*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : MD2007000
CHEMICAL NAME : Glycyrrhiza extract
CAS REGISTRY NUMBER : 68916-91-6
OTHER CAS REGISTRY NOS. : 8008-94-4
8057-63-4
LAST UPDATED : 199612
DATA ITEMS CITED : 11
COMPOUND DESCRIPTOR : Drug
Mutagen
Natural Product
SYNONYMS/TRADE NAMES :
* Glycyrrhiza
* Glycyrrhizae (Latin)
* Kanzo
* Kanzou
* Licorice
* Licorice extract
* Licorice root
* Licorice root extract
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 14200 mg/kg
TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea
Kidney, Ureter, Bladder - other changes
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 14,535,1977
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1420 mg/kg
TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea
Kidney, Ureter, Bladder - other changes
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 14,535,1977
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 4200 mg/kg
TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea
Kidney, Ureter, Bladder - other changes
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 14,535,1977
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : >7500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 14,535,1977
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1500 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Blood - changes in spleen
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 14,535,1977
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 4 gm/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Blood - changes in spleen
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 14,535,1977
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 37500 ug/kg/30D-C
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in bladder weight
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 14,535,1977
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 114 mg/kg/13W-C
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in bladder weight
Endocrine - changes in thymus weight
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 14,535,1977
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 2700 gm/kg/90D-C
TOXIC EFFECTS :
Liver - changes in liver weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - death
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year:
31,343,1993
** MUTATION DATA **
TYPE OF TEST : DNA repair
TEST SYSTEM : Bacteria - Bacillus subtilis
DOSE/DURATION : 100 gm/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 97,81,1982
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X8576
No. of Facilities: 29 (estimated)
No. of Industries: 1
No. of Occupations: 2
No. of Employees: 316 (estimated)
*** END OF RECORD ***
|
|
|
ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
| NAME | CAS |
Glycols, polyethylene-polypropylene, pluronic F68
| 9003-11-6 |
Glycols, polythylene-polypropylene, pluronic L44
| 9003-11-6 |
Glycols, polyethylene-polypropylene, pluronic L62
| 9003-11-6 |
Glycols, polyethylene-polypropylene, pluronic L64
| 9003-11-6 |
Glycols, polyethylene-polypropylene, pluronic L-81
| 9003-11-6 |
Glycine, 1,1'-(1,7-dioxo-1,7-heptanediyl)bis(glycyl-
| 143673-92-1 |
Glycols, polyethylene-polypropylene, poloxamer-188
| 9003-11-6 |
Glycols, polyethylene-polypropylene, RC 102
| 9003-11-6 |
Glycols, polypropylene, bis(2-aminopropyl) ether, DA200SUBSTANCE DEFINITION :With a molecular weight of 200REFERENCE :GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene andOccupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)V.1-36, 1957-1992. For publisher information, see MTPEEI
| 9003-11-6 |
Glycols, polypropylene, bis(2-aminopropyl) ether,DA-500SUBSTANCE DEFINITION :With a molecular weight of 500REFERENCE :GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/OMezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
| 9003-11-6 |
Glycols, polypropylene, bis(2-aminopropyl) ether, DA1000SUBSTANCE DEFINITION :With a molecular weight of 1000REFERENCE :GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene andOccupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)V.1-36, 1957-1992. For publisher information, see MTPEEI
| 9003-11-6 |
Glycols, polypropylene, 1,2,3-propanetriyl ether
| 25791-96-2 |
Glycols, polypropylene, tris(2-aminopropyl) ether,TA750SUBSTANCE DEFINITION :With a molecular weight of 750REFERENCE :GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene andOccupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)V.1-36, 1957-1992. For publisher information, see MTPEEI
| 25791-96-2 |
Glycols, polypropylene, tris(2-aminopropyl) ether,TA-1100SUBSTANCE DEFINITION :With a molecular weight of 1100REFERENCE :GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/OMezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
| 25791-96-2 |
Glycols, polypropylene, tris(2-aminopropyl) ether,TA1500SUBSTANCE DEFINITION :With a molecular weight of 1500REFERENCE :GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene andOccupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)V.1-36, 1957-1992. For publisher information, see MTPEEI
| 25791-96-2 |
Glycols, polytetramethylene
| 25190-06-1 |
Glycine, N,N-dimethyl-,((2,3-dihydro-6-chloroimidazo(2,1-b)thiazol-5-yl)methylene)hydrazide
| 102410-40-2 |
Glycine, N,N'-(1,6-dioxo-1,6-hexanediyl)bis-
| 91717-13-4 |
Glycoluril, 3a,6a-dimethyl-
| 28115-25-5 |
Glycoluril, 3a,6a-diphenyl-
| 5157-15-3 |
Glycoluril, 1,3,4,6-tetrachloro-3a,6a-diphenyl-
| 51592-06-4 |
Glycoprotein toxins, from Candida albicansSUBSTANCE DEFINITION :Glycoprotein complex isolated from the cell walls of the 29-3-109 strain ofCandida albicansREFERENCE :40YJAX "Evaluation of Embryotoxicity, Mutagenicity and Carcinogenicity RisksIn New Drugs, Proceedings of the Symposium on Toxicological Testing forSafety of New Drugs, 3rd, Prague, 1976," Benesova, O., et al., eds., Prague,Czechoslovakia, Univerzita Karlova, 1979
| 51592-06-4 |
Glycosmis arborea (roxb.) DC., extract excludingrootsSUBSTANCE DEFINITION :Plant belonging to the family RutaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
| 51592-06-4 |
Glycosmis mauritiana (lam.) Tanaka, root extractSUBSTANCE DEFINITION :Plant belonging to the family RutaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
| 51592-06-4 |
Glycosmis mauritiana (Lam.) Tanaka var. andamanensis(Naray.) Tanaka, extractSUBSTANCE DEFINITION :Plant belonging to the family RutaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 28,619,1990
| 51592-06-4 |
Glycosmis pentaphylla Correa, extractSUBSTANCE DEFINITION :Plant belonging to the family RutaceaeREFERENCE :CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA,1255 Howard St., San Francisco, CA 94103) V.6- 1958-
| 51592-06-4 |
Glycyrrhiza extract
| 68916-91-6 |
Glycyrrhiza glabra Linn., root extractSUBSTANCE DEFINITION :Plant belonging to the family FabaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 22,312,1984
| 68916-91-6 |
Glycine, N,N'-(1,6-dioxo-1,6-hexanediyl)bis-, diethylester
| 92377-71-4 |
Glycyrrhiza uralensis Fish., extract
| 92377-71-4 |
Glycyrrhizinic acid
| 1405-86-3 |
Glyoxal
| 107-22-2 |
Glyoxal, 29.2%
| 107-22-2 |
Glyoxal, 40%
| 107-22-2 |
Glyoxal, biphenylyl-, diethyl hydrazone
| 24342-51-6 |
Glyoxal, bis(ethoxycarbonylamido-
| 35896-51-6 |
Glyoxal, p-chlorophenyl-, diethyl hydrazone
| 24346-21-2 |
Glyoxal, p-chlorophenyl-, dimethyl hydrazone
| 24346-19-8 |
Glyoxal, (3,4-dihydroxyphenyl)-, dioxime
| 65561-73-1 |
Glycine, N,N'-(1,9-dioxo-1,9-nonanediyl)bis-
| 143673-89-6 |
Glyoxal, dioxime
| 557-30-2 |
Glyoxal, p-methoxyphenyl-, dimethyl hydrazone
| 25555-11-7 |
Glyoxal, p-nitrophenyl-, diethyl hydrazone
| 24342-44-7 |
Glyoxal, p-nitrophenyl-, dimethyl hydrazone
| 25555-13-9 |
Glyoxal, (p-phenethylphenyl)-
| 24585-99-7 |
Glyoxal, (p-phenethylphenyl)-, compd. with sodiumbisulfite
| 2983-58-6 |
Glyoxal, (p-phenoxyphenyl)-
| 70-97-3 |
Glyoxal, p-phenoxyphenyl-, dimethyl hydrazone
| 24346-20-1 |
Glyoxal, phenyl-
| 1074-12-0 |
Glyoxal, phenyl-, 2-(diethyl acetal)
| 6175-45-7 |
|
|