*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : XT1300000
CHEMICAL NAME : Toluene, dinitro-
CAS REGISTRY NUMBER : 25321-14-6
LAST UPDATED : 199803
DATA ITEMS CITED : 34
MOLECULAR FORMULA : C7-H6-N2-O4
MOLECULAR WEIGHT : 182.15
WISWESSER LINE NOTATION : WNR X1 XNW
COMPOUND DESCRIPTOR : Tumorigen
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Benzene, methyldinitro-
* Dinitrophenylmethane
* Dinitrotoluene
* Methyldinitrobenzene
* Toluene, ar,ar-dinitro-
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 750 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
SRTCAC Science Reports of the Research Institutes, Tohoku University, Series
C: Medicine. (Tohoku University, Research Institute for Tuberculosis and
Cancer, 4-1 Seiryo-machi, Sendai, Japan) V.1- 1949-
Volume(issue)/page/year: 36(1-4),10,1989
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 1300 mg/kg
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
Lungs, Thorax, or Respiration - dyspnea
Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 42(10),17,1977
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 4550 ug/kg/26W-I
TOXIC EFFECTS :
Blood - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - other esterases
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - other oxidoreductases
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 42(10),17,1977
** TUMORIGENIC DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 12775 mg/kg/Y-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Liver - tumors
REFERENCE :
PAACA3 Proceedings of the American Association for Cancer Research. (Waverly
Press, 428 E. Preston St., Baltimore, MD 21202) V.1- 1954-
Volume(issue)/page/year: 24,91,1983
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 1050 mg/kg
SEX/DURATION : female 7-20 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - blood and lymphatic
systems (including spleen and marrow)
Reproductive - Effects on Newborn - delayed effects
REFERENCE :
CIIT** Chemical Industry Institute of Toxicology, Docket Reports. (POB
12137, Research Triangle Park, NC 27709) Volume(issue)/page/year: DOCKET
#10992,1982
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 196 mg/kg
SEX/DURATION : female 7-20 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - behavioral
REFERENCE :
CIIT** Chemical Industry Institute of Toxicology, Docket Reports. (POB
12137, Research Triangle Park, NC 27709) Volume(issue)/page/year: DOCKET
#10992,1982
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 2100 mg/kg
SEX/DURATION : female 7-20 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year:
5,948,1985
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 1400 mg/kg
SEX/DURATION : female 7-20 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - blood and lymphatic
systems (including spleen and marrow)
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year:
5,948,1985
** MUTATION DATA **
TYPE OF TEST : Morphological transformation
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Rodent - rat
DOSE/DURATION : 294 mg/kg/3W (Continuous)
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
Volume(issue)/page/year: 7,1797,1986
TYPE OF TEST : Unscheduled DNA synthesis
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Rodent - rat
DOSE/DURATION : 35 mg/kg
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E.
11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year:
14,155,1989
*** REVIEWS ***
ACGIH TLV-Animal carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 0.2 mg/m3 (skin)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 1.5 mg/m3 (skin)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,93,1971
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-ARAB Republic of Egypt:TWA 1.5 mg/m3;Skin JAN 1993
OEL-AUSTRALIA:TWA 1.5 mg/m3;Skin JAN 1993
OEL-BELGIUM:TWA 1.5 mg/m3;Skin JAN 1993
OEL-DENMARK:TWA 1.5 mg/m3;Skin JAN 1993
OEL-FINLAND:TWA 1.5 mg/m3;STEL 3 mg/m3;Skin JAN 1993
OEL-GERMANY;Skin;Carcinogen JAN 1993
OEL-INDIA:TWA 1.5 mg/m3;Skin JAN 1993
OEL-THE NETHERLANDS:TWA 1.5 mg/m3 JAN 1993
OEL-THE PHILIPPINES:TWA 1.5 mg/m3;Skin JAN 1993
OEL-POLAND:TWA 1 mg/m3 JAN 1993
OEL-SWITZERLAND:TWA 1.5 mg/m3;Skin;Carcinogen JAN 1993
OEL-TURKEY:TWA 1.5 mg/m3;Skin JAN 1993
OEL-UNITED KINGDOM:TWA 1.5 mg/m3;STEL 5 mg/m3;Skin JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO DINITROTOLUENE-air:10H CA TWA 1.5 mg/m3 (Sk)
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: Sperm morphology-human
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
NIOSH CURRENT INTELLIGENCE BULLETIN #44
*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
| NAME | CAS |
Toluene, alpha-chloro-o-nitro-
| 612-23-7 |
Toluene, alpha-chloro-p-nitro-
| 100-14-1 |
Toluene, 2-chloro-4-nitro-
| 121-86-8 |
9H-Thioxanthen-9-one,1-((2-(diethylamino)ethyl)amino)-4-(hydroxymethyl)-,monomethanesulfonate (salt)
| 23255-93-8 |
Toluene, 2-chloro-6-nitro-
| 83-42-1 |
Toluene, 5-chloro-2-nitro-
| 5367-28-2 |
Toluene,4-chloro-3-nitro-alpha,alpha,alpha-trifluoro-
| 121-17-5 |
Toluene, p-chloro-alpha,alpha,alpha-trifluoro-
| 98-56-6 |
Toluene concentrate
| 98-56-6 |
Toluenediamine
| 25376-45-8 |
Toluene-2,3-diamine
| 2687-25-4 |
Toluene-2,4-diamine
| 95-80-7 |
Toluene-2,5-diamine
| 95-70-5 |
Toluene-2,6-diamine
| 823-40-5 |
Thioxanthen-9-one,1-((2-(diethylamino)ethyl)amino)-4-(hydroxymethyl)-,N-oxide
| 54484-90-1 |
Toluene-3,4-diamine
| 496-72-0 |
Toluene-2,4-diamine, N(sup 4)-acetyl-N(sup2)-trifluoromethylsulfonyl-
| 47000-92-0 |
Toluene-alpha,4-diamine, N,N-bis(2-chloroethyl)-N(supalpha),N(sup alpha)-diallyl-, dihydrochloride
| 47000-92-0 |
Toluene-alpha,3-diamine, N,N-bis(2-chloroethyl)-N(supalpha),N(sup alpha)-diallyl-, picrolonate
| 47000-92-0 |
Toluene-alpha,4-diamine, N(sup alpha),N(supalpha)-bis(2-chloroethyl)-, dihydrochloride
| 102395-97-1 |
Toluene-alpha,2-diamine, 3,5-dibromo-N(supalpha)-cyclohexyl-N-(sup alpha)-methyl-,monohydrochloride
| 611-75-6 |
Toluene-2,4-diamine, N(sup 4),N(sup4)-diethyl-3,5-dinitro-alpha,alpha,alpha-trifluoro-
| 29091-05-2 |
Toluene-2,4-diamine, dihydrochloride
| 636-23-7 |
Toluene-2,5-diamine, dihydrochloride
| 615-45-2 |
Toluene-2,6-diamine, dihydrochloride
| 15481-70-6 |
Thioxanthene-2-sulfonamide,N,N-dimethyl-9-(3-(dimethylamino)propylidene)-,hydrochloride, (E)-
| 25658-52-0 |
9H-Thioxanthen-9-one,1-((2-(diethylamino)ethyl)amino)-4-hydroxy-, 10-oxide
| 37599-14-7 |
Toluene-2,4-diamine, 5,5'-methylenebis-
| 97-22-3 |
Toluene-alpha,3-diamine,6,6'-pentamethylenedioxybis(N(sup 1),N(sup1)-diethyl-, dihydrochloride
| 97-22-3 |
Toluene-2,5-diamine, sulfate
| 6369-59-1 |
Toluene-2,5-diamine, sulfate (11)
| 615-50-9 |
Toluene-2,3-diamine, and toluene-3,4-diamine
| 615-50-9 |
Toluene-2,3-diamine, mixed with toluene-3,4-diamine(2:3)
| 615-50-9 |
o-Toluenediazonium, 5-nitro-,1,5-naphthalenedisulfonate, (1:1) sodium salt
| 34459-52-4 |
o-Toluenediazonium, 4-nitro-, tetrafluoroborate(1-)
| 455-90-3 |
p-Toluenediazonium, sulfate (11)
| 32066-79-8 |
p-Toluenediazonium, tetrafluoroborate (1-)
| 459-44-9 |
Thioxanthen-9-one,1-((2-(diethylamino)ethyl)amino)-4-methoxy-
| 73909-11-2 |
Toluene, alpha,2-dibromo-4,5-methylenedioxy-
| 5434-47-9 |
Toluene, p,alpha-dichloro-
| 104-83-6 |
Toluene, 2,4-dichloro-
| 95-73-8 |
Toluene, alpha,alpha-dichloro-alpha-fluoro-
| 498-67-9 |
Toluene, dinitro-
| 25321-14-6 |
Toluene, 2,3-dinitro-
| 602-01-7 |
Toluene, 2,4-dinitro-
| 121-14-2 |
Toluene, 2,5-dinitro-
| 619-15-8 |
Toluene, 2,6-dinitro-
| 606-20-2 |
Toluene, 3,4-dinitro-
| 610-39-9 |
Thioxanthen-9-one,1-((2-(diethylamino)ethyl)amino)-4-methyl-
| 479-50-5 |
Toluene, 3,5-dinitro-
| 618-85-9 |
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