*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : SJ6303000
CHEMICAL NAME : Phenol, 4-amino-2-nitro-
CAS REGISTRY NUMBER : 119-34-6
BEILSTEIN REFERENCE NO. : 1368435
REFERENCE : 4-13-00-01284 (Beilstein Handbook Reference)
LAST UPDATED : 199701
DATA ITEMS CITED : 23
MOLECULAR FORMULA : C6-H6-N2-O3
MOLECULAR WEIGHT : 154.14
WISWESSER LINE NOTATION : ZR DQ CNW
COMPOUND DESCRIPTOR : Tumorigen
Mutagen
Primary Irritant
SYNONYMS/TRADE NAMES :
* 4-Amino-2-nitrofenol
* 4-Amino-2-nitrophenol
* C.I. 76555
* Fourrine 57
* Fourrine Brown PR
* Fourrine Brown Propyl
* 4-Hydroxy-3-nitroaniline
* NCI-C03963
* o-Nitro-p-aminophenol
* 2-Nitro-4-aminophenol
* Oxidation Base 25
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration into the eye
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 100 mg/24H
REACTION SEVERITY : Severe
REFERENCE :
28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku,"
Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu
Praha, Czechoslovakia, 1972 Volume(issue)/page/year: -,107,1972
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1470 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NCILB* Progress Report for Contract No. NIH-NCI-E-C-72-3252, Submitted to
the National Cancer Institute by Litton Bionetics, Inc. (Bethesda, MD)
Volume(issue)/page/year: NCI-E-C-72-3252,1973
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 302 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
Volume(issue)/page/year: 2,657,1977
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1470 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NCILB* Progress Report for Contract No. NIH-NCI-E-C-72-3252, Submitted to
the National Cancer Institute by Litton Bionetics, Inc. (Bethesda, MD)
Volume(issue)/page/year: NCI-E-C-72-3252,1973
** TUMORIGENIC DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 108 gm/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Kidney, Ureter, Bladder - tumors
REFERENCE :
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-94,1978
** MUTATION DATA **
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 100 ug/plate
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 7(Suppl
5),1,1985
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 50 ug/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 44,9,1977
TYPE OF TEST : Morphological transformation
TEST SYSTEM : Rodent - rat Embryo
DOSE/DURATION : 11 ug/plate
REFERENCE :
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins
Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
Volume(issue)/page/year: 1,190,1981
TYPE OF TEST : Micronucleus test
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 400 mg/kg/24H (Continuous)
REFERENCE :
CYTOAN Cytologia. (Japan Pub. Trading Co. (USA), 1255 Howard St., San
Francisco, CA 94103) V.1- 1929- Volume(issue)/page/year: 57,149,1992
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Rodent - mouse Lymphocyte
DOSE/DURATION : 2500 ug/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E.
11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year:
12(Suppl 13),103,1988
TYPE OF TEST : Morphological transformation
TEST SYSTEM : Rodent - mouse Embryo
DOSE/DURATION : 80 ug/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E.
11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year:
12,21,1988
TYPE OF TEST : Mutation in mammalian somatic cells
TEST SYSTEM : Rodent - mouse Lymphocyte
DOSE/DURATION : 7680 ug/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E.
11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year:
12(Suppl 13),37,1988
*** REVIEWS ***
IARC Cancer Review:Animal Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 16,43,1978
IARC Cancer Review:Human No Adequate Data
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 16,43,1978
IARC Cancer Review:Group 3
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year:
7,56,1987
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-GERMANY;Carcinogen JAN 1993
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X1706
No. of Facilities: 1356 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 11981 (estimated)
No. of Female Employees: 9309 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-RLV F344 rat embryo
EPA GENETOX PROGRAM 1988, Positive/limited: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Negative: Rodent dominant lethal
EPA TSCA Section 8(b) CHEMICAL INVENTORY
NCI Carcinogenesis Bioassay (feed);clear evidence:rat
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-94,78
NCI Carcinogenesis Bioassay (feed);no evidence:mouse
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-94,78
*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
| NAME | CAS |
Phenol, 4-chloro-2-ethyl-
| 18979-90-3 |
Phenol, 4-chloro-2-ethyl-, acetate
| 53347-16-3 |
Phenol, 2-(((2-chloroethyl)amino)methyl)-4-nitro-
| 56538-00-2 |
Phenol, 4-chloro-2-ethyl-6-nitro-
| 53347-03-8 |
Phenol, 4-chloro-2-ethyl-6-propyl-
| 53346-77-3 |
Phenol, 4-chloro-2-hexyl-
| 18979-94-7 |
Phenol,4-chloro-2-((2-fluorophenyl)(pentylimino)methyl)-
| 18979-94-7 |
Phenol,4-((7-chloro-2-methoxybenzo(b)-1,5-naphthyridin-10-yl)amino)-2,6-bis(1-pyr rolidinyl methyl)-, phosphate(1:4)
| 76748-86-2 |
Phenol, 4-amino-2-nitro-
| 119-34-6 |
Phenol, 2-(2-chloro-1-methoxyethoxy)-,methylcarbamate
| 51487-69-5 |
Phenol,4-(2-((3-(2-chloro-4-(2-methoxyethyl)phenoxy)-2-hydroxypropyl)amino)propyl )-, hydrochloride
| 74027-40-0 |
Phenol, 2-chloro-5-methyl-
| 615-74-7 |
Phenol, 4-(chloromethyl)-, acetate
| 39720-27-9 |
Phenol, 3-(1-chloro-2-(methylamino)ethyl)-,hydrochloride
| 39720-27-9 |
Phenol, 4-chloro-3-methyl-2-(1-methylethyl)-
| 39720-27-9 |
Phenol, 2-(chloromethyl)-4-nitro-
| 2973-19-5 |
Phenol, 2-chloro-4-(methylsulfonyl)-
| 20945-65-7 |
Phenol, 2-chloro-4-nitro-
| 619-08-9 |
Phenol, 3-chloro-4-nitro-
| 491-11-2 |
Phenol, 2-amino-4-nitro-, hydrochloride
| 65407-97-8 |
Phenol, 2-chloro-4-nitro-, sodium salt
| 38731-70-3 |
Phenol, 4-chloro-2-(phenylmethyl)-, sodium salt
| 3184-65-4 |
Phenol,2-(5-((4-chlorophenyl)amino)-4-phenyl-4H-1,2,4-triazol-3-yl)-
| 82619-90-7 |
Phenol, p-((p-chlorophenyl)azo)-
| 2703-27-7 |
Phenol, 2-chloro-4-(phenylazo)-
| 6657-05-2 |
Phenol, p-((p-chlorophenyl)azo)-, piperazine salt
| 6657-05-2 |
Phenol,o-(4-(m-chlorophenyl)-3H-1,5-benzodiazepin-2-yl)-
| 6657-05-2 |
Phenol,o-(4-(o-chlorophenyl)-3H-1,5-benzodiazepin-2-yl)-
| 6657-05-2 |
Phenol,o-(4-(p-chlorophenyl)-3H-1,5-benzodiazepin-2-yl)-
| 6657-05-2 |
Phenol, 4-chloro-2-(phenylmethyl)-, potassium salt
| 35471-49-9 |
Phenol, 4-amino-2-nitro-, hydrochloride
| 35471-49-9 |
Phenol,2-((2-chlorophenyl)(pentylimino)methyl)-4-fluoro-
| 35471-49-9 |
Phenol, 4-(6-chloro-4-phenyl-2-quinazolinyl)-
| 49797-12-8 |
Phenol, p-chloro-, potassium salt
| 1121-74-0 |
Phenol,4-((7-chloro-4-quinolinyl)amino)-2,6-bis(1-pyrrolidinylmethyl)-, trihydrochloride
| 86489-54-5 |
Phenol,4-((7-chloro-4-quinolinyl)amino)-2-(phenyl-1-piperidinylmethyl)-
| 59614-92-5 |
Phenol,2,2'-(((6-chloro-2-quinoxalinyl)methylene)bis(3-(1,1-dimethylethyl)-4-meth oxy-, N,N'-dioxide
| 105301-24-4 |
Phenol,3-chloro-2-(4,5,6,7-tetrahydro-4,7-methanoisoindol-2-yl)-6-nitro-
| 78593-84-7 |
Phenol,2-(7-chloro-4H-(1,2,4)triazolo(3,4-c)(1,4)benzothiazin-1-yl)-
| 93300-02-8 |
Phenol, p-chloro-m-trifluoromethyl-
| 6294-93-5 |
Phenol, 3-(2-chloro-4-(trifluoromethyl)phenoxy)-,acetate
| 50594-77-9 |
Phenol, 2-amino-4-nitro-, sodium salt
| 61702-43-0 |
Phenol,2,2'-(2-(p-cyanophenyl)-1,3-imidazolidenedimethylene)di-
| 20063-36-9 |
Phenol,3-(6-(cyclobutylmethyl)-6-azabicyclo(3.2.1)oct-1-yl)-, hydrochloride, (+-)-
| 61226-57-1 |
Phenol, p-(1-cyclohexen-1-yl)-
| 709-08-0 |
Phenol, 2-(3-cyclohexenyl)-4,6-dinitro-
| 73758-38-0 |
Phenol, 2-((cyclohexylamino)methyl)-6-methoxy-
| 59004-61-4 |
Phenol, 2-cyclohexyl-4,6-dinitro-
| 131-89-5 |
Phenol, 2-cyclohexyl-4,6-dinitro-, Compd withdicylohexylamine
| 317-83-9 |
Phenol, 4,4'-(cyclohexylidenemethylene)di-,bis(dihydrogen phosphate) tetrasodium salt
| 15480-76-9 |
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