===================== Product Identification =====================
MSDS NAME:CHLORPROMAZINE HYDROCHLORIDE, THORAZINE
NIIN:00-129-6709
MSDS Number: BPXVL
=== Responsible Party ===
Company:SMITHKLINE BEECHAM CORP
Address:709 SWEDELAND RD
Box:1539
City:KING OF PRUSSIA
State:PA
ZIP:19406-0939
Country:US
Info Phone Num:215-270-7807
Emergency Phone Num:215-270-7807
CAGE:SMITH
=== Contractor Identification ===
Company:SMITHKLINE ANIMAL HEALTH PRODUCTS
Address:1600 PAOLI PIKE
Box:City:WEST CHESTER
State:PA
ZIP:19380
Phone:(215) 251-7410
CAGE:93544
Company:SMITHKLINE BEECHAM CORP
Address:709 SWEDELAND RD
City:KING OF PRUSSIA
State:PA
ZIP:19406
Country:US
Phone:215-270-7807
CAGE:SMITH
============= Composition/Information on Ingredients =============
Name:PHENOTHIAZINE, 2-CHLORO-10-(3-(DIMETHYLAMINO)
PROPYL)-MONOHYDROCHLORIDE; (CHLORPROMAZINE HYDROCHLORIDE)
CAS:69-09-0
RTECS #:SO1750000
Fraction by Wt: >98%
OSHA PEL:0.04 MG/M3 (MFR)
Name:SUPP DATA: DEFECTS)/OTHER ADVERSE EFTS ON DEVELOPING
OFFSPRING CAN OCCUR, BASED ON ANIMAL STUDIES. USE OF MATL (ING 3)
RTECS #:9999999ZZ
Name:ING 2: IS NOT RECOM BY PREGNANT WOMEN. OTHER EFTS: THIS
MATL IS USED AS A TRANQULIZER & ANTIEMETIC.
RTECS #:9999999ZZ
Name:FIRST AID PROC: OF TOX DEVELOP MANY HRS AFTER EXPOS.
INGEST: SEEK IMMED MED ASSISTANCE. DO NOT INDUCE VOMIT (ING 5)
RTECS #:9999999ZZ
Name:ING 4: BECAUSE OF POSSIBILITY FOR NECK MUSCLE SPASMS
LEADING TO ASPIR OF VOMITUS. EARLY GASTRIC LAVAGE IS (ING 6)
RTECS #:9999999ZZ
Name:ING 5: RECOM. NOTE TO PHYS: SUBJECT MAY EXPER
EXTRAPYRAMIDAL SYMP. IN CASE OF OVEREXP, REFER TO MOST (ING 7)
RTECS #:9999999ZZ
Name:ING 6:RECENT EDITION OF PHYS DESK REFERENCE FOR TREATMENT
OF PHENOTHIAZINE OVERDOSAGES.
RTECS #:9999999ZZ
Name:SPILL PROC: DAMPEN MATL TO REDUCE CHANCES FOR DUST
EXPOSURE.
RTECS #:9999999ZZ
Name:OTHER PROT EQUIP: WASH STATION SHOULD BE READILY AVAILABLE.
RTECS #:9999999ZZ
Name:HYGIENE PRACT: SPILLS IMMEDIATELY.
RTECS #:9999999ZZ
===================== Hazards Identification =====================
LD50 LC50 Mixture:LD50:(ORAL,RAT)141 MG/KG
Routes of Entry: Inhalation:YES Skin:YES Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and Chronic:SKIN: ASSUME DIRECT CONT CAN PRDCE GEN
TOX/IRRIT. SYMP OF GEN TOX MIGHT INCL DROW, MUSCLE
TREMORS/RIGIDITY, STUPOR, COMA & DEATH IN EXTREME CASES. AFTER
CHRONIC EXPOS, SYMP MIGHT INCL LIVER DAM, TREMO RS, DERM & EFTS ON
EYES. SYMP IF IRRIT SUCH AS RED/SWELL MIGHT BE IMMED/DELAYED. EYE:
SEV IRRIT CAN (EFTS OF OVEREXP)
Explanation of Carcinogenicity:NOT RELEVANT
Effects of Overexposure:HLTH HAZ:OCCUR FOLLOW DIRECT CONT. SERIOUS EYE
DAM IS POSS. INHAL:DUST CAN BE HARMFUL IF INHALED, POSS FATAL @
HIGH CONC BASED ON ANIMAL STUDIES. SYMP MIGHT INCL DROW, MUSCLE
TREMORS/RIGIDITY, STUPOR, COMA & DEATH IN EXTREME CASES. AFTER
CHRONIC EXPOS, SYMP MIGHT INCL LIVER DAM/TREMORS, DERM & EFTS ON
EYES. (SUPP DATA)
Medical Cond Aggravated by Exposure:INDIVIDUALS W/HEART PROBLEMS MAY BE
SENSITIVE TO CARDIOVASCULAR EFTS OF MATL. DEPRESSANT EFTS OF
ALCOHOL & DRUGS SUCH AS BARBITURATES CAN BE ENHANCED BY THIS
MATERIAL.
======================= First Aid Measures =======================
First Aid:SKIN: REMOVE CONTAMD CLTHG, WASH EXPOSED AREA W/SOAP/H*2O.
OBTAIN MED ASSISTANCE IF IRRIT OCCURS, EVEN IF DELAYED. IF
PHOTOSENSITIVITY DEVELOPS, AVOID DIRECT SUNLIGHT. EYE: WASH W/H*2O
FOR @ LST 30 MI N THEN SEEK MED ASSISTANCE. INHAL: MOVETO FRESH
AIR. SEE PHYS IF SUBJECT EXPER DFCLTY BRTHG. IF BRTHG HAS STOPPED,
PERFORM CPR & OBTAIN IMMED MED ASSISTANCE. SEEK MED ASSISTANCE IF
SYMP OF (ING 4)
===================== Fire Fighting Measures =====================
Flash Point:>131F,>55C
Extinguishing Media:USE WATER, CO*2, FOAM OR DRY POWDER SUITABLE FOR
SURROUNDING FIRE.
Fire Fighting Procedures:NIOSH/MSHA APPRVD SCBA & FULL PROT EQUIP.
TOX/CORR GASES INCL CO*X, NO*X & SO*X TOGETHER W/CHLORINE & HCL ARE
EXPECTED IN FIRES INVOLVING MATL.(SUPP DATA)
Unusual Fire/Explosion Hazard:MATL IS SLIGHTLY COMBUST. LIKE MOST ORG
DUSTS, IT IS EXPECTED TO EXPLODE WHEN IGNITED AS A DUST CLOUD. CARE
SHOULD BE TAKEN TO AVOID DISPERSION AS A DUST CLOUD.
================== Accidental Release Measures ==================
Spill Release Procedures:RESTRICT ENTRY UNTIL AREA IS THORO CLEANED.
WEAR SUITABLE PROT CLTHG TO AVOID BRTHG DUST, EYE/SKIN CONT. FOR
SPILLS OF DRY POWDER, USE A CLEAN SHOVEL & PLACE MATL INTO CLEAN,
DRY CONTRS THEN COVER. MO VE CONTRS AWAY FROM SPILL AREA. IF POSS,
(ING 7)
Neutralizing Agent:NONE SPECIFIED BY MANUFACTURER.
====================== Handling and Storage ======================
Handling and Storage Precautions:KEEP AWAY FROM MOISTURE. STORE IN
PLASTIC-LINED FIBER DRUMS. AVOID STORAGE @ ELEVATED TEMP (>24C).
Other Precautions:NONE SPECIFIED BY MANUFACTURER.
============= Exposure Controls/Personal Protection =============
Respiratory Protection:IF DUST IS >0.04MG/CUBIC METER, A NIOSH/MSHA
FUME HOOD/APPRVD RESP MUST BE USED. WEAR A NIOSH/MSHA APPRVD
FULLFACE, AIR SUPPLIED RESP/A FULLFACE RESP W/CARTRIDGE SUITABLE
FOR DUST CONC PRESENT. FOLLOW LOC REGS FOR RESP USE IN WORKPLACE.
Ventilation:USE A FUME HOOD WHEN WORKING W/DUST. LOC EXHAUST SHOULD BE
USED WHEN HNDLG THIS MATL IN BULK QTY.
Protective Gloves:IMPERVIOUS GLOVES, LATEX FOR DRY MATL.
Eye Protection:CHEM WORK GOG OR FULL LNGTH FSHLD.
Other Protective Equipment:WEAR PROT CLTHG W/LONG SLEEVES. IN
PRODUCTION AREAS, IT SHOULD BE LAUNDERED/DISCARDED AFTER EACH USE.
AN EYE (ING 8)
Work Hygienic Practices:IN PRODUCTION AREAS, A SHOWER AFTER EACH SHIFT
IS RECOM. AVOID EAT/DRINK IN AREAS WHERE MATL IS HNDLD.CLEAN UP
(ING 9)
Supplemental Safety and Health
U/I:10-2ML AMPS/PKG-12PKG/BOX 25 MG. FIRE FIGHT PROC: MOVE CONTRS FROM
FIRE AREA IF POSS W/OUT INCR PERSONAL RISK. DIKE AREA IF POSS TO
CNTN H*2O FOR LATER DISP. EFTS OF OVEREXP: INGEST: CAN BE HARMFU L,
POSS FATAL IN LG AMTS. SYMP OF TOXICITY & CHRONIC EXPOS SAME AS IN
INHAL. REPROD EFTS:TERATOGENIC EFTS (BIRTH (ING 2)
================== Physical/Chemical Properties ==================
Melt/Freeze Pt:M.P/F.P Text:383F,195C
pH:4-5.5
Evaporation Rate & Reference:NEGLIGIBLE
Solubility in Water:SOLUBLE
Appearance and Odor:WHITE, ODORLESS CRYSTALLINE POWDER THAT DARKENS ON
PROLONGED EXPOSURE TO LIGHT.
================= Stability and Reactivity Data =================
Stability Indicator/Materials to Avoid:YES
NONE KNOWN.
Stability Condition to Avoid:DECOMPOSES @ TEMPS >194C.
Hazardous Decomposition Products:NONE KNOWN.
==================== Disposal Considerations ====================
Waste Disposal Methods:DISPOSE OF WASTE ON SITE IN A CHEMICAL
INCINERATOR IF ALLOWED BY THE INCINERATOR PERMIT. IF NO ON-SITE
INCINERATOR IS AVAILABLE, DISPOSE OF WASTE IN A LICENSED CHEMICAL
INCINERATOR. DISPOSE OF I/A/W F EDERAL, STATE & LOCAL REGULATIONS .
Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.
*** END OF RECORD *** |
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