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MSDS  : Tylosin, tartrate
CAS  : 1405-54-5
SYNONYMS  : * Pharmasin * Tylosin, (R-(R*,R*)-2,3-dihydroxybutanedioate) (salt)
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : YP0875000
CHEMICAL NAME : Tylosin, tartrate
CAS REGISTRY NUMBER : 1405-54-5
LAST UPDATED : 199806
DATA ITEMS CITED : 12
MOLECULAR FORMULA : C45-H77-N-O17.C4-H6-O6
MOLECULAR WEIGHT : 1054.33
COMPOUND DESCRIPTOR : Drug
SYNONYMS/TRADE NAMES :
* Pharmasin
* Tylosin, (R-(R*,R*)-2,3-dihydroxybutanedioate) (salt)

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >6200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AAGAAW Antimicrobial Agents Annual. (New York, NY) 1960. For publisher
information, see AMACCQ. Volume(issue)/page/year: -,595,1960

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 695 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 4,1,1966

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : >6200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AAGAAW Antimicrobial Agents Annual. (New York, NY) 1960. For publisher
information, see AMACCQ. Volume(issue)/page/year: -,595,1960

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1354 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 4,1,1966

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 589 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 4,1,1966

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : >1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AAGAAW Antimicrobial Agents Annual. (New York, NY) 1960. For publisher
information, see AMACCQ. Volume(issue)/page/year: -,595,1960

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Bird - chicken
DOSE/DURATION : 5400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AAGAAW Antimicrobial Agents Annual. (New York, NY) 1960. For publisher
information, see AMACCQ. Volume(issue)/page/year: -,595,1960

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Bird - chicken
DOSE/DURATION : 620 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - food intake (animal)
Behavioral - irritability
REFERENCE :
VMDNAV Veterinarno-Meditsinski Nauki. Veterinary Science. (Hemus, Blvd.
Russki 6, Sofia, Bulgaria) V.1- 1964- Volume(issue)/page/year:
15,52,1978

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Bird - chicken
DOSE/DURATION : 48 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - food intake (animal)
Behavioral - irritability
REFERENCE :
VMDNAV Veterinarno-Meditsinski Nauki. Veterinary Science. (Hemus, Blvd.
Russki 6, Sofia, Bulgaria) V.1- 1964- Volume(issue)/page/year:
15,52,1978

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Bird - chicken
DOSE/DURATION : 432 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AAGAAW Antimicrobial Agents Annual. (New York, NY) 1960. For publisher
information, see AMACCQ. Volume(issue)/page/year: -,595,1960

** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Bird - chicken
DOSE/DURATION : 5400 mg/kg/6W-I
TOXIC EFFECTS :
Blood - other changes
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - transaminases
REFERENCE :
VMDNAV Veterinarno-Meditsinski Nauki. Veterinary Science. (Hemus, Blvd.
Russki 6, Sofia, Bulgaria) V.1- 1964- Volume(issue)/page/year:
15,52,1978

*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - M2751
No. of Facilities: 33 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 99 (estimated)


*** END OF RECORD ***
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