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MSDS  : Tubocurarine, dichloride, (+)-
CAS  : 57-94-3
SYNONYMS  : * Amerizol * Curarin-haf * Delacurarine * Dextrotubocurarine chloride * d-7',12'-Dihydroxy-6,6'-dimethoxy-2,2',2'-trimethyltubocuraranium chloride * Intocostrin * Intocostrine T * d-Paracurarine chloride * Tubadil * Tubarine * Tubocurarine chloride * Tubocurarine, chloride, hydrochloride, (+)- * (+)-Tubocurarine chloride * d-Tubocurarine chloride * d-Tubocurarine dichloride * Tubocurarine hydrochloride * (+)-Tubocurarine hydrochloride * d-Tubocurarine hydrochloride
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : YO4900000
CHEMICAL NAME : Tubocurarine, dichloride, (+)-
CAS REGISTRY NUMBER : 57-94-3
LAST UPDATED : 199707
DATA ITEMS CITED : 13
MOLECULAR FORMULA : C38-H44-N2-O6.2Cl
MOLECULAR WEIGHT : 695.74
WISWESSER LINE NOTATION : T E6 J6 J-6 T6-18-6 B6 A E- E-- T- 2BJ- I& IO QK B&O
I&K&&T&T&TJ KQ LO1 Q1 Q1 WQ D&O1 I&1 I&1
COMPOUND DESCRIPTOR : Drug
Mutagen
SYNONYMS/TRADE NAMES :
* Amerizol
* Curarin-haf
* Delacurarine
* Dextrotubocurarine chloride
* d-7',12'-Dihydroxy-6,6'-dimethoxy-2,2',2'-trimethyltubocuraranium
chloride
* Intocostrin
* Intocostrine T
* d-Paracurarine chloride
* Tubadil
* Tubarine
* Tubocurarine chloride
* Tubocurarine, chloride, hydrochloride, (+)-
* (+)-Tubocurarine chloride
* d-Tubocurarine chloride
* d-Tubocurarine dichloride
* Tubocurarine hydrochloride
* (+)-Tubocurarine hydrochloride
* d-Tubocurarine hydrochloride

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 28 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
Volume(issue)/page/year: 120,511,1965

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 340 ug/kg
TOXIC EFFECTS :
Behavioral - muscle weakness
Lungs, Thorax, or Respiration - respiratory depression
Lungs, Thorax, or Respiration - other changes
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 9,117,1975

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 310 ug/kg
TOXIC EFFECTS :
Behavioral - muscle weakness
Lungs, Thorax, or Respiration - respiratory depression
Lungs, Thorax, or Respiration - other changes
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 9,117,1975

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 66 ug/kg
TOXIC EFFECTS :
Behavioral - muscle weakness
Lungs, Thorax, or Respiration - respiratory depression
Lungs, Thorax, or Respiration - other changes
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 9,117,1975

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 33 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
Volume(issue)/page/year: 120,511,1965

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 420 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
RPTOAN Russian Pharmacology and Toxicology (English Translation).
Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey,
UK) V.30- 1967- Volume(issue)/page/year: 32,74,1969

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 640 ug/kg
TOXIC EFFECTS :
Behavioral - muscle weakness
Lungs, Thorax, or Respiration - respiratory depression
Lungs, Thorax, or Respiration - other changes
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 9,117,1975

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 97 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4-
1898- Volume(issue)/page/year: 109,191,1957

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 540 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KHFZAN Khimiko-Farmatsevticheskii Zhurnal. Chemical Pharmaceutical Journal.
For English translation, see PCJOAU. (V/O Mezhdunarodnaya Kniga, 113095
Moscow, USSR) V.1- 1967- Volume(issue)/page/year: 24(12),24,1990

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 170 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KHFZAN Khimiko-Farmatsevticheskii Zhurnal. Chemical Pharmaceutical Journal.
For English translation, see PCJOAU. (V/O Mezhdunarodnaya Kniga, 113095
Moscow, USSR) V.1- 1967- Volume(issue)/page/year: 24(12),24,1990

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 66 ug/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - other changes
REFERENCE :
JLCMAK Journal of Laboratory and Clinical Medicine. (C.V. Mosby Co., 11830
Westline Industrial Dr., St. Louis, MO 63141) V.1- 1915-
Volume(issue)/page/year: 34,516,1949

*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X5569
No. of Facilities: 34 (estimated)
No. of Industries: 1
No. of Occupations: 3
No. of Employees: 1010 (estimated)
No. of Female Employees: 668 (estimated)

*** STATUS IN U.S. ***

EPA GENETOX PROGRAM 1988, Inconclusive: E coli polA without S9; Histidine
reversion-Ames test


*** END OF RECORD ***
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NAMECAS
Tryptophan, 5-hydroxy-, DL-, pyrolyzateSUBSTANCE DEFINITION :Smoke condensate obtained by pyrolysis of 5-hydroxy-DL-tryptophanREFERENCE :CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. IrelandLtd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year:2,335,1977 114-03-4
Tryptophan, 5-hydroxy-, L- 4350-09-8
Tryptophan, 5-hydroxy- L- and(-)-L-alpha-hydrazino-3,4-dihydroxy-alpha-methylhydrocinnamic acid, monohydrate 4350-09-8
Tryptophan, 5-hydroxy-, (L), mixed with sodiumnitrite 4350-09-8
Tryptophan, 5-methoxy- 2504-22-5
1-alpha-H,5-alpha-H-Tropanium,6-beta,7-beta-epoxy-3-alpha-hydroxy-8-methyl-,nitrate, (-)- tropate 6106-46-3
L-Tryptophan, 1-methyl- 21339-55-9
Tryptophan, 5-methyl- 154-06-3
Tryptophan, 1-methyl-, DL-, mixed with sodium nitrite 154-06-3
Tryptophan, 7-nitro-, hydrochloride, DL- 74051-46-0
L-Tryptophan,2-(2-oxo-2-(10H-phenothiazin-10-yl)ethyl)hydrazide 84409-83-6
D-Tryptophan, N-(3-oxo-3-phenylpropyl)- 92515-11-2
D-Tryptophan, N-D-phenylalanyl- 58607-70-8
D-Tryptophan, N-L-phenylalanyl- 66421-20-3
L-Tryptophan, N-D-phenylalanyl- 76327-05-4
L-Tryptophan, N-L-phenylalanyl- 24587-41-5
1-alpha-H,5-alpha-H-Tropanium,8-(p-ethylbenzyl)-3-hydroxy-, bromide, benzoate(ester), cis- 102432-91-7
D-Tryptophan, N-D-phenylalanyl-, methyl ester,monohydrochloride 76327-08-7
Tryptophan mixed with sodium nitrite 76327-08-7
Tryptophan, D-, mixed with sodium nitrite 76327-08-7
Tryptophan, L-, mixed with sodium nitrite 76327-08-7
L-Tryptophan, N-(1-thioxoethyl)-, methyl ester 54774-15-1
Tryptophan, N-L-tryptophyl-, L-, pyrolyzate 54774-15-1
L-Tryptophan, L-tryptophyl-, mixed with sodiumnitrite 54774-15-1
Trysben R200-acid 54774-15-1
T-40517, sodium saltSUBSTANCE DEFINITION :Produced by S. hygroscopicus T-40517 (FERM-P 2366,ifo-13574)REFERENCE :JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968-Volume(issue)/page/year: 30,77-82,1977 54774-15-1
Tsushimycin 11054-63-0
1-alpha-H,5-alpha-H-Tropanium,8-(p-ethylbenzyl)-3-hydroxy-, bromide, benzoate(ester), trans- 11054-63-0
Tuberactinomycin 11075-36-8
Tubermycin A, sodium salt 102646-67-3
Tuberosin-ISUBSTANCE DEFINITION :Isolated from Solanum tubersumREFERENCE :85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., BocaRaton, FL, CRC Press, 1980- Volume(issue)/page/year: 8(Pt 1),108,1982 102646-67-3
Tubocuraranium,7',12'-dihydroxy-6,6'-dimethoxy-2,2,2',2'-tetramethyl-, diiodide, (1'-alpha)- 76786-15-7
Tubocuraranium,6,6',7',12'-tetramethoxy-2,2,2',2'-tetramethyl-,dichloride, (1-beta)- 76786-17-9
Tubocuraranium,6,6',7',12'-tetramethoxy-2,2,2',2'-tetramethyl-,diiodide 7601-55-0
Tubocuraranium,6,6',7',12'-tetramethoxy-2,2,2',2'-tetramethyl-,diiodide, (1-beta)- 16240-52-1
Tubocurarine, (+)- 57-95-4
Tubocurarine, dichloride, (+)- 57-94-3
Tubocurarine, dichloride, pentahydrate, (+)- 6989-98-6
1-alpha-H,5-alpha-H-Tropanium,8-(p-ethylbenzyl)-3-hydroxy-, bromide, 2-hydroxy-2-phenylacetate (ester) 78371-76-3
Tubocurarine, O,O'-dimethyl-, (+)- 5152-30-7
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Tumescal-OP 5152-30-7
Tungsten 7440-33-7
Tungsten carbide 12070-12-1
Tungsten carbide, mixed with cobalt (85%15%) 11107-01-0
Tungsten carbide, mixed with cobalt (92%8%) 12718-69-3
Tungsten carbide, mixed with cobalt and titanium(78%:14%:8%) 37329-49-0
Tungsten chloride, (OC-6-11)- 13283-01-7
1-alpha-H,5-alpha-H-Tropanium,8-(p-ethylbenzyl)-3-hydroxy-, bromide,alpha-phenylcyclohexaneacetate 102432-93-9

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