===================== Product Identification =====================
MSDS NAME:LIPOPOLYSACCHARIDE PSEUDOMONAS AERUGINOSA, 437640
NIIN:00N092956
Status Code:A
MSDS Number: CJWTB
=== Responsible Party ===
Company:CALBIOCHEM
Box:12087
City:LA JOLLA
State:CA
ZIP:92039-2087
Country:US
Info Phone Num:619-450-5558; 800-854-3417
Emergency Phone Num:202-783-7616
Resp. Party Other MSDS Num.:437640
Chemtrec Ind/Phone:(800)424-9300
CAGE:29089
=== Contractor Identification ===
Company:CALBIOCHEM
Box:12087
City:LA JOLLA
State:CA
ZIP:92039-2087
Country:US
Phone:619-450-5558; 800-854-3417
CAGE:29089
============= Composition/Information on Ingredients =============
Name:LIPOPOLYSACCHARIDE; (LIPOPOLYSACCHARIDE, PSEUDOMONAS
AERUGINOSA)
RTECS #:UX2990000
Code:F
= Wt:100.
===================== Hazards Identification =====================
Routes of Entry: Inhalation:YES Skin:YES Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and Chronic:ACUTE: MAY BE HARMFUL BY INGESTION,
INHALATION OR ABSORPTION THROUGH SKIN. MATERIAL MAY BE HARMFUL IF
ALLOWED TO CONTAMINATE OPEN CUTS OR WOUNDS. MATERIAL IS HIGHLY
PYROGENIC; MAY CAUSE FEVER. CHRONIC : THERE IS LIMITED EVIDENCE
THAT LIPOPOLYSACCHARIDES ARE TERATOGENIC IN LABORATORY ANIMALS.
UNTIL FURTHER TESTING HAS BEEN DONE, THEY SHOULD BE TREATED AS
POSSIBLE TERATOGENS IN HUMANS.
Effects of Overexposure:SEE HEALTH HAZARDS.
======================= First Aid Measures =======================
First Aid:SKIN: WASH WITH COPIOUS AMOUNTS OF WATER FOR AT LEASST 15
MINUTES. REMOVE CONTAMINATED CLOTHING AND SHOES AND WASH BEFORE
WEARING. CONSULT A PHYSICIAN. EYE: FLUSH WITH COPIOUS AMOUNTS OF
WATER FOR AT LEAST 15 MINUTES. ASSURE ADEQUATE FLUSHING BY
SEPARATING THE EYELIDS WITH FINGERS. CONSULT A PHYSICIAN.
INHALATION: REMOVE TO FRESH AIR AND MONITOR BREATHING. IF BREATHING
BECOMES DIFFICULT, GIVE OXYG EN AND CONSULT A PHYSICIAN. IF
BREATHING STOPS, GIVE ARTIFICIAL RESPIRATION AND CONSULT A
PHYSICIAN. INGESTION: WASH MOUTH OUT WITH WATER AND CONSULT THE
LOCAL POISON CENTER AND A PHYSICIAN.
===================== Fire Fighting Measures =====================
Extinguishing Media:DRY CHEMICAL POWDER, CARBON DIOXIDE, WATER SPRAY,
ALCOHOL OR POLYMER FOAM.
Fire Fighting Procedures:USE NIOSH APPROVED SCBA & FULL PROTECTIVE
EQUIPMENT .
Unusual Fire/Explosion Hazard:UPON THERMAL DECOMPOSITION, IT MAY EMIT
TOXIC GASES.
================== Accidental Release Measures ==================
Spill Release Procedures:WEAR NIOSH APPROVED SELF-CONTAINED BREATHING
APPARATUS, RUBBER BOOTS, AND HEAVY RUBBER GLOVES. SWEEP UP AND
PLACE IN A SUITABLE CONTAINER. AVOID RAISING DUST. HOLD FOR
APPROPRIATE DISPOSAL. WASH SPILL SITE AND VENTILATE AREA AFTER
MATERIAL PICKUP IS COMPLETE.
====================== Handling and Storage ======================
Handling and Storage Precautions:STORE IN A TIGHTLY CLOSED CONTAINER IN
A +4C REFRIGERATOR. MATERIAL IS TOXIC. POSSIBLE TERATOGEN. DO NOT
WORK WITH MATERIAL IF SKIN IS CUT OR SCRATCHED. AVOID CONTACT WITH
MATERIAL. AVOID PROLONGED OR REPEATED EXPOSURE. LAB SHOULD BE
EQUIPPED WITH A SAFETY SHOWER AND EYE WASH STATION.
============= Exposure Controls/Personal Protection =============
Respiratory Protection:USE A NIOSH APPROVED RESPIRATOR.
Ventilation:HANDLE IN A CHEMICAL FUME HOOD WITH ADEQUATE VENTILATION.
Protective Gloves:CHEMICAL RESISTANT GLOVES.
Eye Protection:ANSI APPROVED CHEMICAL WORKERS GOGGLES .
Other Protective Equipment:EYE WASH AND DELUGE SHOWER MEETING ANSI
DESIGN CRITERIA .
Work Hygienic Practices:WASH THOROUGHLY AFTER HANDLING MATERIAL.
Supplemental Safety and Health
================== Physical/Chemical Properties ==================
Solubility in Water:SOLUBLE IN WATER.
Appearance and Odor:LYOPHILIZED SOLID.
================= Stability and Reactivity Data =================
Stability Indicator/Materials to Avoid:YES
NOT APPLICABLE.
Hazardous Decomposition Products:UPON THERMAL DECOMPOSITION, MAY EMIT
TOXIC GASES INCLUDING CARBON MONOXIDE AND CARBON DIOXIDE.
=================== Toxicological Information ===================
Toxicological Information:NOTE: TO BEST OF MFR'S KNOWLEDGE,
TOXICOLOGICAL PROPERTIES OF LIPOPOLYSACCHARIDE, PSEUDOMONAS
AERUGINOSA HAVE NOT BEEN THOROUGHLY INVESTIGATED. INFO BELOW
PERTAINS TO SIMILAR COMPOUDS, ENDOXTOXIN, PSE UDOMONAS AERUGINOSA &
LIPOPOLYSACCHARIDE (NON SPECIES SPECIFIC). RTECS NUMBER: JZ2692000
(ENDOTOXIN, PSEUDOMONAS AERUGINOSA). TOXICITY DATA & REFERENCES:
IPR; MUS; LD50: 20 MG/KG 1978. CURRENT MICROBI OLOGY. 1,263.
GENETIC DATA & REFERENCES: LYM; HMN; DOSE: 1G/L DNA INHIBITION
1977. ZENTRALBLATT FUER BAKTERIOLOGIE, PARASITENKUNDE,
INFEKTIONSKRANKHEITEN AND HYGIENE, ABTEILUNG 1: (STATE REGULATORY
IN FO)
===================== Ecological Information =====================
Ecological:NO INFORMATION AVAILABLE.
==================== Disposal Considerations ====================
Waste Disposal Methods:COUNTRY, FEDERAL, STATE, AND LOCAL REGULATIONS
ARE VARIED AND CHANGE FREQUENTLY. FOR THIS REASON, MANUFACTURER
RECOMMENDS THAT YOU CONTACT YOUR LOCAL DEPARTMENT OF HEALTH
SERVICES FOR INFORMATION ON T HE DISPOSAL OF THIS PRODUCT OR
ARRANGE FOR DOSPOSAL BY A LICENSED DISPOSAL COMPANY.
=================== MSDS Transport Information ===================
Transport Information:UN NUMBER: UN3172. PROPER SHIPPING NAME: TOXINS,
EXTRACTED FROM LIVING SOURCES, SOLID, N.O.S. IATA CLASS: 6.1. IATA
PACKING GROUP: III.
===================== Regulatory Information =====================
SARA Title III Information:N/P --ST REGS: IVN; RBT; LD50: 150 UG/KG
1968. NIPPON YAKURIGAKU ZASSHI. JAPANESE JOURNAL OF PHARAMACOLOGY.
64, 314. REPRO EFTS & REFERENCES: IPR; RAT; DOSE: 210 UG/KG EXTRA
EMBRYONIC STRUCTURES; FETO TOXICITY 1996. FREE RADICAL BIOLOGY &
MEDICINE. 21,619. PAR; RAT; DOSE: 2 MG/KG PRE-IMPLANTATION
MORTALITY 1975. OYO YAKURI. PHARMACOMETRICS. 9, 579. GENETIC DATA &
REFERENCES: LEU; MUS; DOSE: 50 MG/L UNSCHEDULED DNA SYNTHESIS
1983. CANCER RESEARCH. 43, 2536. REFER TO REGISTRY OF TOXIC EFFECTS
OF CHEM SUBSTANCES (RTECS) FOR DEFINITION OF ABBREVIATIONS USED IN
ABOVE TEXT & FOR ADDNL INFO. THIS RPT CNTNS ONLY SELECTED INFO
FROM RTECS.
Federal Regulatory Information:REGULATORY INFORMATION: T. RISK PHRASES:
R23/24/25: TOXIC BY INHALATION, IN CONTACT WITH SKIN AND IF
SWALLOWED. R47: MAY CAUSE BIRTH DEFECTS. SAFETY PHRASES: S22: DO
NOT BREATHE DUST. S24/25: AVOID CO NTACT WITH SKIN AND EYES.
S36/37/39: WEAR SUITABLE PROTECTIVE CLOTHING, GLOVES AND EYE/FACE
PROTECTION. S45: IN CASE OF ACCIDENT OR IF YOU FEEL UNWELL, SEEK
MEDICAL ADVICE IMMEDIATELY. S53: AVOID EXPO SURE-OBTAIN SPECIAL
INSTRUCTIONS BEFORE USE.
State Regulatory Information:TOXICOLOGICAL INFORMATION: ORIGINALE,
REIHE A: MEDIZINISCHE MIKROBIOLOGIE UND PARASITOLOGIE. 237, 274.
LYM; HMN; DOSE: 1 G/L OTHER MUTATION TEST SYSTEMS 1977.
ZENTRALBLATT FUER BAKTERIOLOGIE, PARASITE NKUNDE,
INFEKTIONSKRANKHEITEN UND HYGIENE, ABTEILUNG 1: ORIGINAL, REIHE A:
MEDIZINISCHE MIKROBIOLOGIE UND PARASITOLOGIE. 237,274. RTECS NUMBER
UX299000 (LIPOPOLYSACCHARIDE). TOXICITY DATA & REFERENCES : IPR:
MUS: LD50 20 MG/KG 1985. NIPPON YAKURIGAKU ZASSHI. JAPANESE JOURNAL
OF PHARMACOLOGY, 85, 99P. IVN;RAT;LD50 4900 UG/KG 1982. NIPPON
YAKURIGAKU ZASSHI. JAPANESE JOURNAL OF PHARMACOLOGY 79,357. (SARA
TITLE III)
======================= Other Information =======================
Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.
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