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MSDS  : o-Cresol, 4-chloro-alpha-phenyl-
CAS  : 120-32-1
SYNONYMS  : * Benzylchlorophenol * o-Benzyl-p-chlorophenol * 2-Benzyl-4-chlorophenol * Bio-Clave * 5-Chloro-2-hydroxydiphenylmethane * Chlorophene * 4-Chloro-alpha-phenyl-o-cresol * 4-Chloro-2-(phenylmethyl)phenol * Clorofene * Clorophene * Ketolin-H * NCI-C61201 * Neosabenyl * Orthobenzyl-p-chlorophenol * Orthobenzylparachlorophenol * Phenol, 4-chloro-2-(phenylmethyl)- * Santophen * Santophen 1 * Santophen 1 flake * Santophen 1 solution * Santophen I * Santophen I germicide * Septiphene
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : GO7175000
CHEMICAL NAME : o-Cresol, 4-chloro-alpha-phenyl-
CAS REGISTRY NUMBER : 120-32-1
BEILSTEIN REFERENCE NO. : 1959194
REFERENCE : 4-06-00-04636 (Beilstein Handbook Reference)
LAST UPDATED : 199710
DATA ITEMS CITED : 30
MOLECULAR FORMULA : C13-H11-Cl-O
MOLECULAR WEIGHT : 218.69
WISWESSER LINE NOTATION : QR DG B1R
COMPOUND DESCRIPTOR : Agricultural Chemical
Tumorigen
Mutagen
SYNONYMS/TRADE NAMES :
* Benzylchlorophenol
* o-Benzyl-p-chlorophenol
* 2-Benzyl-4-chlorophenol
* Bio-Clave
* 5-Chloro-2-hydroxydiphenylmethane
* Chlorophene
* 4-Chloro-alpha-phenyl-o-cresol
* 4-Chloro-2-(phenylmethyl)phenol
* Clorofene
* Clorophene
* Ketolin-H
* NCI-C61201
* Neosabenyl
* Orthobenzyl-p-chlorophenol
* Orthobenzylparachlorophenol
* Phenol, 4-chloro-2-(phenylmethyl)-
* Santophen
* Santophen 1
* Santophen 1 flake
* Santophen 1 solution
* Santophen I
* Santophen I germicide
* Septiphene

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1700 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc.,
2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961-
Volume(issue)/page/year: 63,1068,1974

TYPE OF TEST : LC - Lethal concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >13200 mg/m3/6H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0520434

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 65 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
PHTXA6 Pharmacology and Toxicology. English translation of FATOAO. (New
York, NY) V.20-22, 1957-59. Discontinued. Volume(issue)/page/year:
22,270,1959

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 350 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
PHTXA6 Pharmacology and Toxicology. English translation of FATOAO. (New
York, NY) V.20-22, 1957-59. Discontinued. Volume(issue)/page/year:
22,270,1959

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 620 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0518161

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 5010 mg/kg
TOXIC EFFECTS :
Behavioral - muscle weakness
Liver - change in gall bladder structure or function
Blood - changes in spleen
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0520434

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 3 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0520317

** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 43680 mg/kg/2Y-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
acute tubular necrosis)
Kidney, Ureter, Bladder - changes in bladder weight
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year:
27,252,1995

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 12 gm/kg/2W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in both tubules and glomeruli
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year:
7,615,1986

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 31200 mg/kg/13W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in bladder weight
Endocrine - changes in thymus weight
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year:
7,615,1986

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 12 gm/kg/2W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in both tubules and glomeruli
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year:
7,615,1986

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 42250 mg/kg/13W-I
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in bladder weight
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year:
7,615,1986

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 87360 mg/kg/2Y-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
acute tubular necrosis)
Kidney, Ureter, Bladder - changes in bladder weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year:
27,252,1995

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 80 mL/kg/2W-I
TOXIC EFFECTS :
Skin and Appendages - dermatitis, other (after systemic exposure)
Related to Chronic Data - death
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0518161

** TUMORIGENIC DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 87600 mg/kg/2Y-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Kidney, Ureter, Bladder - Kidney tumors
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-424,1994

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 175 gm/kg/2Y-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Kidney, Ureter, Bladder - Kidney tumors
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-424,1994

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 14 gm/kg/34W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Skin and Appendages - tumors
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
19,413,1959

** MUTATION DATA **

TYPE OF TEST : Mutation in mammalian somatic cells
TEST SYSTEM : Human Lymphocyte
DOSE/DURATION : 40 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 196,61,1988

TYPE OF TEST : Mutation in mammalian somatic cells
TEST SYSTEM : Rodent - mouse Lymphocyte
DOSE/DURATION : 25 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 196,61,1988

*** U.S. STANDARDS AND REGULATIONS ***

EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year:
54,7740,1989

*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 11610
No. of Facilities: 11150 (estimated)
No. of Industries: 98
No. of Occupations: 56
No. of Employees: 236872 (estimated)

NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 11610
No. of Facilities: 8083 (estimated)
No. of Industries: 59
No. of Occupations: 71
No. of Employees: 347634 (estimated)
No. of Female Employees: 244212 (estimated)

*** STATUS IN U.S. ***

EPA TSCA Section 8(b) CHEMICAL INVENTORY

EPA TSCA Section 8(d) unpublished health/safety studies

EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9188;8EHQ-0892-9200

EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8880;8EHQ-0892-9226

EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9239;8EHQ-0892-9264

EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998

NTP Carcinogenesis studies (gavage);some evidence:mouse
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-424,94

NTP Carcinogenesis studies (gavage);equivocal evidence:rat
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-424,94


*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
NAMECAS
o-Cresol, 4-(p-aminophenylazo)-6-methyl- 21554-20-1
o-Cresol, 4-(2-aminopropyl)-, hydrobromide 21554-20-1
Coagulase 9001-13-2
o-Cresol, 4-(alpha-(2-aminopropyl)-p-hydroxybenzyl)- 13957-35-2
p-Cresol, 2-amino-alpha,alpha,alpha-trifluoro- 454-81-9
p-Cresol, 2-(2H-benzotriazol-2-yl)- 2440-22-4
o-Cresol, alpha,5-bis(dimethylamino)-,methylcarbamate (ester), dihydrochloride 2440-22-4
p-Cresol, 2,6-bis(alpha-methylbenzyl)- 1817-68-1
p-Cresol, 2-(exo-2-bornyl)- 1817-68-1
o-Cresol, 4-bromo- 2362-12-1
p-Cresol, 2-bromo- 6627-55-0
o-Cresol,4-bromo-alpha-(alpha,alpha-dimethylphenethylamino)-6-methoxy-, hydrochloride 68398-10-7
p-Cresol,3-bromo-alpha-(alpha,alpha-dimethylphenethylamino)-6-methoxy-, maleate 68397-84-2
Coagumin 68397-84-2
p-Cresol,3-bromo-5-methoxy-alpha-(alpha-methylphenethylamino)-, maleate 68397-86-4
o-Cresol, 4-bromo-6-methoxy-alpha-(phenethylamino)-,hydrochloride 68398-07-2
p-Cresol, 2-bromo-6-methoxy-alpha-(phenethylamino)-,hydrochloride 68398-03-8
o-Cresol, alpha-(p-bromophenylimino)- 886-34-0
m-Cresol, 6-butyl- 5736-70-9
p-Cresol, 2-tert-butyl- 2409-55-4
m-Cresol, 6-tert-butyl-4-chloro- 30894-16-7
o-Cresol,4-tert-butyl-6-chloro-alpha-(2,4-dichlorophenyl)- 23802-22-4
o-Cresol,4-tert-butyl-6-chloro-alpha-(3,4-dichlorophenyl)- 23843-04-1
o-Cresol, 4-sec-butyl-alpha-(p-chlorophenyl)- 23802-14-4
Coal conversion materials, SRC-II heavy distillate 23802-14-4
o-Cresol, 4-tert-butyl-alpha-(p-chlorophenyl)- 20121-09-9
o-Cresol, 4-tert-butyl-alpha-(2,4-dichlorophenyl)- 23802-18-8
o-Cresol, 4-sec-butyl-alpha-(3,4-dichlorophenyl)- 23802-21-3
o-Cresol, 4-tert-butyl-alpha-(3,4-dichlorophenyl)- 23802-20-2
m-Cresol, 4,4'-butylidenebis(6-tert-butyl- 85-60-9
m-Cresol, 6-tert-butyl-4-nitro- 72373-70-7
m-Cresol, 4-chloro- 59-50-7
o-Cresol, 4-chloro- 1570-64-5
o-Cresol, 6-chloro- 87-64-9
o-Cresol, 4-chloro-6-ethyl- 53346-75-1
Coal-derived complex organic mixtureSUBSTANCE DEFINITION :A high-boiling (288-454 degrees C) complexREFERENCE :FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year:13,662,1989 53346-75-1
o-Cresol, 4-chloro-6-ethyl-alpha-(methylimino)- 56911-71-8
m-Cresol, chlorohexyl- 56911-71-8
o-Cresol,4-((3-chloro-7-methoxy-9-acridinyl)amino)-alpha-(diethylamino)-, dihydrochloride 56911-71-8
o-Cresol, 4-chloro-alpha-(methylimino)- 49649-27-6
o-Cresol, 6-chloro-4-nitroso- 73791-20-5
o-Cresol, 4-chloro-alpha-phenyl- 120-32-1
o-Cresol,4-((7-chloro-4-quinolyl)amino)-alpha-(diethylamino)- 86-42-0
o-Cresol,4-((7-chloro-4-quinolyl)amino)-alpha-(diethylamino)-,dihydrochloride 69-44-3
o-Cresol,4-((7-chloro-4-quinolyl)amino)-alpha-1-pyrrolidinyl-,dihydrochloride 10350-81-9
o-Cresol, 4-chloro-alpha-(3,4-xylyl)- 6955-53-9
Coal dust 6955-53-9
o-Cresol, 4-cyclohexyl-alpha-(diethylamino)-,hydrochloride 106609-25-0
o-Cresol,4-cyclohexyl-alpha-(3,5-dimethylpiperidino)- 106609-24-9
p-Cresol,alpha-cyclohexylidene-alpha-(p-hydroxyphenyl)- 5189-40-2

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