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MSDS  : 1-Butanol, 2,2'-(ethylenediimino)di-, dihydrochloride, (+)-
CAS  : 1070-11-7
SYNONYMS  : * 1-Butanol, 2,2'-(1,2-ethanediyldiimino)bis-, dihydrochloride, (R-(R*,R*))- * CL 40881 * Dadibutol * Ethambutol dihydrochloride * Ethambutol hydrochloride * Myambutol
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : EL3854000
CHEMICAL NAME : 1-Butanol, 2,2'-(ethylenediimino)di-,
dihydrochloride, (+)-
CAS REGISTRY NUMBER : 1070-11-7
LAST UPDATED : 199706
DATA ITEMS CITED : 14
MOLECULAR FORMULA : C10-H24-N2-O2.2Cl-H
MOLECULAR WEIGHT : 277.28
WISWESSER LINE NOTATION : Q1Y2&M2MY2&1Q &GH 2
COMPOUND DESCRIPTOR : Drug
Mutagen
Human
SYNONYMS/TRADE NAMES :
* 1-Butanol, 2,2'-(1,2-ethanediyldiimino)bis-, dihydrochloride,
(R-(R*,R*))-
* CL 40881
* Dadibutol
* Ethambutol dihydrochloride
* Ethambutol hydrochloride
* Myambutol

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - man
DOSE/DURATION : 45 mg/kg/3D-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - visual field changes
Sense Organs and Special Senses (Eye) - effect, not otherwise specified
REFERENCE :
BJDCAT British Journal of Diseases of the Chest. (Bailliere Tindall, 33 The
Avenue, Eastbourne BN21 3UN, UK) V.53- 1959- Volume(issue)/page/year:
80,288,1986

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - man
DOSE/DURATION : 46 mg/kg/3D-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - visual field changes
REFERENCE :
PGMJAO Postgraduate Medical Journal. (Blackwell Scientific Pub. Ltd., POB
88, Oxford, UK) V.1- 1925- Volume(issue)/page/year: 61,811,1985

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Human - woman
DOSE/DURATION : 720 mg/kg/48D
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - visual field changes
REFERENCE :
ANOPB5 Annals of Ophthalmology. (American Soc. of Contemporary
Ophthalmology, POB 64025, Baltimore, MD 21264) V.1- 1969-
Volume(issue)/page/year: 2,578,1970

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 6800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 2,70,1968

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 2,70,1968

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 2,70,1968

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 8900 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 2,70,1968

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 2,70,1968

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 230 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 2,70,1968

** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 31200 mg/kg/22W-C
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - chronic pulmonary edema
Cardiac - other changes
Liver - other changes
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
7,844,1965

** MUTATION DATA **

TYPE OF TEST : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Insect - Drosophila melanogaster
DOSE/DURATION : 4400 mg/L
REFERENCE :
IMSCE2 IRCS Medical Science. (Lancaster, UK) V.12-14, 1984-86. For
publisher information, see MSCREJ. Volume(issue)/page/year: 14,745,1986

TYPE OF TEST : Micronucleus test
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 50 mg/kg
REFERENCE :
IRLCDZ IRCS Medical Science: Library Compendium. (Lancaster, UK) V.3-11,
1975-83. For publisher information, see IMSCE2. Volume(issue)/page/year:
10,135,1982

TYPE OF TEST : Sperm Morphology
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 12500 ug/kg
REFERENCE :
IRLCDZ IRCS Medical Science: Library Compendium. (Lancaster, UK) V.3-11,
1975-83. For publisher information, see IMSCE2. Volume(issue)/page/year:
10,135,1982

*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X5347
No. of Facilities: 93 (estimated)
No. of Industries: 1
No. of Occupations: 2
No. of Employees: 590 (estimated)
No. of Female Employees: 430 (estimated)


*** END OF RECORD ***
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NAMECAS
1-Butanol, 4-((1,1-dimethylethyl)nitrosoamino)- 61734-87-0
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2-Butanol, 1,2-diphenyl-4-(methylamino)-3-methyl-,propionate (ester) 66796-40-5
2-Butanol, 1,2-diphenyl-3-methyl-4-(methylamino)-,propionate (ester) 3376-94-1
1-Butanol, 2,2-diphenyl-4-morpholino- 66859-69-6
1-Butanol, 3-(dipropylamino)-1,1-di(thien-3-yl)-,methiodide 17532-08-0
1-Butanol, 1,1-di(thien-3-yl)-3-morpholino-,hydrobromide 17532-12-6
1-Butanol, 1,1-di(thien-3-yl)-3-piperidino-,hydrobromide 17532-11-5
1-Butanol, 1,1-di(thien-3-yl)-3-pyrrolidino-,methiodide 17532-09-1
Butane, 2-iodo- 513-48-4
1-Butanol, 2,2'-(1,2-ethanediyldiimino)bis-, (R)- 74-55-5
1-Butanol, 4-ethoxy- 111-73-9
1-Butanol, 2-ethyl- 97-95-0
Butanol, 2,2'-(ethylenebis(nitrosoimino))bis- 65229-18-7
1-Butanol, 2,2'-(ethylenediimino)di-,dihydrochloride, (+)- 1070-11-7
1-Butanol, 2,2'-(ethylenediimino)di-,dihydrochloride, (+-)- 22196-75-4
1-Butanol, 2,2'-(ethylenediimino)di-,dihydrochloride, mixed with sodium nitrite (1:1) 22196-75-4
1-Butanol,4-(N-ethyl-N-(4-methoxy-alpha-methylphenethyl)amino)- 14367-47-6
1-Butanol, 4-(ethylnitrosoamino)- 54897-62-0
1-Butanol, 4-(N-ethyl-N-phenethylamino)- 66859-70-9
Butane, 1-iodo-3-methyl- 541-28-6
1-Butanol, 4-fluoro- 372-93-0
1-Butanol, 2,2,3,3,4,4,4-heptafluoro- 375-01-9
1-Butanol, 4,4'-(1,6-hexanediylbis(thio))bis(2-amino- 68704-89-2
2-Butanol, 3-(1-hexenyl-ONN-azoxy)-,(S-(R*,R*-(Z,E)))- 122547-71-1
Butanol, 4-((2-hydroxyethyl)nitrosoamino)- 62018-89-7
1-Butanol, 4-(N-(2-hydroxypropyl)-N-nitrosoamino)- 63934-41-8
1-Butanol, 4-(N-(3-hydroxypropyl)-N-nitrosoamino)- 62018-90-0
2-Butanol, 4-(N-(2-hydroxypropyl)-N-nitrosoamino)- 63934-40-7
1-Butanol,1-(N-(2-imidazolin-2-yl)-N-(2-(p-methoxyphenyl)-3-indolylmethyl)amino)-, hydriodide 77587-86-1
2-Butanol,2-(N-(2-imidazolin-2-yl)-N-(2-(p-methoxyphenyl)-3-indolylmethyl)amino)-, hydriodide 100482-45-9
Butane, 2-methoxy-2-methyl- 994-05-8
1-Butanol,1-(N-(2-imidazolin-2-yl)-N-(2-phenyl-3-indolylmethyl)amino)-, hydriodide 77587-78-1
1-Butanol, 2-(p-iodobenzyl)- 60075-61-8
1-Butanol, 3-(p-iodophenyl)- 60075-81-2
2-Butanol, 1-(isopropylamino)-4-phenyl-,hydrochloride 22820-57-1
1-Butanol, 4-methoxy- 111-32-0
1-Butanol, 3-methoxy-, acetate 4435-53-4
2-Butanol,1-(4-methoxybutyl)amino-3-methyl-3-phenoxy- 7565-18-6
2-Butanol, 1-(4-methoxybutyl)amino-3-phenoxy- 7614-42-8
2-Butanol,2-((2-methoxyethyl)amino)-3-methyl-3-phenoxy- 7584-78-3
2-Butanol, 1-(2-methoxyethyl)amino-3-phenoxy- 7565-14-2
Butane, 2-methyl- 78-78-4
2-Butanol, 4-methoxy-3-(1-octenyl-ONN-azoxy)-,(E,Z)-(2S,3S)- 23315-05-1
1-Butanol,4-(4-(o-methoxyphenyl)piperazinyl)-1-(3,4,5-trimethoxyphenyl)-, dihydrochloride 16785-29-8
1-Butanol,4-((3-(4-methoxyphenyl)-1,2,4-triazolo(3,4-a)phthalazin-6-yl)oxy)- 87540-58-7
2-Butanol,1-(3-methoxypropyl)amino-3-methyl-3-phenoxy- 7565-17-5
2-Butanol, 1-(3-methoxypropyl)amino-3-phenoxy- 7565-15-3
1-Butanol, 2-methyl- 137-32-6

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