*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : AS3676000
CHEMICAL NAME : Acrylamide, N-methyl-
CAS REGISTRY NUMBER : 1187-59-3
BEILSTEIN REFERENCE NO. : 1737696
REFERENCE : 4-04-00-00189 (Beilstein Handbook Reference)
LAST UPDATED : 199701
DATA ITEMS CITED : 11
MOLECULAR FORMULA : C4-H7-N-O
MOLECULAR WEIGHT : 85.12
WISWESSER LINE NOTATION : 1U1VM1
COMPOUND DESCRIPTOR : Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* N-Methylacrylamide
* N-Methyl-2-propenamide
* 2-Propenamide, N-methyl-
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 476 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NEZAAQ Nippon Eiseigaku Zasshi. Japanese Journal of Hygiene. (Nippon Eisei
Gakkai, c/o Kyoto Daigaku Igakubu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606,
Japan) V.1- 1946- Volume(issue)/page/year: 34,183,1979
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 477 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000
Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year:
47,179,1981
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 6500 mg/kg/13W-I
TOXIC EFFECTS :
Peripheral Nerve and Sensation - structural change in nerve or sheath
Autonomic Nervous System - other (direct) parasympathomimetic
Behavioral - muscle weakness
REFERENCE :
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 3,153,1983
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 4988 mg/kg/18W-C
TOXIC EFFECTS :
Behavioral - muscle weakness
REFERENCE :
BJIMAG British Journal of Industrial Medicine. (British Medical Journal,
Box 560B, Kennebunkport, ME 04046) V.1- 1944- Volume(issue)/page/year:
27,147,1970
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 2587 mg/kg/8W-I
TOXIC EFFECTS :
Related to Chronic Data - changes in testicular weight
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000
Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year:
47,179,1981
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE : 2544 mg/kg
SEX/DURATION : male 16 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000
Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year:
47,179,1981
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE : 595 gm/kg
SEX/DURATION : male 5 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
sperm morphology, motility, and count)
Reproductive - Paternal Effects - testes, epididymis, sperm duct
Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland,
accessory glands
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000
Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year:
59,201,1986
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE : 595 gm/kg
SEX/DURATION : male 5 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - male fertility index (e.g. # males impregnating
females per # males exposed to fertile nonpregnant females)
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000
Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year:
59,201,1986
** MUTATION DATA **
TYPE OF TEST : Sperm Morphology
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 596 mg/kg/5W (Continuous)
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000
Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year:
59,201,1986
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X1046
No. of Facilities: 122 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 367 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
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Acrolein, 2,3-dichloro-, (E,Z)-
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Acrolein, 3,3-dichloro-2-(dichloromethyl)-
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Acrolein, 3-ethoxy-
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Acrolein, beta-hydroxy-, sodium salt
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Acrolein, 3-(p-nitrophenoxy)-
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Acrolein, 3,3'-oxydi-
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Acrolein phenylhydrazone
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9-Acridinamine, 1,2,3,4-tetrahydro-N-cycloheptyl-
| 113106-23-3 |
Acrolein, 2,3,3-trichloro-
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Acronycine, nitro-
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| 99020-76-5 |
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| 99020-76-5 |
Acroylamide, trichloro-
| 3880-18-0 |
Acrylamide
| 79-06-1 |
Acrylamide, 2,3-bis(2-furyl)-
| 101952-44-7 |
Acrylamide, N-(3-bromopropionamidomethyl)-
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Acrylamide, N-butoxymethyl-
| 1852-16-0 |
Acrylamide, N-tert-butyl-
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Acridan, 10-(2-(dimethylamino)ethyl)-, hydrochloride
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9-Acridinamine, 1,2,3,4-tetrahydro-N-cyclohexyl-,monohydrochloride
| 113106-04-0 |
Acrylamide, 2-cyano-3,3-dimercapto-, disodium salt
| 7341-00-6 |
Acrylamide, N,N-diethyl-
| 2675-94-7 |
Acrylamide, N-(1,1-dimethyl-3-oxobutyl)-
| 2873-97-4 |
Acrylamide, N-(4-(3-ethoxy-2-hydroxypropoxy)phenyl)-
| 2873-97-4 |
Acrylamide, N-(fluoren-2-yl)-
| 60550-89-2 |
Acrylamide, N-(2-fluorenyl)-2-methyl-
| 60550-95-0 |
Acrylamide,3-formyl-N-(5-propyl-1,3,4-thiadiazol-2-yl)-, (E)-
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Acrylamide, 2-(2-furyl)-3-(5-nitro-2-furyl)-
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Acrylamide, 2-(2-furyl)-3-(5-nitro-2-furyl)- (E)-
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Acrylamide, 3-hydroxyiminoacetamido-
| 2508-65-8 |
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Acrylamide, N-(hydroxymethyl)-
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Acrylamide, N-(isobutoxymethyl)-
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Acrylamide, N-isopropyl-
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Acrylamide, N-methyl-
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Acrylamide, N,N'-methylenebis-
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Acrylamide, 3-(2-(methyl-aci-nitro)acetamido)-
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Acrylamide, polymers
| 9003-05-8 |
Acrylamidine, hydrochloride
| 9003-05-8 |
Acrylanilide,4'-(2-chloroethylthio)-3-(5-nitro-2-furyl)-
| 64046-89-5 |
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