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MSDS  : Imidazo(2,1-b)thiazole, 2,3,5,6-tetrahydro-6-phenyl-, (S)-
CAS  : 14769-73-4
SYNONYMS  : * Ketrax * Lepuron * Levamisol * Levamisole * Levomysol * L-2,3,5,6-Tetrahyro-6-phenylimidazo(2,1-b)thiazole * (-)-Tetramisole * l-Tetramisole
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : NJ5940000
CHEMICAL NAME : Imidazo(2,1-b)thiazole, 2,3,5,6-tetrahydro-6-phenyl-,
(S)-
CAS REGISTRY NUMBER : 14769-73-4
LAST UPDATED : 199512
DATA ITEMS CITED : 13
MOLECULAR FORMULA : C11-H12-N2-S
MOLECULAR WEIGHT : 204.31
COMPOUND DESCRIPTOR : Drug
Mutagen
SYNONYMS/TRADE NAMES :
* Ketrax
* Lepuron
* Levamisol
* Levamisole
* Levomysol
* L-2,3,5,6-Tetrahyro-6-phenylimidazo(2,1-b)thiazole
* (-)-Tetramisole
* l-Tetramisole

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 480 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - effect, not otherwise specified
Behavioral - convulsions or effect on seizure threshold
Behavioral - excitement
REFERENCE :
PBPSDY Pharmacological and Biochemical Properties of Drug Substances.
(American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC
20037) V.1- 1977- Volume(issue)/page/year: 2,407,1979

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 120 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - ataxia
Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
MBIID4 MBI, Mediko Biologicheskaya Informatsiya. Medical-Biological
Information. ("Ivana Vazova" No. 3, Sofia 1000, Bulgaria) 1967-
Volume(issue)/page/year: (6),27,1985

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 24 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - effect, not otherwise specified
Behavioral - convulsions or effect on seizure threshold
Behavioral - excitement
REFERENCE :
PBPSDY Pharmacological and Biochemical Properties of Drug Substances.
(American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC
20037) V.1- 1977- Volume(issue)/page/year: 2,407,1979

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 210 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - effect, not otherwise specified
Behavioral - convulsions or effect on seizure threshold
Behavioral - excitement
REFERENCE :
PBPSDY Pharmacological and Biochemical Properties of Drug Substances.
(American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC
20037) V.1- 1977- Volume(issue)/page/year: 2,407,1979

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 84 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - effect, not otherwise specified
Behavioral - convulsions or effect on seizure threshold
Behavioral - excitement
REFERENCE :
PBPSDY Pharmacological and Biochemical Properties of Drug Substances.
(American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC
20037) V.1- 1977- Volume(issue)/page/year: 2,407,1979

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 22 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - effect, not otherwise specified
Behavioral - convulsions or effect on seizure threshold
Behavioral - excitement
REFERENCE :
PBPSDY Pharmacological and Biochemical Properties of Drug Substances.
(American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC
20037) V.1- 1977- Volume(issue)/page/year: 2,407,1979

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 700 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - effect, not otherwise specified
Behavioral - convulsions or effect on seizure threshold
Behavioral - excitement
REFERENCE :
PBPSDY Pharmacological and Biochemical Properties of Drug Substances.
(American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC
20037) V.1- 1977- Volume(issue)/page/year: 2,407,1979

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 15 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - effect, not otherwise specified
Behavioral - convulsions or effect on seizure threshold
Behavioral - excitement
REFERENCE :
PBPSDY Pharmacological and Biochemical Properties of Drug Substances.
(American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC
20037) V.1- 1977- Volume(issue)/page/year: 2,407,1979

** MUTATION DATA **

TYPE OF TEST : Mutation test systems - not otherwise specified
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 50 mg/L
REFERENCE :
RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD
Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970-
Volume(issue)/page/year: 14,651,1976

TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Human Lymphocyte
DOSE/DURATION : 25 mg/L
REFERENCE :
PTBIAN Pathologie Biologie. (Expansion Scientifique Francaise, 15, rue St.
Benoit, F-75278 Paris Cedex 06, France) V.17- 1969-
Volume(issue)/page/year: 28,323,1980

TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Human
DOSE/DURATION : 2142 ug/kg
REFERENCE :
PTBIAN Pathologie Biologie. (Expansion Scientifique Francaise, 15, rue St.
Benoit, F-75278 Paris Cedex 06, France) V.17- 1969-
Volume(issue)/page/year: 28,323,1980

TYPE OF TEST : Sister chromatid exchange
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Human
DOSE/DURATION : 2142 ug/kg
REFERENCE :
PTBIAN Pathologie Biologie. (Expansion Scientifique Francaise, 15, rue St.
Benoit, F-75278 Paris Cedex 06, France) V.17- 1969-
Volume(issue)/page/year: 28,323,1980

*** REVIEWS ***

TOXICOLOGY REVIEW
PBPSDY Pharmacological and Biochemical Properties of Drug Substances.
(American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC
20037) V.1- 1977- Volume(issue)/page/year: 2,407,1979


*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
NAMECAS
Imidazo(2,1-b)thiazole-2-carboxamide,5,6-dihydro-3,6-dimethyl-N-mesityl- 101692-37-9
Imidazo(2,1-b)thiazole-2-carboxamide,5,6-dihydro-N-(o-fluorophenyl)-3-methyl-,hydrochloride 64107-88-6
Imidazo(2,1-b)thiazole-2-carboxamide,5,6-dihydro-N-mesityl-3-methyl-, hydrochloride 64107-87-5
Imidazo(2,1-b)thiazole-2-carboxamide,5,6-dihydro-N-mesityl-3-phenyl-, hydrochloride 64107-69-3
Imidazo(1,2-b)pyridazine,2-(p-methylsulfonylphenyl)-, hydrobromide 3415-20-1
Imidazo(2,1-b)thiazole-2-carboxamide,5,6-dihydro-N-mesityl-3,6,6-trimethyl-, hydrochloride 77006-44-1
Imidazo(2,1-b)thiazole-2-carboxamide,3-methyl-N-(alpha,alpha,alpha-trifluoro-m-tolyl)-,hydrochloride 64129-59-5
Imidazo(2,1-b)thiazole-5-carboximidamide,6-chloro-N-hydroxy- 120107-56-4
Imidazo(2,1-b)thiazole-5-carboximidamide,2,3-dihydro-6-chloro-N-hydroxy- 120107-57-5
Imidazo(2,1-b)thiazole-2-carboxylic acid,5,6-dihydro-3-methyl-, ethyl ester, hydrochloride 34467-12-4
Imidazo(2,1-b)thiazole, 6-(p-chlorophenyl)-5-nitro- 106671-89-0
Imidazo(2,1-b)thiazole, 6-(p-chlorophenyl)-5-nitroso- 106671-91-4
Imidazo(2,1-b)thiazole,5,6-dihydro-3-(5-bromo-2-propoxyphenyl)-,monohydrochloride 130623-64-2
Imidazo(2,1-b)thiazole,5,6-dihydro-3-(4-butoxy-3-chlorophenyl)-,monohydrochloride 82492-70-4
Imidazo(2,1-b)thiazole,5,6-dihydro-3-(3-chloro-4-(hexyloxy)phenyl)-,monohydrochloride 160518-42-3
Imidazo(1,2-b)pyridazinium,1-((7-(((5-amino-1,2,4-thiadiazol-3-yl)(methoxyimino)acetyl)amino)-2-carboxy-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-3-yl)methyl)-, hydroxide, inner salt,monohydrochloride, (6R-(6-alpha,7-beta(Z)))- 160518-42-3
Imidazo(2,1-b)thiazole,5,6-dihydro-3-(3-chloro-4-(pentyloxy)phenyl)-,monohydrochloride 160518-41-2
Imidazo(2,1-b)thiazole,2,3-dihydro-6-(p-chlorophenyl)-5-nitro- 106636-49-1
Imidazo(2,1-b)thiazole,5,6-dihydro-3-(3-chloro-4-propoxyphenyl)-,monohydrochloride 82492-69-1
Imidazo(2,1-b)thiazole,5,6-dihydro-6,6-dimethyl-3-phenyl-, hydrobromide 77006-43-0
Imidazo(2,1-b)thiazole,5,6-dihydro-2-(2,5-dimethyl-1-pyrrolidinylcarbonyl)-3-methyl-, hydrochloride, (Z)- 101692-38-0
Imidazo(2,1-b)thiazole, 5,6-dihydro-2,3-diphenyl-,hydrobromide 77006-45-2
Imidazo(2,1-b)thiazole,2,3-dihydro-6-(p-fluorophenyl)-5-(4-pyridyl)-,dihydrochloride 77006-45-2
4H-Imidazo(2,1-b)thiazole,2,3-dihydro-3-(m-hydroxyphenylimino)-5-phenyl- 77006-45-2
4H-Imidazo(2,1-b)thiazole,2,3-dihydro-3-(p-hydroxyphenylimino)-5-phenyl- 77006-45-2
Imidazo(2,1-b)thiazole,5,6-dihydro-2-(methylsulfonyl)-3-phenyl- 64107-91-1
1H-Imidazo(4,5-c)pyridin-4-amine,N,N-dimethyl-1-((2-fluorophenyl)methyl)-,monohydrochloride 120537-53-3
Imidazo(2,1-b)thiazole,2,3-dihydro-5-nitro-6-(p-nitrophenyl)- 106636-48-0
Imidazo(2,1-b)thiazole,5,6-dihydro-3-(3-nitro-4-(pentyloxy)phenyl)-,monohydrochloride 130623-67-5
Imidazo(2,1-b)thiazole,5,6-dihydro-3-(3-nitro-4-propoxyphenyl)-,monohydrochloride 130623-66-4
Imidazo(2,1-b)thiazole,2,3-dihydro-5-nitro-6-p-tolyl- 106636-50-4
4H-Imidazo(2,1-b)thiazole,2,3-dihydro-3-phenylimino-5-phenyl- 106636-50-4
Imidazo(2,1-b)thiazole,5,6-dihydro-3-(4-propoxyphenyl)-, monohydrochloride 130623-59-5
4H-Imidazo(2,1-b)thiazole,2,3-dihydro-3-(p-tolylimino)-5-phenyl- 130623-59-5
Imidazo(2,1-b)thiazole, 5,6-dihydro-3,6,6-trimethyl-,hydrochloride 77006-42-9
Imidazo(2,1-b)thiazole,2-methyl-5-nitro-6-(p-nitrophenyl)- 95152-79-7
Imidazo(2,1-b)thiazole,2-methyl-6-(p-nitrophenyl)-5-nitroso- 106636-46-8
1H-Imidazo(4,5-c)pyridin-4-amine,N,N-dimethyl-1-(phenylmethyl)- 120537-47-5
Imidazo(2,1-b)thiazole,6-(p-methylsulfonylphenyl)-5-(morpholinomethyl)- 3415-16-5
Imidazo(2,1-b)thiazole, 5-nitro-6-(p-nitrophenyl)- 16311-38-9
Imidazo(2,1-b)thiazole, 6-(p-nitrophenyl)-5-nitroso- 106671-90-3
Imidazo(2,1-b)thiazole, 2,3,5,6-tetrahydro-6-phenyl- 6649-23-6
Imidazo(2,1-b)thiazole, 2,3,5,6-tetrahydro-6-phenyl-,(S)- 14769-73-4
Imidazo(2,1-b)thiazole, 2,3,5,6-tetrahydro-6-phenyl-,monohydrochloride, (+-)- 5086-74-8
Imidazo(2,1-b)thiazole, 2,3,5,6-tetrahydro-6-phenyl-,monohydrochloride, L-(-)- 16595-80-5
Imidazo(2,1-b)thiazole, 2,3,5,6-tetrahydro-6-phenyl-,monohydrochloride, (R)-(+)- 16595-76-9
Imidazo(2,1-b)thiazole, 2,3,5,6-tetrahydro-6-phenyl-,(S)-, phosphate (1:1) 32093-35-9
7H-Imidazo(2,1-b)thiazol-4-ium,5,6-dihydro-3-(p-bromophenyl)-, bromide 74038-89-4
1H-Imidazo(4,5-c)pyridin-4-amine,1-((2-fluorophenyl)methyl)-N-methyl-,monohydrochloride 120537-54-4
7H-Imidazo(2,1-b)thiazol-1-ium,5,6-dihydro-3-(p-chlorophenyl)-, bromide 36103-99-8

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