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MSDS  : Acetic acid, (4-(bis(2-chloroethyl)amino)phenyl)-, cholesteryl ester
CAS  : 3546-10-9
SYNONYMS  : * (p-(Bis(2-chloroethyl)amino)phenyl)acetic acid cholesterol ester * Cholest-5-en-3-ol, (3-beta)-, 4-(bis(2-chloroethyl)amino)benzeneacetate * 5-Cholesten-3-beta-ol 3-(p-(bis(2-chloroethyl)amino)phenyl)acetate * Cholesterol, (p-(bis(2-chloroethyl)amino)phenyl) acetate * Cholesteryl p-bis(2-chloroethyl)amino phenylacetate * Fenesterin * Fenestrin * NCI-C01558 * NSC 104469 * Phenesterin * Phenesterine * Phenestrin
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : AF5457000
CHEMICAL NAME : Acetic acid, (4-(bis(2-chloroethyl)amino)phenyl)-,
cholesteryl ester
CAS REGISTRY NUMBER : 3546-10-9
LAST UPDATED : 199701
DATA ITEMS CITED : 10
MOLECULAR FORMULA : C39-H59-Cl2-N-O2
MOLECULAR WEIGHT : 644.89
WISWESSER LINE NOTATION : L E5 B666 LUTJ A1 E1 FY1&3Y1&1 OOV1R DN2G2G
COMPOUND DESCRIPTOR : Tumorigen
Drug
Mutagen
SYNONYMS/TRADE NAMES :
* (p-(Bis(2-chloroethyl)amino)phenyl)acetic acid cholesterol ester
* Cholest-5-en-3-ol, (3-beta)-, 4-(bis(2-chloroethyl)amino)benzeneacetate
* 5-Cholesten-3-beta-ol 3-(p-(bis(2-chloroethyl)amino)phenyl)acetate
* Cholesterol, (p-(bis(2-chloroethyl)amino)phenyl) acetate
* Cholesteryl p-bis(2-chloroethyl)amino phenylacetate
* Fenesterin
* Fenestrin
* NCI-C01558
* NSC 104469
* Phenesterin
* Phenesterine
* Phenestrin

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Parenteral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc.,
Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
20037) V.6- 1963- Volume(issue)/page/year: 12,810,1969

** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 700 mg/kg/28D-I
TOXIC EFFECTS :
Blood - thrombocytopenia
Blood - changes in bone marrow (not otherwise specified)
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
CCYPBY Cancer Chemotherapy Reports, Part 3. (Washington, DC) V.1-6,
1968-75. For publisher information, see CTRRDO. Volume(issue)/page/year:
4,121,1973

** TUMORIGENIC DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 780 mg/kg/52W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Skin and Appendages - tumors
REFERENCE :
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-60,1978

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1092 mg/kg/1Y-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Blood - tumors
REFERENCE :
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-60,1978

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 2400 mg/kg/8W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
33,3069,1973

TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1560 mg/kg/1Y-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Skin and Appendages - tumors
REFERENCE :
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-60,1978

TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 2340 mg/kg/1Y-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Blood - tumors
REFERENCE :
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-60,1978

TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 4680 mg/kg/1Y-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Blood - tumors
REFERENCE :
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-60,1978

*** STATUS IN U.S. ***

EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat

NCI Carcinogenesis Bioassay (gavage);clear evidence:mouse,rat
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-60,78


*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
NAMECAS
Acetic acid,6,7-dichloro-2-methyl-1-oxo-5-indanyloxy- 27366-35-4
Acetic acid,(2,3-dichloro-4-(5-methyl-2-thenoyl)phenoxy)- 55901-70-7
Acetic acid,(o-(2,4-dichloro-1-naphthylamino)phenyl)-, sodiumsalt 62809-33-0
Acetic acid, (2,4-dichloro-6-nitrophenyl) ester 37169-10-1
Acetic acid, (2,3-dichloro-4-(1-oxobutyl)phenoxy)- 1217-67-0
Acetic acid, 2-(N,N-bis(2-chloroethyl)aminophenyl)-,butyl ester 66232-25-5
Acetic acid,2,2'-((3,6-dichloro-9-oxo-9H-fluorene-2,7-diyl)bis(oxy))bis-, dipropyl ester 123278-17-1
Acetic acid, (2,4-dichlorophenoxy)- 94-75-7
Acetic acid, (3,4-dichlorophenoxy)- 588-22-7
Acetic acid, (2,4-dichlorophenoxy)-, compd. with2-aminoethanol (1:1) 3599-58-4
Acetic acid, (2,4-dichlorophenoxy)-, compd. with1-amino-2-propanol (1:1) 6365-72-6
Acetic acid, (2,4-dichlorophenoxy)-, ammonium salt 2307-55-3
Acetic acid, 2,4-dichlorophenoxy-, 2-butenyl ester 14600-07-8
Acetic acid, (2,4-dichlorophenoxy)-,3-(2-butoxyethoxy)propyl ester 1928-57-0
Acetic acid, (2,4-dichlorophenoxy)-, butoxyethylester 1929-73-3
Acetic acid, (2,4-dichlorophenoxy)-,2-butoxy-2-oxoethyl ester 52671-26-8
Acetic acid, (4-(bis(2-chloroethyl)amino)phenyl)-,cholesteryl ester 3546-10-9
Acetic acid, 2,4-dichlorophenoxy-, 3-butoxypropylester 1928-45-6
Acetic acid, dichlorophenoxy-, butyl ester 64047-35-4
Acetic acid, (2,4-dichlorophenoxy)-, butyl ester 94-80-4
Acetic acid, 2,4-dichlorophenoxy-, butyl ester and2,4,5-trichlorophenoxyacetic acid (45.5%: 48.2%) 39277-47-9
Acetic acid, 2,4-dichlorophenoxy-, 4-chloro-2-butenylester 2971-38-2
Acetic acid, (2,4-dichlorophenoxy)-, diethanolaminesalt 5742-19-8
Acetic acid, (2,4-dichlorophenoxy)-, diethylaminesalt 20940-37-8
Acetic acid, (2,4-dichlorophenoxy)-, compd. withN,N-diethylethanamine (1:1) 2646-78-8
Acetic acid, (2,4-dichlorophenoxy)-, compd. withdimethylamine (1:1) 2008-39-1
Acetic acid, 2,4-dichlorophenoxy-,2-dimethylaminoethyl ester, hydrochloride 64046-52-2
Acetic acid, 2-(N,N-bis(2-chloroethyl)aminophenyl)-,decyl ester 66276-87-7
Acetic acid, (2,4-dichlorophenoxy)-, compd. with(Z,Z)-N,N-dimethyl-9,12-octadecadien- 1-amine (1:1),mixt. with (Z)-N,N-dimethyl-9-octadecen-1-amine (2,4-dichlorophenoxy)acetate 55256-32-1
Acetic acid, (2,4-dichlorophenoxy)-, compd. with(Z)-N,N-dimethyl-9-octadecen-1- amine (1:1) 53535-36-7
Acetic acid, (2,4-dichlorophenoxy)-, compd. with1-dodecanamine (1:1) 2212-54-6
Acetic acid, (2,4-dichlorophenoxy)-, ethyl ester 533-23-3
Acetic acid, (2,4-dichlorophenoxy)-, 2-ethylhexylester 1928-43-4
Acetic acid, (2,4-dichlorophenoxy)-, mixt. withN-ethyl-N'-(1-methylethyl)-6-(methylthio)-1,3,5-triazine-2,4-diamine 8073-61-8
Acetic acid, (2,4-dichlorophenoxy)-,2-ethyl-4-methylpentyl ester 53404-37-8
Acetic acid, (2,4-dichlorophenoxy)-, isobutyl ester 1713-15-1
Acetic acid, (2,4-dichlorophenoxy)-, isooctyl ester 25168-26-7
Acetic acid, (2,4-dichlorophenoxy)-, isooctyl ester,mixed with 2-(2,4-dichlorophenoxy) propionic acid,butoxyethyl ester and dicamba 25168-26-7
Acetic acid, (p-(bis(2-chloroethyl)amino)phenyl)-,10a,12a-dimethyl-2-oxohexahydro-5-alpha-2H-phenanthro(2,1-b)pyran-8-yl ester 60696-44-8
Acetic acid, (2,4-dichlorophenoxy)-, isopropyl ester 94-11-1
Acetic acid, 2,4-dichlorophenoxy-, lithium salt 3766-27-6
Acetic acid, (2,4-dichlorophenoxy)-, methyl ester 1928-38-7
Acetic acid, (2,4-dichlorophenoxy)-, 1-methylheptylester 1917-97-1
Acetic acid, (2,4-dichlorophenoxy)-, compd. withmorpholine (1:1) 6365-73-7
Acetic acid, (2,4-dichlorophenoxy)-,2-(1-naphthalenyl)-4-(4-(phenylmethyl)-1-piperidinyl)butyl ester, hydrochloride 119607-21-5
Acetic acid, (2,4-dichlorophenoxy)-, compd. with1,1',1''-nitrilotris(2-propanol) 32341-80-3
Acetic acid, (2,4-dichlorophenoxy)-, compd. withoctylamine (1:1) 2212-53-5
Acetic acid, 2,4-dichlorophenoxy-, octyl ester 1928-44-5
Acetic acid, (2,4-dichlorophenoxy)-, pentyl ester 1917-92-6
Acetic acid, 2-(N,N-bis(2-chloroethyl)aminophenyl)-,dodecyl ester 66232-27-7

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