**** SECTION 2 - COMPOSITION, INFORMATION ON INGREDIENTS ****
+----------------+--------------------------------------+----------+-----------+
| CAS# | Chemical Name | % | EINECS# |
|----------------|--------------------------------------|----------|-----------|
|----------------|--------------------------------------|----------|-----------|
|----------------|--------------------------------------|----------|-----------|
| 1076-43-3 |Benzene-d6 | 100 | 214-061-8 |
+----------------+--------------------------------------+----------+-----------+
Text for R-phrases: see Section 16
Hazard Symbols: T F
Risk Phrases: 11 45 48/23/24/25
**** SECTION 3 - HAZARDS IDENTIFICATION ****
EMERGENCY OVERVIEW
Highly flammable. May cause cancer. Toxic : danger of serious damage
to health by prolonged exposure through inhalation, contact with skin
and if swallowed.
Potential Health Effects
Eye:
Causes eye irritation.
Skin:
Causes skin irritation. Harmful if absorbed through the skin.
Prolonged and/or repeated contact may cause defatting of the skin
and dermatitis.
Ingestion:
May cause central nervous system depression, characterized by
excitement, followed by headache, dizziness, drowsiness, and nausea.
Advanced stages may cause collapse, unconsciousness, coma and
possible death due to respiratory failure. May cause effects similar
to those for inhalation exposure. Aspiration of material into the
lungs may cause chemical pneumonitis, which may be fatal.
Inhalation:
Causes respiratory tract irritation. May cause drowsiness,
unconsciousness, and central nervous system depression. Exposure may
lead to irreversible bone marrow injury. Exposure may lead to
aplastic anemia.
Chronic:
May cause bone marrow abnormalities with damage to blood forming
tissues. May cause anemia and other blood cell abnormalities. Chronic
exposure to benzene has been associated with an increased incidence
of leukemia and multiple myeloma (tumor composed of cells of the type
normally found in the bone marrow). Immunodepressive effects have
been reported. This substance has caused adverse reproductive and
fetal effects in laboratory animals.
**** SECTION 4 - FIRST AID MEASURES ****
Eyes:
In case of contact, immediately flush eyes with plenty of water for
at least 15 minutes. Get medical aid.
Skin:
In case of contact, flush skin with plenty of water. Remove
contaminated clothing and shoes. Get medical aid if irritation
develops and persists. Wash clothing before reuse.
Ingestion:
Potential for aspiration if swallowed. Get medical aid immediately.
Do not induce vomiting unless directed to do so by medical
personnel. Never give anything by mouth to an unconscious person.
Inhalation:
If inhaled, remove to fresh air. If not breathing, give artificial
respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
**** SECTION 5 - FIRE FIGHTING MEASURES ****
General Information:
As in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full
protective gear. Use water spray to keep fire-exposed containers
cool. Extremely flammable liquid and vapor. Vapor may cause flash
fire. Approach fire from upwind to avoid hazardous vapors and toxic
decomposition products. Vapors are heavier than air and may travel to
a source of ignition and flash back. Vapors can spread along the
ground and collect in low or confined areas. This liquid floats on
water and may travel to a source of ignition and spread fire. May
accumulate static electricity.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or appropriate foam.
**** SECTION 6 - ACCIDENTAL RELEASE MEASURES ****
General Information: Use proper personal protective equipment as indicated
in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth),
then place in suitable container. Avoid runoff into storm sewers and
ditches which lead to waterways. Remove all sources of ignition.
Provide ventilation. Approach spill from upwind. Use water spray to
cool and disperse vapors, protect personnel, and dilute spills to
form nonflammable mixtures.
**** SECTION 7 - HANDLING and STORAGE ****
Handling:
Wash thoroughly after handling. Remove contaminated clothing and
wash before reuse. Ground and bond containers when transferring
material. Avoid contact with eyes, skin, and clothing. Empty
containers retain product residue, (liquid and/or vapor), and can be
dangerous. Take precautionary measures against static discharges.
Keep container tightly closed. Do not pressurize, cut, weld, braze,
solder, drill, grind, or expose empty containers to heat, sparks or
open flames. Use only with adequate ventilation. Keep away from heat,
sparks and flame. Avoid breathing vapor.
Storage:
Keep away from sources of ignition. Store in a tightly closed
container. Keep from contact with oxidizing materials. Store in a
cool, dry, well-ventilated area away from incompatible substances.
Store protected from moisture.
**** SECTION 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION ****
Engineering Controls:
Use process enclosure, local exhaust ventilation, or other
engineering controls to control airborne levels below recommended
exposure limits. Use explosion-proof ventilation equipment.
Facilities storing or utilizing this material should be equipped with
an eyewash facility and a safety shower. See 29CFR 1910.1028 for the
regulatory requirements for the control of employee exposure to
benzene.
Exposure Limits
CAS# 71-43-2:
United Kingdom, WEL - TWA: 1 ppm TWA
United Kingdom, WEL - STEL: 3 ppm STEL
United States OSHA: 10 ppm TWA (apply only to exempt industry
segments); 25 ppm Ceiling; 1 ppm PEL; 5 ppm STEL; 0.5 ppm Action
Level (Cancer hazard, Flammable - see 29 C FR 1910.1028)
Belgium - TWA: 1 ppm VLE; 3.25 mg/m3 VLE
France - VME: 1 ppm VME; 3.25 mg/m3 VME
Germany: 1 ppm TWA; 3.25 mg/m3 TWA
Germany: Skin absorber
Japan: 1 ppm OEL (reference value)
Malaysia: 0.5 ppm TWA; 1.6 mg/m3 TWA
Netherlands: 1 ppm MAC; 3.25 mg/m3 MAC
Russia: 15 mg/m3 TWA
Russia: 5 mg/m3 STEL
Spain: 1 ppm VLA-ED; 3.25 mg/m3 VLA-ED
CAS# 1076-43-3:
Personal Protective Equipment
Eyes:
Wear appropriate protective eyeglasses or chemical
safety goggles as described by OSHA's eye and face
protection regulations in 29 CFR 1910.133 or European
Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin
exposure.
Clothing:
Wear appropriate protective clothing to prevent skin
exposure.
Respirators:
A respiratory protection program that meets OSHA's 29
CFR 1910.134 and ANSI Z88.2 requirements or European
Standard EN 149 must be followed whenever workplace
conditions warrant respirator use.
**** SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES ****
Physical State: Liquid
Color: clear colorless
Odor: sweetish odor - aromatic odor
pH: Not applicable.
Vapor Pressure: 75 mm Hg @ 20 deg C
Viscosity: 0.647mPa @ 20 deg C
Boiling Point: 79 deg C
Freezing/Melting Point: 6.8 deg C
Autoignition Temperature: 498 deg C ( 928.40 deg F)
Flash Point: -11 deg C ( 12.20 deg F)
Explosion Limits, lower: 1.3 vol %
Explosion Limits, upper: 7.1 vol %
Decomposition Temperature: Not available.
Solubility in water: 0.180 g/100 ml @ 25C
Specific Gravity/Density: 0.95
Molecular Formula: C6D6
Molecular Weight: 84.15
**** SECTION 10 - STABILITY AND REACTIVITY ****
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Ignition sources, moisture, excess heat, confined spaces.
Incompatibilities with Other Materials:
Strong oxidizing agents.
Hazardous Decomposition Products:
Carbon monoxide, carbon dioxide.
Hazardous Polymerization: Has not been reported.
**** SECTION 11 - TOXICOLOGICAL INFORMATION ****
RTECS#:
CAS# 71-43-2: CY1400000
CAS# 1076-43-3 unlisted.
LD50/LC50:
CAS# 71-43-2: Dermal, guinea pig: LD50 = >9400 uL/kg; Draize test,
rabbit, eye: 88 mg Moderate; Draize test, rabbit, eye: 2 mg/24H
Severe; Draize test, rabbit, skin: 20 mg/24H Moderate; Inhalation,
mouse: LC50 = 9980 ppm; Inhalation, mouse: LC50 = 24 mL/kg/2H;
Inhalation, rat: LC50 = 10000 ppm/7H; Inhalation, rat: LC50 = 34
mL/kg/2H; Inhalation, rat: LC50 = 6.5 mL/kg/4H; Oral, mouse: LD50 =
4700 mg/kg; Oral, rat: LD50 = 930 mg/kg; Oral, rat: LD50 = 1 mL/kg;
Oral, rat: LD50 = 1800 mg/kg; Skin, rabbit: LD50 = >9400 uL/kg.
CAS# 1076-43-3.
Benzene is considered very toxic; probable human oral lethal dose
would be 50-500 mg/kg. Human inhalation of approximately 20,000 ppm
(2% in air) was fatal in 5-10 minutes.While percutaneous absorption
of liquid benzene through intact human skin can be limited (e.g.,
0.05% of the applied dose), the absorbed dose via direct dermal
contact combined with that received from body surface exposure to
benzene in workplace air is such that a substantial fraction (20-40%)
of the total exposure is due to skin absorption.
Carcinogenicity:
Benzene -
ACGIH: A1 - Confirmed Human Carcinogen
California: carcinogen, initial date 2/27/87
NTP: Known carcinogen
IARC: Group 1 carcinogen
Benzene-d6 -
Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.
**** SECTION 12 - ECOLOGICAL INFORMATION ****
Ecotoxicity:
Fish: Mosquito Fish: TLm = 395 mg/L; 24 Hr; UnspecifiedFish:
Goldfish: LC50 =46 mg/L; 24 Hr; Modified ASTM D 1345Fish: Fathead
Minnow: LC50 = 15.1 mg/L; 96 Hr; Flow-through at 25C (pH
7.9-8.0)Fish: Rainbow trout: LC50 = 5.3 mg/L; 96 Hr; Flow-through at
25C (pH 7.9-8.0)Fish: Bluegill/Sunfish: LD50 = 20 mg/L; 24-48 Hr;
UnspecifiedIf benzene is released to soil, it will be subject to
rapid volatilization near the surface and that which does not
evaporate will be highly to very highly mobile in the soil and may
leach to groundwater. If benzene is released to water, it will be
subject to rapid volatilization. It will not be expected to
**** SECTION 13 - DISPOSAL CONSIDERATIONS ****
Dispose of in a manner consistent with federal, state, and local regulations.
**** SECTION 14 - TRANSPORT INFORMATION ****
IATA
Shipping Name: BENZENE
Hazard Class: 3
UN Number: 1114
Packing Group: II
IMO
Shipping Name: BENZENE
Hazard Class: 3.2
UN Number: 1114
Packing Group: II
RID/ADR
Shipping Name: BENZENE
Hazard Class: 3
UN Number: 1114
Packing group: II
USA RQ: CAS# 71-43-2: 10 lb final RQ (receives an adjustable RQ of 10 lbs based
**** SECTION 15 - REGULATORY INFORMATION ****
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: T F
Risk Phrases:
R 45 May cause cancer.
R 11 Highly flammable.
R 48/23/24/25 Toxic : danger of serious damage to
health by prolonged exposure through inhalation,
contact with skin and if swallowed.
Safety Phrases:
S 53 Avoid exposure - obtain special instructions
before use.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 71-43-2: 3
CAS# 1076-43-3: No information available.
Canada
CAS# 71-43-2 is listed on Canada's DSL List.
CAS# 1076-43-3 is listed on Canada's NDSL List.
CAS# 71-43-2 is listed on Canada's Ingredient Disclosure List.
CAS# 1076-43-3 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 71-43-2 is listed on the TSCA inventory.
CAS# 1076-43-3 is listed on the TSCA inventory.
**** SECTION 16 - ADDITIONAL INFORMATION ****
Text for R-phrases from Section 2
MSDS Creation Date: 1/16/2002 Revision #3 Date: 2/06/2003
The information above is believed to be accurate and represents the best
information currently available to us. However, we make no warranty of
merchantability or any other warranty, express or implied, with respect to
such information, and we assume no liability resulting from its use. Users
should make their own investigations to determine the suitability of the
information for their particular purposes. In no way shall the company be
liable for any claims, losses, or damages of any third party or for lost
profits or any special, indirect, incidental, consequential or exemplary
damages, howsoever arising, even if the company has been advised of
the possibility of such damages.
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