*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : TH6333500
CHEMICAL NAME : Photofrin II
CAS REGISTRY NUMBER : 87806-31-3
LAST UPDATED : 199806
DATA ITEMS CITED : 10
COMPOUND DESCRIPTOR : Drug
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Polyhematoporphyrin ether
* Porfimer Sodium
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 75 mg/kg
TOXIC EFFECTS :
Behavioral - food intake (animal)
Skin and Appendages - hair
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 49,439,1995
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : >125 mg/kg
TOXIC EFFECTS :
Skin and Appendages - dermatitis, other (after systemic exposure)
Skin and Appendages - hair
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 49,439,1995
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 50 mg/kg
TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea
Gastrointestinal - nausea or vomiting
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 49,439,1995
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 65 mg/kg/13W-I
TOXIC EFFECTS :
Liver - changes in liver weight
Endocrine - changes in spleen weight
Blood - normocytic anemia
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 49,439,1995
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 97500 ug/kg/13W-I
TOXIC EFFECTS :
Endocrine - changes in spleen weight
Blood - normocytic anemia
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - phosphatases
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 49,439,1995
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE : 44 mg/kg
SEX/DURATION : female 7-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - other effects
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 49,427,1995
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE : 88 mg/kg
SEX/DURATION : female 7-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - parturition
Reproductive - Maternal Effects - other effects
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 49,427,1995
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE : 84 mg/kg
SEX/DURATION : male 63 day(s) pre-mating
female 14 day(s) pre-mating - 7 day(s) after
conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - other effects
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 49,427,1995
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE : 104 mg/kg
SEX/DURATION : female 17 day(s) after conception - 21 day(s)
post-birth
TOXIC EFFECTS :
Reproductive - Maternal Effects - other effects
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
gain)
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 49,427,1995
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rabbit
DOSE : 52 mg/kg
SEX/DURATION : female 6-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Fertility - abortion
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 49,427,1995
*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
| NAME | CAS |
Phosphorous acid, tris(1-methylethyl) ester
| 116-17-6 |
Phosphorous triamide, hexamethyl-
| 1608-26-0 |
Phosphorodithioic acid, O,O-dimethyl ester, S-esterwith 4-(mercaptomethyl)-2-methoxy- delta(sup2)-1,3,4-thiadiazolin-5-one
| 950-37-8 |
Phosphorothioic acid, O,O-dimethylO-(o-sulfamoylphenyl) ester
| 950-37-8 |
Phosphor Red 2Zh600RT
| 950-37-8 |
Phosphorus (red)
| 7723-14-0 |
Phosphorus (white)
| 7723-14-0 |
Phosphorus(1+),bis(N-methylmethanaminato)methyl(1,4,7,10-tetraoxa-13-azacyclopentadecanat o- N)-, iodide, (T-4)-
| 139194-04-0 |
Phosphorus chloride
| 7719-12-2 |
Phosphorus dichloridemonofluoride
| 15597-63-4 |
Phosphorus difluoridemonochloride
| 14335-40-1 |
Phosphorus fluoride
| 7783-55-3 |
Phosphorus oxide
| 1314-56-3 |
Phosphorodithioic acid, O,O-dimethyl ester, S-esterwith 4-(mercaptomethyl)-5-methoxy- delta(sup4)-1,3,4-thiadiazolin-2-one
| 1314-56-3 |
Phosphorus pentafluoride
| 7647-19-0 |
Phosphorus sesquisulfide
| 1314-85-8 |
Phosphorus sulfide
| 1314-80-3 |
Phosphorus(1+),mu-1,4,10,13-tetraoxa-7,16-diazacyclooctadecane-7,16-diyldifluorobis(N- methylmethanaminato)dimethyl-,diiodide
| 139194-05-1 |
Phosphorus(1+),mu-1,4,10,13-tetraoxa-7,16-diazacyclooctadecane-7,16-diyltetrakis (N-methylmethanaminato)dimethyl-,diiodide
| 139194-01-7 |
Phosphorus tribromide
| 7789-60-8 |
Phosphoryl chloride
| 10025-87-3 |
Phosphoryl dichloridemonofluoride
| 13769-76-1 |
Phosphotungstic acid
| 12067-99-1 |
Phosphotungstic acid, sodium salt
| 51312-42-6 |
Phosphorodithioic acid, O,O-dimethyl ester, S-esterwith 2-(mercaptomethyl)-6-methyl-3(2H)- pyridazinone
| 51356-08-2 |
PhosterolSUBSTANCE DEFINITION :Composed of hydroxyethyl tetraalkylphosphonate pentaerythritol in which N is1.5 to 2.0REFERENCE :85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under SingleExposure," Izmerov, N.F., et al., Moscow, Centre of International Projects,GKNT, 1982 Volume(issue)/page/year: -,76,1982
| 51356-08-2 |
Photinia arguta Lindl., extract excluding rootSUBSTANCE DEFINITION :Indian plant belonging to the family RosaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 26,883,1988
| 51356-08-2 |
Photinia cuspidata (Bertol.) Balakr., extractSUBSTANCE DEFINITION :Plant belonging to the family RosaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
| 51356-08-2 |
Photinia integrifolia Lindl., extract excluding rootsSUBSTANCE DEFINITION :Plant belonging to the family RosaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 9,91,1971
| 51356-08-2 |
Photinia notoniana W. & A., extract excluding rootsSUBSTANCE DEFINITION :Plant belonging to the family RosaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 12,512,1974
| 51356-08-2 |
Photinia serratifolia (desf.) Kalkman, extractexcluding rootsSUBSTANCE DEFINITION :Plant belonging to the family RosaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
| 51356-08-2 |
Photocopy extractsSUBSTANCE DEFINITION :Extracted in a soxhlet with acetone overnight, may contain dinitropyrenesREFERENCE :SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 HSt., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year:209,1037,1980
| 51356-08-2 |
Photofrin II
| 87806-31-3 |
Photosensitizer, psd-007
| 103939-18-0 |
Phragmites maxima (forsk.) Blatt. & Mcc., extractexcluding rootsSUBSTANCE DEFINITION :Plant belonging to the family GramineaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
| 103939-18-0 |
Phosphorodithioic acid, S,S-diethyl O-methyl ester
| 22082-34-4 |
Phosphorodithioic acid, O,O-dimethyl ester, S-esterwith 2-mercapto-N-methyl-N-nitroso acetamide
| 63124-33-4 |
Phrynium pubinerve B1., extractSUBSTANCE DEFINITION :Plant belonging to the family ZingiberaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 26,883,1988
| 63124-33-4 |
Phthalaldehyde
| 643-79-8 |
Phthalaldehyde, dioxime
| 37919-50-9 |
Phthalaldehydic acid
| 119-67-5 |
Phthalaldehydic acid, 5,6-dimethoxy-,2-(isonicotinoylhydrazone)
| 2779-55-7 |
Phthalaldehydic acid,2-((5-nitro-2-pyridyl)hydrazone)
| 28058-41-5 |
Phthalaldehydic anhydride
| 101976-08-3 |
Phthalamic acid, 3-amino-N,N-diethyl-,2-(diethylamino)ethyl ester, hydrochloride
| 101976-08-3 |
Phthalamic acid, N-(5-(p-aminophenoxy)pentyl)-,lithium salt
| 111498-38-5 |
Phthalamic acid, N-(6-butoxy-3-pyridyl)-
| 111498-38-5 |
Phosphorodithioic acid, O,O-dimethyl ester, S-esterwith 3-(mercaptomethyl)-1,3,4-oxadiazol- 2(3H)-one
| 42565-17-3 |
Phthalamic acid, N-carbamoyl-
| 13435-16-0 |
Phthalamic acid,N-(5-carboxymethyl-4-(p-chlorophenyl)-2-thiazolyl)-
| 71013-49-5 |
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