LD50 LC50 Mixture:ORAL LD50 (RAT): 180-320 MG/KG (SUPP)
Routes of Entry: Inhalation:YES Skin:NO Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and Chronic:EYES/SKIN: IRRITATION.
METHOTREXATE-DEPRESSION OF BONE MARROW
FUNCTION/LEUKOPENIA/THROMBOCYTOPENIA/GI BLEEDING/LIVER
DAMAGE/EFFECTS ON FERTILITY/MENSTRUAL DYSFUNCTION/HEMATOLOGIC
CHANGES/SUPPRESSION O F IMMUNE SYSTEM/INDUCED LUNG
DISEASE/CHROMOSOMAL CHANGES/ABNORMAL FETAL
DEVELOPMENT/ABORTIONS/MALFORMATIONS. (SEE SUPP)
Explanation of Carcinogenicity:NONE
Effects of Overexposure:IRRITATION. METHOTREXATE-NAUSEA, VOMITING, LOSS
OF APPETITE, DIARRHEA, CONGESTION OF LUNGS, COUGH, ANEMIA.
Medical Cond Aggravated by Exposure:PRE-EXISTING KIDNEY FUNCTION
IMPAIRMENT.
======================= First Aid Measures =======================
Eyes: FLUSH W/WATER FOR 20 MINS. SKIN: WASH W/SOAP & WATER.
INHALATION: REMOVE TO FRESH AIR. GIVE CPR/OXYGEN IF NEEDED.
INGESTION: INDUCE VOMITING IMMEDIATELY AS DIRECTED BY MEDICAL
PERSONNEL. NEVER G IVE ANYTHING BY MOUTH/INDUCE VOMITING IF
UNCONSCIOUS. OBTAIN MEDICAL ATTENTION IN ALL CASES. NOTE TO
PHYSICIAN: CALCIUM LEUCOVORIN IS A POTENT AGENT FOR NEUTRALIZING
METHOTREXATE EFFECTS (SEE SUPP)
===================== Fire Fighting Measures =====================
Flash Point:COMBUSTIBLE
Unusual Fire/Explosion Hazard:METHOTREXATE DUST IS A CLASS ST-O DUST
EXPLOSION HAZARD.
Respiratory Protection:WEAR AN APPROVED AIR-PURIFYING RESPIRATOR
W/HIGH-EFFICIENCY CARTRIDGES IF APPLICABLE ACCO TWA-PEL IS
EXCEEDED.
Ventilation:CLOSED SYSTEM HANDLING/LOCAL EXHAUST ADEQUATE TO CONTROL
DUST/MIST.
Protective Gloves:REQUIRED
Work Hygienic Practices:REMOVE/LAUNDER CONTAMINATED CLOTHING BEFORE
REUSE. DESTROY CONTAMINATED LEATHER ITEMS.
Supplemental Safety and Health
ORAL LD50/DECOMPOSITION TEMP INFORMATION IS FOR METHOTREXATE. HEALTH
HAZARDS CONT'D: METHOTREXATE-WELL ABSORBED FROM GI TRACT.
STARCH-DERMAL GRANULOMATOUS LESIONS. ACUTE ORAL LETHAL DOSE IN
HUMANS >10 MG/KG. FIRST AID CONT'D: ON BLOOD FORMING SYSTEM.
COMPLETE HOMOGRAMS
Waste Disposal Methods:DISPOSE OF IAW/FEDERAL, STATE & LOCAL
REGULATIONS. INCINERATION IS RECOMMENDED.
Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.