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MSDS  : 1-Butanol, 4-(ethylnitrosoamino)-
CAS  : 54897-62-0
SYNONYMS  : * EHBN * N-Ethyl-N-(4-hydroxybutyl)nitrosoamine
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : EL3870000
CHEMICAL NAME : 1-Butanol, 4-(ethylnitrosoamino)-
CAS REGISTRY NUMBER : 54897-62-0
BEILSTEIN REFERENCE NO. : 2240539
LAST UPDATED : 199612
DATA ITEMS CITED : 11
MOLECULAR FORMULA : C6-H14-N2-O2
MOLECULAR WEIGHT : 146.22
WISWESSER LINE NOTATION : Q4N2&NO
COMPOUND DESCRIPTOR : Tumorigen
Mutagen
SYNONYMS/TRADE NAMES :
* EHBN
* N-Ethyl-N-(4-hydroxybutyl)nitrosoamine

*** HEALTH HAZARD DATA ***

** TUMORIGENIC DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 4375 mg/kg/20W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Kidney, Ureter, Bladder - tumors
REFERENCE :
GANNA2 Gann. Japanese Journal of Cancer Research. (Tokyo, Japan) V.1-75,
1907-84. For publisher information, see JJCREP. Volume(issue)/page/year:
67,175,1976

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 4900 mg/kg/14W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Kidney, Ureter, Bladder - tumors
REFERENCE :
GANNA2 Gann. Japanese Journal of Cancer Research. (Tokyo, Japan) V.1-75,
1907-84. For publisher information, see JJCREP. Volume(issue)/page/year:
72,647,1981

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - hamster
DOSE/DURATION : 24 gm/kg/20W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Kidney, Ureter, Bladder - tumors
REFERENCE :
GANNA2 Gann. Japanese Journal of Cancer Research. (Tokyo, Japan) V.1-75,
1907-84. For publisher information, see JJCREP. Volume(issue)/page/year:
67,175,1976

TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 59 gm/kg/20W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Kidney, Ureter, Bladder - tumors
REFERENCE :
GANNA2 Gann. Japanese Journal of Cancer Research. (Tokyo, Japan) V.1-75,
1907-84. For publisher information, see JJCREP. Volume(issue)/page/year:
67,825,1976

TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 5300 mg/kg/20W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Kidney, Ureter, Bladder - tumors
REFERENCE :
GANNA2 Gann. Japanese Journal of Cancer Research. (Tokyo, Japan) V.1-75,
1907-84. For publisher information, see JJCREP. Volume(issue)/page/year:
65,565,1974

TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 9800 mg/kg/14W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Kidney, Ureter, Bladder - tumors
REFERENCE :
GANNA2 Gann. Japanese Journal of Cancer Research. (Tokyo, Japan) V.1-75,
1907-84. For publisher information, see JJCREP. Volume(issue)/page/year:
72,647,1981

TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 7 gm/kg/120W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Kidney, Ureter, Bladder - tumors
REFERENCE :
GANNA2 Gann. Japanese Journal of Cancer Research. (Tokyo, Japan) V.1-75,
1907-84. For publisher information, see JJCREP. Volume(issue)/page/year:
67,175,1976

TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 7000 mg/kg/20W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Kidney, Ureter, Bladder - tumors
REFERENCE :
GANNA2 Gann. Japanese Journal of Cancer Research. (Tokyo, Japan) V.1-75,
1907-84. For publisher information, see JJCREP. Volume(issue)/page/year:
72,647,1981

TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 4704 mg/kg/20W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Kidney, Ureter, Bladder - tumors
REFERENCE :
GANNA2 Gann. Japanese Journal of Cancer Research. (Tokyo, Japan) V.1-75,
1907-84. For publisher information, see JJCREP. Volume(issue)/page/year:
72,539,1981

** MUTATION DATA **

TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 35 umol/plate
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
37,399,1977

*** STATUS IN U.S. ***

EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test


*** END OF RECORD ***
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NAMECAS
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1-Butanol, 2,2-diphenyl-4-morpholino- 66859-69-6
1-Butanol, 3-(dipropylamino)-1,1-di(thien-3-yl)-,methiodide 17532-08-0
1-Butanol, 1,1-di(thien-3-yl)-3-morpholino-,hydrobromide 17532-12-6
1-Butanol, 1,1-di(thien-3-yl)-3-piperidino-,hydrobromide 17532-11-5
1-Butanol, 1,1-di(thien-3-yl)-3-pyrrolidino-,methiodide 17532-09-1
Butane, 2-iodo- 513-48-4
1-Butanol, 2,2'-(1,2-ethanediyldiimino)bis-, (R)- 74-55-5
1-Butanol, 4-ethoxy- 111-73-9
1-Butanol, 2-ethyl- 97-95-0
Butanol, 2,2'-(ethylenebis(nitrosoimino))bis- 65229-18-7
1-Butanol, 2,2'-(ethylenediimino)di-,dihydrochloride, (+)- 1070-11-7
1-Butanol, 2,2'-(ethylenediimino)di-,dihydrochloride, (+-)- 22196-75-4
1-Butanol, 2,2'-(ethylenediimino)di-,dihydrochloride, mixed with sodium nitrite (1:1) 22196-75-4
1-Butanol,4-(N-ethyl-N-(4-methoxy-alpha-methylphenethyl)amino)- 14367-47-6
1-Butanol, 4-(ethylnitrosoamino)- 54897-62-0
1-Butanol, 4-(N-ethyl-N-phenethylamino)- 66859-70-9
Butane, 1-iodo-3-methyl- 541-28-6
1-Butanol, 4-fluoro- 372-93-0
1-Butanol, 2,2,3,3,4,4,4-heptafluoro- 375-01-9
1-Butanol, 4,4'-(1,6-hexanediylbis(thio))bis(2-amino- 68704-89-2
2-Butanol, 3-(1-hexenyl-ONN-azoxy)-,(S-(R*,R*-(Z,E)))- 122547-71-1
Butanol, 4-((2-hydroxyethyl)nitrosoamino)- 62018-89-7
1-Butanol, 4-(N-(2-hydroxypropyl)-N-nitrosoamino)- 63934-41-8
1-Butanol, 4-(N-(3-hydroxypropyl)-N-nitrosoamino)- 62018-90-0
2-Butanol, 4-(N-(2-hydroxypropyl)-N-nitrosoamino)- 63934-40-7
1-Butanol,1-(N-(2-imidazolin-2-yl)-N-(2-(p-methoxyphenyl)-3-indolylmethyl)amino)-, hydriodide 77587-86-1
2-Butanol,2-(N-(2-imidazolin-2-yl)-N-(2-(p-methoxyphenyl)-3-indolylmethyl)amino)-, hydriodide 100482-45-9
Butane, 2-methoxy-2-methyl- 994-05-8
1-Butanol,1-(N-(2-imidazolin-2-yl)-N-(2-phenyl-3-indolylmethyl)amino)-, hydriodide 77587-78-1
1-Butanol, 2-(p-iodobenzyl)- 60075-61-8
1-Butanol, 3-(p-iodophenyl)- 60075-81-2
2-Butanol, 1-(isopropylamino)-4-phenyl-,hydrochloride 22820-57-1
1-Butanol, 4-methoxy- 111-32-0
1-Butanol, 3-methoxy-, acetate 4435-53-4
2-Butanol,1-(4-methoxybutyl)amino-3-methyl-3-phenoxy- 7565-18-6
2-Butanol, 1-(4-methoxybutyl)amino-3-phenoxy- 7614-42-8
2-Butanol,2-((2-methoxyethyl)amino)-3-methyl-3-phenoxy- 7584-78-3
2-Butanol, 1-(2-methoxyethyl)amino-3-phenoxy- 7565-14-2
Butane, 2-methyl- 78-78-4
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1-Butanol,4-(4-(o-methoxyphenyl)piperazinyl)-1-(3,4,5-trimethoxyphenyl)-, dihydrochloride 16785-29-8
1-Butanol,4-((3-(4-methoxyphenyl)-1,2,4-triazolo(3,4-a)phthalazin-6-yl)oxy)- 87540-58-7
2-Butanol,1-(3-methoxypropyl)amino-3-methyl-3-phenoxy- 7565-17-5
2-Butanol, 1-(3-methoxypropyl)amino-3-phenoxy- 7565-15-3
1-Butanol, 2-methyl- 137-32-6

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