RTECS NUMBER : YP0175000
CHEMICAL NAME : Tylocrebrine
CAS REGISTRY NUMBER : 6879-02-3
BEILSTEIN REFERENCE NO. : 1555044
LAST UPDATED : 199612
DATA ITEMS CITED : 6
MOLECULAR FORMULA : C24-H27-N-O4
MOLECULAR WEIGHT : 393.52
WISWESSER LINE NOTATION : T D5 B6 K666 DNJ MO1 NO1 RO1 SO1
COMPOUND DESCRIPTOR : Drug
SYNONYMS/TRADE NAMES :
* Dibenzo(f,h)pyrrolo(1,2-b)isoquinoline,
9,11,12,13,13a,14-hexahydro-2,3,5,6-tetramethoxy-
* NSC-60387
* (-)-Tylocrebrine
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 65 mg/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay)
Gastrointestinal - hypermotility, diarrhea
Skin and Appendages - hair
REFERENCE :
NCICP* Progress Report Submitted to the National Cancer Institute by Charles
Pfizer & Co. Volume(issue)/page/year: -,77,1964
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 32 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - ataxia
Gastrointestinal - hypermotility, diarrhea
REFERENCE :
NCICP* Progress Report Submitted to the National Cancer Institute by Charles
Pfizer & Co. Volume(issue)/page/year: -,77,1964
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 50 mg/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay)
Behavioral - ataxia
Gastrointestinal - hypermotility, diarrhea
REFERENCE :
NCICP* Progress Report Submitted to the National Cancer Institute by Charles
Pfizer & Co. Volume(issue)/page/year: -,77,1964
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 42 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - convulsions or effect on seizure threshold
Behavioral - ataxia
REFERENCE :
NCICP* Progress Report Submitted to the National Cancer Institute by Charles
Pfizer & Co. Volume(issue)/page/year: -,77,1964
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 12 mg/kg/24D-I
TOXIC EFFECTS :
Gastrointestinal - changes in structure or function of esophagus
Gastrointestinal - ulceration or bleeding from large intestine
Blood - other changes
REFERENCE :
NCICP* Progress Report Submitted to the National Cancer Institute by Charles
Pfizer & Co. Volume(issue)/page/year: -,77,1964
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Primate - monkey
DOSE/DURATION : 24 mg/kg/24D-I
TOXIC EFFECTS :
Liver - other changes
Blood - pigmented or nucleated red blood cells
Blood - changes in erythrocyte (RBC) count
REFERENCE :
NCICP* Progress Report Submitted to the National Cancer Institute by Charles
Pfizer & Co. Volume(issue)/page/year: -,77,1964
*** END OF RECORD ***
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