=====================  Product Identification  =====================

MSDS NAME:22600 DOXYCYCLINE HYCLATE 200 MG
NIIN:00F056424
MSDS Number: CHNCM
=== Responsible Party ===
Company:UNITED STATES PHARMACOPEIAL CONVENTION INC
Address:12601 TWINBROOK PKWY
City:ROCKVILLE
State:MD
ZIP:20852-1717
Country:US
Info Phone Num:301-881-0666
Emergency Phone Num:301-881-0666
Preparer's Name:JEROME HALPERIN
CAGE:14128
=== Contractor Identification ===
Company:UNITED STATES PHARMACOPEIAL CONVENTION INC
Address:12601 TWINBROOK PKWY
Box:City:ROCKVILLE
State:MD
ZIP:20852-1717
Country:US
Phone:301-881-0666
CAGE:14128

=============  Composition/Information on Ingredients  =============

Name:DOXYCYCLINE HYCLATE
CAS:24390-14-5

=====================  Hazards Identification  =====================

Routes of Entry: Inhalation:YES  Skin:NO  Ingestion:YES
Reports of Carcinogenicity:NTP:NO    IARC:NO	OSHA:NO
Health Hazards Acute and Chronic:POSSIBLE EYE, SKIN, GI &/RESPIRATORY
    TRACT IRRITATION. POSSIBLE HYPERSENSITIZATION & LIVER TOXICITY.
    TETRACYCLINES MAY CAUSE PERMANENT DISCOLORATION OF TEETH, ENAMEL
    HYPOPLASIA & INHIBITION OF SKELETA L GROWTH IN THE FETUS. THE ORAL
    ADULT DOSE OF DOXYCYCLINE HYCLATE IS 150 MG EVERY TWELVE HOURS.
Explanation of Carcinogenicity:NONE
Effects of Overexposure:DIZZINESS, UNSTEADINESS, STOMACH PAIN,
    DIARRHEA, NAUSEA, VOMITING, ITCHING OF RECTAL/GENITAL AREAS,
    DISCOLORED/SORE TONGUE, HEADACHE, VISUAL CHANGES, IRRITATION.
Medical Cond Aggravated by Exposure:ACUTE PORPHYRIA & IMPAIRED LIVER
    FUNCTION.

=======================  First Aid Measures  =======================

First Aid:INHALATION: REMOVE TO FRESH AIR. GIVE CPR/OXYGEN IF NEEDED.
    OBTAIN MEDICAL ATTENTION IN ALL CASES. OVERDOSE SHOULD BE TREATED
    SYMPTOMATICALLY & SUPPORTIVELY. DIALYSIS ISN'T BENEFICIAL.

=====================  Fire Fighting Measures  =====================

Lower Limits:7
Upper Limits:60
Extinguishing Media:WATER SPRAY, DRY CHEMICAL, CO2/FOAM AS APPROPRIATE
    FOR SURROUNDING FIRE & MATERIALS.
Fire Fighting Procedures:EVACUATE PERSONNEL TO A SAFE AREA. USE SCBA
    EQUIPMENT & PROTECTIVE CLOTHING.
Unusual Fire/Explosion Hazard:COMBUSTIBLE. AS W/ALL DRY POWDERS, GROUND
    MECHANICAL EQUIPMENT W/DRY MATERIAL TO DISSIPATE THE BUILDUP OF
    STATIC ELECTRICITY. AUTOIGNITION TEMP: 1652F.

==================  Accidental Release Measures  ==================

Spill Release Procedures:WEAR APPROVED EQUIPMENT & PROTECTIVE CLOTHING.
    WIPE UP/COLLECT USING A HIGH EFFICIENCY VACUUM CLEANER. AVOID
    BREATHING DUST. PLACE IN APPROPRIATELY LABELLED CONTAINER FOR
    DISPOSAL. WASH AREA SITE.

======================	Handling and Storage  ======================

Handling and Storage Precautions:STORE IN TIGHT, LIGHT RESISTANT
    CONTAINER. HANDLE & STORE PER LABEL INSTRUCTIONS TO ENSURE PROPER
    PRODUCT INTEGRITY.
Other Precautions:AVOID CONTACT & INHALATION OF DUST, MISTS/VAPORS.

=============  Exposure Controls/Personal Protection  =============

Respiratory Protection:USE A NIOSH APPROVED RESPIRATOR, IF DETERMINED
    TO BE NECESSARY BY AN INDUSTRIAL HYGIENE SURVEY INVOLVING AIR
    MONITORING. IF RESPIRATOR ISN'T REQUIRED, AN APPROVED DUST MASK
    SHOULD BE USED.
Ventilation:RECOMMENDED
Protective Gloves:RUBBER
Eye Protection:SAFETY GOGGLES
Work Hygienic Practices:REMOVE/LAUNDER CONTAMINATED CLOTHING BEFORE
    REUSE. WASH THOROUGHLY AFTER HANDLING.
Supplemental Safety and Health

==================  Physical/Chemical Properties  ==================

Melt/Freeze Pt:M.P/F.P Text:393.8F
Vapor Pres:<1
Solubility in Water:COMPLETE
Appearance and Odor:LIGHT YELLOW CRYSTALLINE POWDER; ESSENTIALLY
    ODORLESS

=================  Stability and Reactivity Data  =================

Stability Indicator/Materials to Avoid:YES
Stability Condition to Avoid:LIGHT & MOISTURE.
Hazardous Decomposition Products:NITROGEN OXIDES & HYDROGEN CHLORIDE.

====================  Disposal Considerations  ====================

Waste Disposal Methods:DISPOSE OF WASTE IAW/FEDERAL, STATE & LOCAL
    REGULATIONS.

 Disclaimer (provided with this information by the compiling agencies):
 This information is formulated for use by elements of the Department
 of Defense.  The United States of America in no manner whatsoever,
 expressly or implied, warrants this information to be accurate and
 disclaims all liability for its use.  Any person utilizing this
 document should seek competent professional advice to verify and
 assume responsibility for the suitability of this information to their
 particular situation.

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