===================== Product Identification =====================
MSDS NAME:52212 DIAZEPAM 2 ML
NIIN:00-137-5891
MSDS Number: BXNWH
=== Responsible Party ===
Company:HOFFMAN-LA ROCHE INC ROCHE LABORATORIES DIV
Address:340 KINGSLAND ST
City:NUTLEY
State:NJ
ZIP:07110-1199
Country:US
Info Phone Num:800-526-1247/201-235-6660
Emergency Phone Num:201-235-6660/800-526-6367
Preparer's Name:HESHAM M SOLIMAN
CAGE:04493
=== Contractor Identification ===
Company:HOFFMAN-LA ROCHE INC
Address:340 KINGSLAND ST
City:NUTLEY
State:NJ
ZIP:07110-1141
Country:US
Phone:201-235-2323
CAGE:04493
Company:ROCHE LABORATORIES, DIV. OF HOFFMANN-LA ROCHE INC.
Address:340 KINGSLAND STREET
Box:City:NUTLEY
State:NJ
ZIP:07110-1199
Country:US
Phone:201-235-6660/800-526-6367
CAGE:66002
============= Composition/Information on Ingredients =============
Name:DIAZEPAM (IARC CARCINOGEN - GROUP 3) *95-2*
CAS:439-14-5
RTECS #:DF1575000
Fraction by Wt: >98.5%
===================== Hazards Identification =====================
LD50 LC50 Mixture:ORAL LD50(RAT): 4000 MG/KG
Routes of Entry: Inhalation:YES Skin:NO Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and Chronic:CAUSES CNS DEPRESSION. SKIN: ALLERGIC
REACTIONS. INCREASED RISK OF CONGENITAL MALFORMATIONS ASSOCIATED
W/USE OF MINOR TRANQUILIZERS, SUCH AS DIAZEPAM & CHLORDIAZEPOXIDE
DURING THE FIRST TRIMESTER OF P REGNANCY HAS BEEN SUGGESTED. AVOID
IF PREGNANT.(SEE SUPP)
Explanation of Carcinogenicity:NONE
Effects of Overexposure:HEADACHE, DIZZINESS, DROWSINESS, FATIGUE, LACK
OF MUSCULAR COORDINATION.
Medical Cond Aggravated by Exposure:HYPERSENSITIVITY, ACUTE NARROW
ANGLE GLAUCOMA.
======================= First Aid Measures =======================
First Aid:INHALATION: REMOVE TO FRESH AIR. GIVE CPR/OXYGEN IF NEEDED.
SKIN: WASH W/SOAP & PLENTY OF WATER. EYES: IMMEDIATELY FLUSH
W/PLENTY OF WATER. INGESTION: DON'T INDUCE VOMITING UNLESS DIRECTED
BY MEDICAL PERSONNEL. NEVER GIVE ANYTHING BY MOUTHTO AN
UNCONSCIOUS PERSON. OBTAIN MEDICAL ATTENTION IN ALL CASES.
===================== Fire Fighting Measures =====================
Extinguishing Media:WATER, CO2, DRY CHEMICAL, FOAM.
Fire Fighting Procedures:WEAR NIOSH/MSHA APPROVED POSITIVE PRESSURE,
SELF CONTAINED BREATHING APPARATUS & FULL PROTECTIVE TURN OUT GEAR.
USE CAUTION. USE WATER TO KEEP CONTAINERS COOL.
Unusual Fire/Explosion Hazard:SEVERE DUST EXPLOSION HAZARD. TOXIC &
CORROSIVE EMISSIONS MAY BE GIVEN OFF IN FIRE.
================== Accidental Release Measures ==================
Spill Release Procedures:SHUT OFF SOURCE OF LEAK SAFELY. SCOOP/SHOVEL
MATERIAL INTO A SUITABLE LABELED OPEN HEAD DRUM. SECURE DRUM COVER
& MOVE THE CONTAINER TO SAFE HOLDING AREA. WASH AREA THOROUGHLY
W/SOAPY WATER.
====================== Handling and Storage ======================
Handling and Storage Precautions:STORE AT TEMP <77F. SENSITIVITY TO
MOISTURE/LIGHT, AIR. DON'T HEAT >248F. DONT' GENERATE DUST/EXPOSE
TO IGNITION SOURCES. STORE IN COOL/DRY AREA.
Other Precautions:GROUND/BOND TRANSFER EQUIPMENT. MILLING/MIXING/DRYING
SHOULD BE DONE AT LOWEST POSSIBLE TEMP UNDER VACCUM/INERT
CONDITIONS. AVOID EYE/SKIN & CLOTHING CONTACT & BREATHING DUST. USE
ADEQUATE VENTILATION . (SEE SUPP)
============= Exposure Controls/Personal Protection =============
Respiratory Protection:HALF FACE, NEGATIVE PRESSURE AIR PURIFYING,
TOXIC DUST, MIST, FUME HIGH EFFICIENCY FILTER FOR LAB USE. FOR
PRODUCTION USE: A SUPPLIED AIR FULL FACEPIECE RESPIRATOR/SUPPLIED
AIR HOOD IS REQUIRED.
Ventilation:LOCAL VENTILATION IS REQUIRED. USE IN A LAB HOOD.
Protective Gloves:PLASTIC/RUBBER
Eye Protection:SAFETY GLASSES/GOGGLES REQUIRED.
Other Protective Equipment:DISPOSABLE COVERALLS/LAB COATS.
Work Hygienic Practices:REMOVE/LAUNDER CONTAMINATED CLOTHING/SHOES
BEFORE REUSE. POST WORK AREA & LIMIT ACCESS TO AUTHORIZED PERSONNEL
ONLY.
Supplemental Safety and Health
HEALTH HAZARDS CONT'D: EXERCISE CAUTION REGARDING EXPOSURE. MATERIAL
MAY CAUSE IMPAIRMENT OF MENTAL/PHYSICAL ABILITIES WHICH ARE
REQUIRED TO PERFORM HAZARDOUS TASKS. HANDLING & STORAGE CONT'D:
KEEP CO NTAINER TIGHTLY CLOSED WHEN NOT IN USE & IN LIGHT RESISTANT
CONTAINERS. WASTE CONT'D: RECYCLING/REUSE.
================== Physical/Chemical Properties ==================
Melt/Freeze Pt:M.P/F.P Text:267.8-275F
Solubility in Water:SLIGHTLY
Appearance and Odor:OFF WHITE TO YELLOW CRYSTALLINE POWDER
W/PRACTICALLY NO ODOR.
================= Stability and Reactivity Data =================
Stability Indicator/Materials to Avoid:YES
STRONG BASES, OXIDIZING AGENTS, MINERAL ACIDS.
Stability Condition to Avoid:TEMP >212F, DUST ACCUMULATION, AIRBORNE
DUST, IGNITION SOURCES, MOISTURE, LIGHT & AIR.
Hazardous Decomposition Products:CO, CO2, OXIDES OF NITROGEN, HYDROGEN
CHLORIDE.
==================== Disposal Considerations ====================
Waste Disposal Methods:SUITABLE FOR INCINERATION. DISPOSE OF IN A
MANNER APPROVED FOR U.S. DRUG ENFORCEMENT AGENCY SCHEDULE. USE
PROCESSING/ALTERATION/CONTAMINATION MAY AFFECT THESE DISPOSAL
RECOMMENDATIONS. EMPTY CONTAINER S MUST BE TRIPLE RINSED PRIOR TO
DISPOSAL. (SUPP)
======================================================================
Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.
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