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MSDS  : o-Cresol, 4-((7-chloro-4-quinolyl)amino)-alpha-1-pyrrolidinyl-, dihydrochloride
CAS  : 10350-81-9
SYNONYMS  : * Amopyroquin dihydrochloride * 4-((7-Chloro-4-quinolyl)amino)-alpha-1-pyrrolidinyl-o-cresol dihydrochloride * Phenol, 4-((7-chloro-4-quinolinyl)amino)-2-(1-pyrrolidinylmethyl)-, dihydrochloride * Propoquin dihydrochloride
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : GO7350000
CHEMICAL NAME : o-Cresol,
4-((7-chloro-4-quinolyl)amino)-alpha-1-pyrrolidinyl-,
dihydrochloride
CAS REGISTRY NUMBER : 10350-81-9
OTHER CAS REGISTRY NOS. : 10449-05-5
LAST UPDATED : 199709
DATA ITEMS CITED : 8
MOLECULAR FORMULA : C20-H20-Cl-N3-O.2Cl-H
MOLECULAR WEIGHT : 426.80
WISWESSER LINE NOTATION : T66 BNJ IG EMR DQ C1- AT5NTJ &GH 2
COMPOUND DESCRIPTOR : Drug
SYNONYMS/TRADE NAMES :
* Amopyroquin dihydrochloride
* 4-((7-Chloro-4-quinolyl)amino)-alpha-1-pyrrolidinyl-o-cresol
dihydrochloride
* Phenol, 4-((7-chloro-4-quinolinyl)amino)-2-(1-pyrrolidinylmethyl)-,
dihydrochloride
* Propoquin dihydrochloride

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 410 mg/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay)
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC)
V.1-12, 1951-62. For publisher information, see CLMEA3.
Volume(issue)/page/year: 8,450,1958

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 34 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC)
V.1-12, 1951-62. For publisher information, see CLMEA3.
Volume(issue)/page/year: 8,450,1958

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 580 mg/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay)
Lungs, Thorax, or Respiration - dyspnea
Lungs, Thorax, or Respiration - other changes
REFERENCE :
ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC)
V.1-12, 1951-62. For publisher information, see CLMEA3.
Volume(issue)/page/year: 8,450,1958

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 35 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC)
V.1-12, 1951-62. For publisher information, see CLMEA3.
Volume(issue)/page/year: 8,450,1958

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Primate - monkey
DOSE/DURATION : 30 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
REFERENCE :
AJTHAB American Journal of Tropical Medicine and Hygiene. (Allen Press,
1041 New Hampshire St., Lawrence, KS 66044) V.1- 1952-
Volume(issue)/page/year: 6,987,1957

** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 36876 mg/kg/12W-C
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Nutritional and Gross Metabolic - dehydration
Related to Chronic Data - death
REFERENCE :
ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC)
V.1-12, 1951-62. For publisher information, see CLMEA3.
Volume(issue)/page/year: 8,450,1958

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 1320 mg/kg/2W-I
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Gastrointestinal - nausea or vomiting
Related to Chronic Data - death
REFERENCE :
ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC)
V.1-12, 1951-62. For publisher information, see CLMEA3.
Volume(issue)/page/year: 8,450,1958

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Primate - monkey
DOSE/DURATION : 120 mg/kg/16D-I
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
REFERENCE :
ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC)
V.1-12, 1951-62. For publisher information, see CLMEA3.
Volume(issue)/page/year: 8,450,1958

*** END OF RECORD ***
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NAMECAS
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o-Cresol, 4-bromo-6-methoxy-alpha-(phenethylamino)-,hydrochloride 68398-07-2
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o-Cresol, 4-chloro-alpha-phenyl- 120-32-1
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