**** SECTION 2 - COMPOSITION, INFORMATION ON INGREDIENTS ****
+----------------+--------------------------------------+----------+-----------+
| CAS# | Chemical Name | % | EINECS# |
|----------------|--------------------------------------|----------|-----------|
|----------------|--------------------------------------|----------|-----------|
|----------------|--------------------------------------|----------|-----------|
| 19547-00-3 |Acetophenone-d8 | 99 | unlisted |
+----------------+--------------------------------------+----------+-----------+
Text for R-phrases: see Section 16
Hazard Symbols: XN
Risk Phrases: 22 36
**** SECTION 3 - HAZARDS IDENTIFICATION ****
EMERGENCY OVERVIEW
Harmful if swallowed. Irritating to eyes.Hygroscopic (absorbs
moisture from the air).
Potential Health Effects
Eye:
May cause transient corneal injury. Causes severe eye irritation
and possible injury.
Skin:
May cause skin irritation.
Ingestion:
May cause gastrointestinal irritation with nausea, vomiting and
diarrhea. May cause central nervous system depression, characterized
by excitement, followed by headache, dizziness, drowsiness, and
nausea. Advanced stages may cause collapse, unconsciousness, coma
and possible death due to respiratory failure. May be harmful if
swallowed.
Inhalation:
Inhalation of high concentrations may cause central nervous system
effects characterized by nausea, headache, dizziness, unconsciousness
and coma. Material has a low vapor pressure, so exposure to vapor is
not likely.
Chronic:
Prolonged or repeated eye contact may cause conjunctivitis.
Prolonged or repeated skin contact may cause defatting and
dermatitis. Narcotic in high concentrations.
**** SECTION 4 - FIRST AID MEASURES ****
Eyes:
In case of contact, immediately flush eyes with plenty of water for
at least 15 minutes. Get medical aid.
Skin:
In case of contact, flush skin with plenty of water. Remove
contaminated clothing and shoes. Get medical aid if irritation
develops and persists. Wash clothing before reuse.
Ingestion:
If swallowed, do not induce vomiting unless directed to do so by
medical personnel. Never give anything by mouth to an unconscious
person. Get medical aid.
Inhalation:
If inhaled, remove to fresh air. If not breathing, give artificial
respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
Exposure indicators: Acetophenone in expired air and hippuric acid
in urine. Treat symptomatically and supportively.
**** SECTION 5 - FIRE FIGHTING MEASURES ****
General Information:
As in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full
protective gear. During a fire, irritating and highly toxic gases
may be generated by thermal decomposition or combustion. Use water
spray to keep fire-exposed containers cool. Combustible liquid and
vapor.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or appropriate foam.
**** SECTION 6 - ACCIDENTAL RELEASE MEASURES ****
General Information: Use proper personal protective equipment as indicated
in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth),
then place in suitable container. Clean up spills immediately,
observing precautions in the Protective Equipment section. Remove all
sources of ignition. Use a spark-proof tool. Provide ventilation.
**** SECTION 7 - HANDLING and STORAGE ****
Handling:
Wash thoroughly after handling. Remove contaminated clothing and
wash before reuse. Use spark-proof tools and explosion proof
equipment. Avoid contact with eyes, skin, and clothing. Empty
containers retain product residue, (liquid and/or vapor), and can be
dangerous. Avoid ingestion and inhalation. Do not pressurize, cut,
weld, braze, solder, drill, grind, or expose empty containers to
heat, sparks or open flames. Use only with adequate ventilation. Keep
away from heat and flame. Avoid breathing spray or mist.
Storage:
Keep away from heat and flame. Keep away from sources of ignition.
Store in a tightly closed container. Store in a cool, dry,
well-ventilated area away from incompatible substances.
**** SECTION 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION ****
Engineering Controls:
Use process enclosure, local exhaust ventilation, or other
engineering controls to control airborne levels below recommended
exposure limits. Facilities storing or utilizing this material should
be equipped with an eyewash facility and a safety shower.
Exposure Limits
CAS# 98-86-2:
Belgium - TWA: 10 ppm VLE; 50 mg/m3 VLE
Malaysia: 10 ppm TWA; 49 mg/m3 TWA
Netherlands: 10 ppm MAC; 49 mg/m3 MAC
Russia: 5 mg/m3 TWA
Spain: 10 ppm VLA-ED; 50 mg/m3 VLA-ED
CAS# 19547-00-3:
Personal Protective Equipment
Eyes:
Wear chemical splash goggles.
Skin:
Wear appropriate protective gloves to prevent skin
exposure.
Clothing:
Wear appropriate protective clothing to minimize
contact with skin.
Respirators:
A respiratory protection program that meets OSHA's 29
CFR 1910.134 and ANSI Z88.2 requirements or European
Standard EN 149 must be followed whenever workplace
conditions warrant respirator use.
**** SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES ****
Physical State: Liquid
Color: colorless - slightly oily
Odor: orange blossom
pH: Not available.
Vapor Pressure: 0.33 mm Hg @ 20 deg C
Viscosity: 1.62 cP @ 25 deg C
Boiling Point: 202 deg C @ 760 mm Hg
Freezing/Melting Point: 19.6 deg C
Autoignition Temperature: 570 deg C ( 1,058.00 deg F)
Flash Point: 82 deg C ( 179.60 deg F)
Explosion Limits, lower: 1.1%
Explosion Limits, upper: 6.7%
Decomposition Temperature: Not available.
Solubility in water: Insoluble.
Specific Gravity/Density: 1.09 @ 20C
Molecular Formula: C8D8O
Molecular Weight: 128.20
**** SECTION 10 - STABILITY AND REACTIVITY ****
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Ignition sources, moisture, excess heat.
Incompatibilities with Other Materials:
Strong oxidizing agents, strong reducing agents, strong bases,
perchloric acid, aldehydes, nitric acid + hydrogen peroxide.
Hazardous Decomposition Products:
Carbon monoxide, carbon dioxide.
Hazardous Polymerization: Has not been reported.
**** SECTION 11 - TOXICOLOGICAL INFORMATION ****
RTECS#:
CAS# 98-86-2: AM5250000
CAS# 19547-00-3 unlisted.
LD50/LC50:
CAS# 98-86-2: Dermal, guinea pig: LD50 = >20 mL/kg; Draize test,
rabbit, eye: 750 ug Severe; Inhalation, mouse: LC50 = 1200 mg/m3/4H;
Oral, mouse: LD50 = 740 mg/kg; Oral, mouse: LD50 = 1250 mg/kg; Oral,
rat: LD50 = 815 mg/kg; Oral, rat: LD50 = 2650 mg/kg; Skin, rabbit:
LD50 = 15900 uL/kg.
CAS# 19547-00-3.
Carcinogenicity:
Acetophenone -
Not listed by ACGIH, IARC, or NTP.
Acetophenone-d8 -
Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.
**** SECTION 12 - ECOLOGICAL INFORMATION ****
Ecotoxicity:
Fish: Fathead Minnow: LC50 = 196 mg/L; 96 Hr; Flow-through at 24.6 C
(pH 7.83)Bacteria: Phytobacterium phosphoreum: EC50 = 15.5 mg/L;
5,15,30 min; Microtox test at 15 CIf released to soil, microbial
degradation is likely to be the major degradation pathway. It is
expected to be moderately to highly mobile in soil and may evaporate
from dry soil surfaces. Biodegradation and volatilization are
expected to be the major loss processes in water. The estimated
biodegradation half-lives in groundwater, river water and lake water
samples were 32 days, 8 days and 4.5 days, respectively.
**** SECTION 13 - DISPOSAL CONSIDERATIONS ****
Dispose of in a manner consistent with federal, state, and local regulations.
**** SECTION 14 - TRANSPORT INFORMATION ****
IATA
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing Group:
IMO
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing Group:
RID/ADR
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing group:
USA RQ: CAS# 98-86-2: 5000 lb final RQ; 2270 kg final RQ
**** SECTION 15 - REGULATORY INFORMATION ****
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XN
Risk Phrases:
R 22 Harmful if swallowed.
R 36 Irritating to eyes.
Safety Phrases:
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
WGK (Water Danger/Protection)
CAS# 98-86-2: 1
CAS# 19547-00-3: No information available.
Canada
CAS# 98-86-2 is listed on Canada's DSL List.
CAS# 98-86-2 is listed on Canada's Ingredient Disclosure List.
CAS# 19547-00-3 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 98-86-2 is listed on the TSCA inventory.
CAS# 19547-00-3 is not listed on the TSCA inventory.
It is for research and development use only.
**** SECTION 16 - ADDITIONAL INFORMATION ****
Text for R-phrases from Section 2
MSDS Creation Date: 1/20/1998 Revision #4 Date: 8/08/2003
The information above is believed to be accurate and represents the best
information currently available to us. However, we make no warranty of
merchantability or any other warranty, express or implied, with respect to
such information, and we assume no liability resulting from its use. Users
should make their own investigations to determine the suitability of the
information for their particular purposes. In no way shall the company be
liable for any claims, losses, or damages of any third party or for lost
profits or any special, indirect, incidental, consequential or exemplary
damages, howsoever arising, even if the company has been advised of
the possibility of such damages.
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