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MSDS  : 1-Butanol, 2,2'-(1,2-ethanediyldiimino)bis-, (R)-
CAS  : 74-55-5
SYNONYMS  : * d,N,N'-Bis(1-hydroxymethylpropyl)ethylenediamine * Diambutol * EMB * Ethambutol * (+)-Ethambutol * d-Ethambutol * (+)-S,S-Ethambutol * (R)-2,2'-(1,2-Ethanediyldiimino)bis-1-butanol * (+)-2,2'-(Ethylenediimino)di-1-butanol * Tibutol
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : EL3640000
CHEMICAL NAME : 1-Butanol, 2,2'-(1,2-ethanediyldiimino)bis-, (R)-
CAS REGISTRY NUMBER : 74-55-5
LAST UPDATED : 199706
DATA ITEMS CITED : 8
MOLECULAR FORMULA : C10-H24-N2-O2
MOLECULAR WEIGHT : 204.36
WISWESSER LINE NOTATION : Q1Y2&M2MY2&1Q -D
COMPOUND DESCRIPTOR : Drug
Human
SYNONYMS/TRADE NAMES :
* d,N,N'-Bis(1-hydroxymethylpropyl)ethylenediamine
* Diambutol
* EMB
* Ethambutol
* (+)-Ethambutol
* d-Ethambutol
* (+)-S,S-Ethambutol
* (R)-2,2'-(1,2-Ethanediyldiimino)bis-1-butanol
* (+)-2,2'-(Ethylenediimino)di-1-butanol
* Tibutol

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - woman
DOSE/DURATION : 900 mg/kg/60D-I
TOXIC EFFECTS :
Liver - jaundice, cholestatic
REFERENCE :
BMJOAE British Medical Journal. (British Medical Assoc., BMA House,
Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year:
292,866,1986

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - man
DOSE/DURATION : 600 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - structural change in nerve or sheath
Behavioral - changes in motor activity (specific assay)
Kidney, Ureter, Bladder - other changes in urine composition
REFERENCE :
BMJOAE British Medical Journal. (British Medical Assoc., BMA House,
Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year:
2,1105,1976

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - man
DOSE/DURATION : 1200 mg/kg
TOXIC EFFECTS :
Skin and Appendages - dermatitis, other (after systemic exposure)
Immunological Including Allergic - anaphylaxis
REFERENCE :
BMJOAE British Medical Journal. (British Medical Assoc., BMA House,
Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year:
2,1105,1976

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 8700 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
DPHFAK Dissertationes Pharmaceuticae et Pharmacologicae. (Warsaw, Poland)
V.18-24, 1966-72. For publisher information, see PJPPAA.
Volume(issue)/page/year: 23,463,1971

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1075 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
DPHFAK Dissertationes Pharmaceuticae et Pharmacologicae. (Warsaw, Poland)
V.18-24, 1966-72. For publisher information, see PJPPAA.
Volume(issue)/page/year: 23,463,1971

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 240 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
DPHFAK Dissertationes Pharmaceuticae et Pharmacologicae. (Warsaw, Poland)
V.18-24, 1966-72. For publisher information, see PJPPAA.
Volume(issue)/page/year: 23,463,1971

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Mammal - species unspecified
DOSE/DURATION : 890 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
REFERENCE :
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon
Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho,
Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year:
63(3),114S,1967

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Mammal - species unspecified
DOSE/DURATION : 350 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
REFERENCE :
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon
Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho,
Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year:
63(3),114S,1967

*** END OF RECORD ***
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NAMECAS
1-Butanol, 4-((1,1-dimethylethyl)nitrosoamino)- 61734-87-0
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2-Butanol, 1,2-diphenyl-4-(methylamino)-3-methyl-,propionate (ester) 66796-40-5
2-Butanol, 1,2-diphenyl-3-methyl-4-(methylamino)-,propionate (ester) 3376-94-1
1-Butanol, 2,2-diphenyl-4-morpholino- 66859-69-6
1-Butanol, 3-(dipropylamino)-1,1-di(thien-3-yl)-,methiodide 17532-08-0
1-Butanol, 1,1-di(thien-3-yl)-3-morpholino-,hydrobromide 17532-12-6
1-Butanol, 1,1-di(thien-3-yl)-3-piperidino-,hydrobromide 17532-11-5
1-Butanol, 1,1-di(thien-3-yl)-3-pyrrolidino-,methiodide 17532-09-1
Butane, 2-iodo- 513-48-4
1-Butanol, 2,2'-(1,2-ethanediyldiimino)bis-, (R)- 74-55-5
1-Butanol, 4-ethoxy- 111-73-9
1-Butanol, 2-ethyl- 97-95-0
Butanol, 2,2'-(ethylenebis(nitrosoimino))bis- 65229-18-7
1-Butanol, 2,2'-(ethylenediimino)di-,dihydrochloride, (+)- 1070-11-7
1-Butanol, 2,2'-(ethylenediimino)di-,dihydrochloride, (+-)- 22196-75-4
1-Butanol, 2,2'-(ethylenediimino)di-,dihydrochloride, mixed with sodium nitrite (1:1) 22196-75-4
1-Butanol,4-(N-ethyl-N-(4-methoxy-alpha-methylphenethyl)amino)- 14367-47-6
1-Butanol, 4-(ethylnitrosoamino)- 54897-62-0
1-Butanol, 4-(N-ethyl-N-phenethylamino)- 66859-70-9
Butane, 1-iodo-3-methyl- 541-28-6
1-Butanol, 4-fluoro- 372-93-0
1-Butanol, 2,2,3,3,4,4,4-heptafluoro- 375-01-9
1-Butanol, 4,4'-(1,6-hexanediylbis(thio))bis(2-amino- 68704-89-2
2-Butanol, 3-(1-hexenyl-ONN-azoxy)-,(S-(R*,R*-(Z,E)))- 122547-71-1
Butanol, 4-((2-hydroxyethyl)nitrosoamino)- 62018-89-7
1-Butanol, 4-(N-(2-hydroxypropyl)-N-nitrosoamino)- 63934-41-8
1-Butanol, 4-(N-(3-hydroxypropyl)-N-nitrosoamino)- 62018-90-0
2-Butanol, 4-(N-(2-hydroxypropyl)-N-nitrosoamino)- 63934-40-7
1-Butanol,1-(N-(2-imidazolin-2-yl)-N-(2-(p-methoxyphenyl)-3-indolylmethyl)amino)-, hydriodide 77587-86-1
2-Butanol,2-(N-(2-imidazolin-2-yl)-N-(2-(p-methoxyphenyl)-3-indolylmethyl)amino)-, hydriodide 100482-45-9
Butane, 2-methoxy-2-methyl- 994-05-8
1-Butanol,1-(N-(2-imidazolin-2-yl)-N-(2-phenyl-3-indolylmethyl)amino)-, hydriodide 77587-78-1
1-Butanol, 2-(p-iodobenzyl)- 60075-61-8
1-Butanol, 3-(p-iodophenyl)- 60075-81-2
2-Butanol, 1-(isopropylamino)-4-phenyl-,hydrochloride 22820-57-1
1-Butanol, 4-methoxy- 111-32-0
1-Butanol, 3-methoxy-, acetate 4435-53-4
2-Butanol,1-(4-methoxybutyl)amino-3-methyl-3-phenoxy- 7565-18-6
2-Butanol, 1-(4-methoxybutyl)amino-3-phenoxy- 7614-42-8
2-Butanol,2-((2-methoxyethyl)amino)-3-methyl-3-phenoxy- 7584-78-3
2-Butanol, 1-(2-methoxyethyl)amino-3-phenoxy- 7565-14-2
Butane, 2-methyl- 78-78-4
2-Butanol, 4-methoxy-3-(1-octenyl-ONN-azoxy)-,(E,Z)-(2S,3S)- 23315-05-1
1-Butanol,4-(4-(o-methoxyphenyl)piperazinyl)-1-(3,4,5-trimethoxyphenyl)-, dihydrochloride 16785-29-8
1-Butanol,4-((3-(4-methoxyphenyl)-1,2,4-triazolo(3,4-a)phthalazin-6-yl)oxy)- 87540-58-7
2-Butanol,1-(3-methoxypropyl)amino-3-methyl-3-phenoxy- 7565-17-5
2-Butanol, 1-(3-methoxypropyl)amino-3-phenoxy- 7565-15-3
1-Butanol, 2-methyl- 137-32-6

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