*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : PB2100000
CHEMICAL NAME : Methanesulfonic acid, ethyl ester
CAS REGISTRY NUMBER : 62-50-0
BEILSTEIN REFERENCE NO. : 0773969
REFERENCE : 4-04-00-00012 (Beilstein Handbook Reference)
LAST UPDATED : 199710
DATA ITEMS CITED : 313
MOLECULAR FORMULA : C3-H8-O3-S
MOLECULAR WEIGHT : 124.17
WISWESSER LINE NOTATION : WS1&O2
COMPOUND DESCRIPTOR : Tumorigen
Drug
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* EMS
* ENT 26396
* Ethylester kyseliny methansulfonove
* Ethyl ester of methanesulfonic acid
* Ethyl ester of methanesulphonic acid
* Ethyl ester of methylsulfonic acid
* Ethyl ester of methylsulphonic acid
* Ethyl methanesulfonate
* Ethyl methanesulphonate
* Ethyl methansulfonate
* Ethyl methansulphonate
* Half-myleran
* Methanesulphonic acid ethyl ester
* Methylsulfonic acid, ethyl ester
* NSC 26805
* RCRA waste number U119
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 350 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA,
1255 Howard St., San Francisco, CA 94103) V.6- 1958-
Volume(issue)/page/year: 8,807,1960
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 470 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 223,373,1989
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 435 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland
Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year:
3,117,1971
** TUMORIGENIC DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1043 gm/kg/12W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Skin and Appendages - tumors
REFERENCE :
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland
Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year:
56,225,1991
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 300 mg/kg
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Kidney, Ureter, Bladder - Kidney tumors
Skin and Appendages - tumors
REFERENCE :
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills,
Basingstoke, Hants. RG21 2XS, UK) V.1- 1947- Volume(issue)/page/year:
29,50,1974
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 100 mg/kg
female 21 day(s) after conception
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Reproductive - Tumorigenic effects - transplacental tumorigenesis
Brain and Coverings - tumors
REFERENCE :
EXPTAX Experimentelle Pathologie (1967-1980). (Jena, Ger. Dem. Rep.)
V.1-18, 1967-80. For publisher information, see EXPADD.
Volume(issue)/page/year: 16,157,1978
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1650 mg/kg/2W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Brain and Coverings - tumors
REFERENCE :
43XWAI "Brain Tumors and Chemical Injuries to the Central Nervous System,
Proceedings of the International Neuropathological Symposium, Warsaw, 1976,"
Mossakowski, M.J., ed., Warsaw, Poland, Panstwowy Zaklad Wydawnictw
Lekarskich, 1978 Volume(issue)/page/year: -,15,1978
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Parenteral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 800 mg/kg/3W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Skin and Appendages - tumors
REFERENCE :
RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD
Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970-
Volume(issue)/page/year: 7,25,1974
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 373 mg/kg
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland
Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year:
3,117,1971
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 825 mg/kg/10D-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Kidney, Ureter, Bladder - Kidney tumors
REFERENCE :
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
V.1- 1869- Volume(issue)/page/year: 223,947,1969
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 413 mg/kg/10D-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Kidney, Ureter, Bladder - Kidney tumors
REFERENCE :
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
V.1- 1869- Volume(issue)/page/year: 223,947,1969
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 3353 mg/kg/13W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Skin and Appendages - tumors
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
Volume(issue)/page/year: 2,1223,1981
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 600 mg/kg/6W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Kidney, Ureter, Bladder - Kidney tumors
REFERENCE :
BECCAN Annual Report--Cancer Research Campaign. (Cancer Research Campaign,
2 Carlton House Terrace, London SW1Y 5AR, UK) V.1- 1924-
Volume(issue)/page/year: 39,77,1961
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1650 mg/kg/30W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Brain and Coverings - tumors
REFERENCE :
EXPTAX Experimentelle Pathologie (1967-1980). (Jena, Ger. Dem. Rep.)
V.1-18, 1967-80. For publisher information, see EXPADD.
Volume(issue)/page/year: 16,157,1978
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1050 gm/kg/12W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Skin and Appendages - tumors
REFERENCE :
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland
Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year:
7,79,1979
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 500 mg/kg
SEX/DURATION : male 5 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - male fertility index (e.g. # males impregnating
females per # males exposed to fertile nonpregnant females)
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora lutea)
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
70,303,1983
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE : 300 mg/kg
SEX/DURATION : male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - male fertility index (e.g. # males impregnating
females per # males exposed to fertile nonpregnant females)
REFERENCE :
85GUAJ "Antifertility Compounds in the Male and Female," Jackson, H.,
Springfield, IL, Charles C. Thomas, 1966 Volume(issue)/page/year: -,55,1966
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE : 200 mg/kg
SEX/DURATION : female 13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot,
POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960-
Volume(issue)/page/year: 17,325,1968
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE : 200 mg/kg
SEX/DURATION : male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
KDIKAX Kobe Daigaku Igakubu Kiyo. Journal of the Medical Faculty of Kobe
University. (Kobe Daigaku Igakubu, 7-chome, Kusumoto-cho, Chuo-ku, Kobe
650, Japan) V.30- 1968- Volume(issue)/page/year: 41,141,1980
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE : 50 mg/kg
SEX/DURATION : male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc.,
41 E. 11th St., New York, NY 10003) V.1- 1980- Volume(issue)/page/year:
7,497,1987
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE : 200 mg/kg
SEX/DURATION : female 15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - germ cell effects (in offspring)
Reproductive - Effects on Newborn - delayed effects
REFERENCE :
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot,
POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960-
Volume(issue)/page/year: 18,15,1969
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE : 62 mg/kg
SEX/DURATION : female 18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - other effects to embryo
REFERENCE :
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc.,
41 E. 11th St., New York, NY 10003) V.1- 1980- Volume(issue)/page/year:
9,157,1989
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE : 1 gm/kg
SEX/DURATION : male 5 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - mating performance (e.g. # sperm positive females
per # females mated; # copulations per # estrus cycles)
Reproductive - Fertility - male fertility index (e.g. # males impregnating
females per # males exposed to fertile nonpregnant females)
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing
Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
Volume(issue)/page/year: 21,71,1977
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE : 1750 mg/kg
SEX/DURATION : male 7 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - male fertility index (e.g. # males impregnating
females per # males exposed to fertile nonpregnant females)
Reproductive - Effects on Newborn - live birth index (measured after birth)
REFERENCE :
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert,
Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued.
Volume(issue)/page/year: 2(2),209,1983
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE : 625 mg/kg
SEX/DURATION : male 5 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Effects on Newborn - germ cell effects (in offspring)
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 70,109,1980
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE : 200 mg/kg
SEX/DURATION : male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 5,417,1968
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE : 200 mg/kg
SEX/DURATION : female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
before birth)
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 13,171,1971
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE : 175 mg/kg
SEX/DURATION : female 11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000
Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year:
51,1,1982
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE : 195 mg/kg
SEX/DURATION : female 11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000
Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year:
51,1,1982
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE : 200 mg/kg
SEX/DURATION : male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora lutea)
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970-
Volume(issue)/page/year: 11,559,1980
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE : 350 mg/kg
SEX/DURATION : male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological
Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku,
Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 4,127,1979
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Parenteral
SPECIES OBSERVED : Rodent - mouse
DOSE : 100 mg/kg
SEX/DURATION : female 10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - other developmental
abnormalities
REFERENCE :
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing
Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
Volume(issue)/page/year: 24,113,1978
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - mouse
DOSE : 1250 mg/kg
SEX/DURATION : male 5 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert,
Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued.
Volume(issue)/page/year: 3(2),158,1984
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - hamster
DOSE : 25 mg/kg
SEX/DURATION : male 5 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
sperm morphology, motility, and count)
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
Volume(issue)/page/year: 8,929,1981
** MUTATION DATA **
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 10 ug/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 188,197,1987
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 300 ng/plate
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 6(Suppl
2),1,1984
TYPE OF TEST : Mutation test systems - not otherwise specified
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 2300 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 192,239,1987
TYPE OF TEST : DNA repair
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 12 ug/disc
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 39,285,1977
TYPE OF TEST : Phage inhibition capacity
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 10umol/plate
REFERENCE :
PPTCBY Proceedings of the International Symposium of the Princess Takamatsu
Cancer Research Fund. (Japan Scientific Soc. Press, 6-2-10 Hongo, Bunkyo-ku,
Tokyo 113, Japan) 1st- 1971- Volume(issue)/page/year: 9,337,1979
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 100 ug/plate
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 6(Suppl
2),1,1984
TYPE OF TEST : Mutation test systems - not otherwise specified
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 490 nmol/tube
REFERENCE :
PNASA6 Proceedings of the National Academy of Sciences of the United States
of America. (National Academy of Sciences, Printing & Pub. Office, 2101
Constitution Ave., Washington, DC 20418) V.1- 1915-
Volume(issue)/page/year: 79,5971,1982
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 1 ug/L
REFERENCE :
RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD
Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970-
Volume(issue)/page/year: 16,523,1977
TYPE OF TEST : DNA repair
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 2 mg/disc
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 97,1,1982
TYPE OF TEST : DNA damage
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 20 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 52,161,1978
TYPE OF TEST : Phage inhibition capacity
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 400 mmol/L
REFERENCE :
PRLBA4 Proceedings of the Royal Society of London, Series B: Biological
Sciences. (Royal Soc., 6 Carlton House Terrace, London SW1Y 5AG, UK) V.76-
1905- Volume(issue)/page/year: 150,497,1959
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Bacillus subtilis
DOSE/DURATION : 450 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 13,93,1971
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 10 pph
REFERENCE :
BICMBE Biochimie. (SPPIF, B.P.22, F-41353 Vineuil, France) V.53- 1971-
Volume(issue)/page/year: 56,1471,1974
TYPE OF TEST : DNA repair
TEST SYSTEM : Bacteria - Bacillus subtilis
DOSE/DURATION : 2 mg/disc
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 97,1,1982
TYPE OF TEST : DNA damage
TEST SYSTEM : Bacteria - Bacillus subtilis
DOSE/DURATION : 290 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 9,141,1970
TYPE OF TEST : Phage inhibition capacity
TEST SYSTEM : Bacteria - Bacillus subtilis
DOSE/DURATION : 50 mmol/L
REFERENCE :
IJEBA6 Indian Journal of Experimental Biology. (Publications & Information
Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
Volume(issue)/page/year: 22,338,1984
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Serratia marcescens
DOSE/DURATION : 25 mg/L
REFERENCE :
ATXKA8 Archiv fuer Toxikologie. (Berlin, Fed. Rep. Ger.) V.15-31, 1954-74.
For publisher information, see ARTODN. Volume(issue)/page/year: 30,67,1972
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Haemophilus influenzae
DOSE/DURATION : 160 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 30,9,1975
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 150 uL
REFERENCE :
JGMIAN Journal of General Microbiology. (Soc. for General Microbiology,
Journal Sales, 62 London Rd., Reading, RG1 5AS, UK) V.1- 1947-
Volume(issue)/page/year: 128,427,1982
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 1 gm/L/4H (Continuous)
REFERENCE :
JGMIAN Journal of General Microbiology. (Soc. for General Microbiology,
Journal Sales, 62 London Rd., Reading, RG1 5AS, UK) V.1- 1947-
Volume(issue)/page/year: 121,349,1980
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 150 uL
REFERENCE :
JOBAAY Journal of Bacteriology. (American Soc. for Microbiology, 1913 I
St., NW, Washington, DC 20006) V.1- 1916- Volume(issue)/page/year:
112,356,1972
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 50 mmol/L/18H
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 7,19,1969
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 15 mmol/L/48H
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 19,313,1973
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 3000 ppm/1H
REFERENCE :
JOPAA2 Journal of Parasitology. (American Soc. of Parasitologists, 1041 New
Hamphsire St., Lawrence, KS 60044) V.1- 1914- Volume(issue)/page/year:
69,239,1983
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 200 mmol/L
REFERENCE :
FOMIAZ Folia Microbiologica (Prague). (Academia, Vodickova 40, 112 29
Prague 1, Czechoslavakia) V.4- 1959- Volume(issue)/page/year: 17,81,1972
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 250 mmol/L
REFERENCE :
FOMIAZ Folia Microbiologica (Prague). (Academia, Vodickova 40, 112 29
Prague 1, Czechoslavakia) V.4- 1959- Volume(issue)/page/year: 29,99,1984
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 1 pph
REFERENCE :
JOBAAY Journal of Bacteriology. (American Soc. for Microbiology, 1913 I
St., NW, Washington, DC 20006) V.1- 1916- Volume(issue)/page/year:
160,288,1984
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 100 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 162,137,1986
TYPE OF TEST : DNA damage
TEST SYSTEM : Bacteria - Haemophilus influenzae
DOSE/DURATION : 100 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 125,15,1984
TYPE OF TEST : Phage inhibition capacity
TEST SYSTEM : Bacteria - Haemophilus influenzae
DOSE/DURATION : 100 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 125,15,1984
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 1 mmol/L
REFERENCE :
CUGED5 Current Genetics. (Springer-Verlag New York, Inc., Service Center,
44 Hartz Way, Secaucus, NJ 07094) V.1- 1979- Volume(issue)/page/year:
5,119,1982
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 20 mmol/L
REFERENCE :
JOVIAM Journal of Virology. (American Soc. for Microbiology, 1913 I St.,
NW, Washington, DC 20006) V.1- 1967- Volume(issue)/page/year:
37,936,1981
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 150 uL
REFERENCE :
AMICCW Archives of Microbiology. (Springer-Verlag New York, Inc., Service
Center, 44 Hartz Way, Secacus, NJ 07094) V.95- 1974-
Volume(issue)/page/year: 103,141,1975
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 50 mmol/L/18H
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 4,409,1967
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 400 mmol/L
REFERENCE :
MGGEAE Molecular and General Genetics. (Springer-Verlag, Heidelberger Pl.
3, D-1000 Berlin 33, Fed. Rep. Ger.) V.99- 1967-
Volume(issue)/page/year: 141,23,1975
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 258 mmol/L
REFERENCE :
BIJOAK Biochemical Journal. (Biochemical Soc. Book Depot, POB 32, Commerce
Way, Colchester, Essex CO2 8HP, UK) V.1- 1906- Volume(issue)/page/year:
145,85,1975
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 200 mmol/L
REFERENCE :
FOMIAZ Folia Microbiologica (Prague). (Academia, Vodickova 40, 112 29
Prague 1, Czechoslavakia) V.4- 1959- Volume(issue)/page/year:
14,194,1969
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 1 pph/60M (Continuous)
REFERENCE :
FOMIAZ Folia Microbiologica (Prague). (Academia, Vodickova 40, 112 29
Prague 1, Czechoslavakia) V.4- 1959- Volume(issue)/page/year:
16,197,1971
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 190 mmol/L/4H (Continuous)
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 33,135,1975
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 50 nmol/L
REFERENCE :
GENRA8 Genetical Research. (Cambridge Univ. Press, 32 E. 57th St., New
York, NY 10022) V.1- 1960- Volume(issue)/page/year: 29,65,1977
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 150 mmol/L
REFERENCE :
FOMIAZ Folia Microbiologica (Prague). (Academia, Vodickova 40, 112 29
Prague 1, Czechoslavakia) V.4- 1959- Volume(issue)/page/year: 15,34,1970
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 10 mmol/L
REFERENCE :
PNASA6 Proceedings of the National Academy of Sciences of the United States
of America. (National Academy of Sciences, Printing & Pub. Office, 2101
Constitution Ave., Washington, DC 20418) V.1- 1915-
Volume(issue)/page/year: 70,1335,1973
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 200 mmol/L
REFERENCE :
AMBBBR Acta Microbiologica Polonica, Series B: Microbiologica Applicata.
(Warsaw, Poland) V.1-7, 1969-75. For publisher information, see AMPOAX.
Volume(issue)/page/year: 6,15,1974
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 200 mmol/L
REFERENCE :
AMBBBR Acta Microbiologica Polonica, Series B: Microbiologica Applicata.
(Warsaw, Poland) V.1-7, 1969-75. For publisher information, see AMPOAX.
Volume(issue)/page/year: 6,15,1974
TYPE OF TEST : DNA repair
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 620 ug/plate
REFERENCE :
BIZNAT Biologisches Zentralblatt. (VEB Georg Thieme, Postfach 946, Leipzig
DDR-7010, Ger. Dem. Rep.) V.1- 1881- Volume(issue)/page/year:
95,463,1976
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 1 mL/plate
REFERENCE :
JMMIAV Journal of Medical Microbiology. (Longman Group UK Ltd., Longman
House, Burnt Mill, Harlow, Essex CM20 2JE, UK) V.1- 1968-
Volume(issue)/page/year: 8,265,1975
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 1 pph
REFERENCE :
MGGEAE Molecular and General Genetics. (Springer-Verlag, Heidelberger Pl.
3, D-1000 Berlin 33, Fed. Rep. Ger.) V.99- 1967-
Volume(issue)/page/year: 133,345,1974
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 4 pph
REFERENCE :
JMOBAK Journal of Molecular Biology. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 9,352,1964
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 4 pph
REFERENCE :
JMOBAK Journal of Molecular Biology. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 9,352,1964
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 19 gm/L
REFERENCE :
JOBAAY Journal of Bacteriology. (American Soc. for Microbiology, 1913 I
St., NW, Washington, DC 20006) V.1- 1916- Volume(issue)/page/year:
101,921,1970
TYPE OF TEST : DNA damage
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 20 mmol
REFERENCE :
BBACAQ Biochimica et Biophysica Acta. (Elsevier Science Pub. B.V., POB 211,
1000 AE Amsterdam, Netherlands) V.1- 1947- Volume(issue)/page/year:
174,674,1969
TYPE OF TEST : DNA damage
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 258 mmol/L
REFERENCE :
BIJOAK Biochemical Journal. (Biochemical Soc. Book Depot, POB 32, Commerce
Way, Colchester, Essex CO2 8HP, UK) V.1- 1906- Volume(issue)/page/year:
145,85,1975
TYPE OF TEST : DNA damage
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 250 mmol/L
REFERENCE :
VIRLAX Virology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)
V.1- 1955- Volume(issue)/page/year: 35,601,1968
TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 1 mg/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
Volume(issue)/page/year: 2,417,1981
TYPE OF TEST : DNA inhibition
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 5 mmol/L
REFERENCE :
MGGEAE Molecular and General Genetics. (Springer-Verlag, Heidelberger Pl.
3, D-1000 Berlin 33, Fed. Rep. Ger.) V.99- 1967-
Volume(issue)/page/year: 150,301,1977
TYPE OF TEST : Phage inhibition capacity
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 400 mmol/L
REFERENCE :
NNBYA7 Nature (London), New Biology. (Basingstoke, Hants., UK) V.229-246,
1971-73. For publisher information, see NATUAS. Volume(issue)/page/year:
234,186,1971
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 1 gm/L
REFERENCE :
JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8
Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968-
Volume(issue)/page/year: 31,662,1978
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 20 mg/L
REFERENCE :
JOBAAY Journal of Bacteriology. (American Soc. for Microbiology, 1913 I
St., NW, Washington, DC 20006) V.1- 1916- Volume(issue)/page/year:
135,911,1978
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 200 mmol/L
REFERENCE :
MGGEAE Molecular and General Genetics. (Springer-Verlag, Heidelberger Pl.
3, D-1000 Berlin 33, Fed. Rep. Ger.) V.99- 1967-
Volume(issue)/page/year: 179,191,1980
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 25 gm/L
REFERENCE :
JGMIAN Journal of General Microbiology. (Soc. for General Microbiology,
Journal Sales, 62 London Rd., Reading, RG1 5AS, UK) V.1- 1947-
Volume(issue)/page/year: 128,1401,1982
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 100 mmol/L
REFERENCE :
JGMIAN Journal of General Microbiology. (Soc. for General Microbiology,
Journal Sales, 62 London Rd., Reading, RG1 5AS, UK) V.1- 1947-
Volume(issue)/page/year: 128,1529,1982
TYPE OF TEST : Gene conversion and mitotic recombination
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 2000 ppm/2H
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 51,181,1978
TYPE OF TEST : Phage inhibition capacity
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 400 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 36,265,1976
TYPE OF TEST : Specific locus test
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Insect - Drosophila melanogaster
DOSE/DURATION : 1 pph
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 9,323,1970
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 100 mmol/L
REFERENCE :
MCBIA7 Microbios. (Faculty Press, 88 Regent St., Cambridge, UK) V.1- 1969-
Volume(issue)/page/year: 35,39,1982
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 45 nmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 178,195,1987
TYPE OF TEST : Unscheduled DNA synthesis
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Insect - Drosophila melanogaster
DOSE/DURATION : 25 mmol/L
REFERENCE :
GENTAE Genetics. (Genetics Business Office, POB 64025, Baltimore, MD 21264)
V.1- 1916- Volume(issue)/page/year: 104,279,1983
TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Insect - Drosophila melanogaster
DOSE/DURATION : 25 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 10,597,1970
TYPE OF TEST : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Insect - Drosophila melanogaster
DOSE/DURATION : 500 ppm
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 7(Suppl
3),76,1985
TYPE OF TEST : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE : Parenteral
TEST SYSTEM : Insect - Drosophila melanogaster
DOSE/DURATION : 5 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 4,90,1967
TYPE OF TEST : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE : Unreported
TEST SYSTEM : Insect - Drosophila melanogaster
DOSE/DURATION : 20 mmol/L
REFERENCE :
NNBYA7 Nature (London), New Biology. (Basingstoke, Hants., UK) V.229-246,
1971-73. For publisher information, see NATUAS. Volume(issue)/page/year:
241,15,1973
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Mold - Neurospora crassa
DOSE/DURATION : 1 pph/330M
REFERENCE :
GENTAE Genetics. (Genetics Business Office, POB 64025, Baltimore, MD 21264)
V.1- 1916- Volume(issue)/page/year: 63,281,1969
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Yeast - Saccharomyces cerevisiae
DOSE/DURATION : 6 pph
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: DE84-002180
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Yeast - Saccharomyces cerevisiae
DOSE/DURATION : 8 gm/L/1H
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 48,173,1977
TYPE OF TEST : DNA repair
TEST SYSTEM : Yeast - Saccharomyces cerevisiae
DOSE/DURATION : 2500 nmol/L
REFERENCE :
CNJGA8 Canadian Journal of Genetics and Cytology. (National Research
Council of Canada, Publication Sales and Distribution, Ottawa ON K1A OR6,
Canada) V.1- 1959- Volume(issue)/page/year: 24,771,1982
TYPE OF TEST : Gene conversion and mitotic recombination
TEST SYSTEM : Yeast - Saccharomyces cerevisiae
DOSE/DURATION : 5 pph
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: DE84-002180
TYPE OF TEST : Sex chromosome loss and nondisjunction
TEST SYSTEM : Yeast - Saccharomyces cerevisiae
DOSE/DURATION : 2 pph/10M
REFERENCE :
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing
Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
Volume(issue)/page/year: 31,97,1979
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Mold - Aspergillus nidulans
DOSE/DURATION : 100 mmol/L/30M
REFERENCE :
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
V.1- 1869- Volume(issue)/page/year: 210,593,1966
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Yeast - Schizosaccharomyces pombe
DOSE/DURATION : 25 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 25,197,1974
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Protozoa - Chlamydomonas reinhardi
DOSE/DURATION : 270 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 14,381,1972
TYPE OF TEST : DNA repair
TEST SYSTEM : Yeast - Schizosaccharomyces pombe
DOSE/DURATION : 2500 nmol/L
REFERENCE :
CNJGA8 Canadian Journal of Genetics and Cytology. (National Research
Council of Canada, Publication Sales and Distribution, Ottawa ON K1A OR6,
Canada) V.1- 1959- Volume(issue)/page/year: 24,771,1982
TYPE OF TEST : Specific locus test
ROUTE OF EXPOSURE : Parenteral
TEST SYSTEM : Insect - silkworm
DOSE/DURATION : 100 ppm
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 7,425,1969
TYPE OF TEST : Specific locus test
ROUTE OF EXPOSURE : Administration onto the skin
TEST SYSTEM : Insect - not otherwise specified
DOSE/DURATION : 25 mmol/L
REFERENCE :
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H
St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year:
187,760,1975
TYPE OF TEST : Dominant lethal test
ROUTE OF EXPOSURE : Parenteral
TEST SYSTEM : Insect - silkworm
DOSE/DURATION : 500 ppm
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 56,299,1978
TYPE OF TEST : Sperm Morphology
TEST SYSTEM : Insect - silkworm Cells - not otherwise specified
DOSE/DURATION : 500 ppm
REFERENCE :
IDZAAW Japanese Journal of Genetics. Idengaku Zasshi. (Genetics Soc. of
Japan, 111 Tanida, Mishima, Shizuoka-ken, Japan) V.1- 1921-
Volume(issue)/page/year: 50,179,1975
TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Parenteral
TEST SYSTEM : Insect - grasshopper
DOSE/DURATION : 100 mmol/L
REFERENCE :
IJEBA6 Indian Journal of Experimental Biology. (Publications & Information
Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
Volume(issue)/page/year: 24,460,1986
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Fish - not otherwise specified Embryo
DOSE/DURATION : 100 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 68,381,1979
TYPE OF TEST : Micronucleus test
ROUTE OF EXPOSURE : Multiple routes
TEST SYSTEM : Non-mammalian species
DOSE/DURATION : 24 ppm/8D (Continuous)
REFERENCE :
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,
Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year: 1,211,1986
TYPE OF TEST : Micronucleus test
ROUTE OF EXPOSURE : Multiple routes
TEST SYSTEM : Non-mammalian species
DOSE/DURATION : 10 ppm/12D (Continuous)
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 164,245,1986
TYPE OF TEST : Micronucleus test
TEST SYSTEM : Fish - not otherwise specified Lymphocyte
DOSE/DURATION : 8 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 104,147,1982
TYPE OF TEST : Specific locus test
TEST SYSTEM : Insect - not otherwise specified Cells - not
otherwise specified
DOSE/DURATION : 100 umol/L
REFERENCE :
SCGTDW Somatic Cell Genetics. (New York, NY) V.1-9, 1975-83. For
publisher information, see SCMGDN. Volume(issue)/page/year: 4,179,1978
TYPE OF TEST : Specific locus test
ROUTE OF EXPOSURE : Administration onto the skin
TEST SYSTEM : Non-mammalian species
DOSE/DURATION : 600 ppm/20H (Continuous)
REFERENCE :
NEMAAT Nematologica. (E.J. Brill, POB 9000, 2300 PA Leiden, Netherlands)
V.1- 1956- Volume(issue)/page/year: 19,117,1973
TYPE OF TEST : Specific locus test
ROUTE OF EXPOSURE : Unreported
TEST SYSTEM : Non-mammalian species
DOSE/DURATION : 50 mmol/L
REFERENCE :
CNJGA8 Canadian Journal of Genetics and Cytology. (National Research
Council of Canada, Publication Sales and Distribution, Ottawa ON K1A OR6,
Canada) V.1- 1959- Volume(issue)/page/year: 22,295,1980
TYPE OF TEST : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE : Multiple routes
TEST SYSTEM : Non-mammalian species
DOSE/DURATION : 4 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 110,39,1983
TYPE OF TEST : DNA damage
TEST SYSTEM : Fish - salmon Sperm
DOSE/DURATION : 200 mmol/L
REFERENCE :
EJBCAI European Journal of Biochemistry. (Springer-Verlag New York, Inc.,
Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1967-
Volume(issue)/page/year: 31,103,1972
TYPE OF TEST : DNA adduct
TEST SYSTEM : Fish - salmon Sperm
DOSE/DURATION : 39 umol/6H (Continuous)
REFERENCE :
BIJOAK Biochemical Journal. (Biochemical Soc. Book Depot, POB 32, Commerce
Way, Colchester, Essex CO2 8HP, UK) V.1- 1906- Volume(issue)/page/year:
145,73,1975
TYPE OF TEST : DNA damage
TEST SYSTEM : Fish - not otherwise specified Testis
DOSE/DURATION : 170 mmol/L
REFERENCE :
ABBIA4 Archives of Biochemistry and Biophysics. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.31- 1951- Volume(issue)/page/year:
97,80,1962
TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Fish - not otherwise specified Liver
DOSE/DURATION : 10 mmol/L
REFERENCE :
AECTCV Archives of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ
070944) V.1- 1973- Volume(issue)/page/year: 14,555,1985
TYPE OF TEST : DNA inhibition
ROUTE OF EXPOSURE : Administration onto the skin
TEST SYSTEM : Insect - not otherwise specified
DOSE/DURATION : 1 ug
REFERENCE :
CCUPAD Ciencia e Cultura (Sao Paulo). Science and Culture. (Sociedade
Brasileira para o Progresso da Ciencia, Caixa Postal 1 1008, 05420 Sao
Paulo, Brazil) V.1- 1949- Volume(issue)/page/year: 28,352,1976
TYPE OF TEST : Sister chromatid exchange
ROUTE OF EXPOSURE : Multiple routes
TEST SYSTEM : Fish - not otherwise specified
DOSE/DURATION : 24 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 97,35,1982
TYPE OF TEST : Sister chromatid exchange
ROUTE OF EXPOSURE : Multiple routes
TEST SYSTEM : Fish - not otherwise specified
DOSE/DURATION : 24 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 97,35,1982
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Fish - not otherwise specified Leukocyte
DOSE/DURATION : 62 mg/L
REFERENCE :
37KXA7 "Water Chlorination: Environmental Impact and Health Effects,
Proceedings of the Conferences on the Environment," Jolley, R.L., et al.,
eds., Ann Arbor, MI, Ann Arbor Science Pub. Inc., 1975-
Volume(issue)/page/year: 3,835,1980
TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Administration onto the skin
TEST SYSTEM : Fish - not otherwise specified
DOSE/DURATION : 8 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 91,347,1981
TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Administration onto the skin
TEST SYSTEM : Insect - not otherwise specified
DOSE/DURATION : 1 ug
REFERENCE :
CCUPAD Ciencia e Cultura (Sao Paulo). Science and Culture. (Sociedade
Brasileira para o Progresso da Ciencia, Caixa Postal 1 1008, 05420 Sao
Paulo, Brazil) V.1- 1949- Volume(issue)/page/year: 28,352,1976
TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Administration onto the skin
TEST SYSTEM : Fish - not otherwise specified
DOSE/DURATION : 8 mg/L
REFERENCE :
EESADV Ecotoxicology and Environmental Safety. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1977- Volume(issue)/page/year:
5,261,1981
TYPE OF TEST : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE : Unreported
TEST SYSTEM : Insect - not otherwise specified
DOSE/DURATION : 2000 ppm
REFERENCE :
MGGEAE Molecular and General Genetics. (Springer-Verlag, Heidelberger Pl.
3, D-1000 Berlin 33, Fed. Rep. Ger.) V.99- 1967-
Volume(issue)/page/year: 128,117,1974
TYPE OF TEST : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Insect - not otherwise specified
DOSE/DURATION : 5 mmol/L
REFERENCE :
GENRA8 Genetical Research. (Cambridge Univ. Press, 32 E. 57th St., New
York, NY 10022) V.1- 1960- Volume(issue)/page/year: 23,63,1974
TYPE OF TEST : Dominant lethal test
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Insect - not otherwise specified
DOSE/DURATION : 5000 ppm
REFERENCE :
AESAAI Annals of the Entomological Society of America. (Entomological Soc.
of America, 4603 Calvert Rd., College Park, MD 20740) V.1- 1908-
Volume(issue)/page/year: 62,790,1969
TYPE OF TEST : Dominant lethal test
ROUTE OF EXPOSURE : Administration onto the skin
TEST SYSTEM : Insect - not otherwise specified
DOSE/DURATION : 5000 ppm
REFERENCE :
AESAAI Annals of the Entomological Society of America. (Entomological Soc.
of America, 4603 Calvert Rd., College Park, MD 20740) V.1- 1908-
Volume(issue)/page/year: 62,790,1969
TYPE OF TEST : Sperm Morphology
ROUTE OF EXPOSURE : Administration onto the skin
TEST SYSTEM : Insect - not otherwise specified
DOSE/DURATION : 1 ug
REFERENCE :
CCUPAD Ciencia e Cultura (Sao Paulo). Science and Culture. (Sociedade
Brasileira para o Progresso da Ciencia, Caixa Postal 1 1008, 05420 Sao
Paulo, Brazil) V.1- 1949- Volume(issue)/page/year: 28,352,1976
TYPE OF TEST : Dominant lethal test
TEST SYSTEM : Insect - not otherwise specified Sperm
DOSE/DURATION : mmol/L
REFERENCE :
AESAAI Annals of the Entomological Society of America. (Entomological Soc.
of America, 4603 Calvert Rd., College Park, MD 20740) V.1- 1908-
Volume(issue)/page/year: 67,756,1974
TYPE OF TEST : Dominant lethal test
ROUTE OF EXPOSURE : Parenteral
TEST SYSTEM : Insect - not otherwise specified
DOSE/DURATION : 20 ug
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 7,63,1969
TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Non-mammalian species
DOSE/DURATION : 248 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 172,165,1986
TYPE OF TEST : Sister chromatid exchange
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Non-mammalian species
DOSE/DURATION : 124 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 172,165,1986
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Insect - not otherwise specified Cells - not
otherwise specified
DOSE/DURATION : 40 mg/L
REFERENCE :
CYTBAI Cytobios. (Faculty Press, 88 Regent St., Cambridge, UK) V.1- 1969-
Volume(issue)/page/year: 46,181,1986
TYPE OF TEST : DNA repair
TEST SYSTEM : Human Fibroblast
DOSE/DURATION : 20 umol/L
REFERENCE :
33AQAA "Biology of Radiation Carcinogenesis, Symposium, 1975," Yuhas, J.M.,
et al., eds., New York, Raven Press, 1976 Volume(issue)/page/year:
-,103,1976
TYPE OF TEST : Morphological transformation
TEST SYSTEM : Human Cells - not otherwise specified
DOSE/DURATION : 10 mg/L
REFERENCE :
ITCSAF In Vitro. (Rockville, MD) V.1-20, 1965-85. For publisher
information, see ICDBEO. Volume(issue)/page/year: 17,719,1981
TYPE OF TEST : DNA damage
TEST SYSTEM : Human Cells - not otherwise specified
DOSE/DURATION : 3 mmol/L
REFERENCE :
TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview
Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 6,149,1992
TYPE OF TEST : DNA adduct
TEST SYSTEM : Human HeLa cell
DOSE/DURATION : 5 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 89,95,1981
TYPE OF TEST : DNA damage
TEST SYSTEM : Human Fibroblast
DOSE/DURATION : 50 mmol/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
Volume(issue)/page/year: 3,7,1982
TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Human Cells - not otherwise specified
DOSE/DURATION : 500 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 271,201,1992
TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Human Fibroblast
DOSE/DURATION : 1 mmol/L/3H
REFERENCE :
IJCNAW International Journal of Cancer. (International Union Against
Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland) V.1- 1966-
Volume(issue)/page/year: 16,284,1975
TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Human HeLa cell
DOSE/DURATION : 1 mmol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
38,2621,1978
TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Human Lung
DOSE/DURATION : 400 mg/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 5,177,1983
TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Human Cells - not otherwise specified
DOSE/DURATION : 500 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 140,43,1984
TYPE OF TEST : DNA inhibition
TEST SYSTEM : Human HeLa cell
DOSE/DURATION : 10 mmol/L/30M (Continuous)
REFERENCE :
JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest
South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC.
Volume(issue)/page/year: 2(1),65,1978
TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Human Cells - not otherwise specified
DOSE/DURATION : 1 mmol/L
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
79,28,1985
TYPE OF TEST : Mutation test systems - not otherwise specified
TEST SYSTEM : Human Lymphocyte
DOSE/DURATION : 400 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 155,75,1985
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Human Fibroblast
DOSE/DURATION : 1 umol/L
REFERENCE :
EVSRBT Environmental Science Research. (Plenum Pub. Corp., 233 Spring St.,
New York, NY 10013) V.1- 1972- Volume(issue)/page/year: 24,433,1981
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Human Lymphocyte
DOSE/DURATION : 250 mg/L
REFERENCE :
PNASA6 Proceedings of the National Academy of Sciences of the United States
of America. (National Academy of Sciences, Printing & Pub. Office, 2101
Constitution Ave., Washington, DC 20418) V.1- 1915-
Volume(issue)/page/year: 72,4066,1975
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Human Cells - not otherwise specified
DOSE/DURATION : 3 mmol/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E.
11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year:
18,139,1991
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Human Lymphocyte
DOSE/DURATION : 500 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 46,375,1977
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Human Fibroblast
DOSE/DURATION : 1 umol/L
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
Volume(issue)/page/year: 2,1387,1977
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Human Lung
DOSE/DURATION : 60 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 117,317,1983
TYPE OF TEST : Mutation in mammalian somatic cells
TEST SYSTEM : Human Lymphocyte
DOSE/DURATION : 50 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 128,221,1984
TYPE OF TEST : Mutation in mammalian somatic cells
TEST SYSTEM : Human Fibroblast
DOSE/DURATION : 500 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 22,281,1974
TYPE OF TEST : Mutation in mammalian somatic cells
TEST SYSTEM : Human Cells - not otherwise specified
DOSE/DURATION : 150 mg/L
REFERENCE :
SCGTDW Somatic Cell Genetics. (New York, NY) V.1-9, 1975-83. For
publisher information, see SCMGDN. Volume(issue)/page/year: 4,531,1978
TYPE OF TEST : Micronucleus test
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - rat
DOSE/DURATION : 100 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 58,79,1978
TYPE OF TEST : DNA damage
ROUTE OF EXPOSURE : Intravenous
TEST SYSTEM : Rodent - rat
DOSE/DURATION : 31 mg/kg
REFERENCE :
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc.,
41 E. 11th St., New York, NY 10003) V.1- 1980- Volume(issue)/page/year:
7,175,1987
TYPE OF TEST : DNA damage
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - rat
DOSE/DURATION : 33800 ug/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 130,283,1984
TYPE OF TEST : DNA damage
ROUTE OF EXPOSURE : Parenteral
TEST SYSTEM : Rodent - rat
DOSE/DURATION : 110 mg/kg
REFERENCE :
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland
Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year:
11,199,1980
TYPE OF TEST : DNA damage
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Rodent - rat
DOSE/DURATION : 500 mg/kg/2D (Intermittent)
REFERENCE :
PAACA3 Proceedings of the American Association for Cancer Research. (Waverly
Press, 428 E. Preston St., Baltimore, MD 21202) V.1- 1954-
Volume(issue)/page/year: 14,28,1973
TYPE OF TEST : DNA damage
TEST SYSTEM : Rodent - rat Liver
DOSE/DURATION : 30 umol/L
REFERENCE :
SinJF# Personal Communication from J.F. Sina, Merck Institute for
Therapeutic Research, West Point, PA 19486, Oct. 26, 1982
Volume(issue)/page/year: 26OCT1982
TYPE OF TEST : Unscheduled DNA synthesis
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Rodent - rat
DOSE/DURATION : 20 mg/kg
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 4,553,1982
TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Rodent - rat Liver
DOSE/DURATION : 200 mg/L
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland
Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year:
29,303,1980
TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Rodent - rat Cells - not otherwise specified
DOSE/DURATION : 32 mmol/L
REFERENCE :
SHKKAN Shika Kiso Igakkai Zasshi. Journal of the Japanese Association for
Basic Dentistry. (Shika Kiso Igakkai, Hanayama Bldg., 1-44-2 Komagome,
Toshima-ku, Tokyo 170, Japan) V.1- 1959- Volume(issue)/page/year:
22,300,1980
TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Rodent - rat Cells - not otherwise specified
DOSE/DURATION : 1 mmol/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 5,481,1983
TYPE OF TEST : Unscheduled DNA synthesis
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - rat
DOSE/DURATION : 50 mg/kg
REFERENCE :
JCLBA3 Journal of Cell Biology. (Rockefeller Univ. Press, 1230 York Ave.,
New York, NY 10003) V.12- 1962- Volume(issue)/page/year: 92(2,Pt
2),171a,1982
TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Rodent - rat Sperm
DOSE/DURATION : 1 mmol/L
REFERENCE :
BANRDU Banbury Report. (Cold Spring Harbor Laboratory, POB 100, Cold Spring
Harbor, NY 11724) V.1- 1979- Volume(issue)/page/year: 13,101,1982
TYPE OF TEST : DNA inhibition
TEST SYSTEM : Rodent - rat Sperm
DOSE/DURATION : 1 gm/L
REFERENCE :
HEREAY Hereditas (Lund, Sweden). (Gjoerloffsgatan 121, S-261 34 Landskrona,
Sweden) V.1- 1947- Volume(issue)/page/year: 99,269,1983
TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Rodent - rat
DOSE/DURATION : 300 mg/kg
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970-
Volume(issue)/page/year: 11,566,1980
TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - rat
DOSE/DURATION : 125 mg/kg/48H (Continuous)
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E.
11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year:
12,235,1988
TYPE OF TEST : Sister chromatid exchange
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - rat
DOSE/DURATION : 200 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 107,131,1983
TYPE OF TEST : Dominant lethal test
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - rat
DOSE/DURATION : 50 mg/kg
REFERENCE :
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc.,
41 E. 11th St., New York, NY 10003) V.1- 1980- Volume(issue)/page/year:
7,497,1987
TYPE OF TEST : Mutation in mammalian somatic cells
TEST SYSTEM : Rodent - rat Cells - not otherwise specified
DOSE/DURATION : 10 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 34,481,1976
TYPE OF TEST : Mutation in mammalian somatic cells
TEST SYSTEM : Rodent - rat Cells - not otherwise specified
DOSE/DURATION : 300 mg/L
REFERENCE :
PNASA6 Proceedings of the National Academy of Sciences of the United States
of America. (National Academy of Sciences, Printing & Pub. Office, 2101
Constitution Ave., Washington, DC 20418) V.1- 1915-
Volume(issue)/page/year: 79,2967,1982
TYPE OF TEST : Mutation in mammalian somatic cells
TEST SYSTEM : Rodent - rat Liver
DOSE/DURATION : 600 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 107,433,1983
TYPE OF TEST : Heritable translocation test
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - rat
DOSE/DURATION : 75 mg/kg
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 5,153,1983
TYPE OF TEST : Micronucleus test
ROUTE OF EXPOSURE : Parenteral
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 200 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 53,164,1978
TYPE OF TEST : Micronucleus test
ROUTE OF EXPOSURE : Intravenous
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 800 mg/kg/24H
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 23,239,1974
TYPE OF TEST : Micronucleus test
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 200 mg/kg
REFERENCE :
PSDTAP Proceedings of the European Society for the Study of Drug Toxicity.
(Princeton, NJ 08540) V.1-15, 1963-74. For publisher information, see
PESTD5. Volume(issue)/page/year: 15,275,1974
TYPE OF TEST : Micronucleus test
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 200 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 43,441,1977
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Rodent - mouse Bone marrow
DOSE/DURATION : 300 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 81,215,1981
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Rodent - mouse Lymphocyte
DOSE/DURATION : 10 mg/L/4H
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 59,61,1979
TYPE OF TEST : Specific locus test
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 50 mg/kg
REFERENCE :
MGGEAE Molecular and General Genetics. (Springer-Verlag, Heidelberger Pl.
3, D-1000 Berlin 33, Fed. Rep. Ger.) V.99- 1967-
Volume(issue)/page/year: 138,309,1975
TYPE OF TEST : Specific locus test
ROUTE OF EXPOSURE : Unreported
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 100 mg/kg
REFERENCE :
GENTAE Genetics. (Genetics Business Office, POB 64025, Baltimore, MD 21264)
V.1- 1916- Volume(issue)/page/year: 92,S153,1979
TYPE OF TEST : Specific locus test
ROUTE OF EXPOSURE : Parenteral
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 100 mg/kg
REFERENCE :
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing
Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
Volume(issue)/page/year: 24,113,1978
TYPE OF TEST : Morphological transformation
TEST SYSTEM : Rodent - mouse Embryo
DOSE/DURATION : 2 mg/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E.
11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year:
12,21,1988
TYPE OF TEST : Morphological transformation
TEST SYSTEM : Rodent - mouse Fibroblast
DOSE/DURATION : 50 mg/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
Volume(issue)/page/year: 5,459,1984
TYPE OF TEST : DNA damage
TEST SYSTEM : Rodent - mouse Lymphocyte
DOSE/DURATION : 2500 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 203,155,1988
TYPE OF TEST : DNA damage
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 150 mg/kg
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E.
11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year:
17(Suppl 19),19,1991
TYPE OF TEST : DNA damage
ROUTE OF EXPOSURE : Unreported
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 240 mg/kg
REFERENCE :
PACHAS Pure and Applied Chemistry. (Pergamon Press Ltd., Headington Hill
Hall, Oxford OX3 0BW, UK) V.1- 1960- Volume(issue)/page/year:
42,209,1975
TYPE OF TEST : DNA adduct
TEST SYSTEM : Rodent - mouse Ascites tumor
DOSE/DURATION : 5 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 89,95,1981
TYPE OF TEST : Unscheduled DNA synthesis
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 100 mg/kg
REFERENCE :
IDZAAW Japanese Journal of Genetics. Idengaku Zasshi. (Genetics Soc. of
Japan, 111 Tanida, Mishima, Shizuoka-ken, Japan) V.1- 1921-
Volume(issue)/page/year: 54,405,1979
TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Rodent - mouse Testis
DOSE/DURATION : 1 mmol/L/3H
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000
Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year:
37,195,1977
TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Rodent - mouse Cells - not otherwise specified
DOSE/DURATION : 100 ug/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
Volume(issue)/page/year: 9,1197,1988
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Rodent - mouse Ascites tumor
DOSE/DURATION : 250 mg/kg
REFERENCE :
GENTAE Genetics. (Genetics Business Office, POB 64025, Baltimore, MD 21264)
V.1- 1916- Volume(issue)/page/year: 64(Suppl),12,1970
TYPE OF TEST : DNA inhibition
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 300 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 46,305,1977
TYPE OF TEST : DNA inhibition
TEST SYSTEM : Rodent - mouse Embryo
DOSE/DURATION : 5 mmol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
40,682,1980
TYPE OF TEST : Mutation test systems - not otherwise specified
TEST SYSTEM : Rodent - mouse Lymphocyte
DOSE/DURATION : 10 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 299,19,1993
TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 360 mg/kg
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
30,107,1974
TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 300 mg/kg
REFERENCE :
GENTAE Genetics. (Genetics Business Office, POB 64025, Baltimore, MD 21264)
V.1- 1916- Volume(issue)/page/year: 76,109,1974
TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Subcutaneous
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 175 mg/kg
REFERENCE :
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological
Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku,
Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 12,33,1987
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Rodent - mouse Lymphocyte
DOSE/DURATION : 5 mmol/L
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 24,703,1982
TYPE OF TEST : Sister chromatid exchange
ROUTE OF EXPOSURE : Intravenous
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 200 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 60,329,1979
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Rodent - mouse Lymphocyte
DOSE/DURATION : 5 mmol/L
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 24,703,1982
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Rodent - mouse Cells - not otherwise specified
DOSE/DURATION : 100 mg/L
REFERENCE :
JCHODP Journal of Clinical Hematology and Oncology. (Cancer Center at
Wadley Institutes, POB 35988, Dallas, TX 75235) V.5(3)- 1975-
Volume(issue)/page/year: 13,1,1983
TYPE OF TEST : Sister chromatid exchange
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 90 mg/kg
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 6,408,1984
TYPE OF TEST : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 400 mg/kg
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E.
11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year:
20,106,1992
TYPE OF TEST : Dominant lethal test
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 76 mg/kg
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
23,288,1972
TYPE OF TEST : Dominant lethal test
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 300 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 53,21,1978
TYPE OF TEST : Host-mediated assay
TEST SYSTEM : Rodent - mouse Leukocyte
DOSE/DURATION : 250 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 26,501,1974
TYPE OF TEST : Mutation in mammalian somatic cells
TEST SYSTEM : Rodent - mouse Fibroblast
DOSE/DURATION : 10 mmol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
41,3095,1981
TYPE OF TEST : Mutation in mammalian somatic cells
TEST SYSTEM : Rodent - mouse Lymphocyte
DOSE/DURATION : 100 umol/L/30H
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 41,377,1976
TYPE OF TEST : Mutation in mammalian somatic cells
TEST SYSTEM : Rodent - mouse Mammary gland
DOSE/DURATION : 500 umol/L/18H (Continuous)
REFERENCE :
CELLB5 Cell (Cambridge, Mass.). (MIT Press, 28 Carleton St., Cambridge, MA
02142) V.1- 1974- Volume(issue)/page/year: 9,383,1976
TYPE OF TEST : Mutation in mammalian somatic cells
TEST SYSTEM : Rodent - mouse Leukocyte
DOSE/DURATION : 5 mmol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
34,3073,1974
TYPE OF TEST : Mutation in mammalian somatic cells
TEST SYSTEM : Rodent - mouse Ovary
DOSE/DURATION : 400 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 51,77,1978
TYPE OF TEST : Host-mediated assay
TEST SYSTEM : Rodent - mouse Yeast - Saccharomyces cerevisiae
DOSE/DURATION : 14 mmol/kg
REFERENCE :
AGACBH Agents and Actions, A Swiss Journal of Pharmacology. (Birkhaeuser
Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1969/70-
Volume(issue)/page/year: 3,99,1973
TYPE OF TEST : Host-mediated assay
TEST SYSTEM : Rodent - mouse Yeast - Schizosaccharomyces pombe
DOSE/DURATION : 600 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 25,197,1974
TYPE OF TEST : Host-mediated assay
TEST SYSTEM : Rodent - mouse Mold - Neurospora crassa
DOSE/DURATION : 3100 ug/kg
REFERENCE :
EVSRBT Environmental Science Research. (Plenum Pub. Corp., 233 Spring St.,
New York, NY 10013) V.1- 1972- Volume(issue)/page/year: 24,109,1981
TYPE OF TEST : Sperm Morphology
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 625 mg/kg/5D
REFERENCE :
PNASA6 Proceedings of the National Academy of Sciences of the United States
of America. (National Academy of Sciences, Printing & Pub. Office, 2101
Constitution Ave., Washington, DC 20418) V.1- 1915-
Volume(issue)/page/year: 72,4425,1975
TYPE OF TEST : Host-mediated assay
TEST SYSTEM : Rodent - mouse Ovary
DOSE/DURATION : 400 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 51,77,1978
TYPE OF TEST : Host-mediated assay
TEST SYSTEM : Rodent - mouse Bacteria - Salmonella typhimurium
DOSE/DURATION : 35 mg/kg
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
30,107,1974
TYPE OF TEST : Heritable translocation test
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 50 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 21,32,1973
TYPE OF TEST : Mutation in mammalian somatic cells
TEST SYSTEM : Rodent - mouse Liver
DOSE/DURATION : 250 mg/L
REFERENCE :
SCGTDW Somatic Cell Genetics. (New York, NY) V.1-9, 1975-83. For
publisher information, see SCMGDN. Volume(issue)/page/year: 7,373,1981
TYPE OF TEST : Mutation in mammalian somatic cells
TEST SYSTEM : Rodent - mouse Cells - not otherwise specified
DOSE/DURATION : 420 mg/L
REFERENCE :
43VMAC "Microsomes, Drug Oxidations, and Chemical Carcinogenesis,
International Symposium on Microsomes and Drug Oxidations, 4th, 1979," Coon,
M.J., et al., eds., New York, Academic Press, Inc., 1980
Volume(issue)/page/year: 4,1149,1980
TYPE OF TEST : Micronucleus test
TEST SYSTEM : Rodent - hamster Lung
DOSE/DURATION : 100 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 130,273,1984
TYPE OF TEST : Specific locus test
TEST SYSTEM : Rodent - hamster Ovary
DOSE/DURATION : 280 mg/L
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc., 52
Vanderbilt Ave., New York, NY 10017) V.1- 1981- Volume(issue)/page/year:
1,594,1981
TYPE OF TEST : Morphological transformation
TEST SYSTEM : Rodent - hamster Embryo
DOSE/DURATION : 400 mg/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
37,3508,1977
TYPE OF TEST : Morphological transformation
TEST SYSTEM : Rodent - hamster Kidney
DOSE/DURATION : 80 ug/L
REFERENCE :
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills,
Basingstoke, Hants. RG21 2XS, UK) V.1- 1947- Volume(issue)/page/year:
37,873,1978
TYPE OF TEST : DNA damage
TEST SYSTEM : Rodent - hamster Lung
DOSE/DURATION : 1 mmol/L/1H
REFERENCE :
BBRCA9 Biochemical and Biophysical Research Communications. (Academic
Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
Volume(issue)/page/year: 72,732,1976
TYPE OF TEST : DNA damage
TEST SYSTEM : Rodent - hamster Ovary
DOSE/DURATION : 25 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 92,361,1982
TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Rodent - hamster Lung
DOSE/DURATION : 8 mg/L
REFERENCE :
PNASA6 Proceedings of the National Academy of Sciences of the United States
of America. (National Academy of Sciences, Printing & Pub. Office, 2101
Constitution Ave., Washington, DC 20418) V.1- 1915-
Volume(issue)/page/year: 77,6072,1980
TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Rodent - hamster Embryo
DOSE/DURATION : 10 mmol/L
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
Volume(issue)/page/year: 6,333,1980
TYPE OF TEST : DNA inhibition
TEST SYSTEM : Rodent - hamster Lung
DOSE/DURATION : 4 mmol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
40,682,1980
TYPE OF TEST : Mutation test systems - not otherwise specified
TEST SYSTEM : Rodent - hamster Lung
DOSE/DURATION : 20 mmol/L
REFERENCE :
TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview
Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 4,717,1990
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Rodent - mouse Lymphocyte
DOSE/DURATION : 200 mg/L
REFERENCE :
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,
Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year: 4,394,1989
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Rodent - hamster Ovary
DOSE/DURATION : 200 mg/L
REFERENCE :
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,
Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year: 4,394,1989
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Rodent - hamster Fibroblast
DOSE/DURATION : 1 mmol/L
REFERENCE :
CSFUDY Cell Structure and Function. (Japan Soc. for Cell Biology, Nakanishi
Printing Co., Shimotachiuri-ogawa, Kamigyo-Ku, Kyoto 602, Japan) V.1-
1975- Volume(issue)/page/year: 5,175,1980
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Rodent - hamster Lung
DOSE/DURATION : 200 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 67,249,1979
TYPE OF TEST : Sister chromatid exchange
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Rodent - hamster
DOSE/DURATION : 75 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 113,33,1983
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Rodent - hamster Ovary
DOSE/DURATION : 10 umol/L/24H
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 41,343,1976
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Rodent - hamster Kidney
DOSE/DURATION : 300 mg/L
REFERENCE :
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
V.1- 1869- Volume(issue)/page/year: 271,662,1978
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Rodent - hamster Fibroblast
DOSE/DURATION : 1 mmol/L
REFERENCE :
CSFUDY Cell Structure and Function. (Japan Soc. for Cell Biology, Nakanishi
Printing Co., Shimotachiuri-ogawa, Kamigyo-Ku, Kyoto 602, Japan) V.1-
1975- Volume(issue)/page/year: 5,175,1980
TYPE OF TEST : Sister chromatid exchange
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - hamster
DOSE/DURATION : 75 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 113,33,1983
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Rodent - hamster Lung
DOSE/DURATION : 1 mmol/L
REFERENCE :
GANNA2 Gann. Japanese Journal of Cancer Research. (Tokyo, Japan) V.1-75,
1907-84. For publisher information, see JJCREP. Volume(issue)/page/year:
73,912,1982
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Rodent - hamster Cells - not otherwise specified
DOSE/DURATION : 200 umol/L
REFERENCE :
SOGEBZ Soviet Genetics. English translation of GNKAA5. (Plenum Pub. Corp.,
233 Spring St., New York, NY 10013) V.2- 1966- Volume(issue)/page/year:
18,210,1982
TYPE OF TEST : Mutation in mammalian somatic cells
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - hamster
DOSE/DURATION : 100 mg/kg
REFERENCE :
DTESD7 52 Vanderbilt Ave., New York, NY 10017) V.1-15, 1977-87.
Discontinued 52 Vanderbilt Ave., New York, NY 10017) V.1- 1977-
Volume(issue)/page/year: 2,201,1977
TYPE OF TEST : Mutation in mammalian somatic cells
TEST SYSTEM : Rodent - hamster Ovary
DOSE/DURATION : 100 ug/L/16H
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 45,91,1977
TYPE OF TEST : Mutation in mammalian somatic cells
TEST SYSTEM : Rodent - hamster Lung
DOSE/DURATION : 100 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 177,283,1987
TYPE OF TEST : Mutation in mammalian somatic cells
TEST SYSTEM : Rodent - hamster Kidney
DOSE/DURATION : 300 mg/L
REFERENCE :
GENTAE Genetics. (Genetics Business Office, POB 64025, Baltimore, MD 21264)
V.1- 1916- Volume(issue)/page/year: 77,309,1974
TYPE OF TEST : Mutation in mammalian somatic cells
TEST SYSTEM : Rodent - hamster Fibroblast
DOSE/DURATION : 200 mg/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
42,389,1982
TYPE OF TEST : Sperm Morphology
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - hamster
DOSE/DURATION : 25 mg/kg/5D
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
Volume(issue)/page/year: 8,929,1981
TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Mammal - domestic Kidney
DOSE/DURATION : 1 umol/L
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland
Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year:
13,243,1976
TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Bird - chicken
DOSE/DURATION : 133 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 96,53,1982
TYPE OF TEST : Micronucleus test
ROUTE OF EXPOSURE : Multiple routes
TEST SYSTEM : Amphibian - frog
DOSE/DURATION : 50 ppm
REFERENCE :
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,
Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year: 4,12,1989
TYPE OF TEST : Micronucleus test
TEST SYSTEM : Mammal - dog Lymphocyte
DOSE/DURATION : 2 mmol/L
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD-A075-605
TYPE OF TEST : DNA damage
TEST SYSTEM : Mammal - species unspecified Kidney
DOSE/DURATION : 100 umol/L
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
Volume(issue)/page/year: 6,333,1980
TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Mammal - species unspecified Lymphocyte
DOSE/DURATION : 1 umol/L
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland
Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year:
8,113,1974
TYPE OF TEST : Mutation test systems - not otherwise specified
TEST SYSTEM : Mammal - species unspecified Lymphocyte
DOSE/DURATION : 49 mmol/L
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland
Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year:
46,179,1983
TYPE OF TEST : Sister chromatid exchange
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - rabbit
DOSE/DURATION : 50 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 41,333,1976
TYPE OF TEST : Sister chromatid exchange
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Bird - chicken
DOSE/DURATION : 50 ug/kg
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 2,435,1980
TYPE OF TEST : Sister chromatid exchange
ROUTE OF EXPOSURE : Multiple routes
TEST SYSTEM : Amphibian - frog
DOSE/DURATION : 300 mg/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 8(Suppl
6),30,1986
TYPE OF TEST : Dominant lethal test
ROUTE OF EXPOSURE : Multiple routes
TEST SYSTEM : Amphibian - frog
DOSE/DURATION : 400 mg/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 6,719,1984
*** REVIEWS ***
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 7,245,1974
IARC Cancer Review:Human No Adequate Data
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 7,245,1974
IARC Cancer Review:Group 2B
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year:
7,56,1987
TOXICOLOGY REVIEW
ATXKA8 Archiv fuer Toxikologie. (Berlin, Fed. Rep. Ger.) V.15-31, 1954-74.
For publisher information, see ARTODN. Volume(issue)/page/year:
28,135,1971
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-FINLAND;Carcinogen JAN 1993
OEL-SWEDEN;Carcinogen JAN 1993
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X6247
No. of Facilities: 75 (estimated)
No. of Industries: 1
No. of Occupations: 2
No. of Employees: 971 (estimated)
No. of Female Employees: 448 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: Aspergillus-forward mutation;
Aspergillus-reversion
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat; SHE-clonal
assay
EPA GENETOX PROGRAM 1988, Positive: SHE-focus assay; Cell transform.-SA7/SHE
EPA GENETOX PROGRAM 1988, Positive: In vivo cytogenetics-nonhuman bone
marrow
EPA GENETOX PROGRAM 1988, Positive: D melanogaster-reciprocal translocation
EPA GENETOX PROGRAM 1988, Positive: Host-mediated assay; L5178Y cells in
vitro-TK test
EPA GENETOX PROGRAM 1988, Positive: Mammalian micronucleus
EPA GENETOX PROGRAM 1988, Positive: In vitro human lymphocyte micronucleus;
Mouse spot test
EPA GENETOX PROGRAM 1988, Positive: N crassa-forward mutation; N
crassa-reversion
EPA GENETOX PROGRAM 1988, Positive: E coli polA without S9; In vitro
SCE-human lymphocytes
EPA GENETOX PROGRAM 1988, Positive: Mouse specific locus; Sperm
morphology-mouse F1
EPA GENETOX PROGRAM 1988, Positive: Sperm morphology-mouse; D melanogaster
Sex-linked lethal
EPA GENETOX PROGRAM 1988, Positive: UDS in mouse germ cells; V79 cell
culture-gene mutation
EPA GENETOX PROGRAM 1988, Positive: TRP reversion; S cerevisiae gene
conversion
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae-forward mutation; S
cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae-aneuploidy; S
cerevisiae-reversion
EPA GENETOX PROGRAM 1988, Positive: S pombe-forward mutation; S
pombe-reversion
EPA GENETOX PROGRAM 1988, Positive/dose response: Rodent dominant lethal
EPA GENETOX PROGRAM 1988, Positive/dose response: Rodent heritable
translocation
EPA GENETOX PROGRAM 1988, Positive/dose response: In vitro SCE-human; In
vitro SCE-nonhuman
EPA GENETOX PROGRAM 1988, Positive/dose response: In vivo SCE-nonhuman
EPA GENETOX PROGRAM 1988, Positive/dose response: In vitro UDS-human
fibroblast
EPA GENETOX PROGRAM 1988, Negative: N crassa-aneuploidy
EPA GENETOX PROGRAM 1988, Inconclusive: Cytogenetics-male germ cell
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
NTP 7th Annual Report on Carcinogens, 1992 : anticipated to be carcinogen
*** END OF RECORD ***
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