MATERIAL SAFETY DATA SHEET
Prepared to U.S. OSHA, CMA, ANSI and Canadian WHMIS Standards
PART I What is the material and what do I need to know in an emergency?
1. PRODUCT IDENTIFICATION
CORNEAL STORAGE MEDIA
TRADE NAME (AS LABELED):
SYNONYMS: OPTISOL (50004-OPT)
OPTISOL GS (50006-OPT)
DEXSOL (50003-DEX)
McCAREY- KAUFMAN MEDIA (50001-MK)
DOSE: Not applicable.
MANUFACTURED FOR: BAUSCH & LOMB
BY: 9342 Jeronimo Road
Irvine, CA 92718
EMERGENCY PHONE: CHEMTREC: 800-424-9300, Intl: 1-202-483-7616
MORE INFO? CUSTOMER SERVICE: 1-800-338-2020
2. COMPOSITION and INFORMATION ON INGREDIENTS
% w/w
CHEMICAL NAME CAS # EXPOSURE LIMITS IN AIR
ACGIH OSHA
TLV STE PEL STEL IDLH OTHER
L
ppm ppm ppm ppm ppm ppm
OPTISOL
Chondroitin Sulfate 9082-07-9 <1 NE NE NE NE NE NE
Dextran 40 9004-54-0 <1 NE NE NE NE NE NE
Optisol Base Powder Mixture <1 NE NE NE NE NE NE
Sodium Bicarbonate 144-55-8 <1 NE NE NE NE NE NE
Gentamycin 1403-66-3 <1 NE NE NE NE NE NE
Amino Acids Mixture <1 NE NE NE NE NE NE
Sodium Pyruvate 113-24-6 <1 NE NE NE NE NE NE
L-Glutamine 56-85-9 <1 NE NE NE NE NE NE
2-Mercaptoethanol 60-24-2 <1 NE NE NE NE NE NE
Water 7732-18-5 Balance NE NE NE NE NE NE
CORNEAL STORAGE MEDIA - (OPTISOL , OPTISOL GS , and DEXSOL ) MSDS
PAGE 1 OF 8
2. COMPOSITION and INFORMATION ON INGREDIENTS (Continued)
% w/w
CHEMICAL NAME CAS # EXPOSURE LIMITS IN AIR
ACGIH OSHA
TLV STE PEL STEL IDLH OTHER
L
ppm ppm ppm ppm ppm ppm
OPTISOL-GS
Chondroitin Sulfate 9082-07-9 <1 NE NE NE NE NE NE
Dextran 40 9004-54-0 <1 NE NE NE NE NE NE
Optisol Base Powder Mixture <1 NE NE NE NE NE NE
Sodium Bicarbonate 144-55-8 <1 NE NE NE NE NE NE
Gentamycin 1403-66-3 <1 NE NE NE NE NE NE
Streptomycin Sulfate 3810-74-0 <1 NE NE NE NE NE NE
Amino Acids Mixture <1 NE NE NE NE NE NE
Sodium Pyruvate 113-24-6 <1 NE NE NE NE NE NE
L-Glutamine 56-85-9 <1 NE NE NE NE NE NE
2-Mercaptoethanol 60-24-2 <1 NE NE NE NE NE NE
Water 7732-18-5 Balance NE NE NE NE NE NE
% w/w
CHEMICAL NAME CAS # EXPOSURE LIMITS IN AIR
ACGIH OSHA
TLV STE PEL STEL IDLH OTHER
L
ppm ppm ppm ppm ppm ppm
DEXSOL
Chondroitin Sulfate 9082-07-9 <1 NE NE NE NE NE NE
Dextran 40 9004-54-0 <1 NE NE NE NE NE NE
Dexsol Base Powder Mixture <1 NE NE NE NE NE NE
Sodium Bicarbonate 144-55-8 <1 NE NE NE NE NE NE
Gentamycin 1403-66-3 <1 NE NE NE NE NE NE
Amino Acids Mixture <1 NE NE NE NE NE NE
Sodium Pyruvate 113-24-6 <1 NE NE NE NE NE NE
L-Glutamine 56-85-9 <1 NE NE NE NE NE NE
2-Mercaptoethanol 60-24-2 <1 NE NE NE NE NE NE
Water 7732-18-5 Balance NE NE NE NE NE NE
CORNEAL STORAGE MEDIA - (OPTISOL , OPTISOL GS , and DEXSOL ) MSDS
PAGE 2 OF 8
2. COMPOSITION and INFORMATION ON INGREDIENTS (Continued)
% w/w
CHEMICAL NAME CAS # EXPOSURE LIMITS IN AIR
ACGIH OSHA
TLV STE PEL STEL IDLH OTHER
L
ppm ppm ppm ppm ppm ppm
McCAREY-KAUFMAN
MEDIUM
Dextran 40 9004-54-0 <1 NE NE NE NE NE NE
MK Base Powder Mixture <1 NE NE NE NE NE NE
HEPES Buffer 75277-39-3 <1 NE NE NE NE NE NE
Sodium Bicarbonate 144-55-8 <1 NE NE NE NE NE NE
Phenol Red 143-74-8 <1 NE NE NE NE NE NE
Gentamycin 1403-66-3 <1 NE NE NE NE NE NE
Water 7732-18-5 Balance NE NE NE NE NE NE
NE = Not Established C = Ceiling Level See Section 16 for Definitions of Terms Used.
NOTE: all WHMIS required information is included. It is located in appropriate sections based on the ANSI Z400.1-1993 format.
The remainder of this MSDS applies to each of these products.
3. HAZARD IDENTIFICATION
EMERGENCY OVERVIEW: This product is a clear, orange colored solution, used for storage and preservation of human tissue.
The primary hazard associated with the solutions of this product is the potential for mild irritation of contaminated tissue following
prolonged contact. In the event of a fire, this product will not contribute significant additional hazards.
SYMPTOMS OF OVER-EXPOSURE BY ROUTE OF EXPOSURE: No adverse
HAZARDOUS MATERIAL INFORMATION
health effects should occur from routine use of this material in the manner
SYSTEM
specified by the manufacturer's instructions. The only likely symptom of
exposure would be reddening or inflammation after accidental injection. The
HEALTH
potential health effects from the individual components are as follows: 1
(BLUE)
INHALATION: Inhalation of a vapor or mist of this product鈥檚 solutions may
cause mild irritation. Symptoms are generally alleviated upon breathing fresh
air.
FLAMMABILITY 0
(RED)
CONTACT WITH SKIN or EYES: Contact with the skin or eyes may cause mild
irritation, which is alleviated upon rinsing.
SKIN ABSORPTION: This product鈥檚 solutions are not known to absorb through
the skin.
REACTIVITY (YELLOW ) 0
INGESTION: Ingestion of this product鈥檚 solutions, especially in large volumes,
may cause gastric distress.
INJECTION: Injection of this product鈥檚 solutions may cause local reddening,
tissue swelling, and discomfort. B
PROTECTIVE EQUIPMENT
HEALTH EFFECTS OR RISKS FROM EXPOSURE: An Explanation in Lay
Terms. This solution is not known to cause significant acute or chronic health EYES HANDS BODY
RESPIRATORY
effects.
See See
ACUTE: Beyond mild irritation of the skin or eyes, contact with this product does Section 8 Section 8
not usually cause acute health effects.
CHRONIC: This product is not known to cause any significant chronic health For routine industrial applications
effects.
CORNEAL STORAGE MEDIA - (OPTISOL , OPTISOL GS , and DEXSOL ) MSDS
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PART II What should I do if a hazardous situation occurs?
4. FIRST-AID MEASURES
SKIN EXPOSURE: Basic work place hygiene should prevent any problems. If contact with this product leads to reddening, inflammation,
or irritation, flush the exposed area with running water. Remove any contaminated clothing, taking care not to contaminate eyes.
EYE EXPOSURE: If chemical is splashed in eyes, open person's eyes while under gentle running water. Use sufficient force to open
eyelids. Have person "roll" eyes. Minimum flushing is for 15 minutes.
INHALATION: If vapor or mist of this product is inhaled, causing irritation, remove person to fresh air. If necessary, use artificial respiration
to support vital functions. Remove or cover gross contamination to avoid exposure to rescuers.
INGESTION: If chemical is swallowed, CALL PHYSICIAN OR POISON CONTROL CENTER FOR MOST CURRENT INFORMATION. If
professional advice is not available, do not induce vomiting. Person should drink milk, egg whites, or large quantities of water. Never
induce vomiting or give diluents (milk or water) to someone who is unconscious, having convulsions, or who cannot swallow.
Persons who may be over-exposed to a chemical, must be taken for medical attention. Rescuers should be taken for medical attention, if
necessary. Take copy of label and MSDS to physician or health professional with the person.
5. FIRE-FIGHTING MEASURES
NFPA RATING
FLASH POINT, 掳C (method): Not applicable.
AUTOIGNITION TEMPERATURE, 掳C: Not applicable.
FLAMMABLE LIMITS (in air by volume, %): Lower (LEL): Not applicable.
FLAMMABILITY
Upper (UEL): Not applicable.
0
FIRE EXTINGUISHING MATERIALS: In the event of a fire, use suppression methods for surrounding
materials. 0
1
HEALTH REACTIVITY
Water Spray: YES Carbon Dioxide: YES Foam: YES
Dry Chemical: YES Halon: YES Other: Any "ABC" Class.
OTHER
UNUSUAL FIRE AND EXPLOSION HAZARDS: When involved in a fire, this material may
decompose and produce irritating fumes and toxic gases including carbon monoxide, carbon dioxide,
and oxides of nitrogen.
Explosion Sensitivity to Mechanical Impact: Not sensitive.
Explosion Sensitivity to Static Discharge: Not sensitive.
SPECIAL FIRE-FIGHTING PROCEDURES: Incipient fire responders should wear eye protection. Structural fire fighters must wear Self-
Contained Breathing Apparatus and full protective equipment.
6. ACCIDENTAL RELEASE MEASURES
SPILL AND LEAK RESPONSE: For small releases (< 1 liter), take basic hygiene precautions. Lightweight gloves, a lab coat and eye
protection should be worn. Absorb spilled liquid with paper towels. Wash contaminated area with soap and water, absorb with paper
towels, and rinse with water. Large releases (> 1 liter) which are not immediately controlled, should be responded to by trained personnel
using pre-planned procedures. Proper protective equipment should be used. In case of a spill, clear the affected area, protect people, and
respond with trained personnel. Minimum Personal Protective Equipment should be Level D: lab-gloves, chemically resistant apron,
boots, and splash goggles. Respiratory protection should not be necessary. Absorb spilled liquid with polypads or other suitable
absorbent materials. Decontaminate the area thoroughly. Place all spill residue in a double plastic bag and seal. Dispose of in
accordance with Federal, State, and local hazardous waste disposal regulations (see Section 13).
CORNEAL STORAGE MEDIA - (OPTISOL , OPTISOL GS , and DEXSOL ) MSDS
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PART III How can I prevent hazardous situations from occurring?
7. HANDLING and STORAGE
WORK PRACTICES AND HYGIENE PRACTICES: Avoid getting chemicals ON YOU or IN YOU. Wash hands after handling chemicals.
Avoid splashing or spraying this product. Do not eat or drink while handling chemicals.
STORAGE AND HANDLING PRACTICES: All employees who handle this material should be trained to handle it safely. Avoid breathing
vapors or mists generated by this product. Store vials in a cool, dry location, away from direct sunlight, sources of intense heat, or where
freezing is possible. Keep vials tightly closed when not in use. Wash thoroughly after using this material. Read instructions provided with
the product prior to use.
PROTECTIVE PRACTICES DURING MAINTENANCE OF CONTAMINATED EQUIPMENT: Follow practices indicated in Section 6
(Accidental Release Measures). Make certain application equipment is locked and tagged-out safely, as applicable. Always use this
product in areas where adequate ventilation is provided. Decontaminate equipment using soapy water before maintenance begins.
Collect all rinsates and dispose of according to applicable Federal, State, or local procedures where adequate ventilation is provided.
Decontaminate equipment using soapy water before maintenance begins. Collect all rinsates and dispose of according to applicable
Federal, State, or local procedures.
8. EXPOSURE CONTROLS - PERSONAL PROTECTION
VENTILATION AND ENGINEERING CONTROLS: Use with adequate ventilation.
RESPIRATORY PROTECTION: Respiratory protection is not generally needed when using this product. Maintain airborne contaminant
concentrations below guidelines listed in Section 2. If respiratory protection is needed, use only protection authorized in 29 CFR 1910.134,
or applicable State regulations. Use supplied air respiration protection if oxygen levels are below 19.5% or are unknown.
EYE PROTECTION: Splash goggles or safety glasses.
HAND PROTECTION: Wear laboratory gloves for routine industrial use.
BODY PROTECTION: Use body protection appropriate for task (i.e. laboratory coat).
9. PHYSICAL and CHEMICAL PROPERTIES
VAPOR DENSITY: Not available. EVAPORATION RATE (water = 1): 1
SPECIFIC GRAVITY: 1.0 MELTING POINT or RANGE: Approximately 0掳C.
SOLUBILITY IN WATER: Soluble. BOILING POINT: Approximately 100掳C.
VAPOR PRESSURE, mm Hg @ 20 掳C: 18 pH: 7.0-8.0
APPEARANCE AND COLOR: Clear, orange-colored solution. The solution has properties similar to water.
HOW TO DETECT THIS SUBSTANCE (warning properties): The solution does not have any unique warning properties. If spilled, the
orange color may change to dark red or purple.
10. STABILITY and REACTIVITY
STABILITY: Stable.
DECOMPOSITION PRODUCTS: Thermal decomposition of the components of this product may produce carbon dioxide, carbon
monoxide, and oxides of nitrogen.
MATERIALS WITH WHICH SUBSTANCE IS INCOMPATIBLE: This product is not compatible with strong acids or bases and strong
oxidizers.
HAZARDOUS POLYMERIZATION: Will not occur.
CONDITIONS TO AVOID: Any conditions which are incompatible with water. Avoid mixing this product with incompatible chemicals.
CORNEAL STORAGE MEDIA - (OPTISOL , OPTISOL GS , and DEXSOL ) MSDS
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PART IV Is there any other useful information about this material?
11. TOXICOLOGICAL INFORMATION
TOXICITY DATA: While not tested, this product is not expected to be toxic. Mild eye irritation may occur if this product is splashed in the
eye.
SUSPECTED CANCER AGENT: The product鈥檚 ingredients are not found on the following lists: NTP, IARC, Federal OSHA. Z List,
CAL/OSHA.
IRRITANCY OF PRODUCT: While not tested, this product is not expected to cause irritancy to the skin. Mild eye irritation may occur if
this product is splashed in the eye.
SENSITIZATION TO THE PRODUCT: No component is known to be a sensitizer.
REPRODUCTIVE TOXICITY INFORMATION: Listed below is information concerning the effects of this product and its components on the
human reproductive system.
Mutagenicity: Due to the dilute concentration of components, this product is not expected to cause mutation effects in humans.
Teratogenicity: Due to the dilute concentration of components, this product is not expected to cause teratogenic effects in humans.
Reproductive Toxicity: Due to the dilute concentration of components, this product is not expected to cause adverse reproductive
effects in humans.
A mutagen is a chemical which causes permanent changes to genetic material (DNA) such that the changes will propagate through
generational lines. A teratogen is a chemical which causes damage to a developing fetus, but the damage does not propagate across
generational lines. A reproductive toxin is any substance which interferes in any way with the reproductive process.
MEDICAL CONDITIONS AGGRAVATED BY EXPOSURE: No specific medical conditions are known to be aggravated by exposure to this
product.
RECOMMENDATIONS TO PHYSICIANS: This product is not expected to cause clinical symptoms. If such symptoms occur, treat the
symptoms, while alleviating the cause. Biological Exposure Indices (BEIs) are not applicable to the components of this product.
12. ECOLOGICAL INFORMATION
ENVIRONMENTAL STABILITY: The components of this product will degrade in the environment into smaller organic and inorganic
constituents.
EFFECT OF MATERIAL ON PLANTS or ANIMALS: No unusual effects on plants or animals are expected if this product is released into
the environment; however, as with all chemicals, work practices should be aimed at minimizing environmental releases.
EFFECT OF CHEMICAL ON AQUATIC LIFE: This product is not known to cause adverse effects on aquatic life; however, as with all
chemicals, work practices should be aimed at minimizing environmental releases.
13. DISPOSAL CONSIDERATIONS
PREPARING WASTES FOR DISPOSAL: Waste disposal must be in accordance with appropriate Federal, State, and local regulations.
This chemical, if unaltered by use, may be disposed of by treatment at a permitted facility or as advised by your local hazardous waste
regulatory authority.
EPA WASTE NUMBER: Not applicable to the product.
CORNEAL STORAGE MEDIA - (OPTISOL , OPTISOL GS , and DEXSOL ) MSDS
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14. TRANSPORTATION INFORMATION
THIS MATERIAL IS NOT HAZARDOUS AS DEFINED BY 49 CFR 172.101 BY THE U.S. DEPARTMENT OF TRANSPORTATION.
PROPER SHIPPING NAME: Not applicable.
HAZARD CLASS NUMBER and DESCRIPTION: Not applicable.
UN IDENTIFICATION NUMBER: Not applicable.
PACKING GROUP: Not applicable.
DOT LABEL(S) REQUIRED: Not applicable.
EMERGENCY RESPONSE GUIDEBOOK NUMBER (1993): Not applicable.
NORTH AMERICAN EMERGENCY RESPONSE GUIDEBOOK NUMBER: Not Applicable.
MARINE POLLUTANT: Not applicable (49 CFR 172.101, Appendix B).
TRANSPORT CANADA TRANSPORTATION OF DANGEROUS GOODS REGULATIONS: THIS MATERIAL IS NOT CONSIDERED AS
DANGEROUS GOODS. Use the above information for the preparation of Canadian Shipments.
15. REGULATORY INFORMATION
SARA REPORTING REQUIREMENTS: No components of this product are subject to the reporting requirements of Sections 302, 304 and
313 of Title III of the Superfund Amendments and Reauthorization Act, as follows:
SARA Threshold Planning Quantity: Not applicable.
TSCA INVENTORY STATUS: The chemicals in this product are listed on the TSCA Inventory.
CERCLA REPORTABLE QUANTITY (RQ): Not applicable.
OTHER FEDERAL REGULATIONS: Not applicable.
STATE REGULATORY INFORMATION: No components of this product are covered under specific State regulations, as denoted below:
Alaska - Designated Toxic and Hazardous Minnesota - List of Hazardous Substances: Pennsylvania - Hazardous Substance List:
Substances: None. None. None.
California - Permissible Exposure Limits for Missouri - Employer Information/Toxic Rhode Island - Hazardous Substance List:
Chemical Contaminants: None. Substance List: None. None.
Florida - Substance List: None. New Jersey - Right to Know Hazardous Texas - Hazardous Substance List: None.
Illinois - Toxic Substance List: None. Substance List: None. West Virginia - Hazardous Substance List:
Kansas - Section 302/313 List: None. North Dakota - List of Hazardous Chemicals, None.
Massachusetts - Substance List: None. Reportable Quantities: None. Wisconsin - Toxic and Hazardous
Substances: None.
CALIFORNIA PROPOSITION 65: No component of this solution is on the California Proposition 65 lists.
LABELING (Precautionary Statements): CAUTION! Exposure to this product through inhalation, ingestion, or skin contact may cause
irritation. Avoid generating splashes, sprays, or mists. Avoid accidental injection. Avoid contact with strong acids, bases, oxidizers.
Consult Material Safety Data Sheet before use.
TARGET ORGANS: Eyes, skin.
WHMIS SYMBOLS: Not applicable.
16. OTHER INFORMATION
PREPARED BY: CHEMICAL SAFETY ASSOCIATES, Inc.
9163 Chesapeake Drive, San Diego, CA 92123-1002
619/565-0302
DATE OF PRINTING: January 29, 2002 (Updated Company information on 1/2202 鈥? No technical changes made.)
The information contained herein is based on data considered accurate. However, no warranty is expressed or implied regarding the accuracy of these data or the results to be
obtained from the use thereof. Bausch & Lomb assumes no responsibility for injury to the vendee or third persons proximately caused by the material if reasonable safety procedures
are not adhered to as stipulated in the data sheet. Additionally, Bausch & Lomb assumes no responsibility for injury to vendee or third persons proximately caused by abnormal use
of the material even if reasonable safety procedures are followed. Furthermore, vendee assumes the risk in his use of the material.
CORNEAL STORAGE MEDIA - (OPTISOL , OPTISOL GS , and DEXSOL ) MSDS
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DEFINITIONS OF TERMS
A large number of abbreviations and acronyms appear on a MSDS. Some of these which TOXICOLOGICAL INFORMATION:
are commonly used include the following: Possible health hazards as derived from human data, animal studies, or from the results of
studies with similar compounds are presented. Definitions of some terms used in this
CAS #: This is the Chemical Abstract Service Number which uniquely identifies each section are: LD50 - Lethal Dose (solids & liquids) which kills 50% of the exposed animals;
constituent. It is used for computer-related searching. LC50 - Lethal Concentration (gases) which kills 50% of the exposed animals; ppm
3
EXPOSURE LIMITS IN AIR: concentration expressed in parts of material per million parts of air or water; mg/m
ACGIH - American Conference of Governmental Industrial Hygienists, a professional concentration expressed in weight of substance per volume of air; mg/kg quantity of
association which establishes exposure limits. material, by weight, administered to a test subject, based on their body weight in kg. Data
TLV - Threshold Limit Value - an airborne concentration of a substance which from several sources are used to evaluate the cancer-causing potential of the material.
represents conditions under which it is generally believed that nearly all workers may be The sources are: IARC - the International Agency for Research on Cancer; NTP - the
repeatedly exposed without adverse effect. The duration must be considered, including National Toxicology Program, RTECS - the Registry of Toxic Effects of Chemical
the 8-hour Time Weighted Average (TWA), the 15-minute Short Term Exposure Limit, Substances, OSHA and CAL/OSHA. IARC and NTP rate chemicals on a scale of
and the instantaneous Ceiling Level. Skin adsorption effects must also be considered. decreasing potential to cause human cancer with rankings from 1 to 4. Subrankings (2A,
OSHA - U.S. Occupational Safety and Health Administration. 2B, etc.) are also used. Other measures of toxicity include TDLo, the lowest dose to cause
PEL - Permissible Exposure Limit - this exposure value means exactly the same as a a symptom and TCLo the lowest concentration to cause a symptom; TDo, LDLo, and
TLV, except that it is enforceable by OSHA. The IDLH - Immediately Dangerous to Life LDo, or TC, TCo, LCLo, and LCo, the lowest dose (or concentration) to cause death. BEI
and Health level represents a concentration from which one can escape within 30- - Biological Exposure Indices, represent the levels of determinants which are most likely to
minutes without suffering escape-preventing or permanent injury. The DFG - MAK is the be observed in specimens collected from a healthy worker who has been exposed to
Republic of Germany鈥檚 Maximum Exposure Level, similar to the U.S. PEL. NIOSH is the chemicals to the same extent as a worker with inhalation exposure to the TLV.
REGULATORY INFORMATION:
National Institute of Occupational Safety and Health, which is the research arm of the U.S.
Occupational Safety and Health Administration (OSHA). NIOSH issues exposure This section explains the impact of various laws and regulations on the material. EPA is
guidelines called Recommended Exposure Levels (RELs). When no exposure guidelines the U.S. Environmental Protection Agency. WHMIS is the Canadian Workplace Hazard
are established, an entry of NE is made for reference. Information System. DOT and CTC are the U.S. Department of Transportation and the
FLAMMABILITY LIMITS IN AIR: Canadian Transportation Commission, respectively. Other acronyms are: Superfund
Much of the information related to fire and explosion is derived from the National Fire Amendments and Reauthorization Act (SARA); the Toxic Substance Control Act
Protection Association (NFPA). LEL - the lowest percent of vapor in air, by volume, that (TSCA); Marine Pollutant status according to the DOT; California's Safe Drinking Water
will explode or ignite in the presence of an ignition source. UEL - the highest percent of Act (Proposition 65); the Comprehensive Environmental Response, Compensation,
vapor in air, by volume, that will explode or ignite in the presence of an ignition source. and Liability Act (CERCLA or Superfund); and various state regulations. This section
also includes information on the precautionary warnings which appear on the materials
package label.
CORNEAL STORAGE MEDIA - (OPTISOL , OPTISOL GS , and DEXSOL ) MSDS
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