**** SECTION 2 - COMPOSITION, INFORMATION ON INGREDIENTS ****
+----------------+--------------------------------------+----------+-----------+
| CAS# | Chemical Name | % | EINECS# |
|----------------|--------------------------------------|----------|-----------|
| 106-47-8 |p-Chloroaniline | 100 | 203-401-0 |
+----------------+--------------------------------------+----------+-----------+
Hazard Symbols: T N
Risk Phrases: 23/24/25 43 45 50/53
**** SECTION 3 - HAZARDS IDENTIFICATION ****
EMERGENCY OVERVIEW
Toxic by inhalation, in contact with skin and if swallowed. May
cause sensitization by skin contact. May cause cancer. Very toxic to
aquatic organisms; may cause long-term adverse effects in the aquatic
environment.Cancer suspect agent.Light sensitive.Air sensitive.
Potential Health Effects
Eye:
Causes severe eye irritation.
Skin:
Causes skin irritation. Harmful if absorbed through the skin.
Prolonged and/or repeated contact may cause irritation and/or
dermatitis. May cause skin sensitization, an allergic reaction,
which becomes evident upon re-exposure to this material.
Ingestion:
Harmful if swallowed. Causes gastrointestinal irritation with
nausea, vomiting and diarrhea. Methemoglobinemia is characterized by
dizziness, drowsiness, headache, breath shortness, cyanosis with
bluish skin, rapid heart rate and chocolate-brown colored blood.
Overexposure may cause methemoglobinemia.
Inhalation:
May cause irritation of the respiratory tract with burning pain in
the nose and throat, coughing, wheezing, shortness of breath and
pulmonary edema. Methemoglobinemia is characterized by dizziness,
drowsiness, headache, breath shortness, cyanosis with bluish skin,
rapid heart rate and chocolate-brown blood. Inhalation of aniline
causes anoxia due to the formation of methemoglobinemia.
Chronic:
May cause liver and kidney damage. May cause methemoglobinemia,
which is characterized by chocolate-brown colored blood, headache,
weakness, dizziness, breath shortness, cyanosis (bluish skin due to
deficient oxygenation of blood), rapid heart rate, unconsciousness
and possible death. May cause cancer according to animal studies.
May cause reproductive and fetal effects.
**** SECTION 4 - FIRST AID MEASURES ****
Eyes:
Immediately flush eyes with plenty of water for at least 15 minutes,
occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Immediately flush skin with plenty of soap and
water for at least 15 minutes while removing contaminated clothing
and shoes. Wash clothing before reuse.
Ingestion:
Do NOT induce vomiting. If victim is conscious and alert, give 2-4
cupfuls of milk or water. Never give anything by mouth to an
unconscious person. Get medical aid immediately.
Inhalation:
Get medical aid immediately. Remove from exposure to fresh air
immediately. If not breathing, give artificial respiration. If
breathing is difficult, give oxygen. Do NOT use mouth-to-mouth
resuscitation.
Notes to Physician:
For methemoglobinemia, administer oxygen alone or with Methylene
blue depending on the methemoglobinemia concentration in the blood.
Antidote:
Methylene blue, alone or in combination with oxygen is indicated as
a treatment in nitrite induced methemoglobinemia.
**** SECTION 5 - FIRE FIGHTING MEASURES ****
General Information:
As in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full
protective gear. During a fire, irritating and highly toxic gases
may be generated by thermal decomposition or combustion.
Extinguishing Media:
In case of fire, use water, dry chemical, chemical foam, or
alcohol-resistant foam.
**** SECTION 6 - ACCIDENTAL RELEASE MEASURES ****
General Information: Use proper personal protective equipment as indicated
in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal
container. Reduce airborne dust and prevent scattering by moistening
with water. Clean up spills immediately, observing precautions in
the Protective Equipment section. Avoid generating dusty conditions.
Provide ventilation.
**** SECTION 7 - HANDLING and STORAGE ****
Handling:
Wash thoroughly after handling. Wash hands before eating. Minimize
dust generation and accumulation. Avoid contact with eyes, skin, and
clothing. Wash clothing before reuse. Use only with adequate
ventilation. Avoid breathing dust.
Storage:
Keep container closed when not in use. Store in a cool, dry,
well-ventilated area away from incompatible substances. Store
protected from light and air.
**** SECTION 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION ****
Engineering Controls:
Facilities storing or utilizing this material should be equipped
with an eyewash facility and a safety shower. Use adequate
ventilation to keep airborne concentrations low.
Personal Protective Equipment
Eyes:
Wear appropriate protective eyeglasses or chemical
safety goggles as described by OSHA's eye and face
protection regulations in 29 CFR 1910.133 or European
Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin
exposure.
Clothing:
Wear appropriate protective clothing to prevent skin
exposure.
Respirators:
Follow the OSHA respirator regulations found in 29CFR
1910.134 or European Standard EN 149. Always use a
NIOSH or European Standard EN 149 approved respirator
when necessary.
**** SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES ****
Physical State: Solid
Appearance: colourless
Odor: None reported.
pH: Not available.
Vapor Pressure: 1 mm Hg @ 58 C
Viscosity: Not available.
Boiling Point: 232 deg C
Freezing/Melting Point: 71 deg C
Autoignition Temperature: > 450 deg C (> 842.00 deg F)
Flash Point: > 120 deg C (> 248.00 deg F)
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature: Not available.
Solubility in water: Soluble in hot water.
Specific Gravity/Density: 1.169
Molecular Formula: C6H6ClN
Molecular Weight: 127.57
**** SECTION 10 - STABILITY AND REACTIVITY ****
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Light, dust generation, excess heat, prolonged exposure to air.
Incompatibilities with Other Materials:
Acids, acid chlorides, acid anhydrides, chloroformates, and strong
oxidizing agents.
Hazardous Decomposition Products:
Hydrogen chloride, nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization: Has not been reported.
**** SECTION 11 - TOXICOLOGICAL INFORMATION ****
RTECS#:
CAS# 106-47-8: BX0700000
LD50/LC50:
CAS# 106-47-8: Draize test, rabbit, eye: 250 ug/24H Severe; Draize
test, rabbit, skin: 500 mg/24H Mild; Inhalation, rat: LC50 = 2340
mg/m3/4H; Oral, mouse: LD50 = 100 mg/kg; Oral, rat: LD50 = 300 mg/kg;
Skin, rabbit: LD50 = 360 mg/kg; Skin, rat: LD50 = 3200 mg/kg.
Carcinogenicity:
p-Chloroaniline -
ACGIH: A3 - Animal Carcinogen (listed as ** undefined **).
California: carcinogen; initial date 10/01/94
NIOSH: occupational carcinogen (listed as ** undefined **)
OSHA: Possible Select carcinogen
IARC: Group 3 carcinogen (listed as ** undefined **).
Other:
See actual entry in RTECS for complete information.
**** SECTION 12 - ECOLOGICAL INFORMATION ****
Other
For more information, see "HANDBOOK OF ENVIRONMENTAL FATE AND
EXPOSURE DATA."
**** SECTION 13 - DISPOSAL CONSIDERATIONS ****
Products which are considered hazardous for supply are classified as Special
Waste and the disposal of such chemicals is covered by regulations which may
vary according to location. Contact a specialist disposal company or the local
waste regulator for advice. Empty containers must be decontaminated before
returning for recycling.
**** SECTION 14 - TRANSPORT INFORMATION ****
IATA
Shipping Name: CHLOROANILINES, SOLID
Hazard Class: 6.1
UN Number: 2018
Packing Group: II
IMO
Shipping Name: CHLOROANILINES, SOLID
Hazard Class: 6.1
UN Number: 2018
Packing Group: II
RID/ADR
Shipping Name: CHLOROANILINES, SOLID
Dangerous Goods Code: 6.1(12B)
UN Number: 2018
**** SECTION 15 - REGULATORY INFORMATION ****
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: T N
Risk Phrases:
R 23/24/25 Toxic by inhalation, in contact with skin
and if swallowed.
R 43 May cause sensitization by skin contact.
R 45 May cause cancer.
R 50/53 Very toxic to aquatic organisms; may cause
long-term adverse effects in the aquatic environment.
Safety Phrases:
S 53 Avoid exposure - obtain special instructions
before use.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
S 60 This material and/or its container must be
disposed of as hazardous waste.
S 61 Avoid release to the environment. Refer to
special instructions/Safety data sheets.
WGK (Water Danger/Protection)
CAS# 106-47-8: 3
United Kingdom Occupational Exposure Limits
Canada
CAS# 106-47-8 is listed on Canada's DSL List.
CAS# 106-47-8 is listed on Canada's Ingredient Disclosure List.
Exposure Limits
CAS# 106-47-8 (listed as ** undefined **): OEL-ARAB Republic of Egypt:
TWA 2 ppm (10 mg/m3);Skin
OEL-AUSTRALIA:TWA 2 ppm (10 mg/m3);Skin
OEL-AUSTRIA:TWA 2 ppm (8 mg/m3);Skin
OEL-BELGIUM:TWA 2 ppm (7.6 mg/m3);Skin
OEL-CZECHOSLOVAKIA:TWA 5 mg/m3;STEL 20 mg/m3 JAN9
OEL-DENMARK:TWA 1 ppm (4 mg/m3);Skin
OEL-FINLAND:TWA 2 ppm (7.6 mg/m3);STEL 4 ppm (15 mg/m3);Skin;CAR
OEL-FRANCE:TWA 2 ppm (10 mg/m3);Skin
OEL-GERMANY:TWA 2 ppm (8 mg/m3);Skin;Carcinogen
OEL-HUNGARY:TWA 5 mg/m3;STEL 10 mg/m3;Skin
OEL-INDIA:TWA 0.2 mg/m3;Skin
OEL-JAPAN:TWA 1 ppm (3.8 mg/m3);Skin
OEL-THE NETHERLANDS:TWA 5 ppm (19 mg/m3);Skin
OEL-THE PHILIPPINES:TWA 5 ppm (19 mg/m3);Skin
OEL-POLAND:TWA 5 mg/m3;STEL 20 mg/m3;Skin
OEL-RUSSIA:TWA 1 ppm;STEL 0.1 mg/m3;Skin
OEL-SWEDEN:TWA 1 ppm (4 mg/m3);STEL 2 ppm (8 mg/m3);Skin
OEL-SWITZERLAND:TWA 2 ppm (8 mg/m3);STEL 10 ppm (40 mg/m3);Skin
OEL-TURKEY:TWA 5 ppm (19 mg/m3);Skin
OEL-UNITED KINGDOM:TWA 2 ppm (10 mg/m3);STEL 5 ppm;Skin
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGI TLV
US FEDERAL
TSCA
CAS# 106-47-8 is listed on the TSCA inventory.
**** SECTION 16 - ADDITIONAL INFORMATION ****
MSDS Creation Date: 12/12/1997 Revision #4 Date: 9/25/2001
The information above is believed to be accurate and represents the best
information currently available to us. However, we make no warranty of
merchantability or any other warranty, express or implied, with respect to
such information, and we assume no liability resulting from its use. Users
should make their own investigations to determine the suitability of the
information for their particular purposes. In no way shall the company be
liable for any claims, losses, or damages of any third party or for lost
profits or any special, indirect, incidental, consequential or exemplary
damages, howsoever arising, even if the company has been advised of
the possibility of such damages.
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