===================== Product Identification =====================
MSDS NAME:ARAMINE (INJECTION)
NIIN:00-753-9601
MSDS Number: CCGGH
=== Responsible Party ===
Company:MERCK & CO INC MERCK-SHARP & DOHME DIV
Address:4 SUMNEYTOWN PIKE
City:WEST POINT
State:PA
ZIP:19486-5000
Country:US
Info Phone Num:800-637-2579/215-661-7300
Emergency Phone Num:800-637-2579/215-661-7300
CAGE:GO622
=== Contractor Identification ===
Company:MERCK & CO INC MERCK-SHARP & DOHME DIV
Address:4 SUMNEYTOWN PIKE
City:WEST POINT
State:PA
ZIP:19486-5000
Country:US
Phone:800-637-2579
CAGE:GO622
Company:MERCK-SHARP AND DOHME DIV OF MERCK AND CO INC
Address:SUMNEYTOWN PIKE
Box:City:WEST POINT
State:PA
ZIP:19486
Country:US
Phone:215-540-8629
CAGE:06990
============= Composition/Information on Ingredients =============
Name:1-1-(M-HYDROXYPHENYL)-2-AMINO-1-PROPANOL-D-HYDROGEN
TARTRATE, METARAMINOL BITARTRATE
CAS:33402-03-8
RTECS #:DN5160000
===================== Hazards Identification =====================
LD50 LC50 Mixture:ORAL LD50(RAT): 240 MG/KG
Routes of Entry: Inhalation:NO Skin:NO Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and Chronic:INGESTION: GI ABSORPTION. MAY CAUSE
CARDIAC ARRYTHMIA. CUMULATIVE EFFECT IS POSSIBLE W/PROLONGED ACTION
OF ARAMINE. VASOCONSTRICTION MAY PREVENT ADEQUATE EXPANSION OF
CIRCULATING VOLUME & MAY CAUSE PE RPETUATION OF SHOCK WHEN USED FOR
LONG PERIODS. (SEE SUPP)
Explanation of Carcinogenicity:NONE
Effects of Overexposure:HYPERTENSION, HEADACHE, NAUSEA, VOMITING,
EUPHORIA.
======================= First Aid Measures =======================
Eyes: FLUSH W/WATER. INGESTION: GIVE PHENTOLAMINE TO REDUCE
HYPERTENSION. PROCAINAMIDE HYDROCHLORIDE MAY ALSO BE REQUIRED.
OBTAIN MEDICAL ATTENTION IN ALL CASES.
===================== Fire Fighting Measures =====================
Fire Fighting Procedures:NONE
================== Accidental Release Measures ==================
Spill Release Procedures:ISOLATE AREA. SMALL: ABSORB ON
VERMICULITE/OTHER SUITABLE ABSORBING MATERIAL & PLACE IN A SEALED
CONTAINER FOR DISPOSAL. LARGE: DIKE & TRANSFER TO AN APPROPRIATE
CONTAINER FOR DISPOSAL. USE SUITABLE P ROTECTIVE EQUIPMENT.
====================== Handling and Storage ======================
Handling and Storage Precautions:STORE CONTAINER IN CARTON UNTIL
CONTENTS HAVE BEEN USED.
============= Exposure Controls/Personal Protection =============
Respiratory Protection:NONE REQUIRED.
Ventilation:NONE REQUIRED.
Protective Gloves:IMPERVIOUS
Eye Protection:NONE REQUIRED
Other Protective Equipment:WORK UNIFORM
Work Hygienic Practices:FOR PURPOSES OF GOOD HYGIENE, INDIVIDUALS
SHOULD WASH HANDS W/SOAP & WATER.
Supplemental Safety and Health
HEALTH HAZARDS CONT'D: IF THERE IS AN EXCESSIVE VASOPRESSOR RESPONSE
THERE MAY BE PROLONGED ELEVATION OF BLOOD PRESSURE EVEN AFTER
DISCONTINUATION OF THERARPY. BLOOD/PLASMA VOLUME EXPANDERS SHOULD
BE USED WHEN THE REASON FOR HYPOTENSION/SHOCK IS DECREASED
CIRCULATING VOLUME.
================== Physical/Chemical Properties ==================
pH:3.5
Solubility in Water:COMPLETE
Appearance and Odor:CLEAR, COLORLESS AQUEOUS SOLUTION.
================= Stability and Reactivity Data =================
Stability Indicator/Materials to Avoid:YES
Stability Condition to Avoid:LIGHT.
==================== Disposal Considerations ====================
Waste Disposal Methods:AVOID CONTACT OF SPILLED MATERIALS & RUNOFF
W/SOIL & SURFACE WATERWAYS. DISPOSE OF/TREAT ALL SPILL RESIDUES
INCLUDING CONTAMINATED SOILD IAW/FEDERAL, STATE & LOCAL
REGULATIONS.
Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.
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