MSDS PAGE: MSDS 61-73-4 CAS Methylene Blue trihydrate, 95% Phenothiazin-5-ium, 3,7-bis(dimethylamino)-, chloride, trihydrate; C.I. Basic Blue 9, trihydrate; C.I. 52015, trihydrate; 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride trihydrate; Methylene Blue trihydrate.

MSDS

 Methylene Blue trihydrate, 95%

CAS

 61-73-4

SYNONYMS

 Phenothiazin-5-ium, 3,7-bis(dimethylamino)-, chloride, trihydrate;     C.I. Basic Blue 9, trihydrate; C.I. 52015, trihydrate;     3,7-Bis(dimethylamino)phenothiazin-5-ium chloride trihydrate;     Methylene Blue trihydrate.

**** SECTION 2 - COMPOSITION, INFORMATION ON INGREDIENTS ****

+----------------+--------------------------------------+----------+-----------+
| CAS# | Chemical Name | % | EINECS# |
|----------------|--------------------------------------|----------|-----------|
|----------------|--------------------------------------|----------|-----------|
|----------------|--------------------------------------|----------|-----------|
| 7220-79-3 |Methylene Blue trihydrate | 95 | unlisted |
+----------------+--------------------------------------+----------+-----------+
Text for R-phrases: see Section 16
Hazard Symbols: XN
Risk Phrases: 22

**** SECTION 3 - HAZARDS IDENTIFICATION ****

EMERGENCY OVERVIEW
Harmful if swallowed.

Potential Health Effects
Eye:
May cause chemical conjunctivitis. Causes eye irritation and
possible injury.
Skin:
Causes skin irritation. Absorption into the body may cause cyanosis
(bluish discoloration of skin due to deficient oxygenation of the
blood).
Ingestion:
May cause gastrointestinal irritation with nausea, vomiting and
diarrhea. May cause hemolytic anemia. May be harmful if swallowed.
Inhalation:
Causes respiratory tract irritation. May cause methemoglobinemia,
cyanosis (bluish discoloration of skin due to deficient oxygenation
of the blood), convulsions, tachycardia, dyspnea (labored
breathing), and death. Can produce delayed pulmonary edema.
Chronic:
Effects may be delayed. Laboratory experiments have resulted in
mutagenic effects. Repeated contact may cause corneal damage. May
cause adverse reproductive effects.

**** SECTION 4 - FIRST AID MEASURES ****

Eyes:
Immediately flush eyes with plenty of water for at least 15 minutes,
occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15
minutes while removing contaminated clothing and shoes. Wash clothing
before reuse.
Ingestion:
If victim is conscious and alert, give 2-4 cupfuls of milk or water.
Never give anything by mouth to an unconscious person. Get medical
aid.
Inhalation:
Remove from exposure and move to fresh air immediately. If not
breathing, give artificial respiration. If breathing is difficult,
give oxygen. Get medical aid. Do NOT use mouth-to-mouth
resuscitation.
Notes to Physician:
Treat symptomatically and supportively.

**** SECTION 5 - FIRE FIGHTING MEASURES ****

General Information:
As in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full
protective gear. During a fire, irritating and highly toxic gases
may be generated by thermal decomposition or combustion. This
material in sufficient quantity and reduced particle size is capable
of creating a dust explosion.
Extinguishing Media:
Use extinguishing media most appropriate for the surrounding fire.

**** SECTION 6 - ACCIDENTAL RELEASE MEASURES ****

General Information: Use proper personal protective equipment as indicated
in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal
container. Clean up spills immediately, observing precautions in the
Protective Equipment section. Avoid generating dusty conditions.
Provide ventilation.

**** SECTION 7 - HANDLING and STORAGE ****

Handling:
Wash thoroughly after handling. Remove contaminated clothing and
wash before reuse. Use with adequate ventilation. Minimize dust
generation and accumulation. Avoid contact with eyes, skin, and
clothing. Avoid breathing dust.
Storage:
Keep container closed when not in use. Store in a cool, dry,
well-ventilated area away from incompatible substances.

**** SECTION 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION ****

Engineering Controls:
Facilities storing or utilizing this material should be equipped
with an eyewash facility and a safety shower. Use adequate
ventilation to keep airborne concentrations low.
Exposure Limits
CAS# 61-73-4:

CAS# 7220-79-3:

Personal Protective Equipment

Eyes:
Wear appropriate protective eyeglasses or chemical
safety goggles as described by OSHA's eye and face
protection regulations in 29 CFR 1910.133 or European
Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin
exposure.
Clothing:
Wear appropriate protective clothing to prevent skin
exposure.
Respirators:
A respiratory protection program that meets OSHA's 29
CFR 1910.134 and ANSI Z88.2 requirements or European
Standard EN 149 must be followed whenever workplace
conditions warrant respirator use.

**** SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES ****

Physical State: Solid
Color: dark green
Odor: odorless
pH: 3-4.5 (1% aq sol)
Vapor Pressure: Negligible.
Viscosity: Not available.
Boiling Point: Decomposes.
Freezing/Melting Point: 190 deg C (dec)
Autoignition Temperature: Not available.
Flash Point: Not applicable.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature: 190 deg C
Solubility in water: Slightly soluble.
Specific Gravity/Density: 1.230
Molecular Formula: C16H18ClN3S.3H2O
Molecular Weight: 373.89

**** SECTION 10 - STABILITY AND REACTIVITY ****

Chemical Stability:
Stable at room temperature in closed containers under normal storage
and handling conditions.
Conditions to Avoid:
Dust generation, excess heat, excess light.
Incompatibilities with Other Materials:
Oxidizing agents, reducing agents, bases, dichromates, alkali
iodides, caustic alkalis.
Hazardous Decomposition Products:
Chlorine, nitrogen oxides, carbon monoxide, oxides of sulfur, carbon
dioxide.
Hazardous Polymerization: Will not occur.

**** SECTION 11 - TOXICOLOGICAL INFORMATION ****

RTECS#:
CAS# 61-73-4: SO5600000
CAS# 7220-79-3: SP5740000
LD50/LC50:
CAS# 61-73-4: Oral, mouse: LD50 = 3500 mg/kg; Oral, rat: LD50 = 1180
mg/kg.
CAS# 7220-79-3.
NTP Carcinogenesis studies; on test (two year studies), October 2000.
Carcinogenicity:
Methylene Blue -
Not listed by ACGIH, IARC, or NTP.
Methylene Blue trihydrate -
Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.

**** SECTION 12 - ECOLOGICAL INFORMATION ****

Ecotoxicity:
Laboratory adsorption studies determined that Methylene Blue was
strongly adsorbed to three different soils. Volatilization of
Methylene Blue will not be important from moist or dry soil
surfaces. If released to water, Methylene Blue would adsorb to
suspended solids and sediment based upon soil adsorption studies. It
will be essentially non-volatile from water surfaces. An estimated
BCF value of 1.5 suggests that Methylene Blue will not bioconcentrate
in aquatic organisms.

**** SECTION 13 - DISPOSAL CONSIDERATIONS ****

Dispose of in a manner consistent with federal, state, and local regulations.

**** SECTION 14 - TRANSPORT INFORMATION ****

IATA
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing Group:
IMO
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing Group:
RID/ADR
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing group:

**** SECTION 15 - REGULATORY INFORMATION ****

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XN
Risk Phrases:
R 22 Harmful if swallowed.
Safety Phrases:
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 36/37/39 Wear suitable protective clothing, gloves
and eye/face protection.
WGK (Water Danger/Protection)
CAS# 61-73-4: 2
CAS# 7220-79-3: No information available.
Canada
CAS# 61-73-4 is listed on Canada's DSL List.
CAS# 61-73-4 is listed on Canada's Ingredient Disclosure List.
CAS# 7220-79-3 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 61-73-4 is listed on the TSCA inventory.
CAS# 7220-79-3 is not listed on the TSCA inventory.
It is for research and development use only.

**** SECTION 16 - ADDITIONAL INFORMATION ****

Text for R-phrases from Section 2
MSDS Creation Date: 8/07/1998 Revision #4 Date: 3/04/2004

The information above is believed to be accurate and represents the best
information currently available to us. However, we make no warranty of
merchantability or any other warranty, express or implied, with respect to
such information, and we assume no liability resulting from its use. Users
should make their own investigations to determine the suitability of the
information for their particular purposes. In no way shall the company be
liable for any claims, losses, or damages of any third party or for lost
profits or any special, indirect, incidental, consequential or exemplary
damages, howsoever arising, even if the company has been advised of
the possibility of such damages.
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