*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : NO5400000
CHEMICAL NAME : Iron(II) chloride (1:2)
CAS REGISTRY NUMBER : 7758-94-3
LAST UPDATED : 199712
DATA ITEMS CITED : 20
MOLECULAR FORMULA : Cl2-Fe
MOLECULAR WEIGHT : 126.75
WISWESSER LINE NOTATION : FE G2
COMPOUND DESCRIPTOR : Mutagen
SYNONYMS/TRADE NAMES :
* Ferrous chloride
* Iron dichloride
* Iron protochloride
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 450 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 39(5),16,1974
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 59 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher
information, see NSAPCC. Volume(issue)/page/year: 244,17,1962
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 6604 mg/kg/30D-C
TOXIC EFFECTS :
Liver - other changes
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - phosphatases
REFERENCE :
VMDKAM Voprosy Meditsinskoi Khimii. Problems of Medical Chemistry. (V/O Me
zhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1955-
Volume(issue)/page/year: 37(1),39,1991
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 200 ug/m3/24H/65D-C
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - true cholinesterase
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 50(7),73,1985
** MUTATION DATA **
TYPE OF TEST : Phage inhibition capacity
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 50 ng/well
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 260,349,1991
TYPE OF TEST : Morphological transformation
TEST SYSTEM : Rodent - hamster Embryo
DOSE/DURATION : 2500 umol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
39,193,1979
*** REVIEWS ***
ACGIH TLV-TWA 1 mg(Fe)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 1 mg(Fe)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,138,1971
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-DENMARK:TWA 1 mg(Fe)/m3 JAN 1993
OEL-FINLAND:TWA 1 mg(Fe)/m3 JAN 1993
OEL-THE NETHERLANDS:TWA 1 mg(Fe)/m3 JAN 1993
OEL-SWITZERLAND:TWA 1 mg(Fe)/m3 JAN 1993
OEL-UNITED KINGDOM:TWA 1 mg(Fe)/m3;STEL 2 mg(Fe)/m3 JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 82179
No. of Facilities: 361 (estimated)
No. of Industries: 12
No. of Occupations: 14
No. of Employees: 2280 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 82179
No. of Facilities: 187 (estimated)
No. of Industries: 6
No. of Occupations: 7
No. of Employees: 7981 (estimated)
No. of Female Employees: 1823 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-SA7/SHE
EPA GENETOX PROGRAM 1988, Negative: B subtilis rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
*** END OF RECORD ***
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Iron(II) chloride (12)
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Iron(2+) chloride, tetrahydrate
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Iron, (ethanedioato(2-)-O,O')bis(methanamine)-
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Iron, ion(Fe 2+)
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Iron(III) oxide
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