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MSDS  : Cyclohexanecarbamic acid, 1,1-diphenyl-2-propynyl ester
CAS  : 10087-89-5
SYNONYMS  : * Carbamic acid, cyclohexyl-, 1,1-diphenyl-2-propynyl ester * 1,1-Diphenyl-2-propynyl-N-cyclohexylcarbamate * Enpromate * 2-Propyn-1-ol, 1,1-diphenyl-, cyclohexanecarbamate
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : GU7175000
CHEMICAL NAME : Cyclohexanecarbamic acid, 1,1-diphenyl-2-propynyl
ester
CAS REGISTRY NUMBER : 10087-89-5
BEILSTEIN REFERENCE NO. : 2669373
LAST UPDATED : 199612
DATA ITEMS CITED : 13
MOLECULAR FORMULA : C22-H23-N-O2
MOLECULAR WEIGHT : 333.46
WISWESSER LINE NOTATION : L6TJ AMVOXR&R&1U1
COMPOUND DESCRIPTOR : Tumorigen
Drug
Mutagen
SYNONYMS/TRADE NAMES :
* Carbamic acid, cyclohexyl-, 1,1-diphenyl-2-propynyl ester
* 1,1-Diphenyl-2-propynyl-N-cyclohexylcarbamate
* Enpromate
* 2-Propyn-1-ol, 1,1-diphenyl-, cyclohexanecarbamate

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GANMAX Gann Monograph. (Tokyo, Japan) No.1-10, 1966-71. For publisher
information, see GMCRDC. Volume(issue)/page/year: 2,261,1966

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 374 mg/kg
TOXIC EFFECTS :
Tumorigenic - active as anti-cancer agent
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc.,
Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
20037) V.6- 1963- Volume(issue)/page/year: 11,1155,1968

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : >250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GANMAX Gann Monograph. (Tokyo, Japan) No.1-10, 1966-71. For publisher
information, see GMCRDC. Volume(issue)/page/year: 2,261,1966

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Primate - monkey
DOSE/DURATION : >250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GANMAX Gann Monograph. (Tokyo, Japan) No.1-10, 1966-71. For publisher
information, see GMCRDC. Volume(issue)/page/year: 2,261,1966

** TUMORIGENIC DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1690 mg/kg/27W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Gastrointestinal - tumors
Skin and Appendages - tumors
REFERENCE :
PAACA3 Proceedings of the American Association for Cancer Research. (Waverly
Press, 428 E. Preston St., Baltimore, MD 21202) V.1- 1954-
Volume(issue)/page/year: 10,35,1969

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 31500 mg/kg/67W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Cardiac - tumors
REFERENCE :
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC)
V.61-79, 1978-87. For publisher information, see JNCIEQ.
Volume(issue)/page/year: 71,211,1983

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1925 mg/kg/11W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Gastrointestinal - tumors
Skin and Appendages - tumors
REFERENCE :
PAACA3 Proceedings of the American Association for Cancer Research. (Waverly
Press, 428 E. Preston St., Baltimore, MD 21202) V.1- 1954-
Volume(issue)/page/year: 10,35,1969

TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 13600 mg/kg/40W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Cardiac - tumors
Gastrointestinal - tumors
REFERENCE :
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC)
V.61-79, 1978-87. For publisher information, see JNCIEQ.
Volume(issue)/page/year: 71,211,1983

** MUTATION DATA **

TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 100 ug/plate
REFERENCE :
PNASA6 Proceedings of the National Academy of Sciences of the United States
of America. (National Academy of Sciences, Printing & Pub. Office, 2101
Constitution Ave., Washington, DC 20418) V.1- 1915-
Volume(issue)/page/year: 72,5135,1975

TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Human Fibroblast
DOSE/DURATION : 10 umol/L/90M
REFERENCE :
IJCNAW International Journal of Cancer. (International Union Against
Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland) V.1- 1966-
Volume(issue)/page/year: 16,284,1975

TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Rodent - rat Liver
DOSE/DURATION : 10 umol/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 3,11,1981

*** STATUS IN U.S. ***

EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test

EPA GENETOX PROGRAM 1988, Inconclusive: In vitro UDS-human fibroblast


*** END OF RECORD ***
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