*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : NJ5107050
CHEMICAL NAME : Imidazo(1,2-b)pyridazinium,
1-((7-(((5-amino-1,2,4-thiadiazol-3-yl)(methoxyimino)
acetyl)
amino)-2-carboxy-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-
2-en-3-yl)methyl)-, hydroxide, inner salt,
monohydrochloride, (6R-(6-alpha,7-beta(Z)))-
LAST UPDATED : 199612
DATA ITEMS CITED : 14
MOLECULAR FORMULA : C19-H17-N9-O5-S2.Cl-H
MOLECULAR WEIGHT : 552.03
COMPOUND DESCRIPTOR : Drug
Reproductive Effector
SYNONYMS/TRADE NAMES :
* SCE-2787 (hydrochloride)
* Vebraside
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >5 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 20(Suppl 11),S2591,199
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 5 gm/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 20(Suppl 11),S2591,199
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 20(Suppl 11),S2591,199
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : >5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 20(Suppl 11),S2591,199
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : >5 gm/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
Lungs, Thorax, or Respiration - respiratory depression
Lungs, Thorax, or Respiration - other changes
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 20(Suppl 11),S2591,199
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : >1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 20(Suppl 11),S2591,199
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 182 gm/kg/26W-I
TOXIC EFFECTS :
Blood - normocytic anemia
Blood - changes in spleen
Related to Chronic Data - changes in testicular weight
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 20(Suppl 11),S2665,199
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 29 gm/kg/4W-I
TOXIC EFFECTS :
Gastrointestinal - other changes
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 20(Suppl 11),S2599,199
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 29 gm/kg/4W-I
TOXIC EFFECTS :
Liver - changes in liver weight
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 20(Suppl 11),S2615,199
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 54600 mg/kg/26W-I
TOXIC EFFECTS :
Vascular - other changes
Blood - changes in spleen
Blood - changes in leukocyte (WBC) count
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 20(Suppl 11),S2687,199
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Primate - monkey
DOSE/DURATION : 29 gm/kg/4W-I
TOXIC EFFECTS :
Liver - other changes
Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
acute tubular necrosis)
Related to Chronic Data - death
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 20(Suppl 11),S2635,199
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 5700 mg/kg
SEX/DURATION : female 14 day(s) pre-mating - 21 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - physical
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 20(Suppl 11),S2707,199
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE : 2800 mg/kg
SEX/DURATION : female 15-21 day(s) after conception
lactating female 21 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - physical
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 20(Suppl 11),S2749,199
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE : 12 gm/kg
SEX/DURATION : female 6-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - other effects
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 20(Suppl 11),S2723,199
*** END OF RECORD ***
|
|
|
ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
| NAME | CAS |
Imidazo(2,1-b)thiazole-2-carboxamide,5,6-dihydro-3,6-dimethyl-N-mesityl-
| 101692-37-9 |
Imidazo(2,1-b)thiazole-2-carboxamide,5,6-dihydro-N-(o-fluorophenyl)-3-methyl-,hydrochloride
| 64107-88-6 |
Imidazo(2,1-b)thiazole-2-carboxamide,5,6-dihydro-N-mesityl-3-methyl-, hydrochloride
| 64107-87-5 |
Imidazo(2,1-b)thiazole-2-carboxamide,5,6-dihydro-N-mesityl-3-phenyl-, hydrochloride
| 64107-69-3 |
Imidazo(1,2-b)pyridazine,2-(p-methylsulfonylphenyl)-, hydrobromide
| 3415-20-1 |
Imidazo(2,1-b)thiazole-2-carboxamide,5,6-dihydro-N-mesityl-3,6,6-trimethyl-, hydrochloride
| 77006-44-1 |
Imidazo(2,1-b)thiazole-2-carboxamide,3-methyl-N-(alpha,alpha,alpha-trifluoro-m-tolyl)-,hydrochloride
| 64129-59-5 |
Imidazo(2,1-b)thiazole-5-carboximidamide,6-chloro-N-hydroxy-
| 120107-56-4 |
Imidazo(2,1-b)thiazole-5-carboximidamide,2,3-dihydro-6-chloro-N-hydroxy-
| 120107-57-5 |
Imidazo(2,1-b)thiazole-2-carboxylic acid,5,6-dihydro-3-methyl-, ethyl ester, hydrochloride
| 34467-12-4 |
Imidazo(2,1-b)thiazole, 6-(p-chlorophenyl)-5-nitro-
| 106671-89-0 |
Imidazo(2,1-b)thiazole, 6-(p-chlorophenyl)-5-nitroso-
| 106671-91-4 |
Imidazo(2,1-b)thiazole,5,6-dihydro-3-(5-bromo-2-propoxyphenyl)-,monohydrochloride
| 130623-64-2 |
Imidazo(2,1-b)thiazole,5,6-dihydro-3-(4-butoxy-3-chlorophenyl)-,monohydrochloride
| 82492-70-4 |
Imidazo(2,1-b)thiazole,5,6-dihydro-3-(3-chloro-4-(hexyloxy)phenyl)-,monohydrochloride
| 160518-42-3 |
Imidazo(1,2-b)pyridazinium,1-((7-(((5-amino-1,2,4-thiadiazol-3-yl)(methoxyimino)acetyl)amino)-2-carboxy-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-3-yl)methyl)-, hydroxide, inner salt,monohydrochloride, (6R-(6-alpha,7-beta(Z)))-
| 160518-42-3 |
Imidazo(2,1-b)thiazole,5,6-dihydro-3-(3-chloro-4-(pentyloxy)phenyl)-,monohydrochloride
| 160518-41-2 |
Imidazo(2,1-b)thiazole,2,3-dihydro-6-(p-chlorophenyl)-5-nitro-
| 106636-49-1 |
Imidazo(2,1-b)thiazole,5,6-dihydro-3-(3-chloro-4-propoxyphenyl)-,monohydrochloride
| 82492-69-1 |
Imidazo(2,1-b)thiazole,5,6-dihydro-6,6-dimethyl-3-phenyl-, hydrobromide
| 77006-43-0 |
Imidazo(2,1-b)thiazole,5,6-dihydro-2-(2,5-dimethyl-1-pyrrolidinylcarbonyl)-3-methyl-, hydrochloride, (Z)-
| 101692-38-0 |
Imidazo(2,1-b)thiazole, 5,6-dihydro-2,3-diphenyl-,hydrobromide
| 77006-45-2 |
Imidazo(2,1-b)thiazole,2,3-dihydro-6-(p-fluorophenyl)-5-(4-pyridyl)-,dihydrochloride
| 77006-45-2 |
4H-Imidazo(2,1-b)thiazole,2,3-dihydro-3-(m-hydroxyphenylimino)-5-phenyl-
| 77006-45-2 |
4H-Imidazo(2,1-b)thiazole,2,3-dihydro-3-(p-hydroxyphenylimino)-5-phenyl-
| 77006-45-2 |
Imidazo(2,1-b)thiazole,5,6-dihydro-2-(methylsulfonyl)-3-phenyl-
| 64107-91-1 |
1H-Imidazo(4,5-c)pyridin-4-amine,N,N-dimethyl-1-((2-fluorophenyl)methyl)-,monohydrochloride
| 120537-53-3 |
Imidazo(2,1-b)thiazole,2,3-dihydro-5-nitro-6-(p-nitrophenyl)-
| 106636-48-0 |
Imidazo(2,1-b)thiazole,5,6-dihydro-3-(3-nitro-4-(pentyloxy)phenyl)-,monohydrochloride
| 130623-67-5 |
Imidazo(2,1-b)thiazole,5,6-dihydro-3-(3-nitro-4-propoxyphenyl)-,monohydrochloride
| 130623-66-4 |
Imidazo(2,1-b)thiazole,2,3-dihydro-5-nitro-6-p-tolyl-
| 106636-50-4 |
4H-Imidazo(2,1-b)thiazole,2,3-dihydro-3-phenylimino-5-phenyl-
| 106636-50-4 |
Imidazo(2,1-b)thiazole,5,6-dihydro-3-(4-propoxyphenyl)-, monohydrochloride
| 130623-59-5 |
4H-Imidazo(2,1-b)thiazole,2,3-dihydro-3-(p-tolylimino)-5-phenyl-
| 130623-59-5 |
Imidazo(2,1-b)thiazole, 5,6-dihydro-3,6,6-trimethyl-,hydrochloride
| 77006-42-9 |
Imidazo(2,1-b)thiazole,2-methyl-5-nitro-6-(p-nitrophenyl)-
| 95152-79-7 |
Imidazo(2,1-b)thiazole,2-methyl-6-(p-nitrophenyl)-5-nitroso-
| 106636-46-8 |
1H-Imidazo(4,5-c)pyridin-4-amine,N,N-dimethyl-1-(phenylmethyl)-
| 120537-47-5 |
Imidazo(2,1-b)thiazole,6-(p-methylsulfonylphenyl)-5-(morpholinomethyl)-
| 3415-16-5 |
Imidazo(2,1-b)thiazole, 5-nitro-6-(p-nitrophenyl)-
| 16311-38-9 |
Imidazo(2,1-b)thiazole, 6-(p-nitrophenyl)-5-nitroso-
| 106671-90-3 |
Imidazo(2,1-b)thiazole, 2,3,5,6-tetrahydro-6-phenyl-
| 6649-23-6 |
Imidazo(2,1-b)thiazole, 2,3,5,6-tetrahydro-6-phenyl-,(S)-
| 14769-73-4 |
Imidazo(2,1-b)thiazole, 2,3,5,6-tetrahydro-6-phenyl-,monohydrochloride, (+-)-
| 5086-74-8 |
Imidazo(2,1-b)thiazole, 2,3,5,6-tetrahydro-6-phenyl-,monohydrochloride, L-(-)-
| 16595-80-5 |
Imidazo(2,1-b)thiazole, 2,3,5,6-tetrahydro-6-phenyl-,monohydrochloride, (R)-(+)-
| 16595-76-9 |
Imidazo(2,1-b)thiazole, 2,3,5,6-tetrahydro-6-phenyl-,(S)-, phosphate (1:1)
| 32093-35-9 |
7H-Imidazo(2,1-b)thiazol-4-ium,5,6-dihydro-3-(p-bromophenyl)-, bromide
| 74038-89-4 |
1H-Imidazo(4,5-c)pyridin-4-amine,1-((2-fluorophenyl)methyl)-N-methyl-,monohydrochloride
| 120537-54-4 |
7H-Imidazo(2,1-b)thiazol-1-ium,5,6-dihydro-3-(p-chlorophenyl)-, bromide
| 36103-99-8 |
|
|