*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : XT0524000
CHEMICAL NAME : Toluene-2,5-diamine, sulfate
CAS REGISTRY NUMBER : 6369-59-1
OTHER CAS REGISTRY NOS. : 81892-73-1
LAST UPDATED : 199710
DATA ITEMS CITED : 18
MOLECULAR FORMULA : C7-H10-N2.xH2-O4-S
MOLECULAR WEIGHT : 808.75
COMPOUND DESCRIPTOR : Tumorigen
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* 1,4-Benzenediamine, 2-methyl-, sulfate
* C.I. 76043
* C.I. Oxidation Base 4
* Fouramine STD
* 2-Methyl-1,4-benzenediamine sulfate
* NCI-C01832
* p-Toluenediamine sulfate
* 2,5-Toluenediamine sulfate
*** HEALTH HAZARD DATA ***
** TUMORIGENIC DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 66 gm/kg/78W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
REFERENCE :
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-126,1978
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 800 mg/kg
SEX/DURATION : female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development. (Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
Volume(issue)/page/year: 33,31A,1986
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE : 800 mg/kg
SEX/DURATION : female 8-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - live birth index (measured after birth)
REFERENCE :
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc.,
41 E. 11th St., New York, NY 10003) V.1- 1980- Volume(issue)/page/year:
6,361,1986
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE : 480 mg/kg
SEX/DURATION : female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development. (Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
Volume(issue)/page/year: 24,253,1981
** MUTATION DATA **
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 1 mg/plate
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E.
11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year:
11(Suppl 12),1,1988
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 33300 ng/plate
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 7(Suppl
5),1,1985
TYPE OF TEST : DNA inhibition
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 40 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 91,75,1981
*** REVIEWS ***
IARC Cancer Review:Animal Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 16,97,1978
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - M1308
No. of Facilities: 1085 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 8680 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - M1308
No. of Facilities: 4100 (estimated)
No. of Industries: 2
No. of Occupations: 2
No. of Employees: 39400 (estimated)
No. of Female Employees: 32217 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Negative: N crassa-aneuploidy
EPA GENETOX PROGRAM 1988, Negative/limited: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Inconclusive: Mammalian micronucleus
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year:
47,26992,82
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
NCI Carcinogenesis Bioassay (feed);inadequate studies:mouse,rat
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-126,78
*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
| NAME | CAS |
Toluene, alpha-chloro-o-nitro-
| 612-23-7 |
Toluene, alpha-chloro-p-nitro-
| 100-14-1 |
Toluene, 2-chloro-4-nitro-
| 121-86-8 |
9H-Thioxanthen-9-one,1-((2-(diethylamino)ethyl)amino)-4-(hydroxymethyl)-,monomethanesulfonate (salt)
| 23255-93-8 |
Toluene, 2-chloro-6-nitro-
| 83-42-1 |
Toluene, 5-chloro-2-nitro-
| 5367-28-2 |
Toluene,4-chloro-3-nitro-alpha,alpha,alpha-trifluoro-
| 121-17-5 |
Toluene, p-chloro-alpha,alpha,alpha-trifluoro-
| 98-56-6 |
Toluene concentrate
| 98-56-6 |
Toluenediamine
| 25376-45-8 |
Toluene-2,3-diamine
| 2687-25-4 |
Toluene-2,4-diamine
| 95-80-7 |
Toluene-2,5-diamine
| 95-70-5 |
Toluene-2,6-diamine
| 823-40-5 |
Thioxanthen-9-one,1-((2-(diethylamino)ethyl)amino)-4-(hydroxymethyl)-,N-oxide
| 54484-90-1 |
Toluene-3,4-diamine
| 496-72-0 |
Toluene-2,4-diamine, N(sup 4)-acetyl-N(sup2)-trifluoromethylsulfonyl-
| 47000-92-0 |
Toluene-alpha,4-diamine, N,N-bis(2-chloroethyl)-N(supalpha),N(sup alpha)-diallyl-, dihydrochloride
| 47000-92-0 |
Toluene-alpha,3-diamine, N,N-bis(2-chloroethyl)-N(supalpha),N(sup alpha)-diallyl-, picrolonate
| 47000-92-0 |
Toluene-alpha,4-diamine, N(sup alpha),N(supalpha)-bis(2-chloroethyl)-, dihydrochloride
| 102395-97-1 |
Toluene-alpha,2-diamine, 3,5-dibromo-N(supalpha)-cyclohexyl-N-(sup alpha)-methyl-,monohydrochloride
| 611-75-6 |
Toluene-2,4-diamine, N(sup 4),N(sup4)-diethyl-3,5-dinitro-alpha,alpha,alpha-trifluoro-
| 29091-05-2 |
Toluene-2,4-diamine, dihydrochloride
| 636-23-7 |
Toluene-2,5-diamine, dihydrochloride
| 615-45-2 |
Toluene-2,6-diamine, dihydrochloride
| 15481-70-6 |
Thioxanthene-2-sulfonamide,N,N-dimethyl-9-(3-(dimethylamino)propylidene)-,hydrochloride, (E)-
| 25658-52-0 |
9H-Thioxanthen-9-one,1-((2-(diethylamino)ethyl)amino)-4-hydroxy-, 10-oxide
| 37599-14-7 |
Toluene-2,4-diamine, 5,5'-methylenebis-
| 97-22-3 |
Toluene-alpha,3-diamine,6,6'-pentamethylenedioxybis(N(sup 1),N(sup1)-diethyl-, dihydrochloride
| 97-22-3 |
Toluene-2,5-diamine, sulfate
| 6369-59-1 |
Toluene-2,5-diamine, sulfate (11)
| 615-50-9 |
Toluene-2,3-diamine, and toluene-3,4-diamine
| 615-50-9 |
Toluene-2,3-diamine, mixed with toluene-3,4-diamine(2:3)
| 615-50-9 |
o-Toluenediazonium, 5-nitro-,1,5-naphthalenedisulfonate, (1:1) sodium salt
| 34459-52-4 |
o-Toluenediazonium, 4-nitro-, tetrafluoroborate(1-)
| 455-90-3 |
p-Toluenediazonium, sulfate (11)
| 32066-79-8 |
p-Toluenediazonium, tetrafluoroborate (1-)
| 459-44-9 |
Thioxanthen-9-one,1-((2-(diethylamino)ethyl)amino)-4-methoxy-
| 73909-11-2 |
Toluene, alpha,2-dibromo-4,5-methylenedioxy-
| 5434-47-9 |
Toluene, p,alpha-dichloro-
| 104-83-6 |
Toluene, 2,4-dichloro-
| 95-73-8 |
Toluene, alpha,alpha-dichloro-alpha-fluoro-
| 498-67-9 |
Toluene, dinitro-
| 25321-14-6 |
Toluene, 2,3-dinitro-
| 602-01-7 |
Toluene, 2,4-dinitro-
| 121-14-2 |
Toluene, 2,5-dinitro-
| 619-15-8 |
Toluene, 2,6-dinitro-
| 606-20-2 |
Toluene, 3,4-dinitro-
| 610-39-9 |
Thioxanthen-9-one,1-((2-(diethylamino)ethyl)amino)-4-methyl-
| 479-50-5 |
Toluene, 3,5-dinitro-
| 618-85-9 |
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