===================== Product Identification =====================
MSDS NAME:5-BROMO-2'-DEOXYURIDINE, B5002
NIIN:00N092570
Status Code:A
MSDS Number: CJTFX
=== Responsible Party ===
Company:SIGMA CHEMICAL CO
Box:14508
City:ST LOUIS
State:MO
ZIP:63178
Country:US
Info Phone Num:314-771-5765
Emergency Phone Num:314-771-5765
CAGE:21076
=== Contractor Identification ===
Company:SIGMA CHEMICAL COMPANY
Address:3050 SPRUCE ST
Box:14508
City:ST LOUIS
State:MO
ZIP:63178
Country:US
Phone:314-771-5765
CAGE:21076
============= Composition/Information on Ingredients =============
Name:URIDINE, 5-BROMO-2'-DEOXY-
CAS:59-14-3
RTECS #:YU7350000
Code:F
= Wt:100.
Other REC Limits:N/K
OSHA PEL:N/K
OSHA STEL:N/K
ACGIH TLV:N/K
ACGIH STEL:N/K
===================== Hazards Identification =====================
LD50 LC50 Mixture:SEE TOXICOLOGICAL INFORMATION.
Routes of Entry: Inhalation:YES Skin:YES Ingestion:YES
Reports of Carcinogenicity:NTP:YES IARC:NO OSHA:NO
Health Hazards Acute and Chronic:ACUTE: HARMFUL IF SWALLOWED, INHALED,
OR ABSORBED THROUGH SKIN. MAY CAUSE IRRITATION. CHRONIC: MAY CAUSE
REPRODUCTIVE DISORDERS. MAY ALTER GENETIC MATERIAL. TARGET ORGANS:
IMMUNE SYSTEM.
Explanation of Carcinogenicity:5-BROMO-2'-DEOXYURIDINE: NTP 8TH ANNUAL
REPORT ON CARCINOGENS, 1998: REASONABLY ANTICIPATED TO BE HUMAN
CARCINOGEN .
Effects of Overexposure:SEE HEALTH HAZARDS.
======================= First Aid Measures =======================
First Aid:EYES/SKIN: IMMEDIATELY FLUSH WITH COPIOUS AMOUNTS OF WATER
FOR AT LEAST 15 MINUTES, WHILE REMOVING CONTAMINATED CLOTHING AND
SHOES. INHALATION: REMOVE TO FRESH AIR. IF NOT BREATHING, GIVE
ARTIFICIAL R ESPIRATION. IF BREATHING IS DIFFICULT, GIVE OXYGEN.
INGESTION: WASH OUT MOUTH WITH WATER PROVIDED PERSON IS CONSCIOUS.
CALL A PHYSICIAN. WASH CONTAMINATED CLOTHING BEFORE REUSE.
===================== Fire Fighting Measures =====================
Extinguishing Media:WATER SPRAY, CARBON DIOXIDE, DRY CHEMICAL POWDER OR
APPROPRIATE FOAM.
Fire Fighting Procedures:WEAR NIOSH APPROVED SCBA AND FULL PROTECTIVE
EQUIPMENT .
Unusual Fire/Explosion Hazard:EMITS TOXIC FUMES UNDER FIRE CONDITIONS.
================== Accidental Release Measures ==================
Spill Release Procedures:EVACUATE AREA. WEAR NIOSH APPROVED
SELF-CONTAINED BREATHING APPARATUS, RUBBER BOOTS AND HEAVY RUBBER
GLOVES. WEAR DISPOSABLE COVERALLS AND DISCARD THEM AFTER USE. SWEEP
UP, PLACE IN A BAG AND HOLD FOR WASTE DISPOSAL. AVOID RAISING
DUST. VENTILATE AREA AND WASH SPILL SITE AFTER MATERIAL PICKUP IS
COMPLETE.
====================== Handling and Storage ======================
Handling and Storage Precautions:DO NOT BREATHE DUST. DO NOT GET IN
EYES, ON SKIN, ON CLOTHING. AVOID PROLONGED OR REPEATED EXPOSURE.
TERATOGEN. MUTAGEN. KEEP TIGHTLY CLOSED. STORE IN A COOL DRY PLACE.
============= Exposure Controls/Personal Protection =============
Respiratory Protection:WEAR APPROPRIATE NIOSH APPROVED RESPIRATOR.
Ventilation:USE ONLY IN A CHEMICAL FUME HOOD.
Protective Gloves:CHEMICAL-RESISTANT GLOVES.
Eye Protection:ANSI APPROVED CHEMICAL WORKERS GOGGLES .
Other Protective Equipment:ANSI APPROVED EMERGENCY EYEWASH AND DELUGE
SHOWER . WEAR PROTECTIVE CLOTHING.
Work Hygienic Practices:WASH THOROUGHLY AFTER HANDLING.
Supplemental Safety and Health
TOX INFO: MORTALITY); EFTS ON EMBRYO/FETUS (CYTOLOGICAL CHANGES,
FETOTOXICITY, FETAL DEATH, OTHER EFTS TO EMBRYO/FETUS); SPECIFIC
DEVEL ABNORMS (CNS, EYE, EAR, CRANIOFACIAL, MUSCULOSKELETAL SYS,
RESP SYS); TUMORIGENIC EFTS (TESTICULAR TUMORS); EFTS ON NEWBORN
(VIABILITY INDEX, WEANING/LACTATION INDEX, (ECOL INFO)
================== Physical/Chemical Properties ==================
Melt/Freeze Pt:>191.C, 375.8F
M.P/F.P Text:191C - 194C
Appearance and Odor:WHITE CRYSTALLINE POWDER.
================= Stability and Reactivity Data =================
STRONG OXIDIZING AGENTS.
Hazardous Decomposition Products:TOXIC FUMES OF CARBON MONOXIDE, CARBON
DIOXIDE, NITROGEN OXIDES, HYDROGEN BROMIDE GAS.
=================== Toxicological Information ===================
Toxicological Information:RTECS #: YU7350000, URIDINE,
5-BROMO-2'-DEOXY-. TOXICITY DATA: ORL-RAT LD50: 8400 MG/KG; IYKEDH
4, 467, 1973. IPR-RAT LD50: 1500 MG/KG; ADTEAS 3, 181, 1968.
SCU-RAT LD50: 3900 MG/KG; TAKHAA 30, 530, 1 971. IVN-RAT LD50: 2320
MG/KG; TAKHAA 30, 735, 1971. UNR-RAT LD50: 2300 MG/KG; NIIRDN 6,
721, 1982. ORL-MUS LD50: 9100 MG/KG; TAKHAA 30, 530, 1971. IPR-MUS
LD50: 3050 MG/KG; TAKHAA 30, 530, 1971. SCU- MUS LD50: 3500 MG/KG;
TAKHAA 30, 530, 1971. IVN-MUS LD50: 2500 MG/KG; TAKHAA 30, 530,
1971. ORL-QAL LD50: >100 MG/KG; EESADV 6, 149, 1982. TARGET ORGAN
DATA: ENDOCRINE (THYROID TUMORS); EFTS ON FERTIL ITY
(POST-IMPLANTATION (SUP DAT)
===================== Ecological Information =====================
Ecological:DATA NOT YET AVAILABLE. --SUPDAT: GROWTH STATISTICS, DELAYED
EFTS); TUMORIGENIC (CARCIN BY RTECS CRITERIA). ONLY SELECTED
REGISTRY OF TOX EFTS OF CHEMICAL SUBSTANCES (RTECS) DATA IS
PRESENTED HERE. SE E ACTUAL ENTRY IN RTECS FOR COMPLETE INFO. --FED
REGS: D MELANOGASTER SEX-LINKED LETHAL. EPA GENTOX PROGRAM 1988,
POS: V79 CELL CULTURE-GENE MUTATION. EPA GENETOX PROGRAM 1988,
POS/DOSE RESPONSE: INVI TRO SCE-WI-38 CELLS, IN CITRO SCE-HUMAN.
EPA GENETOX PROGRAM 1988, POS/DOSE RESPONSE: IN VITRO SCE-NONHUMAN;
INVIVO SCE-NONHUMAN. EPA GENETOX PROGRAM 1988, NEG: CELL
TRANSFORMATION-C3H/10T1/2; IN VITR O UDS-HUMAN FIBROBLAST. (SARA
REGS)
==================== Disposal Considerations ====================
Waste Disposal Methods:DISSOLVE OR MIX THE MATERIAL WITH A COMBUSTIBLE
SOLVENT AND BURN IN A CHEMICAL INCINERATOR EQUIPPED WITH AN
AFTERBURNER AND SCRUBBER. OBSERBE ALL FEDERAL, STATE AND LOCAL
ENVIRONMENTAL REGULATIONS.
=================== MSDS Transport Information ===================
Transport Information:CONTACT SIGMA CHEMICAL COMPANY FOR TRANSPORTATION
INFORMATION.
===================== Regulatory Information =====================
SARA Title III Information:N/P --ECOL INFO: EPA GENETOX PROGRAM 1988,
NEG: S CEREVISIAE-HOMOZYGOSIS. EPA GENETOX PROGRAM 1988,
INCONCLUSIVE: CARCINOGENICITY-MOUSE/RAT; SHE-CLONAL ASSAY. EPA
GENETOX PROGRAM 1988, INCONCLUSIVE: D MELANOGASTER-RECIPROCAL
TRANSLOCATION. EPA GENETOX PROGRAM 1988, INCONCLUSIVE: E COLI POLA
W/OUT S9. EPA GENETOX PROGRAM 1988, POS: CHO GENE MUTATION. EPA
TSCA SECTION 8 (B) CHEMICAL INVENTORY.
Federal Regulatory Information:EUROPEAN INFO: TOX. R 46: MAY CAUSE
HERITABLE GENETIC DMG. R 61: MAY CAUSE HARM TO UNBORN CHILD. R
20/21/22: HARMFUL BY INHAL, IN CONT W/SKIN & IF SWALLOWED. S 45: IN
CASE OF ACCIDENT/IF YOU FEEL UNWE LL, SEEK MED ADVICE IMMED (SHOW
LABEL WHERE POSS). S 36/37/39: WEAR SUITABLE PROT CLTHG, GLOVES &
EYE/FACE PROT. REVIEWS, STDS, & REGS: OEL=MAK. NOES 1983: HZD
X4811; NIS 1; TNF 3; NOS 1; TNE 6; TFE 3 . EPA GENETOX PROGRAM
1988, POS: CELL TRANSFORMATION-SA7/SHE; MAMMALIAN MICRONUCLEUS. EPA
GENETOX PR OGRAM 1988, POS: IN VITRO HUMAN LYMPHOCYTE MICRONUCLEUS.
EPA GENETOX PROGRAM 1988, POS: SPERM MORPHOLOGY-MOUSE; (OTHER INFO)
======================= Other Information =======================
Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.
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