**** SECTION 2 - COMPOSITION, INFORMATION ON INGREDIENTS ****
+----------------+--------------------------------------+----------+-----------+
| CAS# | Chemical Name | % | EINECS# |
|----------------|--------------------------------------|----------|-----------|
| 2206-26-0 |Acetonitrile-d3 | | 218-616-5
+----------------+--------------------------------------+----------+-----------+
Hazard Symbols: T F
Risk Phrases: 11 23/24/25
**** SECTION 3 - HAZARDS IDENTIFICATION ****
EMERGENCY OVERVIEW
Highly flammable. Toxic by inhalation, in contact with skin and if
swallowed.Flammable liquid.Hygroscopic.Lachrymator (substance which
increases the flow of tears).
Potential Health Effects
Eye:
Causes severe eye irritation. Lachrymator (substance which
increases the flow of tears). May produce superficial reversible
injury.
Skin:
Causes mild skin irritation. May be harmful if absorbed through the
skin. May be metabolized to cyanide which in turn acts by inhibiting
cytochrome oxidase impairing cellular respiration.
Ingestion:
May cause gastrointestinal irritation with nausea, vomiting and
diarrhea. May cause muscle tremor and impaired motor function. May
cause liver and kidney damage. May cause methemoglobinemia, cyanosis
(bluish discoloration of skin due to deficient oxygenation of the
blood), convulsions, and death. May cause effects similar to those
for inhalation exposure. May cause severe digestive tract irritation
with abdominal pain, nausea, vomiting and diarrhea.
Methemoglobinemia is characterized by dizziness, drowsiness,
headache, breath shortness, cyanosis with bluish skin, rapid heart
rate and chocolate-brown colored blood. May cause central nervous
system effects. Metabolism may release cyanide, which may result in
headache, dizziness, weakness, collapse, unconsciousness and
possible death. Ingestion may result in symptoms similar to cyanide
poisoning which is characterized by asphyxiation.
Inhalation:
Inhalation of high concentrations may cause central nervous system
effects characterized by nausea, headache, dizziness, unconsciousness
and coma. May cause methemoglobinemia, cyanosis, convulsions,
tachycardia, dyspnea (labored breathing), and death. Aspiration may
lead to pulmonary edema. Methemoglobinemia is characterized by
dizziness, drowsiness, headache, breath shortness, cyanosis with
bluish skin, rapid heart rate and chocolate-brown blood. Vapors may
cause dizziness or suffocation. Causes upper respiratory tract
irritation. Inhalation may lead to dizziness, weakness, and
drowsiness, leading to stupor, unconsciousness, and even death.
Inhalation may lead to hematemesis, convulsions, shock, coma, and
possible death. May be metabolized to cyanide which in turns act by
inhibiting cytochrome oxidase impairing cellular respiration.
Chronic:
Prolonged or repeated skin contact may cause dermatitis. Chronic
inhalation and ingestion may cause effects similar to those of acute
inhalation and ingestion. May cause liver and kidney damage. May
cause methemoglobinemia, which is characterized by chocolate-brown
colored blood, headache, weakness, dizziness, breath shortness,
cyanosis (bluish skin due to deficient oxygenation of blood), rapid
heart rate, unconsciousness and possible death. May cause
reproductive and fetal effects. May be metabolized to cyanide which
in turn acts by inhibiting cytochrome oxidase impairing cellular
respiration. Animal studies have reported that fetal
effects/abnormalities may occur when maternal toxicity is seen.
Laboratory experiments have resulted in mutagenic effects.
**** SECTION 4 - FIRST AID MEASURES ****
Eyes:
Immediately flush eyes with plenty of water for at least 15 minutes,
occasionally lifting the upper and lower eyelids. Get medical aid
immediately. Do NOT allow victim to rub or keep eyes closed.
Skin:
Get medical aid immediately. Flush skin with plenty of soap and
water for at least 15 minutes while removing contaminated clothing
and shoes. Immediately flush skin with plenty of soap and water for
at least 15 minutes while removing contaminated clothing and shoes.
Wash clothing before reuse.
Ingestion:
Do NOT induce vomiting. If victim is conscious and alert, give 2-4
cupfuls of milk or water. Never give anything by mouth to an
unconscious person. Get medical aid immediately. Treat patient as
for inhalation.
Inhalation:
Get medical aid immediately. Remove from exposure to fresh air
immediately. If not breathing, give artificial respiration. If
breathing is difficult, give oxygen. Do NOT use mouth-to-mouth
resuscitation. Keep warm and at rest. If breathing has ceased apply
artificial respiration using oxygen and a suitable mechanical device
such as a bag and a mask.
Notes to Physician:
Exposure should be treated as a cyanide poisoning. Effects may be
delayed. May be partially metabolized to cyanide in the body. For
methemoglobinemia, administer oxygen alone or with Methylene blue
depending on the methemoglobinemia concentration in the blood.
Antidote:
Always have a cyanide antidote kit on hand when working with cyanide
compounds. Get medical advice to use. Methylene blue, alone or in
combination with oxygen is indicated as a treatment in nitrite
induced methemoglobinemia.
**** SECTION 5 - FIRE FIGHTING MEASURES ****
General Information:
Containers can build up pressure if exposed to heat and/or fire. As
in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full
protective gear. Water runoff can cause environmental damage. Dike
and collect water used to fight fire. Vapors may form an explosive
mixture with air. Vapors can travel to a source of ignition and flash
back. During a fire, irritating and highly toxic gases may be
generated by thermal decomposition or combustion. Use water spray to
keep fire-exposed containers cool. Water may be ineffective.
Material is lighter than water and a fire may be spread by the use of
water. Flammable liquid and vapor. Vapors may be heavier than air.
They can spread along the ground and collect in low or confined
areas.
Extinguishing Media:
For small fires, use dry chemical, carbon dioxide, water spray or
alcohol-resistant foam. Water may be ineffective. Do NOT use
straight streams of water. For large fires, use dry chemical, carbon
dioxide, alcohol-resistant foam, or water spray. Cool containers
with flooding quantities of water until well after fire is out.
**** SECTION 6 - ACCIDENTAL RELEASE MEASURES ****
General Information: Use proper personal protective equipment as indicated
in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth),
then place in suitable container. Avoid runoff into storm sewers and
ditches which lead to waterways. Clean up spills immediately,
observing precautions in the Protective Equipment section. Remove all
sources of ignition. Provide ventilation. A vapor suppressing foam
may be used to reduce vapors. Water spray may reduce vapor but may
not prevent ignition in closed spaces.
**** SECTION 7 - HANDLING and STORAGE ****
Handling:
Wash thoroughly after handling. Remove contaminated clothing and
wash before reuse. Use only in a well-ventilated area. Ground and
bond containers when transferring material. Do not breathe dust,
vapor, mist, or gas. Do not get in eyes, on skin, or on clothing.
Empty containers retain product residue, (liquid and/or vapor), and
can be dangerous. Keep container tightly closed. Avoid contact with
heat, sparks and flame. Do not pressurize, cut, weld, braze, solder,
drill, grind, or expose empty containers to heat, sparks or open
flames.
Storage:
Keep away from heat, sparks, and flame. Keep away from sources of
ignition. Store in a tightly closed container. Keep from contact
with oxidizing materials. Store in a cool, dry, well-ventilated area
away from incompatible substances. Flammables-area. Store protected
from moisture. Substance is packaged under argon in 100 ml. acroseal
containers.
**** SECTION 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION ****
Engineering Controls:
Use explosion-proof ventilation equipment. Facilities storing or
utilizing this material should be equipped with an eyewash facility
and a safety shower. Use adequate general or local exhaust
ventilation to keep airborne concentrations below the permissible
exposure limits.
Personal Protective Equipment
Eyes:
Wear appropriate protective eyeglasses or chemical
safety goggles as described by OSHA's eye and face
protection regulations in 29 CFR 1910.133 or European
Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin
exposure.
Clothing:
Wear appropriate protective clothing to prevent skin
exposure.
Respirators:
A respiratory protection program that meets OSHA's 29
CFR 1910.134 and ANSI Z88.2 requirements or European
Standard EN 149 must be followed whenever workplace
conditions warrant a respirator's use.
**** SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES ****
Physical State: Clear liquid
Color: colorless
Odor: aromatic odor - sweetish odor
pH: Not available.
Vapor Pressure: 97 mbar @ 20 deg C
Viscosity: 0.39 cP 20 deg C
Boiling Point: 79-81 deg C @ 760 mmHg
Freezing/Melting Point: -46 deg C
Autoignition Temperature: 525 deg C ( 977.00 deg F)
Flash Point: 2 deg C ( 35.60 deg F)
Explosion Limits, lower: 3.00 vol %
Explosion Limits, upper: 16.00 vol %
Decomposition Temperature:
Solubility in water: Miscible.
Specific Gravity/Density: .8440
Molecular Formula: CD3CN
Molecular Weight: 44.0487
**** SECTION 10 - STABILITY AND REACTIVITY ****
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials, ignition sources, excess heat, exposure to
moist air or water, oxidizers, temperatures above 40C.
Incompatibilities with Other Materials:
Oxidizing agents, reducing agents, acids, bases, alkali metals,
fluorine, nitric acid, perchlorates, sulfuric acid, chlorosulfonic
acid, oleum, dinitrogen tetraoxide, sulfites, indium, moisture,
Attacks some forms of plastics, rubbers, and coatings., nitrating
agents, N-fluoro compounds (e.g. perfluorourea + acetonitrile),
lanthanide perchlorates, iron (III) perchlorate, 2-Cyano-2-propyl
nitrate, trichlorosilane, diphenyl sulfoxide.
Hazardous Decomposition Products:
Hydrogen cyanide, nitrogen oxides, carbon monoxide, irritating and
toxic fumes and gases, carbon dioxide.
Hazardous Polymerization: Will not occur.
**** SECTION 11 - TOXICOLOGICAL INFORMATION ****
RTECS#:
CAS# 2206-26-0 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
Acetonitrile-d3 -
Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA.
Other:
See actual entry in RTECS for complete information.
**** SECTION 12 - ECOLOGICAL INFORMATION ****
Ecotoxicity:
Fish: Fathead Minnow: 1020mg/L; 96hr; hard waterFish:
Bluegill/Sunfish: 1850 mg/L; 96hr; soft waterAlgae: 7300 mg/L; ;Fish:
Fathead Minnow: 1150 ppm; 24 Hr; TLm (hard water)Fish: Fathead
Minnow: 1000 mg/L; 96 Hr; TLm (soft water)Fish: Bluegill/Sunfish:
1850 mg/L; 96 Hr; TLm (soft water)Fish: Fathead Minnow: 1640 mg/L;
96 Hr; LC50 (flow-bioassay)Fish: Fathead Minnow: 1640 mg/L; 96 Hr;
EC50 (flow-bioassay)
Other
Biodegradable.
**** SECTION 13 - DISPOSAL CONSIDERATIONS ****
Dispose of in a manner consistent with federal, state, and local regulations.
**** SECTION 14 - TRANSPORT INFORMATION ****
IATA
Shipping Name: ACETONITRILE
Hazard Class: 3
UN Number: 1648
Packing Group: II
IMO
Shipping Name: ACETONITRILE
Hazard Class: 3
UN Number: 1648
Packing Group: II
RID/ADR
Shipping Name: ACETONITRILE
Hazard Class: 3
UN Number: 1648
Packing group:
**** SECTION 15 - REGULATORY INFORMATION ****
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: T F
Risk Phrases:
R 11 Highly flammable.
R 23/24/25 Toxic by inhalation, in contact with skin
and if swallowed.
Safety Phrases:
S 16 Keep away from sources of ignition - No
smoking.
S 27 Take off immediately all contaminated clothing.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 2206-26-0: No information available.
United Kingdom Occupational Exposure Limits
United Kingdom Maximum Exposure Limits
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 2206-26-0 is not listed on Canada's Ingredient Disclosure List.
Exposure Limits
US FEDERAL
TSCA
CAS# 2206-26-0 is not listed on the TSCA inventory.
It is for research and development use only.
**** SECTION 16 - ADDITIONAL INFORMATION ****
MSDS Creation Date: 1/16/2002 Revision #1 Date: 8/12/2002
The information above is believed to be accurate and represents the best
information currently available to us. However, we make no warranty of
merchantability or any other warranty, express or implied, with respect to
such information, and we assume no liability resulting from its use. Users
should make their own investigations to determine the suitability of the
information for their particular purposes. In no way shall the company be
liable for any claims, losses, or damages of any third party or for lost
profits or any special, indirect, incidental, consequential or exemplary
damages, howsoever arising, even if the company has been advised of
the possibility of such damages.
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