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MSDS  : Phenol, 4-((7-chloro-2-methoxybenzo(b)-1,5-naphthyridin-10-yl )amino)-2,6-bis(1-pyr rolidinyl methyl)-, phosphate (1:4)
CAS  : 76748-86-2
SYNONYMS  : * Pyranoridine phosphate
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : SK4920000
CHEMICAL NAME : Phenol,
4-((7-chloro-2-methoxybenzo(b)-1,5-naphthyridin-10-yl
)amino)-2,6-bis(1-pyr rolidinyl methyl)-, phosphate
(1:4)
CAS REGISTRY NUMBER : 76748-86-2
LAST UPDATED : 199509
DATA ITEMS CITED : 10
MOLECULAR FORMULA : C29-H32-Cl-N5-O2.4H3-O4-P
MOLECULAR WEIGHT : 910.11
COMPOUND DESCRIPTOR : Drug
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Pyranoridine phosphate

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1368 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YHHPAL Yaoxue Xuebao. Acta Pharmaceutica Sinica. Pharmaceutical Journal.
(China International Book Trading Corp., POB 2820, Beijing, Peop. Rep.
China) V.1- 1953- Suspended 1966-78. Volume(issue)/page/year:
15,630,1980

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 251 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YHHPAL Yaoxue Xuebao. Acta Pharmaceutica Sinica. Pharmaceutical Journal.
(China International Book Trading Corp., POB 2820, Beijing, Peop. Rep.
China) V.1- 1953- Suspended 1966-78. Volume(issue)/page/year:
15,630,1980

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 60 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YHHPAL Yaoxue Xuebao. Acta Pharmaceutica Sinica. Pharmaceutical Journal.
(China International Book Trading Corp., POB 2820, Beijing, Peop. Rep.
China) V.1- 1953- Suspended 1966-78. Volume(issue)/page/year:
15,630,1980

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 80 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YHHPAL Yaoxue Xuebao. Acta Pharmaceutica Sinica. Pharmaceutical Journal.
(China International Book Trading Corp., POB 2820, Beijing, Peop. Rep.
China) V.1- 1953- Suspended 1966-78. Volume(issue)/page/year:
15,630,1980

** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 2800 mg/kg/14D-I
TOXIC EFFECTS :
Behavioral - food intake (animal)
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - death
REFERENCE :
YHHPAL Yaoxue Xuebao. Acta Pharmaceutica Sinica. Pharmaceutical Journal.
(China International Book Trading Corp., POB 2820, Beijing, Peop. Rep.
China) V.1- 1953- Suspended 1966-78. Volume(issue)/page/year:
15,630,1980

** REPRODUCTIVE DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 2320 mg/kg
SEX/DURATION : male 9 week(s) pre-mating
female 2 week(s) pre-mating - 3 week(s) post-birth
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
before birth)
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal
of Pharmacology. (China International Book Trading Corp., POB 2820,
Beijing, Peop. Rep. China) V.1- 1980- Volume(issue)/page/year:
6,131,1985

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 1100 mg/kg
SEX/DURATION : female 7 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Specific Developmental Abnormalities - Central Nervous System
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
YHHPAL Yaoxue Xuebao. Acta Pharmaceutica Sinica. Pharmaceutical Journal.
(China International Book Trading Corp., POB 2820, Beijing, Peop. Rep.
China) V.1- 1953- Suspended 1966-78. Volume(issue)/page/year:
17,401,1982

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 990 mg/kg
SEX/DURATION : female 7-9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Specific Developmental Abnormalities - Central Nervous System
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
YHHPAL Yaoxue Xuebao. Acta Pharmaceutica Sinica. Pharmaceutical Journal.
(China International Book Trading Corp., POB 2820, Beijing, Peop. Rep.
China) V.1- 1953- Suspended 1966-78. Volume(issue)/page/year:
17,401,1982

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 252 mg/kg
SEX/DURATION : female 7-9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
YHTPAD Yaoxue Tongbao. Bulletin of Pharmacology. (China International Book
Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.13-23, 1978-88. For
publisher information, see ZYZAEU. Volume(issue)/page/year: 16(11),53,1981

** MUTATION DATA **

TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 100 ug/plate
REFERENCE :
CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal
of Pharmacology. (China International Book Trading Corp., POB 2820,
Beijing, Peop. Rep. China) V.1- 1980- Volume(issue)/page/year:
3,51,1982

*** END OF RECORD ***
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NAMECAS
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Phenol,4-chloro-2-((2-fluorophenyl)(pentylimino)methyl)- 18979-94-7
Phenol,4-((7-chloro-2-methoxybenzo(b)-1,5-naphthyridin-10-yl)amino)-2,6-bis(1-pyr rolidinyl methyl)-, phosphate(1:4) 76748-86-2
Phenol, 4-amino-2-nitro- 119-34-6
Phenol, 2-(2-chloro-1-methoxyethoxy)-,methylcarbamate 51487-69-5
Phenol,4-(2-((3-(2-chloro-4-(2-methoxyethyl)phenoxy)-2-hydroxypropyl)amino)propyl )-, hydrochloride 74027-40-0
Phenol, 2-chloro-5-methyl- 615-74-7
Phenol, 4-(chloromethyl)-, acetate 39720-27-9
Phenol, 3-(1-chloro-2-(methylamino)ethyl)-,hydrochloride 39720-27-9
Phenol, 4-chloro-3-methyl-2-(1-methylethyl)- 39720-27-9
Phenol, 2-(chloromethyl)-4-nitro- 2973-19-5
Phenol, 2-chloro-4-(methylsulfonyl)- 20945-65-7
Phenol, 2-chloro-4-nitro- 619-08-9
Phenol, 3-chloro-4-nitro- 491-11-2
Phenol, 2-amino-4-nitro-, hydrochloride 65407-97-8
Phenol, 2-chloro-4-nitro-, sodium salt 38731-70-3
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Phenol,2-(5-((4-chlorophenyl)amino)-4-phenyl-4H-1,2,4-triazol-3-yl)- 82619-90-7
Phenol, p-((p-chlorophenyl)azo)- 2703-27-7
Phenol, 2-chloro-4-(phenylazo)- 6657-05-2
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Phenol,o-(4-(m-chlorophenyl)-3H-1,5-benzodiazepin-2-yl)- 6657-05-2
Phenol,o-(4-(o-chlorophenyl)-3H-1,5-benzodiazepin-2-yl)- 6657-05-2
Phenol,o-(4-(p-chlorophenyl)-3H-1,5-benzodiazepin-2-yl)- 6657-05-2
Phenol, 4-chloro-2-(phenylmethyl)-, potassium salt 35471-49-9
Phenol, 4-amino-2-nitro-, hydrochloride 35471-49-9
Phenol,2-((2-chlorophenyl)(pentylimino)methyl)-4-fluoro- 35471-49-9
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Phenol,4-((7-chloro-4-quinolinyl)amino)-2-(phenyl-1-piperidinylmethyl)- 59614-92-5
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Phenol,2-(7-chloro-4H-(1,2,4)triazolo(3,4-c)(1,4)benzothiazin-1-yl)- 93300-02-8
Phenol, p-chloro-m-trifluoromethyl- 6294-93-5
Phenol, 3-(2-chloro-4-(trifluoromethyl)phenoxy)-,acetate 50594-77-9
Phenol, 2-amino-4-nitro-, sodium salt 61702-43-0
Phenol,2,2'-(2-(p-cyanophenyl)-1,3-imidazolidenedimethylene)di- 20063-36-9
Phenol,3-(6-(cyclobutylmethyl)-6-azabicyclo(3.2.1)oct-1-yl)-, hydrochloride, (+-)- 61226-57-1
Phenol, p-(1-cyclohexen-1-yl)- 709-08-0
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Phenol, 2-((cyclohexylamino)methyl)-6-methoxy- 59004-61-4
Phenol, 2-cyclohexyl-4,6-dinitro- 131-89-5
Phenol, 2-cyclohexyl-4,6-dinitro-, Compd withdicylohexylamine 317-83-9
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