*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : GU7175000
CHEMICAL NAME : Cyclohexanecarbamic acid, 1,1-diphenyl-2-propynyl
ester
CAS REGISTRY NUMBER : 10087-89-5
BEILSTEIN REFERENCE NO. : 2669373
LAST UPDATED : 199612
DATA ITEMS CITED : 13
MOLECULAR FORMULA : C22-H23-N-O2
MOLECULAR WEIGHT : 333.46
WISWESSER LINE NOTATION : L6TJ AMVOXR&R&1U1
COMPOUND DESCRIPTOR : Tumorigen
Drug
Mutagen
SYNONYMS/TRADE NAMES :
* Carbamic acid, cyclohexyl-, 1,1-diphenyl-2-propynyl ester
* 1,1-Diphenyl-2-propynyl-N-cyclohexylcarbamate
* Enpromate
* 2-Propyn-1-ol, 1,1-diphenyl-, cyclohexanecarbamate
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GANMAX Gann Monograph. (Tokyo, Japan) No.1-10, 1966-71. For publisher
information, see GMCRDC. Volume(issue)/page/year: 2,261,1966
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 374 mg/kg
TOXIC EFFECTS :
Tumorigenic - active as anti-cancer agent
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc.,
Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
20037) V.6- 1963- Volume(issue)/page/year: 11,1155,1968
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : >250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GANMAX Gann Monograph. (Tokyo, Japan) No.1-10, 1966-71. For publisher
information, see GMCRDC. Volume(issue)/page/year: 2,261,1966
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Primate - monkey
DOSE/DURATION : >250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GANMAX Gann Monograph. (Tokyo, Japan) No.1-10, 1966-71. For publisher
information, see GMCRDC. Volume(issue)/page/year: 2,261,1966
** TUMORIGENIC DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1690 mg/kg/27W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Gastrointestinal - tumors
Skin and Appendages - tumors
REFERENCE :
PAACA3 Proceedings of the American Association for Cancer Research. (Waverly
Press, 428 E. Preston St., Baltimore, MD 21202) V.1- 1954-
Volume(issue)/page/year: 10,35,1969
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 31500 mg/kg/67W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Cardiac - tumors
REFERENCE :
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC)
V.61-79, 1978-87. For publisher information, see JNCIEQ.
Volume(issue)/page/year: 71,211,1983
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1925 mg/kg/11W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Gastrointestinal - tumors
Skin and Appendages - tumors
REFERENCE :
PAACA3 Proceedings of the American Association for Cancer Research. (Waverly
Press, 428 E. Preston St., Baltimore, MD 21202) V.1- 1954-
Volume(issue)/page/year: 10,35,1969
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 13600 mg/kg/40W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Cardiac - tumors
Gastrointestinal - tumors
REFERENCE :
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC)
V.61-79, 1978-87. For publisher information, see JNCIEQ.
Volume(issue)/page/year: 71,211,1983
** MUTATION DATA **
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 100 ug/plate
REFERENCE :
PNASA6 Proceedings of the National Academy of Sciences of the United States
of America. (National Academy of Sciences, Printing & Pub. Office, 2101
Constitution Ave., Washington, DC 20418) V.1- 1915-
Volume(issue)/page/year: 72,5135,1975
TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Human Fibroblast
DOSE/DURATION : 10 umol/L/90M
REFERENCE :
IJCNAW International Journal of Cancer. (International Union Against
Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland) V.1- 1966-
Volume(issue)/page/year: 16,284,1975
TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Rodent - rat Liver
DOSE/DURATION : 10 umol/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 3,11,1981
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Inconclusive: In vitro UDS-human fibroblast
*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
| NAME | CAS |
Cyclohexane, 1,2,3,4,5,6-hexachloro-, alpha-isomer
| 319-84-6 |
Cyclohexane, 1,2,3,4,5,6-hexachloro-, beta-isomer
| 319-85-7 |
Cyclohexane, 1,2,3,4,5,6-hexachloro-, delta-isomer
| 319-86-8 |
Cyclohexane, 1,2,3,4,5,6-hexachloro-, gamma-isomer
| 58-89-9 |
Cyclohexane, 1,2,3,4,5,6-hexachloro-, (mixed isomers)
| 58-89-9 |
Cyclohexane, hexadecafluorodimethyl-
| 26637-68-3 |
Cyclohexanecarbamic acid, 2-(diethylamino)ethylester, monohydrochloride
| 26637-68-3 |
Cyclohexane, 1,2,3,4,5,6-hexakis(2-cyanoethoxy)-
| 3055-84-3 |
Cyclohexanehydracrylic acid, alpha-phenyl-,2-(diethylamino)ethyl ester, hydrochloride
| 7477-25-0 |
Cyclohexanemethanol
| 100-49-2 |
Cyclohexanemethanol,alpha-(1-aminoethyl)-alpha-phenyl-, hydrochloride
| 100-49-2 |
Cyclohexanemethanol, alpha-(p-chlorophenyl)-
| 106165-42-8 |
Cyclohexanemethanol, alpha-(1,2-diaminoethyl)-,dihydrochloride, (+-)-
| 106165-42-8 |
Cyclohexanemethanol,alpha-(4-(diethylamino)-1-butynyl)-alpha-phenyl-,hydrochloride
| 4069-27-6 |
Cyclohexanemethanol,alpha-(1-(diethylamino)ethyl)-alpha-phenyl-,hydrochloride
| 4069-27-6 |
Cyclohexanemethanol,alpha-(2-(diethylamino)ethyl)-alpha-phenyl-,hydrochloride
| 13562-21-5 |
Cyclohexanemethanol,alpha-((diethylamino)phenylmethyl)-alpha-phenyl-,hydrochloride
| 13562-21-5 |
Cyclohexanecarbamic acid, 1,1-diphenyl-2-butynylester
| 20930-10-3 |
Cyclohexanemethanol,alpha-(1-(diethylamino)propyl)-alpha-phenyl-,hydrochloride
| 20930-10-3 |
Cyclohexanemethanol,alpha-(3-(diethylamino)-1-propynyl)-alpha-phenyl-,hydrochloride
| 20930-10-3 |
Cyclohexanemethanol,2-(dimethylamino)-alpha,alpha-diphenyl-,hydrochloride
| 20930-10-3 |
Cyclohexanemethanol,3-(dimethylamino)-alpha,alpha-diphenyl-,hydrochloride
| 20930-10-3 |
Cyclohexanemethanol,alpha-(2-(dimethylamino)ethyl)-alpha-phenyl-
| 24252-48-0 |
1,4-Cyclohexanemethanol, divinyl ester
| 17351-75-6 |
Cyclohexanemethanol, alpha-ethynyl-, acetate
| 16169-86-1 |
Cyclohexanemethanol, alpha-ethynyl-, carbamate
| 41416-61-9 |
Cyclohexanemethanol, alpha-ethynyl-4-phenyl-,carbamate, (E)-
| 41416-60-8 |
Cyclohexanemethanol, alpha-(1-hydrazinoethyl)-,hemisulfate (salt)
| 41416-60-8 |
Cyclohexanecarbamic acid, 1,1-diphenyl-2-propynylester
| 10087-89-5 |
Cyclohexanemethanol,4-hydroxy-alpha-(isopropylaminomethyl)-
| 63980-63-2 |
Cyclohexanemethanol,4-hydroxy-alpha-(methylaminomethyl)-
| 63918-84-3 |
Cyclohexanemethanol, alpha-methyl-
| 1193-81-3 |
Cyclohexanemethanol,alpha-(1-methylaminoethyl)-alpha-phenyl-,hydrochloride, DL-
| 1193-81-3 |
Cyclohexanemethanol, alpha-(methylaminomethyl)-
| 21581-48-6 |
Cyclohexanemethanol,alpha-(1-(1-methylhydrazino)ethyl)-, sulfate (2:1)(salt)
| 21581-48-6 |
Cyclohexanemethanol,alpha-(3-morpholino-1-propynyl)-alpha-phenyl-,hydrochloride
| 21581-48-6 |
Cyclohexanemethanol, 1-phenyl-
| 68692-77-3 |
Cyclohexanemethanol, alpha-phenyl-2-piperidino-,acetate, hydrochloride
| 101564-31-2 |
Cyclohexanemethanol, alpha-phenyl-1-piperidino-,hydrochloride
| 101564-32-3 |
Cyclohexanecarbamic acid, N-ethylthio-, S-ethyl ester
| 1134-23-2 |
Cyclohexanemethanol,alpha-phenyl-alpha-(3-piperidino-1-propynyl)-,hydrochloride
| 2269-28-5 |
Cyclohexanemethanol,alpha-phenyl-alpha-(3-(1-pyrrolidinyl)-1-propynyl)-,hydrochloride
| 2269-28-5 |
Cyclohexanemethanol, alpha-((2-pyridylamino)methyl)-,hydrochloride
| 1020-19-5 |
Cyclohexane, methyl-
| 108-87-2 |
Cyclohexanemethylamine
| 3218-02-8 |
Cyclohexanemethylamine,4-(4-aminophenyl)-alpha-methyl-, oxalate, hydrate(2:2:1), (E)-
| 113524-37-1 |
Cyclohexanemethylamine, alpha-benzyl-N,N-dimethyl-,hydrochloride
| 113524-37-1 |
Cyclohexanemethylamine,4-(4-bromophenyl)-alpha-methyl-, hydrochloride, (E)-
| 113524-38-2 |
Cyclohexanemethylamine,N-(2-chloroethyl)-N-ethyl-1-phenyl-, hydrochloride
| 101564-53-8 |
Cyclohexanemethylamine, 2-chloro-2-(m-methoxyphenyl)-
| 73806-38-9 |
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