LD50 LC50 Mixture:ORAL LD50 (RAT): 1705 MG/KG ANTIPYRINE
Routes of Entry: Inhalation:NO Skin:YES Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and Chronic:ANTIPYRINE-INHALATION/SKIN/EYES:
IRRITATION. INGESTION: MODERATELY TOXIC/DEATH/CIRCULATORY
FAILURE/CARDIOVASCULAR COLLAPSE/ACUTE RENAL
FAILURE/EDEMA/EXFOLIATIVE DERMATITIS/ADRENAL NECROSIS/LIVER DAMAG
E. BENZOCAINE-INHALATION/EYES: IRRITATION. SKIN:
IRRITATION/EDEMA/CARDIAC STANDSTILL/SENSITIZATION/CAN BE
ABSOBED/(SUPP)
Explanation of Carcinogenicity:NONE
Effects of
Overexposure:ANTIPYRINE-IRRITABILITY/VOMITING/SWEATING/DILATED
PUPILS/CYANOSIS/CONVULSIONS/COMA/DIZZINESS/NAUSEA/MENTAL
DISTURBANCES/ANOREXIA/OLIGURIA/URTICARIA/JAUNDICE.
BENZOCAINE-ITCHING/ERYTHEMA/EXCORIATION/UR
TICARIA/VESICULATION/OOZING/TINNITUS/CYANOSIS/CHILLS/NAUSEA/VOMITIN
G/DIZZINESS/HEADACHE/LETHARGY/STUPOR/COMA (SEE SUPP)
Medical Cond Aggravated by Exposure:ANTIPYRINE-RENAL DISEASE.
======================= First Aid Measures =======================
First Aid:INHALATION: REMOVE TO FRESH AIR. GIVE CPR IF NEEDED. KEEP
WARM & QUIET. SKIN: WASH W/SOAP/MILD DETERGENT & WATER FOR 15-20
MINS. EYES: FLUSH W/WATER/NORMAL SALINE FOR 15-20 MINS. INGESTION:
IF VOMITIN G OCCURS, KEEP HEAD LOWER THAN HIPS TO PREVENT
ASPIRATION. TREAT SYMPTOMATICALLY & SUPPORTIVELY. OBTAIN MEDICAL
ATTENTION IN ALL CASES.
===================== Fire Fighting Measures =====================
Extinguishing Media:DRY CHEMICAL, CO2, WATER SPRAY, REGULAR FOAM.
LARGE: WATER SPRAY, FOG, REGULAR FOAM. USE MEDIA SUUITABLE FOR
FIRE.
Fire Fighting Procedures:SAFELY REMOVE CONTAINER. DON'T SCATTER SPILLED
MATERIAL W/HIGH-PRESSURE WATER STREAMS. DIKE FIRE-CONTROL WATER FOR
LATER DISPOSAL. KEEP UPWIND. (SUPP)
Unusual Fire/Explosion Hazard:SLIGHT FIRE HAZARD WHEN EXPOSED TO
HEAT/FLAME.
Spill Release Procedures:REMOVE IGNITION SOURCES. SAFELY STOP LEAK. USE
WATER SPRAY TO REDUCE VAPORS. SMALL: TAKE UP W/SAND/OTHER ABSORBENT
MATERIAL & PLACE INTO CONTAINERS FOR LATER DISPOSAL. LARGE: DIKE
FOR LATER DISPOSAL. EVACUATE & ISOLATE AREA.
====================== Handling and Storage ======================
Handling and Storage Precautions:STORE AWAY FROM INCOMPATIBLE
SUBSTANCES & IGNITION SOURCES.
Other Precautions:MAY BURN BUT DOESN'T IGNITE READILY.
Respiratory Protection:WEAR A NIOSH/MSHA APPROVED RESPIRATOR BASED ON
CONTAMINATION LEVELS FOUND IN WORK PLACE, SPECIFIC OPERATION & MUST
NOT EXCEED WORKING LIMITS OF RESPIRATOR.
Ventilation:LOCAL EXHAUST &/GENERAL DILUTION TO MEET PUBLISHED EXPOSURE
LIMITS.
Protective Gloves:RECOMMENDED
Eye Protection:SPLASH-PROOF SAFETY GLASSES
Work Hygienic Practices:REMOVE/LAUNDER CONTAMINATED CLOTHING & SHOES
BEFORE REUSE.
Supplemental Safety and Health
SPECIAL FIRE CONT'D: AVOID BREATHING HAZARDOUS VAPORS. HEALTH HAZARDS
CONT'D: ECZEMATOUS CONTACT DERMATITIS. INGESTION: METHEMOGLOBIN
FORMER/CARDIAC STANDSTILL/DEATH. POISONNG MAY EFFECT HEART/BLOOD/C
NS. SYMPTOMS CONT'D: MUSCULAR TREMORS/CONVULSIONS/BRONCHIAL
SPASM/CHILLS/AGRANULOCYTOSIS/RESPIRATORY DISTRESS.
Waste Disposal Methods:DISPOSE OF IAW/FEDERAL, STATE & LOCAL
REGULATIONS.
Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.