RTECS NUMBER : TH4897000
CHEMICAL NAME : Phosphoryl chloride
CAS REGISTRY NUMBER : 10025-87-3
LAST UPDATED : 199806
DATA ITEMS CITED : 25
MOLECULAR FORMULA : Cl3-O-P
MOLECULAR WEIGHT : 153.32
WISWESSER LINE NOTATION : P O G3
SYNONYMS/TRADE NAMES :
* Fosforoxychlorid
* Oxychlorid fosforecny
* Phosphorus oxychloride
* Phosphorus oxytrichloride
* Phosphoryl trichloride
* Trichlorophosphine oxide
* Trichlorophosphorus oxide
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 36 mg/kg
TOXIC EFFECTS :
Gastrointestinal - other changes
Liver - other changes
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0534840
TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 32 ppm/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku,"
Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu
Praha, Czechoslovakia, 1972 Volume(issue)/page/year: -,17,1972
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 1 gm/kg
TOXIC EFFECTS :
Behavioral - muscle weakness
Liver - other changes
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0534840
TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 53 ppm/4H
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - effect, not otherwise specified
Behavioral - irritability
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year:
25,470,1964
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Mammal - species unspecified
DOSE/DURATION : 1340 ug/m3/17W-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - structural or functional change in trachea
or bronchi
Musculoskeletal - osteoporosis
Immunological Including Allergic - other immediate (humoral): urticaria,
allergic rhinitis, serum sickness
REFERENCE :
JHEMA2 Journal of Hygiene, Epidemiology, Microbiology, and Immunology.
(Avicenum, Malostranske namesti 28, 11802 Prague 1, Czechoslovakia) V.1-
1957- Volume(issue)/page/year: 21,387,1977
*** REVIEWS ***
ACGIH TLV-TWA 0.63 mg/m3 (0.1 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
OEL-UNITED KINGDOM:TWA 0.2 ppm (1.2 mg/m3);STEL 0.6 ppm JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO PHOSPHORUS OXYCHLORIDE-air:10H TWA 0.1 ppm;STEL 0.5 ppm
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 81931
No. of Facilities: 155 (estimated)
No. of Industries: 7
No. of Occupations: 22
No. of Employees: 7258 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 81931
No. of Facilities: 165 (estimated)
No. of Industries: 9
No. of Occupations: 29
No. of Employees: 12587 (estimated)
No. of Female Employees: 2945 (estimated)