*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : MD2025000
CHEMICAL NAME : Glycyrrhizinic acid
CAS REGISTRY NUMBER : 1405-86-3
BEILSTEIN REFERENCE NO. : 0077922
REFERENCE : 4-18-00-05156 (Beilstein Handbook Reference)
LAST UPDATED : 199706
DATA ITEMS CITED : 10
MOLECULAR FORMULA : C42-H62-O16
MOLECULAR WEIGHT : 823.04
COMPOUND DESCRIPTOR : Drug
Mutagen
Human
SYNONYMS/TRADE NAMES :
* Glycyron
* Glycyrrhetinic acid glycoside
* Glycyrrhizic acid
* 18-beta-Glycyrrhizic acid
* Glycyrrhizin
* beta-Glycyrrhizin
* Liquorice
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human
DOSE/DURATION : 280 mg/kg/4W
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Nutritional and Gross Metabolic - changes in phosphorus
REFERENCE :
BMJOAE British Medical Journal. (British Medical Assoc., BMA House,
Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year:
1,488,1977
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - man
DOSE/DURATION : 662 mg/kg/1Y-I
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - muscle weakness
Nutritional and Gross Metabolic - changes in potassium
REFERENCE :
IEDIEP Internal Medicine. (The Japanese Society of Internal Medicine, 34-3,
3-chome, Hongo, Bunkyo-ku, Tokyo 113, Japan) V.31- 1992-
Volume(issue)/page/year: 31,708,1992
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 3 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 5,2041,1977
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 5,2041,1977
TYPE OF TEST : LD - Lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 5,2041,1977
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 4320 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - respiratory stimulation
Lungs, Thorax, or Respiration - other changes
REFERENCE :
ZYZAEU Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. (China
International Book Trading Corp., POB 2820, Beijing, Peop. China) V.24-
1989- Volume(issue)/page/year: 28,215,1993
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 5,2041,1977
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 589 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - respiratory stimulation
Lungs, Thorax, or Respiration - other changes
REFERENCE :
ZYZAEU Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. (China
International Book Trading Corp., POB 2820, Beijing, Peop. China) V.24-
1989- Volume(issue)/page/year: 28,215,1993
** MUTATION DATA **
TYPE OF TEST : Micronucleus test
TEST SYSTEM : Rodent - hamster Ovary
DOSE/DURATION : 100 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 367,99,1996
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
| NAME | CAS |
Glycols, polyethylene-polypropylene, pluronic F68
| 9003-11-6 |
Glycols, polythylene-polypropylene, pluronic L44
| 9003-11-6 |
Glycols, polyethylene-polypropylene, pluronic L62
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Glycols, polyethylene-polypropylene, pluronic L64
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Glycols, polyethylene-polypropylene, pluronic L-81
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Glycine, 1,1'-(1,7-dioxo-1,7-heptanediyl)bis(glycyl-
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Glycols, polyethylene-polypropylene, poloxamer-188
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Glycols, polyethylene-polypropylene, RC 102
| 9003-11-6 |
Glycols, polypropylene, bis(2-aminopropyl) ether, DA200SUBSTANCE DEFINITION :With a molecular weight of 200REFERENCE :GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene andOccupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)V.1-36, 1957-1992. For publisher information, see MTPEEI
| 9003-11-6 |
Glycols, polypropylene, bis(2-aminopropyl) ether,DA-500SUBSTANCE DEFINITION :With a molecular weight of 500REFERENCE :GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/OMezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
| 9003-11-6 |
Glycols, polypropylene, bis(2-aminopropyl) ether, DA1000SUBSTANCE DEFINITION :With a molecular weight of 1000REFERENCE :GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene andOccupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)V.1-36, 1957-1992. For publisher information, see MTPEEI
| 9003-11-6 |
Glycols, polypropylene, 1,2,3-propanetriyl ether
| 25791-96-2 |
Glycols, polypropylene, tris(2-aminopropyl) ether,TA750SUBSTANCE DEFINITION :With a molecular weight of 750REFERENCE :GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene andOccupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)V.1-36, 1957-1992. For publisher information, see MTPEEI
| 25791-96-2 |
Glycols, polypropylene, tris(2-aminopropyl) ether,TA-1100SUBSTANCE DEFINITION :With a molecular weight of 1100REFERENCE :GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/OMezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
| 25791-96-2 |
Glycols, polypropylene, tris(2-aminopropyl) ether,TA1500SUBSTANCE DEFINITION :With a molecular weight of 1500REFERENCE :GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene andOccupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)V.1-36, 1957-1992. For publisher information, see MTPEEI
| 25791-96-2 |
Glycols, polytetramethylene
| 25190-06-1 |
Glycine, N,N-dimethyl-,((2,3-dihydro-6-chloroimidazo(2,1-b)thiazol-5-yl)methylene)hydrazide
| 102410-40-2 |
Glycine, N,N'-(1,6-dioxo-1,6-hexanediyl)bis-
| 91717-13-4 |
Glycoluril, 3a,6a-dimethyl-
| 28115-25-5 |
Glycoluril, 3a,6a-diphenyl-
| 5157-15-3 |
Glycoluril, 1,3,4,6-tetrachloro-3a,6a-diphenyl-
| 51592-06-4 |
Glycoprotein toxins, from Candida albicansSUBSTANCE DEFINITION :Glycoprotein complex isolated from the cell walls of the 29-3-109 strain ofCandida albicansREFERENCE :40YJAX "Evaluation of Embryotoxicity, Mutagenicity and Carcinogenicity RisksIn New Drugs, Proceedings of the Symposium on Toxicological Testing forSafety of New Drugs, 3rd, Prague, 1976," Benesova, O., et al., eds., Prague,Czechoslovakia, Univerzita Karlova, 1979
| 51592-06-4 |
Glycosmis arborea (roxb.) DC., extract excludingrootsSUBSTANCE DEFINITION :Plant belonging to the family RutaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
| 51592-06-4 |
Glycosmis mauritiana (lam.) Tanaka, root extractSUBSTANCE DEFINITION :Plant belonging to the family RutaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
| 51592-06-4 |
Glycosmis mauritiana (Lam.) Tanaka var. andamanensis(Naray.) Tanaka, extractSUBSTANCE DEFINITION :Plant belonging to the family RutaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 28,619,1990
| 51592-06-4 |
Glycosmis pentaphylla Correa, extractSUBSTANCE DEFINITION :Plant belonging to the family RutaceaeREFERENCE :CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA,1255 Howard St., San Francisco, CA 94103) V.6- 1958-
| 51592-06-4 |
Glycyrrhiza extract
| 68916-91-6 |
Glycyrrhiza glabra Linn., root extractSUBSTANCE DEFINITION :Plant belonging to the family FabaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 22,312,1984
| 68916-91-6 |
Glycine, N,N'-(1,6-dioxo-1,6-hexanediyl)bis-, diethylester
| 92377-71-4 |
Glycyrrhiza uralensis Fish., extract
| 92377-71-4 |
Glycyrrhizinic acid
| 1405-86-3 |
Glyoxal
| 107-22-2 |
Glyoxal, 29.2%
| 107-22-2 |
Glyoxal, 40%
| 107-22-2 |
Glyoxal, biphenylyl-, diethyl hydrazone
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Glyoxal, bis(ethoxycarbonylamido-
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Glyoxal, p-chlorophenyl-, diethyl hydrazone
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Glyoxal, p-chlorophenyl-, dimethyl hydrazone
| 24346-19-8 |
Glyoxal, (3,4-dihydroxyphenyl)-, dioxime
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Glycine, N,N'-(1,9-dioxo-1,9-nonanediyl)bis-
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Glyoxal, dioxime
| 557-30-2 |
Glyoxal, p-methoxyphenyl-, dimethyl hydrazone
| 25555-11-7 |
Glyoxal, p-nitrophenyl-, diethyl hydrazone
| 24342-44-7 |
Glyoxal, p-nitrophenyl-, dimethyl hydrazone
| 25555-13-9 |
Glyoxal, (p-phenethylphenyl)-
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Glyoxal, (p-phenethylphenyl)-, compd. with sodiumbisulfite
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Glyoxal, (p-phenoxyphenyl)-
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Glyoxal, p-phenoxyphenyl-, dimethyl hydrazone
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Glyoxal, phenyl-
| 1074-12-0 |
Glyoxal, phenyl-, 2-(diethyl acetal)
| 6175-45-7 |
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