LILLY ELI & PHARMACEUTICAL DIV -- VL7108 VINCRISTINE SULFATE-INJECTION 2 ML
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Material Safety Data Sheet
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MSDS Num: BWYNY
MSDS NAME: VL7108 VINCRISTINE SULFATE-INJECTION 2 ML
Responsible Party
Name: LILLY ELI & CO PHARMACEUTICAL DIV
Address: LILLY CORPORATE CENTER
City: INDIANAPOLIS IN 46285
Info Phone: 317-276-2000
Emergency Phone Number: 317-276-2000
Review Ind: Y
Published: Y
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Preparer Co. when other than Responsible Party Co.
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Assigned Ind: Y
Name: LILLY ELI & CO PHARMACEUTICAL DIV
Address: LILLY CORPORATE CENTER
City: INDIANAPOLIS IN 46285
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Contractor Summary
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Name: LILLY ELI & CO PHARMACEUTICAL DIV
Address: LILLY CORPORATE CENTER
City: INDIANAPOLIS IN 46285
Phone: 317-276-2000
Name: LILLY ELI AND CO PHARMACEUTICAL DIV
Address: LILLY CORPORATE CENTER
City: INDIANAPOLIS IN 46285
Phone: 317-276-2000
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Ingredients
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Cas: 64044-51-5
Name: LACTOSE
% Wt: 0-90
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Cas: 69-65-8
RTECS #: OP2060000
Name: MINNITOL, D- (MANNA SUGAR); MANNITOL
% Wt: 0-90
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Cas: 2068-78-2
RTECS #: OH6340000
Name: VINCRISTINE SULFATE (IARC GROUP 3) * 95-1 *
% Wt: 9.1
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Health Hazards Data
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Route Of Entry Inds - Inhalation: YES
Skin: YES
Ingestion: YES
Carcinogenicity Inds - NTP: NO
IARC: NO
OSHA: NO
Effects of Exposure: VINCRISTINE SULFATE- SKIN: IRRITANT. EYES: SEVERE
IRRITATION. PATIENTS TREATED W/COMBINATION THERAPY HAVE DEVELOPED SECOND
MALIGNANCIES/DECREASE IN FERTILITY. AT INTRAVENOUS DOSES SUPPRESSES BONE MARR
OW FUNCTION, WEAK IMMUNE SUPPRESSION HAS OCCURED IN A FEW PATIENTS. (SEE
SUPP)
Explanation Of Carcinogenicity: NONE
Signs And Symptions Of Overexposure: IRRITATION, DEPIGMENTATION, TEARING, PAIN,
BLURRED VISION, NAUSEA, VOMITING
Medical Cond Aggravated By Exposure: PATIENTS W/CHARCOT-MARIE-TOOTH SYNDROME,
WORKERS W/NEUROMUSCULAR DYSFUNCTION/SENSITIVITY TO VINCRISTINE SULFATE.
First Aid: EYES: FLUSH W/A STEADY, GENTLE STREAM OF WATER FOR 15 MINS. SKIN:
WASH W/PLENTY OF SOAP & WATER. INHALATION: MOVE TO FRESH AIR. IF NOT
BREATHING, GIVE CPR. INGESTION: DON'T INDUCE VOMITING. OBTAIN MED ICAL
ATTENTION IN ALL CASES. NOTE TO PHYSICIAN: A STEROID EYE OINTMENT/DROPS SERVE
TO MINIMIZE INFLAMMATION.
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Handling and Disposal
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Spill Release Procedures: USE EITHER WET CLEANUP METHODS/VACUUM CLEANERS W/HEPA
FILTERS. USE DOUBLE PAIRS OF LATEX DISPOSABLE GLOVES DISPOSING OF WITHIN AN
HOUR, GOGGLES & NIOSH APPROVED DUST-MIST RESPIRATOR.
Neutralizing Agent: MATERIAL MAY BE DECOMPOSED USING A BASIC (PH 10) SODIUM
HYPOCHLORIC SOLUTION.
Waste Disposal Methods: PLACE RESIDUE IN A SEGREGATED, SEALED PLASTIC
CONTAINER. VINCA ALKALOIDS ARE BIODEGRADEABLE. DISPOSE RESIDUE IAW/LOCAL,
STATE& FEDERAL REGULATIONS. IF DISPOSED BY INCINERATION, TEMP OF 850C FOR
SOLIDS & TEMP OF 950C FOR LIQUIDS ARE REQUIRED.
Handling And Storage Precautions: VINCRISTINE SULFATE IS A CYTOTOXIC MATERIAL.
Other Precautions: FOR WORK ENVIRONMENTS, EYE PROTECTION MUST BE PROVIDED &
HAND-TO-EYE CONTACT ELIMINATED. AVOID SKIN CONTACT.
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Fire and Explosion Hazard Information
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Unusual Fire/Explosion Hazard: MATERIAL MAY FORM DUST MIXTURES IN AIR &
EXPLODE IF SUBJECTED TO AN IGNITION SOURCE.
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Control Measures
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Respiratory Protection: USE A NIOSH APPROVED DUST-MIST RESPIRATOR/SAFETY
EQUIPMENT. IN PRODUCTION SETTINGS, AIRLINE-SUPPLIED, HOOD-TYPE RESPIRATORS
ARE PREFERRED TO PROVIDE FACE/EYE & RESPIRATORY PROTECTION.
Ventilation: EXTENSIVE LOCAL EXHAUST/ENCLOSED PROCESS EQUIPMENT
Protective Gloves: NATURAL RUBBER LATEX
Eye Protection: GOGGLES/FULL FACE MASK
Other Protective Equipment: IMPERVIOUS BODY COVERING; LONG SLEEVE
Work Hygienic Practices: REMOVE/LAUNDER CONTAMINATED CLOTHING BEFORE REUSE.
Supplemental Safety and Health: PH: 3.5-5.5 (RECONSTITUTED). HEALTH HAZ CONT'D:
INHALATION-LOCAL IRRITATION OF THE NOSE & THROAT. HOSPITAL EMPLOYEES
& HEALTH CARE PROVIDERS WHO PREPARE CYTOSTATIC DRUGS IN AN UNPROTECTED
ENVIRONMENT HAVE REPORTED HAVING INCREASED LEVELS OF MUTAGENS IN THEIR
URINE.
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Physical/Chemical Properties
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PH: (SUPP)
Solubility in Water: COMPLETE
Appearance and Odor: WHITE TO OFF-WHITE LYOPHILIZED PLUG W/NO ODOR
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Reactivity Data
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Stability Indicator: YES
Stability Condition To Avoid: IGNITION SOURCES
Hazardous Decomposition Products: TOXIC FUMES WHEN HEATED TO DECOMPOSITION
Hazardous Polymerization Indicator: NO
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Toxicological Information
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Ecological Information
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MSDS Transport Information
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Regulatory Information
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Other Information
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HAZCOM Label
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MSDS NAME: VL7108 VINCRISTINE SULFATE-INJECTION 2 ML
Assigned IND: Y
Company: LILLY ELI & CO PHARMACEUTICAL DIV
Street: LILLY CORPORATE CENTER
City: INDIANAPOLIS IN
Zipcode: 46285
Health Emergency Phone: 317-276-2000
Label Required IND: Y
Date Of Label Review: 12/16/1998
Status Code: C
Label Date: 12/16/1998
Origination Code: G
Hazard And Precautions: VINCRISTINE SULFATE- SKIN: IRRITANT. EYES: SEVERE
IRRITATION. PATIENTS TREATED W/COMBINATION THERAPY HAVE DEVELOPED SECOND
MALIGNANCIES/DECREASE IN FERTILITY. AT INTRAVENOUS DOSES SUPPRESSES BONE MARR
OW FUNCTION, WEAK IMMUNE SUPPRESSION HAS OCCURED IN A FEW PATIENTS. (SEE
SUPP) IRRITATION, DEPIGMENTATION,
TEARING, PAIN, BLURRED VISION, NAUSEA, VOMITING
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nor any person or persons contracting with any instrumentality of the United
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