*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : XS9145000
CHEMICAL NAME : Toluene, p-chloro-alpha,alpha,alpha-trifluoro-
CAS REGISTRY NUMBER : 98-56-6
OTHER CAS REGISTRY NOS. : 92709-16-5
BEILSTEIN REFERENCE NO. : 0510203
REFERENCE : 4-05-00-00815 (Beilstein Handbook Reference)
LAST UPDATED : 199712
DATA ITEMS CITED : 17
MOLECULAR FORMULA : C7-H4-Cl-F3
MOLECULAR WEIGHT : 180.56
COMPOUND DESCRIPTOR : Tumorigen
Mutagen
SYNONYMS/TRADE NAMES :
* Benzene, 1-chloro-4-(trifluoromethyl)-
* p-Chlorobenzotrifluoride
* (p-Chlorophenyl)trifluoromethane
* p-Chlorotrifluoromethylbenzene
* 1-Chloro-4-(trifluoromethyl)benzene
* p-(Trifluoromethyl)chlorobenzene
* alpha,alpha,alpha-Trifluoro-4-chlorotoluene
* p-Trifluoromethylphenyl chloride
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 13 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 28(5),49,1984
TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 22 gm/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 28(5),49,1984
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 11500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 28(5),49,1984
TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 20 gm/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 28(5),49,1984
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 5600 mg/kg/14D-I
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in bladder weight
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year:
18,460,1992
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 28 gm/kg/28D-I
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in bladder weight
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year:
25,781,1987
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 440 mg/m3/24H/17W-C
TOXIC EFFECTS :
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Blood - changes in erythrocyte (RBC) count
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - true cholinesterase
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 51(10),82,1986
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 500 ppm/6H/4W-I
TOXIC EFFECTS :
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Nutritional and Gross Metabolic - changes in calcium
Biochemical - Metabolism (Intermediary) - other proteins
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0570838
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 14 gm/kg/14D-I
TOXIC EFFECTS :
Liver - changes in liver weight
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Biochemical - Metabolism (Intermediary) - lipids including transport
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year:
18,460,1992
** MUTATION DATA **
TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Human Embryo
DOSE/DURATION : 1 gm/L
REFERENCE :
AISSAW Annali dell'Istituto Superiore di Sanita. (Istituto Poligrafico e
Zecca dello Stato, Piazza Verdi, 10 Rome, Italy) V.1- 1965-
Volume(issue)/page/year: 18,123,1982
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-RUSSIA:STEL 20 mg/m3;Skin JAN 1993
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 84021
No. of Facilities: 5 (estimated)
No. of Industries: 1
No. of Occupations: 2
No. of Employees: 20 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0493-8771
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
NTP Toxicity studies, RPT# TOX-14, October 1997
*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
| NAME | CAS |
Toluene, alpha-chloro-o-nitro-
| 612-23-7 |
Toluene, alpha-chloro-p-nitro-
| 100-14-1 |
Toluene, 2-chloro-4-nitro-
| 121-86-8 |
9H-Thioxanthen-9-one,1-((2-(diethylamino)ethyl)amino)-4-(hydroxymethyl)-,monomethanesulfonate (salt)
| 23255-93-8 |
Toluene, 2-chloro-6-nitro-
| 83-42-1 |
Toluene, 5-chloro-2-nitro-
| 5367-28-2 |
Toluene,4-chloro-3-nitro-alpha,alpha,alpha-trifluoro-
| 121-17-5 |
Toluene, p-chloro-alpha,alpha,alpha-trifluoro-
| 98-56-6 |
Toluene concentrate
| 98-56-6 |
Toluenediamine
| 25376-45-8 |
Toluene-2,3-diamine
| 2687-25-4 |
Toluene-2,4-diamine
| 95-80-7 |
Toluene-2,5-diamine
| 95-70-5 |
Toluene-2,6-diamine
| 823-40-5 |
Thioxanthen-9-one,1-((2-(diethylamino)ethyl)amino)-4-(hydroxymethyl)-,N-oxide
| 54484-90-1 |
Toluene-3,4-diamine
| 496-72-0 |
Toluene-2,4-diamine, N(sup 4)-acetyl-N(sup2)-trifluoromethylsulfonyl-
| 47000-92-0 |
Toluene-alpha,4-diamine, N,N-bis(2-chloroethyl)-N(supalpha),N(sup alpha)-diallyl-, dihydrochloride
| 47000-92-0 |
Toluene-alpha,3-diamine, N,N-bis(2-chloroethyl)-N(supalpha),N(sup alpha)-diallyl-, picrolonate
| 47000-92-0 |
Toluene-alpha,4-diamine, N(sup alpha),N(supalpha)-bis(2-chloroethyl)-, dihydrochloride
| 102395-97-1 |
Toluene-alpha,2-diamine, 3,5-dibromo-N(supalpha)-cyclohexyl-N-(sup alpha)-methyl-,monohydrochloride
| 611-75-6 |
Toluene-2,4-diamine, N(sup 4),N(sup4)-diethyl-3,5-dinitro-alpha,alpha,alpha-trifluoro-
| 29091-05-2 |
Toluene-2,4-diamine, dihydrochloride
| 636-23-7 |
Toluene-2,5-diamine, dihydrochloride
| 615-45-2 |
Toluene-2,6-diamine, dihydrochloride
| 15481-70-6 |
Thioxanthene-2-sulfonamide,N,N-dimethyl-9-(3-(dimethylamino)propylidene)-,hydrochloride, (E)-
| 25658-52-0 |
9H-Thioxanthen-9-one,1-((2-(diethylamino)ethyl)amino)-4-hydroxy-, 10-oxide
| 37599-14-7 |
Toluene-2,4-diamine, 5,5'-methylenebis-
| 97-22-3 |
Toluene-alpha,3-diamine,6,6'-pentamethylenedioxybis(N(sup 1),N(sup1)-diethyl-, dihydrochloride
| 97-22-3 |
Toluene-2,5-diamine, sulfate
| 6369-59-1 |
Toluene-2,5-diamine, sulfate (11)
| 615-50-9 |
Toluene-2,3-diamine, and toluene-3,4-diamine
| 615-50-9 |
Toluene-2,3-diamine, mixed with toluene-3,4-diamine(2:3)
| 615-50-9 |
o-Toluenediazonium, 5-nitro-,1,5-naphthalenedisulfonate, (1:1) sodium salt
| 34459-52-4 |
o-Toluenediazonium, 4-nitro-, tetrafluoroborate(1-)
| 455-90-3 |
p-Toluenediazonium, sulfate (11)
| 32066-79-8 |
p-Toluenediazonium, tetrafluoroborate (1-)
| 459-44-9 |
Thioxanthen-9-one,1-((2-(diethylamino)ethyl)amino)-4-methoxy-
| 73909-11-2 |
Toluene, alpha,2-dibromo-4,5-methylenedioxy-
| 5434-47-9 |
Toluene, p,alpha-dichloro-
| 104-83-6 |
Toluene, 2,4-dichloro-
| 95-73-8 |
Toluene, alpha,alpha-dichloro-alpha-fluoro-
| 498-67-9 |
Toluene, dinitro-
| 25321-14-6 |
Toluene, 2,3-dinitro-
| 602-01-7 |
Toluene, 2,4-dinitro-
| 121-14-2 |
Toluene, 2,5-dinitro-
| 619-15-8 |
Toluene, 2,6-dinitro-
| 606-20-2 |
Toluene, 3,4-dinitro-
| 610-39-9 |
Thioxanthen-9-one,1-((2-(diethylamino)ethyl)amino)-4-methyl-
| 479-50-5 |
Toluene, 3,5-dinitro-
| 618-85-9 |
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