===================== Product Identification =====================
MSDS NAME:27900 FLUOROURACIL 250 MG
NIIN:00F055832
MSDS Number: CGVTP
=== Responsible Party ===
Company:UNITED STATES PHARMACOPEIAL CONVENTION INC
Address:12601 TWINBROOK PKWY
City:ROCKVILLE
State:MD
ZIP:20852-1717
Country:US
Info Phone Num:301-881-0666
Emergency Phone Num:301-881-0666
Preparer's Name:JEROME A HALPERIN
CAGE:14128
=== Contractor Identification ===
Company:UNITED STATES PHARMACOPEIAL CONVENTION INC
Address:12601 TWINBROOK PKWY
Box:City:ROCKVILLE
State:MD
ZIP:20852-1717
Country:US
Phone:301-881-0666
CAGE:14128
============= Composition/Information on Ingredients =============
Name:FLUOROURACIL, 5-FLUOROURACIL
CAS:51-21-8
RTECS #:YR0350000
===================== Hazards Identification =====================
LD50 LC50 Mixture:ORAL LD50(RAT): 230 MG/KG
Routes of Entry: Inhalation:YES Skin:NO Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and Chronic:THE ADVERSE EFFECTS OF FLUOROURACIL
MAY BE SEVERE & SOMETIMES FATAL. IRRITATING TO EYES, SKIN &
RESPIRATORY TRACT. POSSIBLE HYPERSENSITIZATION. INGESTION:
IRRITATION. BONE MARROW SUPPRESSION ARE DELAY ED ADVERSE EFFECTS.
Explanation of Carcinogenicity:NONE
Effects of Overexposure:LOSS OF APPETITE/STOMACH
CRAMPS/NAUSEA/VOMITING/HEARTBURN/DIFFICULTY INGESTING/INFLAMED
MOUTH/LIPS/DIARRHEA/FEVER/CHILLS/PAIN/BLEEDING/DIFFICULT
URINATION/BLACK & TARRY STOOLS/BRUISING/RED SPOTS/RASH/
ITCHING/SORENESS/BURNING/CHEST PAIN/SHORTNESS OF BREATH/LOSS OF
BALANCE/HAIR LOSS/JAUNDICE/IRRITATION.
Medical Cond Aggravated by Exposure:HYPERSENSITIVITY/IMPAIRED
LIVER/KIDNEY FUNCTION/BONE MARROW DEPRESSION/CHICKENPOX/HERPES
ZOSTER/EYTOTOXIC DRUG THERAPY W/ALKYLATING AGENTS/HIGH DOSE PELVIC
RADIATION THERAPY.
======================= First Aid Measures =======================
First Aid:INHALATION: REMOVE TO FRESH AIR. EYES: FLUSH W/COPIOUS
AMOUNTS OF TEPID WATER FOR 15 MINS. SKIN: FLUSH W/COPIOUS AMOUNTS
OF SOAP & WATER. INGESTION: FLUSH OUT MOUTH W/WATER. OBTAIN MEDICAL
ATTENTION I N ALL CASES.
===================== Fire Fighting Measures =====================
Extinguishing Media:WATER SPRAY, DRY CHEMICAL, CO2/FOAM AS APPROPRIATE
TO SURROUNDING FIRE & MATERIALS.
Fire Fighting Procedures:EVACUATE PERSONNEL TO SAFE AREA. USE SCBA &
PROTECTIVE CLOTHING.
Unusual Fire/Explosion Hazard:COMBUSTIBLE. EMITS TOXIC FUMES UNDER FIRE
CONDITIONS.
================== Accidental Release Measures ==================
Spill Release Procedures:WEAR APPROVED RESPIRATOR & CHEMICALLY
COMPATIBLE GLOVES. VACUUM/SWEEP UP. AVOID DUST. PLACE IN
APPROPRIATE CONTAINER FOR WASTE DISPOSAL. VENTILATE AREA & WASH
AREA SITE.
====================== Handling and Storage ======================
Handling and Storage Precautions:STORE IN TIGHT, LIGHT RESISTANT
CONTAINER. MATERIAL SHOULD BE HANDLED & STORED PER LABEL & OTHER
INSTRUCTIONS TO ENSURE PRODUCT.
Other Precautions:AVOID CONTACT W/EYES, SKIN/CLOTHING. AVOID BREATHING
DUST/MIST. USE W/ADEQUATE DUST CONTROL. DON'T PERMIT EATING,
DRINKING/SMOKING NEAR MATERIAL.
============= Exposure Controls/Personal Protection =============
Respiratory Protection:USE NIOSH APPROVED RESPIRATOR.
Ventilation:LOCAL EXHAUST/MECHANICAL (GENERAL): RECOMMENDED.
Protective Gloves:RUBBER
Eye Protection:SAFETY GOGGLES
Other Protective Equipment:LABORATORY APPAREL.
Work Hygienic Practices:REMOVE/LAUNDER CONTAMINATED CLOTHING BEFORE
REUSE. WASH THOROUGHLY AFTER HANDLING.
Supplemental Safety and Health
MELTING POINT: 539.6-541.4F.
================== Physical/Chemical Properties ==================
Melt/Freeze Pt:M.P/F.P Text:(SEE SUPP)
Solubility in Water:SPARINGLY SOLUBLE
Appearance and Odor:WHITE TO NEARLY WHITE CRYSTALLINE POWDER;
PRACTICALLY ODORLESS
================= Stability and Reactivity Data =================
Stability Indicator/Materials to Avoid:YES
STRONG BASES.
Stability Condition to Avoid:LIGHT & EXTREME HEAT.
Hazardous Decomposition Products:PHOSPHOROUS, NITROGEN OXIDES.
==================== Disposal Considerations ====================
Waste Disposal Methods:DISPOSE OF WASTE IAW/FEDERAL, STATE & LOCAL
REGULATIONS.
Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.
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