Search   
MSDS  
:
 p-Phenylenediamine, N,N-diethyl-
CAS  
:
 93-05-0
SYNONYMS  
:
 * p-Aminodiethylaniline
* p-(Diethylamino)aniline
* 4-(Diethylamino)aniline
* N,N-Diethyl-1,4-benzenediamine
* N,N'-Diethyl-p-fenylendiamin
* N,N'-Diethyl-p-phenylenediamine
* Diethyl-para-phenylenediamine
* DPD

                     *** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : SS9275000
CHEMICAL NAME           : p-Phenylenediamine, N,N-diethyl-
CAS REGISTRY NUMBER     : 93-05-0
LAST UPDATED            : 199712
DATA ITEMS CITED        : 18
MOLECULAR FORMULA       : C10-H16-N2
MOLECULAR WEIGHT        : 164.28
WISWESSER LINE NOTATION : ZR DN2&2
COMPOUND DESCRIPTOR     : Mutagen
                          Human
                          Primary Irritant
SYNONYMS/TRADE NAMES :
   * p-Aminodiethylaniline
   * p-(Diethylamino)aniline
   * 4-(Diethylamino)aniline
   * N,N-Diethyl-1,4-benzenediamine
   * N,N'-Diethyl-p-fenylendiamin
   * N,N'-Diethyl-p-phenylenediamine
   * Diethyl-para-phenylenediamine
   * DPD
 
                       *** HEALTH HAZARD DATA ***
 
                      ** SKIN/EYE IRRITATION DATA **
 
TYPE OF TEST            : Standard Draize test
ROUTE OF EXPOSURE       : Administration into the eye
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 100 uL/24H
REACTION SEVERITY       : Severe
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: OTS0546494
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Human
DOSE/DURATION           : 73 ug/kg
TOXIC EFFECTS :
   Blood - hemorrhage
   Skin and Appendages - primary irritation (after topical exposure)
   Skin and Appendages - dermatitis, allergic (after topical exposure)
REFERENCE :
   JIDHAN Journal of Industrial Hygiene.  (Cambridge, MA)  V.1-17, 1919-35. For
   publisher information, see AEHLAU.  Volume(issue)/page/year: 4,386,1923
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >200 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - muscle weakness
   Gastrointestinal - hypermotility, diarrhea
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: OTS 0546494
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 25 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - food intake (animal)
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: OTS 0546494
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - coma
REFERENCE :
   JIDHAN Journal of Industrial Hygiene.  (Cambridge, MA)  V.1-17, 1919-35. For
   publisher information, see AEHLAU.  Volume(issue)/page/year: 4,386,1923
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Behavioral - food intake (animal)
   Behavioral - muscle weakness
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: OTS 0546494
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 25 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - muscle weakness
   Skin and Appendages - hair
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: OTS 0546494
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 70 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JIDHAN Journal of Industrial Hygiene.  (Cambridge, MA)  V.1-17, 1919-35. For
   publisher information, see AEHLAU.  Volume(issue)/page/year: 4,386,1923
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : 300 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Cardiac - pulse rate increase, without fall in BP
   Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
   JIDHAN Journal of Industrial Hygiene.  (Cambridge, MA)  V.1-17, 1919-35. For
   publisher information, see AEHLAU.  Volume(issue)/page/year: 4,386,1923
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 450 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - coma
REFERENCE :
   JIDHAN Journal of Industrial Hygiene.  (Cambridge, MA)  V.1-17, 1919-35. For
   publisher information, see AEHLAU.  Volume(issue)/page/year: 4,386,1923
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 125 mg/kg
TOXIC EFFECTS :
   Behavioral - general anesthetic
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
   JIDHAN Journal of Industrial Hygiene.  (Cambridge, MA)  V.1-17, 1919-35. For
   publisher information, see AEHLAU.  Volume(issue)/page/year: 4,386,1923
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 250 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - coma
REFERENCE :
   JIDHAN Journal of Industrial Hygiene.  (Cambridge, MA)  V.1-17, 1919-35. For
   publisher information, see AEHLAU.  Volume(issue)/page/year: 4,386,1923
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Cardiac - pulse rate increase, without fall in BP
   Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
   JIDHAN Journal of Industrial Hygiene.  (Cambridge, MA)  V.1-17, 1919-35. For
   publisher information, see AEHLAU.  Volume(issue)/page/year: 4,386,1923
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 666 ug/plate
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   11(Suppl 12),1,1988
 
TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 2500 ug/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 241,175,1990

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY
   
   EPA TSCA Section 8(d) unpublished health/safety studies
   
   EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998

 
                            *** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
NAMECAS
Phenol, pentachloro-, acetate 1441-02-7
DL-Phenylalanine, N-(1H-indol-3-yloxoacetyl)-, ethylester 97529-42-5
DL-Phenylalanine, 2-methoxy-5-nitro-, ethyl ester,monohydrochloride 116366-15-5
L-Phenylalanine,N-(1-(2-methyl-1-oxo-3-((1-oxopropyl)thio)propyl)-L-prolyl)-, (S)- 74259-02-2
L-Phenylalanine,N-((4-(((2-methylpropoxy)carbonyl)amino)phenyl)sulfonyl)-, ethyl ester 81865-24-9
D-Phenylalanine, N-(3-(4-nitrophenyl)-3-oxopropyl)- 85975-29-7
D-Phenylalanine, N-(3-(4-nitrophenyl)-3-oxopropyl)-,monohydrochloride 85975-17-3
DL-Phenylalanine, N-((5-nitro-2-thienyl)carbonyl)-,(3-(5-nitro-2-furanyl)-2-propenylidene) hydrazide 39978-55-7
L-Phenylalanine,2-(2-oxo-2-(10H-phenothiazin-10-yl)ethyl)hydrazide 84409-81-4
DL-Phenylalanine, N-(1-oxo-3-phenyl-2-propenyl)-,methyl ester, (E)- 127750-60-1
DL-Phenylalanine, N-(3-oxo-3-phenylpropyl)- 85995-02-4
Phenol, pentachloro-, mixt. with chlorinated paraffinoils and 1-chloronaphthalene 70645-04-4
DL-Phenylalanine, N-(3-oxo-3-phenylpropyl)-,hydrochloride 85975-14-0
DL-Phenylalanine,N-(3-oxo-3-(4-propoxyphenyl)propyl)- 85975-28-6
DL-Phenylalanine,N-(3-oxo-3-(4-propoxyphenyl)propyl)-, hydrochloride 85975-15-1
Phenylalanine, alpha-phenyl- 56594-95-7
L-Phenylalanine, N-((phenylmethoxy)carbonyl)-,ethenyl ester 64187-42-4
Phenylalanine, 2-(phosphonomethyl)-, hydrate 110762-24-8
L-Phenylalanine, 4-(1-piperidinyl)-, beta- 71825-29-1
L-Phenylalanine,L-seryl-L-valyl-L-seryl-L-alpha-glutamyl-L-isoleucyl-L-glutaminyl-L-leucy- L-methionyl-L-histidyl-L-asparaginyl-L-leucylglycyl-L-lysyl-L-histidyl-L-leu cyl-L-asparaginyl-L-seryl-L-methionyl-L-alpha-glutamyl-L-tryptophyl-L-leucyl-L-arginyl-L-lys yl-L-lysyl-L-leucyl-L-glutaminyl-L-alpha-aspartyl-L-valyl-L-histidyl-L-asparaginyl-, acetate (salt), hydrate 99294-94-7
Phenyl disulfide 882-33-7
m-Phenylenediamine 108-45-2
Phenol, pentachloro-, p-chlorobenzoate 2948-12-1
o-Phenylenediamine 95-54-5
p-Phenylenediamine 106-50-3
o-Phenylenediamine, 4-(p-aminophenoxy)- 6264-66-0
o-Phenylenediamine, 4-arsenoso-, hydrochloride,hydrate (1:1:3) 6264-66-0
p-Phenylenediamine, N,N-bis(2-chloroethyl)- 2067-58-5
p-Phenylenediamine, N,N-bis(2-chloroethyl)-,hydrochloride 36134-83-5
p-Phenylenediamine, N,N'-bis(1,4-dimethylpentyl)- 3081-14-9
p-Phenylenediamine, N,N'-bis(1-ethyl-3-methylpentyl)- 139-60-6
p-Phenylenediamine, N,N-bis(2-hydroxyethyl)-, sulfate(1:1) 63886-75-9
m-Phenylenediamine, 4-butoxy-, dihydrochloride 76486-09-4
Phenol, m-(pentachlorophenoxy)- 76486-09-4
m-Phenylenediamine, 4-chloro- 5131-60-2
o-Phenylenediamine, 4-chloro- 95-83-0
p-Phenylenediamine, 2-chloro- 615-66-7
o-Phenylenediamine,4-chloro-N-(2-(diethylamino)ethyl)- 56756-64-0
p-Phenylenediamine, 2-chloro-, dihydrochloride 615-46-3
p-Phenylenediamine, 2-chloro-, sulfate 6219-71-2
p-Phenylenediamine, N,N'-di-sec-butyl- 101-96-2
p-Phenylenediamine, N,N'-dibutyl-N,N'-dinitroso- 19433-82-0
p-Phenylenediamine, 2,5-dichloro- 20103-09-7
p-Phenylenediamine, 2,6-dichloro- 609-20-1
Phenol, 2-(pentachlorophenoxy)- 78576-68-8
p-Phenylenediamine, N,N'-dicyclohexyl- 4175-38-6
p-Phenylenediamine, N,N-diethyl- 93-05-0
p-Phenylenediamine, N,N'-diethyl- 3010-30-8
o-Phenylenediamine, N-(2-(diethylamino)ethyl)-,dihydrochloride 101976-54-9
p-Phenylenediamine, N,N-diethyl-N',N'-dimethyl- 5775-53-1

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