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MSDS  : Imidazo(2,1-b)thiazole, 2,3,5,6-tetrahydro-6-phenyl-, monohydrochloride, L-(-)-
CAS  : 16595-80-5
SYNONYMS  : * Citarin L * Decaris * Imidazo(2,1-b)thiazole, 2,3,5,6-tetrahydro-6-phenyl-, monohydrochloride, (S)- * KW-2-LE-T * Levamisole hydrochloride * Levomysol hydrochloride * Niratic hydrochloride * Niratic-puron hydrochloride * NSC-177023 * R-12,564 * Ripercol-L * Solaskil * Stimamizol hydrochloride * (-)-2,3,5,6-Tetrahydro-6-phenylimidazo(2,1-b)thiazole hydrochloride * L-(-)-2,3,5,6-Tetrahydro-6-phenyl-imidazo(2,1-b)thiazole hydrochloride * l-Tetramisole hydrochloride * Tramisol * Tramisole * Worm-chek
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : NJ5960000
CHEMICAL NAME : Imidazo(2,1-b)thiazole, 2,3,5,6-tetrahydro-6-phenyl-,
monohydrochloride, L-(-)-
CAS REGISTRY NUMBER : 16595-80-5
OTHER CAS REGISTRY NOS. : 74191-78-9
LAST UPDATED : 199710
DATA ITEMS CITED : 20
MOLECULAR FORMULA : C11-H12-N2-S.Cl-H
MOLECULAR WEIGHT : 240.77
COMPOUND DESCRIPTOR : Drug
Mutagen
Reproductive Effector
Human
SYNONYMS/TRADE NAMES :
* Citarin L
* Decaris
* Imidazo(2,1-b)thiazole, 2,3,5,6-tetrahydro-6-phenyl-, monohydrochloride,
(S)-
* KW-2-LE-T
* Levamisole hydrochloride
* Levomysol hydrochloride
* Niratic hydrochloride
* Niratic-puron hydrochloride
* NSC-177023
* R-12,564
* Ripercol-L
* Solaskil
* Stimamizol hydrochloride
* (-)-2,3,5,6-Tetrahydro-6-phenylimidazo(2,1-b)thiazole hydrochloride
* L-(-)-2,3,5,6-Tetrahydro-6-phenyl-imidazo(2,1-b)thiazole hydrochloride
* l-Tetramisole hydrochloride
* Tramisol
* Tramisole
* Worm-chek

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - woman
DOSE/DURATION : 180 mg/kg/36D
TOXIC EFFECTS :
Blood - thrombocytopenia
REFERENCE :
BMJOAE British Medical Journal. (British Medical Assoc., BMA House,
Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year:
2,555,1977

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 180 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000
Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year:
54,275,1983

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 42 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - other changes
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 10,3141,1982

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 80 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - other changes
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 10,3141,1982

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 26 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - other changes
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 10,3141,1982

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 223 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - other changes
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 10,3141,1982

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 34 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - other changes
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 10,3141,1982

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 52 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - other changes
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 10,3141,1982

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 18 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - other changes
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 10,3141,1982

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 121 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FMDZAR Fortschritte der Medizin. (M.B. Schwappach & Co., Postfach 1220,
8035 Gauting vor Muenchen, Fed. Rep. Ger.) V.1- 1883-
Volume(issue)/page/year: 94,793,1976

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Parenteral
SPECIES OBSERVED : Amphibian - frog
DOSE/DURATION : 363 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4-
1898- Volume(issue)/page/year: 289,278,1987

** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 10800 mg/kg/13W-I
TOXIC EFFECTS :
Endocrine - changes in spleen weight
Blood - normocytic anemia
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 10,3141,1982

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 10800 mg/kg/26W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
acute tubular necrosis)
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - transaminases
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 10,3141,1982

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 1800 mg/kg/13W-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - dyspnea
Blood - normocytic anemia
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - phosphatases
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 10,3141,1982

** REPRODUCTIVE DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 330 mg/kg
SEX/DURATION : female 7-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 10,3155,1982

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 480 mg/kg
SEX/DURATION : female 19-22 day(s) after conception
lactating female 4 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4
per # born alive)
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 10,3155,1982

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 750 mg/kg
SEX/DURATION : female 19-22 day(s) after conception
lactating female 21 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
gain)
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 10,3155,1982

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 2125 mg/kg
SEX/DURATION : female 19-22 day(s) after conception
lactating female 21 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - weaning or lactation index (e.g., #
alive at weaning per # alive at day 4)
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 10,3155,1982

** MUTATION DATA **

TYPE OF TEST : Unscheduled DNA synthesis
ROUTE OF EXPOSURE : Unreported
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 10 mg/kg
REFERENCE :
CCROBU Cancer Chemotherapy Reports, Part 1. (Washington, DC) V.52(6)-59,
1968-75. For publisher information, see CTRRDO. Volume(issue)/page/year:
59,531,1975

*** STATUS IN U.S. ***

EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998


*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
NAMECAS
Imidazo(2,1-b)thiazole-2-carboxamide,5,6-dihydro-3,6-dimethyl-N-mesityl- 101692-37-9
Imidazo(2,1-b)thiazole-2-carboxamide,5,6-dihydro-N-(o-fluorophenyl)-3-methyl-,hydrochloride 64107-88-6
Imidazo(2,1-b)thiazole-2-carboxamide,5,6-dihydro-N-mesityl-3-methyl-, hydrochloride 64107-87-5
Imidazo(2,1-b)thiazole-2-carboxamide,5,6-dihydro-N-mesityl-3-phenyl-, hydrochloride 64107-69-3
Imidazo(1,2-b)pyridazine,2-(p-methylsulfonylphenyl)-, hydrobromide 3415-20-1
Imidazo(2,1-b)thiazole-2-carboxamide,5,6-dihydro-N-mesityl-3,6,6-trimethyl-, hydrochloride 77006-44-1
Imidazo(2,1-b)thiazole-2-carboxamide,3-methyl-N-(alpha,alpha,alpha-trifluoro-m-tolyl)-,hydrochloride 64129-59-5
Imidazo(2,1-b)thiazole-5-carboximidamide,6-chloro-N-hydroxy- 120107-56-4
Imidazo(2,1-b)thiazole-5-carboximidamide,2,3-dihydro-6-chloro-N-hydroxy- 120107-57-5
Imidazo(2,1-b)thiazole-2-carboxylic acid,5,6-dihydro-3-methyl-, ethyl ester, hydrochloride 34467-12-4
Imidazo(2,1-b)thiazole, 6-(p-chlorophenyl)-5-nitro- 106671-89-0
Imidazo(2,1-b)thiazole, 6-(p-chlorophenyl)-5-nitroso- 106671-91-4
Imidazo(2,1-b)thiazole,5,6-dihydro-3-(5-bromo-2-propoxyphenyl)-,monohydrochloride 130623-64-2
Imidazo(2,1-b)thiazole,5,6-dihydro-3-(4-butoxy-3-chlorophenyl)-,monohydrochloride 82492-70-4
Imidazo(2,1-b)thiazole,5,6-dihydro-3-(3-chloro-4-(hexyloxy)phenyl)-,monohydrochloride 160518-42-3
Imidazo(1,2-b)pyridazinium,1-((7-(((5-amino-1,2,4-thiadiazol-3-yl)(methoxyimino)acetyl)amino)-2-carboxy-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-3-yl)methyl)-, hydroxide, inner salt,monohydrochloride, (6R-(6-alpha,7-beta(Z)))- 160518-42-3
Imidazo(2,1-b)thiazole,5,6-dihydro-3-(3-chloro-4-(pentyloxy)phenyl)-,monohydrochloride 160518-41-2
Imidazo(2,1-b)thiazole,2,3-dihydro-6-(p-chlorophenyl)-5-nitro- 106636-49-1
Imidazo(2,1-b)thiazole,5,6-dihydro-3-(3-chloro-4-propoxyphenyl)-,monohydrochloride 82492-69-1
Imidazo(2,1-b)thiazole,5,6-dihydro-6,6-dimethyl-3-phenyl-, hydrobromide 77006-43-0
Imidazo(2,1-b)thiazole,5,6-dihydro-2-(2,5-dimethyl-1-pyrrolidinylcarbonyl)-3-methyl-, hydrochloride, (Z)- 101692-38-0
Imidazo(2,1-b)thiazole, 5,6-dihydro-2,3-diphenyl-,hydrobromide 77006-45-2
Imidazo(2,1-b)thiazole,2,3-dihydro-6-(p-fluorophenyl)-5-(4-pyridyl)-,dihydrochloride 77006-45-2
4H-Imidazo(2,1-b)thiazole,2,3-dihydro-3-(m-hydroxyphenylimino)-5-phenyl- 77006-45-2
4H-Imidazo(2,1-b)thiazole,2,3-dihydro-3-(p-hydroxyphenylimino)-5-phenyl- 77006-45-2
Imidazo(2,1-b)thiazole,5,6-dihydro-2-(methylsulfonyl)-3-phenyl- 64107-91-1
1H-Imidazo(4,5-c)pyridin-4-amine,N,N-dimethyl-1-((2-fluorophenyl)methyl)-,monohydrochloride 120537-53-3
Imidazo(2,1-b)thiazole,2,3-dihydro-5-nitro-6-(p-nitrophenyl)- 106636-48-0
Imidazo(2,1-b)thiazole,5,6-dihydro-3-(3-nitro-4-(pentyloxy)phenyl)-,monohydrochloride 130623-67-5
Imidazo(2,1-b)thiazole,5,6-dihydro-3-(3-nitro-4-propoxyphenyl)-,monohydrochloride 130623-66-4
Imidazo(2,1-b)thiazole,2,3-dihydro-5-nitro-6-p-tolyl- 106636-50-4
4H-Imidazo(2,1-b)thiazole,2,3-dihydro-3-phenylimino-5-phenyl- 106636-50-4
Imidazo(2,1-b)thiazole,5,6-dihydro-3-(4-propoxyphenyl)-, monohydrochloride 130623-59-5
4H-Imidazo(2,1-b)thiazole,2,3-dihydro-3-(p-tolylimino)-5-phenyl- 130623-59-5
Imidazo(2,1-b)thiazole, 5,6-dihydro-3,6,6-trimethyl-,hydrochloride 77006-42-9
Imidazo(2,1-b)thiazole,2-methyl-5-nitro-6-(p-nitrophenyl)- 95152-79-7
Imidazo(2,1-b)thiazole,2-methyl-6-(p-nitrophenyl)-5-nitroso- 106636-46-8
1H-Imidazo(4,5-c)pyridin-4-amine,N,N-dimethyl-1-(phenylmethyl)- 120537-47-5
Imidazo(2,1-b)thiazole,6-(p-methylsulfonylphenyl)-5-(morpholinomethyl)- 3415-16-5
Imidazo(2,1-b)thiazole, 5-nitro-6-(p-nitrophenyl)- 16311-38-9
Imidazo(2,1-b)thiazole, 6-(p-nitrophenyl)-5-nitroso- 106671-90-3
Imidazo(2,1-b)thiazole, 2,3,5,6-tetrahydro-6-phenyl- 6649-23-6
Imidazo(2,1-b)thiazole, 2,3,5,6-tetrahydro-6-phenyl-,(S)- 14769-73-4
Imidazo(2,1-b)thiazole, 2,3,5,6-tetrahydro-6-phenyl-,monohydrochloride, (+-)- 5086-74-8
Imidazo(2,1-b)thiazole, 2,3,5,6-tetrahydro-6-phenyl-,monohydrochloride, L-(-)- 16595-80-5
Imidazo(2,1-b)thiazole, 2,3,5,6-tetrahydro-6-phenyl-,monohydrochloride, (R)-(+)- 16595-76-9
Imidazo(2,1-b)thiazole, 2,3,5,6-tetrahydro-6-phenyl-,(S)-, phosphate (1:1) 32093-35-9
7H-Imidazo(2,1-b)thiazol-4-ium,5,6-dihydro-3-(p-bromophenyl)-, bromide 74038-89-4
1H-Imidazo(4,5-c)pyridin-4-amine,1-((2-fluorophenyl)methyl)-N-methyl-,monohydrochloride 120537-54-4
7H-Imidazo(2,1-b)thiazol-1-ium,5,6-dihydro-3-(p-chlorophenyl)-, bromide 36103-99-8

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