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MSDS  : Phytohemagglutinin
CAS  : 9008-97-3
SYNONYMS  : * Fitohemaglutynina * PHA * Phytohaemagglutinin * Phytohemaglutinins * Pigeon pea phytohemagglutinin
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : TJ3470000
CHEMICAL NAME : Phytohemagglutinin
CAS REGISTRY NUMBER : 9008-97-3
LAST UPDATED : 199504
DATA ITEMS CITED : 8
COMPOUND DESCRIPTOR : Drug
Mutagen
Reproductive Effector
Natural Product
SYNONYMS/TRADE NAMES :
* Fitohemaglutynina
* PHA
* Phytohaemagglutinin
* Phytohemaglutinins
* Pigeon pea phytohemagglutinin

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1470 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - food intake (animal)
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
40,217,1977

** REPRODUCTIVE DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE : 10 mg/kg
SEX/DURATION : female 4-5 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
FOBGA8 Folia Biologica (Krakow). (Ars Polona, POB 1001, 00-068 Warsaw 1,
Poland) V.1- 1953- Volume(issue)/page/year: 24,213,1976

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE : 120 mg/kg
SEX/DURATION : female 4-5 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
FOBGA8 Folia Biologica (Krakow). (Ars Polona, POB 1001, 00-068 Warsaw 1,
Poland) V.1- 1953- Volume(issue)/page/year: 24,213,1976

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE : 20 mg/kg
SEX/DURATION : female 11-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
Reproductive - Specific Developmental Abnormalities - cardiovascular
(circulatory) system
REFERENCE :
FOBGA8 Folia Biologica (Krakow). (Ars Polona, POB 1001, 00-068 Warsaw 1,
Poland) V.1- 1953- Volume(issue)/page/year: 24,213,1976

** MUTATION DATA **

TYPE OF TEST : Mutation test systems - not otherwise specified
TEST SYSTEM : Rodent - rat Lymphocyte
DOSE/DURATION : 1 mg/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E.
11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year:
17,141,1991

TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Rodent - mouse Lymphocyte
DOSE/DURATION : 10 mg/L
REFERENCE :
PLMEAA Planta Medica. (Georg Thieme Verlag, Postfach 732, D-7000 Stuttgart
1, Fed. Rep. Ger.) V.1- 1953- Volume(issue)/page/year: 51,91,1985

TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Rodent - mouse Cells - not otherwise specified
DOSE/DURATION : 40 uL/plate
REFERENCE :
FOMOAJ Folia Morphologica (Warsaw). (Panstwowy Zaklad Wydawnictw
Lekarskich, ul. Dluga 38-40, 00 238 Warsaw, Poland) V.1- 1929-
Volume(issue)/page/year: 33,191,1974

*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X9999
No. of Facilities: 56 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 265 (estimated)
No. of Female Employees: 215 (estimated)


*** END OF RECORD ***
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NAMECAS
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Physalin-X 72497-31-5
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1(2H)-Phthalazinone,4-((4-chlorophenyl)methyl)-2-(8-(phenylmethyl)-8-azabicyclo(3.2.1)oct-3- yl)-, monohydrochloride 110406-75-2
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Physiosol 1-S 110406-75-2
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Physodine B 122051-34-7
Physostigmine 57-47-6
Physostigmine, methiodide 6091-11-8
Physostigmine, salicylate (11) 57-64-7
Physostigmine, tartrate 57-64-7
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Phytic acid, hexacopper (II) salt 63903-50-4
Phytohemagglutinin 9008-97-3
Phytohemagglutinin, dolichos lablab 9008-97-3
Phytohemagglutinin, phaseolus lunatus 9008-97-3
Phytohemagglutinin, pisum sp. 9008-97-3
Phytol 150-86-7
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Phytolacca dodecandra, extract 39278-85-8
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Picibanil 39325-01-4
Picnomon arcana Cass., flower extract 39325-01-4
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Picolinaldehyde, 1,6-dihydro-1-methyl-, oxime,hydrochloride 57619-29-1
Picolinaldehyde, 5-hydroxy-, thiosemicarbazone 19494-89-4
Picolinaldehyde, oxime 873-69-8
Picolinaldehyde, thiosemicarbazone 3608-75-1
Picolinamide, N-(1-adamantyl)- 61876-32-2
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