EMS CATALOG NO: 10000-10016
EMS PRODUCT: Acetone
DATE: 07/08/2007
PAGE NUMBER: One of 8
MATERIAL SAFETY DATA SHEET
The information contained herein is based on data considered accurate. However,
no warranty is expressed or implied regarding the accuracy of these data or the
results to be obtained from the use thereof.
Electron Microscopy Sciences assumes no responsibility for personal injury or
property damage to vendees, users or third parties caused by the material. Such
vendees or users assume all risks associated with the use of the material.
ELECTRON MICROSCOPY SCIENCES
1560 Industry Road
P.O. Box 550
Hatfield, PA 19440
215-412-8400 / fax 215-412-8450
24 HOUR EMERGENCY PHONE NUMBER CHEMTREC: (800) 424-9300
FOR PRODUCT AND SALES INFORMATION
CONTACT ELECTRON MICROSCOPY SCIENCES OFFICE ABOVE.
PRODUCT IDENTIFICATION
COMMON NAME: Acetone
COMMERCIAL NAME(S): Not available.
SYNONYM: 2-propanone; Dimethyl Ketone; Dimethylformaldehyde; Pyroacetic Acid
CHEMICAL NAME: Acetone
CHEMICAL FAMILY: Aliphatic ketone (Solvent)
CHEMICAL FORMULA: C3-H6-0
CAS#: 67-64-1
RTECS: AL3150000
TSCA: TSCA 8(b) inventory: ACETONE
CI#: Not applicable
COMPOSITION AND INFORMATION ON INGREDIENTS
NAME: Acetone
CAS#: 67-64-1
TWA(mg/m3): 500
STEL (mg/m3): 1000
% BY WEIGHT: 100
TOXICOLOGICAL DATA ON INGREDIENTS:
ORAL (LD50): Acute: 5800 mg/kg [Rat]. 3000mg/kg [Mouse]. 5340 mg/kg
[Rabbit].
VAPOR (LC50): Acute: 50100 mg/m鲁 8 hours [Rat].44000 mg/m鲁
4 hours [Mouse].
HAZARDS IDENTIFICATION
POTENTIAL ACUTE HEALTH EFFECTS:
Hazardous in case of skin contact (permeator), of eye
contact (irritant), of ingestion, of inhalation. Slightly
hazardous in case of skin contact (irritant, sensitizer).
POTENTIAL CHRONIC HEALTH EFFECTS:
Hazardous in case of skin contact (permeator), of eye
contact (irritant), of ingestion, of inhalation. Slightly
hazardous in case of skin contact (irritant, sensitizer).
CARCINOGENIC EFFECTS: Classified A5 (Not suspected for
human.) by ACGIHG.
MUTAGENIC EFFECTS: Not available.
TERATOGENIC EFFECTS: Not available
DEVELOPMENTAL TOXICITY: Classified Reproductive system/female,
Reproductive system/toxin/male [SUSPECTED].
The substance is toxic to central nervous system (CNS).
The substance may be toxic to kidneys, the reproductive system, liver, skin.
Repeated or prolonged exposure to the substance can produce target organs
Damage.
FIRST AID MEASURES
EYE CONTACT: Check for and remove any contact lenses. Immediately flush eyes
With running water for at least 15 minutes, keeping eyelids open.
Cold water may be used. Get medical attention.
SKIN CONTACT: In case of contact, immediately flush skin with plenty of water.
Cover the irritated skin with an emollient. Remove contaminated
Clothing and shoes. Cold water may be used. Wash clothing before
Reuse. Thoroughly clean shoes before reuse. Get medical attention.
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SERIOUS SKIN CONTACT: Wash with a disinfectant soap and cover
the contaminated skin with an anti-bacterial cream.
Seek medical attention.
INHALATION: If inhaled, remove to fresh air. If not breathing , give
Artificial respiration. If breathing is difficult, give oxygen. Seek medical
Attention.
SERIOUS INHALATION:
Evacuate the victim to a safe area as soon as possible.
Loosen tight clothing such as a collar, tie, belt or
waistband. If breathing is difficult, administer oxygen.
If the victim is not breathing, perform mouth-to-mouth
resuscitation. Seek immediate medical attention.
INGESTION:
Do NOT induce vomiting. Loosen tight clothing such as a
collar, tie, belt or waistband. If the victim is not
breathing, perform mouth-to-mouth resuscitation. Seek
immediate medical attention.
SERIOUS INGESTION: Not available.
FIRE AND EXPLOSION DATA
FLAMMABILITY OF THE PRODUCT: Flammable.
AUTO-IGNITION TEMPERATURE: 465oC (869oF)
FLASH POINTS: Closed Cup: -20oC (-4oF).
Open Cup: -9oC (15.8oF) (Cleveland)
FLAMMABLE LIMITS: Lower: 2.6% Upper: 12.8%
PRODUCTS OF COMBUSTION: The products are carbon oxides (CO, CO2)
FIRE HAZARDS IN PRESENCE OF VARIOUS SUBSTANCES: Highly flammable in
Presence of open flames and sparks of heat.
EXPLOSION HAZARDS IN PRESENCE OF VARIOUS SUBSTANCES: Risks of
Explosion of the product in presence of mechanical impact: Not available.
Slightly explosive in presence of open flames and sparks, of oxidizing materials, of
Acids.
RISKS OF EXPLOSION OF THE PRODUCT IN PRESENCE OF MECHANICAL
IMPACT: Not available.
RISKS OF EXPLOSION OF THE PRODUCT IN PRESENCE OF STATIC
DISCHARGE: Not available.
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FIRE FIGHTING MEDIA AND INSTRUCTIONS: Flammable liquid, soluble
or dispersed in water.
SMALL FIRE: Use DRY chemical powder.
LARGE FIRE: Use alcohol foam, water spray or fog.
SPECIAL REMARKS ON FIRE HAZARDS: Vapor may travel considerable distance to
Source of ignition and flash back.
SPECIAL REMARKS ON EXPLOSION HAZARDS: Forms explosive mixtures with
hydrogen peroxide, acetic acid, nitric acid, nitric acid + sulfuric acid, chromic anydride,
Chromyl chloride, nitrosyl chloride, hexachloromelamine, nitrosyl perchlorate, nitryl
Perchlorate,permonosulfuric acid, thiodiglycol +hydrogen peroxide, potassium ter-
butoxide, sulfur dichloride, 1-methyl-1,3-butadiene,bromoform,carbon,air,chloroform,
Thitriazylperchlorate.
ACCIDENTAL RELEASE MEASURES
SMALL SPILL:
Dilute with water and mop up, or absorb with an inert dry
material and place in an appropriate waste disposal
container.
LARGE SPILL:
Flammable liquid. Keep away from heat. Keep away from
sources of ignition. Stop leak if without risk. Absorb
with DRY earth, sand or other non-combustible material. Do
not touch spilled material. Prevent entry into sewers,
basements or confined areas; dike if needed. Eliminate all
ignition sources. Be careful that the product is not
present at a concentration level above TLV. Check TLV on
the MSDS and with local authorities.
HANDLING AND STORAGE
PRECAUTIONS:
Keep away from heat. Keep away from sources of ignition.
Ground all equipment containing material. Do not ingest.
Do not breathe gas/fumes/vapor/spray. Wear suitable
protective clothing. In case of insufficient ventilation,
wear suitable respiratory equipment. If ingested, seek
medical advice immediately and show the container or the
label. Avoid contact with skin and eyes. Keep away from incompatibles
such as oxidizing agents, reducing agents, acids, alkalis.
STORAGE:
Store in segregated and approved area (flammables area).
Keep container in a cool, well-ventilated area. Keep container
Tightly closed and sealed until ready for use. Keep away from
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Direct sunlight and heat avoid all possible sources of ignition (spark or flame).
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EXPOSURE CONTROLS/PERSONAL PROTECTION
ENGINEERING CONTROLS:
Provide exhaust ventilation or other engineering controls to
keep the airborne concentrations of vapors below their
respective threshold limit value. Ensure that eyewash
stations and safety showers are proximal to the work-station
location.
PERSONAL PROTECTION:
Splash goggles. Lab coat. Vapor respirator. Be sure to
use an approved/certified respirator or equivalent. Gloves.
PERSONAL PROTECTION IN CASE OF A LARGE SPILL:
Splash goggles. Full suit. Vapor respirator. Boots.
Gloves. A self contained breathing apparatus should be used
to avoid inhalation of the product. Suggested protective
clothing might not be sufficient; consult a specialist
BEFORE handling this product.
EXPOSURE LIMITS:
TWA: 500 STEL: 750 (ppm) from ACGIH (TLV)
TWA: 750 STEL: 1000 (ppm) from OSHA (PEL)
TWA: 1800 STEL: 2400 from OSHA (PEL)
Consult local authorities for acceptable exposure limits.
PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE AND APPEARANCE: Liquid
ODOR: Pungent (Strong).
TASTE: Not available.
COLOR: Colorless.
MOLECULAR WEIGHT: 58.08 g/mole
pH (1% SOLN/WATER): Not Available
BOILING POINT: 56.2掳C (133.2oF)
MELTING POINT: -95.35掳C (-139.2oF)
CRITICAL TEMPERATURE: 235掳 (455掳F)
SPECIFIC GRAVITY: 0.79 (Water =1)
VAPOR PRESSURE: 24 kPa (@ 20oC)
VAPOR DENSITY: 2 (Air = 1)
VOLATILITY: Not available.
ODOR THRESHOLD: 62 ppm
WATER/OIL DIST. COEFF.:The product is more soluble in water;log (oil/water)=0.2
IONICITY (IN WATER): Not available.
DISPERSION PROPERTIES: See solubility in water.
STABILITY AND REACTIVITY DATA
STABILITY: The product is stable.
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INSTABILITY TEMPERATURE: Not available.
CONDITIONS OF INSTABILITY: Excess heat, ignition sources, exposure to moisture,
Air, or water, incompatible materials.
INCOMPATIBILITY WITH VARIOUS SUBSTANCES: Reactive with oxidizing agents,
Reducing agents, acids, alkalis.
CORROSIVITY: Non-corrosive in presence of glass.
SPECIAL REMARKS ON REACTIVITY: Not available.
SPECIAL REMARKS ON CORROSIVITY: Not available.
POLYMERIZATION: Will not occur.
TOXICOLOGICAL INFORMATION
ROUTES OF ENTRY: Dermal contact. Eye contact. Inhalation. Ingestion.
TOXICITY TO ANIMALS:
WARNING: THE LC50 VALUES HEREUNDER ARE ESTIMATED ON THE
BASIS OF A 4-HOUR EXPOSURE.
Acute oral toxicity (LD50): 3800 mg/kg [Mouse].
Acute toxicity of the vapor (LC50):44000mg/m鲁 4 hour(s) [Mouse].
CHRONIC EFFECTS ON HUMANS:
CARCINOGENIC EFFECTS: Classified A4 (Not suspected for
human.) by ACGIH.
TERATOGENIC EFFECTS: Classified None. for human.
DEVELOPMENTAL TOXICITY: Classified Reproductive system/toxin/female,
Reproductive system/toxin/male [SUSPECTED]
The substance is toxic to blood, kidneys, lungs, the nervous
system, liver, mucous membranes. The substance is not toxic
to the reproductive system.
OTHER TOXIC EFFECTS ON HUMANS:
Hazardous in case of skin contact (IRRITANT), of ingestion,
of inhalation. Slightly hazardous in case of skin contact
(PERMEATOR).
SPECIAL REMARKS ON TOXICITY TO ANIMALS: Not available.
SPECIAL REMARKS ON CHRONIC EFFECTS ON HUMANS: May affect genetic
Material (mutagenicity) based on studies with yeast (s. cerevisiae), bacteria, and
Hamster fibroblast cells. May cause reproductive effects (fertility) based upon animal
Studies. May contain trace amounts of benzene and formaldehyde which may cause
Cancer and birth defects. Human: passes the placental barrier.
SPECIAL REMARKS ON OTHER TOXIC EFFECTS ON HUMANS:
May cause skin irritation, characterized by a burning sensation, redness, tearing,
Inflammation, and possible corneal injury.
Inhalation: Inhalation at high concentrations affects the sense organs, brain and
Causes respiratory tract irritation. It also may affect the Central Nervous System
(behavior) characterized by dizzness, drowsiness, confusion, headache, muscle
weakeness, and possible motor incoordination, speech abnormalities, narcotic
effects and coma. Inhalation may also affect the gastrointestinal tract (nausea,
vomiting). Ingestion: May cause the above and also affect the Central Nervous
System (behavior), characterized by depression, fatigue, excitement, stupor, coma,
Headache, altered sleep time, ataxia, tremors as well as the blood, liver, and
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Urinary system (kidney,bladder,ureter) and endocrine system. May also have
Musculoskeletal effects. Chronic Potential Health Effects:
Skin: May cause dermatitis Eyes: Eye irritation Inhalation: May cause effects
Similar to those of acute inhalation. Ingestion: May cause loss of appetite, heartburn,
Gastritis.
No permanent adverse health effects have been found.
ECOLOGICAL INFORMATION
ECOTOXICITY: Ecotoxicity in water (LC50): 5540 mg/l 96 hours [Trout]. 8300 mg/i96
hours [Bluegill]. 7500 mg/l 96 hours [Fatthead Minnow]. 0.1 ppm any hours[Flea}
BOD5 AND COD: Not Available
PRODUCTS OF BIODEGRADATION:
Possibly hazardous short term degredation products are not
likely. However, long term degradation products may arise.
TOXICITY OF THE PRODUCTS OF BIODEGRADATION:
The product itself and its products of degradation are not toxic.
SPECIAL REMARKS ON THE PRODUCTS OF BIODEGRADATION: Not available.
DISPOSAL CONSIDERATIONS
WASTE DISPOSAL: Waste must be disposed of in accordance with federal, state
And local environmental control regulations.
TRANSPORT INFORMATION
DOT CLASSIFICATION: Class 3: Flammable liquid.
IDENTIFICATION: Acetone UN1090 PG: II
SPECIAL PROVISIONS FOR TRANSPORT: Not available.
OTHER REGULATORY INFORMATION
FEDERAL AND STATE REGULATIONS:
PENNSYLVANIA RTK: Acetone
MASSACHUSETTS RTK: Acetone
TSCA 8 (b) INVENTORY: Acetone
CERCLA: Hazardous substances: Acetone: 5000 lbs. (2268 kg)
OTHER REGULATIONS:
OSHA: Hazardous by definition of Hazard Communication
Standard (29 CFR 1910.1200).
OTHER CLASSIFICATIONS:
WHMIS (CANADA): CLASS B-2: Flammable liquid with a flash
point lower than 37.8oC (100oF).
CLASS D-2B: Material causing other toxic
effects (TOXIC).
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DSCLA (EEC): R-11: Highly flammable.
R-36: Irritating to eyes.
HMIS (U.S.A.):
HEALTH HAZARD: 2
FIRE HAZARD: 3
REACTIVITY: 0
PERSONAL PROTECTION: H
NATIONAL FIRE PROTECTION ASSOCIATION (U.S.A.)
HEALTH: 1
FLAMMABILITY: 3
REACTIVITY: 0
SPECIFIC HAZARD:
PROTECTIVE EQUIPMENT:
Gloves (impervious).
Lab coat.
Vapor respirator. Be sure to use an approved/certified
respirator or equivalent. Wear appropriate respirator
when ventilation is inadequate.
Splash goggles.
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