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MSDS  : Cyclohexane, 1,2,3,4,5,6-hexachloro-, (mixed isomers)
CAS  : 58-89-9
SYNONYMS  : * Benzahex * Benzenehexachloride, mixed isomers * Benzex * FBHC * FHCH * 1,2,3,4,5,6-Hexachlorocyclohexane (mixture of isomers) * Hexafor * Kotol * Soprocide * Technical BHC * Technical HCH
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : GV4950000
CHEMICAL NAME : Cyclohexane, 1,2,3,4,5,6-hexachloro-, (mixed isomers)
LAST UPDATED : 199806
DATA ITEMS CITED : 18
MOLECULAR FORMULA : C6-H6-Cl6
MOLECULAR WEIGHT : 290.82
WISWESSER LINE NOTATION : L6TJ AG BG CG DG EG FG
COMPOUND DESCRIPTOR : Tumorigen
Reproductive Effector
Human
SYNONYMS/TRADE NAMES :
* Benzahex
* Benzenehexachloride, mixed isomers
* Benzex
* FBHC
* FHCH
* 1,2,3,4,5,6-Hexachlorocyclohexane (mixture of isomers)
* Hexafor
* Kotol
* Soprocide
* Technical BHC
* Technical HCH

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Human - man
DOSE/DURATION : 643 ug/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
CMEP** "Clinical Memoranda on Economic Poisons," U.S. Dept. HEW, Public
Health Service, Communicable Disease Center, Atlanta, GA, 1956
Volume(issue)/page/year: -,1,1956

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects,
GKNT, 1982 Volume(issue)/page/year: -,73,1982

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 4348 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Lungs, Thorax, or Respiration - dyspnea
Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
VHTODE Veterinary and Human Toxicology. (American College of Veterinary and
Comparative Toxicology, Publication Office, Comparative Toxicology,
Manhattan, KS 66506) V.19- 1977- Volume(issue)/page/year: 31,113,1989

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects,
GKNT, 1982 Volume(issue)/page/year: -,73,1982

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - cat
DOSE/DURATION : 300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects,
GKNT, 1982 Volume(issue)/page/year: -,73,1982

TYPE OF TEST : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Mammal - cat
DOSE/DURATION : 20 mg/m3/6H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects,
GKNT, 1982 Volume(issue)/page/year: -,73,1982

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 1362 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Lungs, Thorax, or Respiration - dyspnea
Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
VHTODE Veterinary and Human Toxicology. (American College of Veterinary and
Comparative Toxicology, Publication Office, Comparative Toxicology,
Manhattan, KS 66506) V.19- 1977- Volume(issue)/page/year: 31,113,1989

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 1494 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Lungs, Thorax, or Respiration - dyspnea
Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
VHTODE Veterinary and Human Toxicology. (American College of Veterinary and
Comparative Toxicology, Publication Office, Comparative Toxicology,
Manhattan, KS 66506) V.19- 1977- Volume(issue)/page/year: 31,113,1989

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Bird - pigeon
DOSE/DURATION : 3732 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Lungs, Thorax, or Respiration - dyspnea
Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
VHTODE Veterinary and Human Toxicology. (American College of Veterinary and
Comparative Toxicology, Publication Office, Comparative Toxicology,
Manhattan, KS 66506) V.19- 1977- Volume(issue)/page/year: 31,113,1989

** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 4860 mg/kg/90D-C
TOXIC EFFECTS :
Liver - changes in liver weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 10,271,1978

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 8736 mg/kg/26W-C
TOXIC EFFECTS :
Liver - changes in liver weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - death
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 100,59,1950

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 3 gm/kg/30D-I
TOXIC EFFECTS :
Liver - fatty liver degeneration
Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
acute tubular necrosis)
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - true cholinesterase
REFERENCE :
IJEBA6 Indian Journal of Experimental Biology. (Publications & Information
Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
Volume(issue)/page/year: 29,149,1991

** TUMORIGENIC DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 13 gm/kg/24W-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Liver - tumors
REFERENCE :
GANNA2 Gann. Japanese Journal of Cancer Research. (Tokyo, Japan) V.1-75,
1907-84. For publisher information, see JJCREP. Volume(issue)/page/year:
62,431,1971

TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 11 gm/kg/26W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Liver - tumors
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 19,31,1981

** REPRODUCTIVE DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rat
DOSE : 6 gm/kg
SEX/DURATION : male 17 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
sperm morphology, motility, and count)
Reproductive - Paternal Effects - other effects on male
REFERENCE :
HETOEA Human & Experimental Toxicology. (Macmillan Press Ltd., Brunel Road,
Houndmills, Basingstoke, Hampshire, RG21 2XS, UK) V.9- 1990-
Volume(issue)/page/year: 14,484,1995

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE : 350 mg/kg
SEX/DURATION : female 6-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
Volume(issue)/page/year: 40,105,1993

*** REVIEWS ***

IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 20,195,1979

IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 5,47,1974


*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
NAMECAS
Cyclohexane, 1,2,3,4,5,6-hexachloro-, alpha-isomer 319-84-6
Cyclohexane, 1,2,3,4,5,6-hexachloro-, beta-isomer 319-85-7
Cyclohexane, 1,2,3,4,5,6-hexachloro-, delta-isomer 319-86-8
Cyclohexane, 1,2,3,4,5,6-hexachloro-, gamma-isomer 58-89-9
Cyclohexane, 1,2,3,4,5,6-hexachloro-, (mixed isomers) 58-89-9
Cyclohexane, hexadecafluorodimethyl- 26637-68-3
Cyclohexanecarbamic acid, 2-(diethylamino)ethylester, monohydrochloride 26637-68-3
Cyclohexane, 1,2,3,4,5,6-hexakis(2-cyanoethoxy)- 3055-84-3
Cyclohexanehydracrylic acid, alpha-phenyl-,2-(diethylamino)ethyl ester, hydrochloride 7477-25-0
Cyclohexanemethanol 100-49-2
Cyclohexanemethanol,alpha-(1-aminoethyl)-alpha-phenyl-, hydrochloride 100-49-2
Cyclohexanemethanol, alpha-(p-chlorophenyl)- 106165-42-8
Cyclohexanemethanol, alpha-(1,2-diaminoethyl)-,dihydrochloride, (+-)- 106165-42-8
Cyclohexanemethanol,alpha-(4-(diethylamino)-1-butynyl)-alpha-phenyl-,hydrochloride 4069-27-6
Cyclohexanemethanol,alpha-(1-(diethylamino)ethyl)-alpha-phenyl-,hydrochloride 4069-27-6
Cyclohexanemethanol,alpha-(2-(diethylamino)ethyl)-alpha-phenyl-,hydrochloride 13562-21-5
Cyclohexanemethanol,alpha-((diethylamino)phenylmethyl)-alpha-phenyl-,hydrochloride 13562-21-5
Cyclohexanecarbamic acid, 1,1-diphenyl-2-butynylester 20930-10-3
Cyclohexanemethanol,alpha-(1-(diethylamino)propyl)-alpha-phenyl-,hydrochloride 20930-10-3
Cyclohexanemethanol,alpha-(3-(diethylamino)-1-propynyl)-alpha-phenyl-,hydrochloride 20930-10-3
Cyclohexanemethanol,2-(dimethylamino)-alpha,alpha-diphenyl-,hydrochloride 20930-10-3
Cyclohexanemethanol,3-(dimethylamino)-alpha,alpha-diphenyl-,hydrochloride 20930-10-3
Cyclohexanemethanol,alpha-(2-(dimethylamino)ethyl)-alpha-phenyl- 24252-48-0
1,4-Cyclohexanemethanol, divinyl ester 17351-75-6
Cyclohexanemethanol, alpha-ethynyl-, acetate 16169-86-1
Cyclohexanemethanol, alpha-ethynyl-, carbamate 41416-61-9
Cyclohexanemethanol, alpha-ethynyl-4-phenyl-,carbamate, (E)- 41416-60-8
Cyclohexanemethanol, alpha-(1-hydrazinoethyl)-,hemisulfate (salt) 41416-60-8
Cyclohexanecarbamic acid, 1,1-diphenyl-2-propynylester 10087-89-5
Cyclohexanemethanol,4-hydroxy-alpha-(isopropylaminomethyl)- 63980-63-2
Cyclohexanemethanol,4-hydroxy-alpha-(methylaminomethyl)- 63918-84-3
Cyclohexanemethanol, alpha-methyl- 1193-81-3
Cyclohexanemethanol,alpha-(1-methylaminoethyl)-alpha-phenyl-,hydrochloride, DL- 1193-81-3
Cyclohexanemethanol, alpha-(methylaminomethyl)- 21581-48-6
Cyclohexanemethanol,alpha-(1-(1-methylhydrazino)ethyl)-, sulfate (2:1)(salt) 21581-48-6
Cyclohexanemethanol,alpha-(3-morpholino-1-propynyl)-alpha-phenyl-,hydrochloride 21581-48-6
Cyclohexanemethanol, 1-phenyl- 68692-77-3
Cyclohexanemethanol, alpha-phenyl-2-piperidino-,acetate, hydrochloride 101564-31-2
Cyclohexanemethanol, alpha-phenyl-1-piperidino-,hydrochloride 101564-32-3
Cyclohexanecarbamic acid, N-ethylthio-, S-ethyl ester 1134-23-2
Cyclohexanemethanol,alpha-phenyl-alpha-(3-piperidino-1-propynyl)-,hydrochloride 2269-28-5
Cyclohexanemethanol,alpha-phenyl-alpha-(3-(1-pyrrolidinyl)-1-propynyl)-,hydrochloride 2269-28-5
Cyclohexanemethanol, alpha-((2-pyridylamino)methyl)-,hydrochloride 1020-19-5
Cyclohexane, methyl- 108-87-2
Cyclohexanemethylamine 3218-02-8
Cyclohexanemethylamine,4-(4-aminophenyl)-alpha-methyl-, oxalate, hydrate(2:2:1), (E)- 113524-37-1
Cyclohexanemethylamine, alpha-benzyl-N,N-dimethyl-,hydrochloride 113524-37-1
Cyclohexanemethylamine,4-(4-bromophenyl)-alpha-methyl-, hydrochloride, (E)- 113524-38-2
Cyclohexanemethylamine,N-(2-chloroethyl)-N-ethyl-1-phenyl-, hydrochloride 101564-53-8
Cyclohexanemethylamine, 2-chloro-2-(m-methoxyphenyl)- 73806-38-9

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