl ester 52671-26-8
Acetic acid, (4-(bis(2-chloroethyl)amino)phenyl)-,cholesteryl ester 3546-10-9
Acetic acid, 2,4-dichlorophenoxy-, 3-butoxypropylester 1928-45-6
Acetic acid, dichlorophenoxy-, butyl ester 64047-35-4
Acetic acid, (2,4-dichlorophenoxy)-, butyl ester 94-80-4
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Acetic acid, 2,4-dichlorophenoxy-, 4-chloro-2-butenylester 2971-38-2
Acetic acid, (2,4-dichlorophenoxy)-, diethanolaminesalt 5742-19-8
Acetic acid, (2,4-dichlorophenoxy)-, diethylaminesalt 20940-37-8
Acetic acid, (2,4-dichlorophenoxy)-, compd. withN,N-diethylethanamine (1:1) 2646-78-8
Acetic acid, (2,4-dichlorophenoxy)-, compd. withdimethylamine (1:1) 2008-39-1
Acetic acid, 2,4-dichlorophenoxy-,2-dimethylaminoethyl ester, hydrochloride 64046-52-2
Acetic acid, 2-(N,N-bis(2-chloroethyl)aminophenyl)-,decyl ester 66276-87-7
Acetic acid, (2,4-dichlorophenoxy)-, compd. with(Z,Z)-N,N-dimethyl-9,12-octadecadien- 1-amine (1:1),mixt. with (Z)-N,N-dimethyl-9-octadecen-1-amine (2,4-dichlorophenoxy)acetate 55256-32-1
Acetic acid, (2,4-dichlorophenoxy)-, compd. with(Z)-N,N-dimethyl-9-octadecen-1- amine (1:1) 53535-36-7
Acetic acid, (2,4-dichlorophenoxy)-, compd. with1-dodecanamine (1:1) 2212-54-6
Acetic acid, (2,4-dichlorophenoxy)-, ethyl ester 533-23-3
Acetic acid, (2,4-dichlorophenoxy)-, 2-ethylhexylester 1928-43-4
Acetic acid, (2,4-dichlorophenoxy)-, mixt. withN-ethyl-N'-(1-methylethyl)-6-(methylthio)-1,3,5-triazine-2,4-diamine 8073-61-8
Acetic acid, (2,4-dichlorophenoxy)-,2-ethyl-4-methylpentyl ester 53404-37-8
Acetic acid, (2,4-dichlorophenoxy)-, isobutyl ester 1713-15-1
Acetic acid, (2,4-dichlorophenoxy)-, isooctyl ester 25168-26-7
Acetic acid, (2,4-dichlorophenoxy)-, isooctyl ester,mixed with 2-(2,4-dichlorophenoxy) propionic acid,butoxyethyl ester and dicamba 25168-26-7
Acetic acid, (p-(bis(2-chloroethyl)amino)phenyl)-,10a,12a-dimethyl-2-oxohexahydro-5-alpha-2H-phenanthro(2,1-b)pyran-8-yl ester 60696-44-8
Acetic acid, (2,4-dichlorophenoxy)-, isopropyl ester 94-11-1
Acetic acid, 2,4-dichlorophenoxy-, lithium salt 3766-27-6
Acetic acid, (2,4-dichlorophenoxy)-, methyl ester 1928-38-7
Acetic acid, (2,4-dichlorophenoxy)-, 1-methylheptylester 1917-97-1
Acetic acid, (2,4-dichlorophenoxy)-, compd. withmorpholine (1:1) 6365-73-7
Acetic acid, (2,4-dichlorophenoxy)-,2-(1-naphthalenyl)-4-(4-(phenylmethyl)-1-piperidinyl)butyl ester, hydrochloride 119607-21-5
Acetic acid, (2,4-dichlorophenoxy)-, compd. with1,1',1''-nitrilotris(2-propanol) 32341-80-3
Acetic acid, (2,4-dichlorophenoxy)-, compd. withoctylamine (1:1) 2212-53-5
Acetic acid, 2,4-dichlorophenoxy-, octyl ester 1928-44-5
Acetic acid, (2,4-dichlorophenoxy)-, pentyl ester 1917-92-6
Acetic acid, 2-(N,N-bis(2-chloroethyl)aminophenyl)-,dodecyl ester 66232-27-7

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