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MSDS  : Tubocurarine, (+)-
CAS  : 57-95-4
SYNONYMS  : * Tubocurarin * Tubocurarine * (+)-Tubocurarine * d-Tubocurarine * Tubocuraranium, 7',12'-dihydroxy-6,6'-dimethoxy-2,2',2'-trimethyl-
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : YO4025000
CHEMICAL NAME : Tubocurarine, (+)-
CAS REGISTRY NUMBER : 57-95-4
OTHER CAS REGISTRY NOS. : 548-18-5
1370-17-8
LAST UPDATED : 199709
DATA ITEMS CITED : 12
MOLECULAR FORMULA : C37-H41-N2-O6
MOLECULAR WEIGHT : 609.80
WISWESSER LINE NOTATION : TA E6 J6 J-6 T6-18-6 B6 A E- E-- T- 2BJ- I& IO QK B&O
I&K&&T&T&TJ &Q &Q -D&L
COMPOUND DESCRIPTOR : Drug
Natural Product
SYNONYMS/TRADE NAMES :
* Tubocurarin
* Tubocurarine
* (+)-Tubocurarine
* d-Tubocurarine
* Tubocuraranium, 7',12'-dihydroxy-6,6'-dimethoxy-2,2',2'-trimethyl-

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 220 ug/kg
TOXIC EFFECTS :
Behavioral - ataxia
Lungs, Thorax, or Respiration - other changes
Cardiac - other changes
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 92,454,1948

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 500 ug/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great
Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949-
Volume(issue)/page/year: 10,638,1958

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 410 ug/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
(usually neuromuscular blockage)
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - true cholinesterase
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4-
1898- Volume(issue)/page/year: 153,308,1965

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 525 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
Volume(issue)/page/year: 85,603,1954

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 130 ug/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
(usually neuromuscular blockage)
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 15,130,1965

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 450 ug/kg
TOXIC EFFECTS :
Autonomic Nervous System - smooth muscle relaxant (mechanism undefined,
spasmolytic)
REFERENCE :
PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation
of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1-
1967- Volume(issue)/page/year: 2,117,1968

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4-
1898- Volume(issue)/page/year: 80,172,1949

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 250 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great
Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949-
Volume(issue)/page/year: 10,638,1958

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85IXA4 "Structure et Activite Pharmacodyanmique des Medicaments du Systeme
Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948
Volume(issue)/page/year: -,631,1948

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 20 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
RISSAF Rendiconti Istituto Superiore di Sanita (Italian Edition). (Rome,
Italy) V.4-27, 1941-64. Volume(issue)/page/year: 13,339,1950

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Bird - chicken
DOSE/DURATION : 700 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4-
1898- Volume(issue)/page/year: 122,152,1959

*** REVIEWS ***

TOXICOLOGY REVIEW
MIANAP Minerva Anestesiologica. (Edizioni Minerva Medica, Casella Postale
491, I-10126 Turin, Italy) V.19- 1953- Volume(issue)/page/year:
46,387,1980


*** END OF RECORD ***
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NAMECAS
Tryptophan, 5-hydroxy-, DL-, pyrolyzateSUBSTANCE DEFINITION :Smoke condensate obtained by pyrolysis of 5-hydroxy-DL-tryptophanREFERENCE :CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. IrelandLtd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year:2,335,1977 114-03-4
Tryptophan, 5-hydroxy-, L- 4350-09-8
Tryptophan, 5-hydroxy- L- and(-)-L-alpha-hydrazino-3,4-dihydroxy-alpha-methylhydrocinnamic acid, monohydrate 4350-09-8
Tryptophan, 5-hydroxy-, (L), mixed with sodiumnitrite 4350-09-8
Tryptophan, 5-methoxy- 2504-22-5
1-alpha-H,5-alpha-H-Tropanium,6-beta,7-beta-epoxy-3-alpha-hydroxy-8-methyl-,nitrate, (-)- tropate 6106-46-3
L-Tryptophan, 1-methyl- 21339-55-9
Tryptophan, 5-methyl- 154-06-3
Tryptophan, 1-methyl-, DL-, mixed with sodium nitrite 154-06-3
Tryptophan, 7-nitro-, hydrochloride, DL- 74051-46-0
L-Tryptophan,2-(2-oxo-2-(10H-phenothiazin-10-yl)ethyl)hydrazide 84409-83-6
D-Tryptophan, N-(3-oxo-3-phenylpropyl)- 92515-11-2
D-Tryptophan, N-D-phenylalanyl- 58607-70-8
D-Tryptophan, N-L-phenylalanyl- 66421-20-3
L-Tryptophan, N-D-phenylalanyl- 76327-05-4
L-Tryptophan, N-L-phenylalanyl- 24587-41-5
1-alpha-H,5-alpha-H-Tropanium,8-(p-ethylbenzyl)-3-hydroxy-, bromide, benzoate(ester), cis- 102432-91-7
D-Tryptophan, N-D-phenylalanyl-, methyl ester,monohydrochloride 76327-08-7
Tryptophan mixed with sodium nitrite 76327-08-7
Tryptophan, D-, mixed with sodium nitrite 76327-08-7
Tryptophan, L-, mixed with sodium nitrite 76327-08-7
L-Tryptophan, N-(1-thioxoethyl)-, methyl ester 54774-15-1
Tryptophan, N-L-tryptophyl-, L-, pyrolyzate 54774-15-1
L-Tryptophan, L-tryptophyl-, mixed with sodiumnitrite 54774-15-1
Trysben R200-acid 54774-15-1
T-40517, sodium saltSUBSTANCE DEFINITION :Produced by S. hygroscopicus T-40517 (FERM-P 2366,ifo-13574)REFERENCE :JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968-Volume(issue)/page/year: 30,77-82,1977 54774-15-1
Tsushimycin 11054-63-0
1-alpha-H,5-alpha-H-Tropanium,8-(p-ethylbenzyl)-3-hydroxy-, bromide, benzoate(ester), trans- 11054-63-0
Tuberactinomycin 11075-36-8
Tubermycin A, sodium salt 102646-67-3
Tuberosin-ISUBSTANCE DEFINITION :Isolated from Solanum tubersumREFERENCE :85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., BocaRaton, FL, CRC Press, 1980- Volume(issue)/page/year: 8(Pt 1),108,1982 102646-67-3
Tubocuraranium,7',12'-dihydroxy-6,6'-dimethoxy-2,2,2',2'-tetramethyl-, diiodide, (1'-alpha)- 76786-15-7
Tubocuraranium,6,6',7',12'-tetramethoxy-2,2,2',2'-tetramethyl-,dichloride, (1-beta)- 76786-17-9
Tubocuraranium,6,6',7',12'-tetramethoxy-2,2,2',2'-tetramethyl-,diiodide 7601-55-0
Tubocuraranium,6,6',7',12'-tetramethoxy-2,2,2',2'-tetramethyl-,diiodide, (1-beta)- 16240-52-1
Tubocurarine, (+)- 57-95-4
Tubocurarine, dichloride, (+)- 57-94-3
Tubocurarine, dichloride, pentahydrate, (+)- 6989-98-6
1-alpha-H,5-alpha-H-Tropanium,8-(p-ethylbenzyl)-3-hydroxy-, bromide, 2-hydroxy-2-phenylacetate (ester) 78371-76-3
Tubocurarine, O,O'-dimethyl-, (+)- 5152-30-7
TUCSUBSTANCE DEFINITION :Containing 5% methyl salicylate and 7.5% l-mentholREFERENCE :KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, KandaSuda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-Volume(issue)/page/year: 12,2153,1978 5152-30-7
TUHSUBSTANCE DEFINITION :Containing 5% methyl salicylate and 1.5% capsicum extractREFERENCE :KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, KandaSuda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-Volume(issue)/page/year: 12,2153,1978 5152-30-7
Tumescal-OP 5152-30-7
Tungsten 7440-33-7
Tungsten carbide 12070-12-1
Tungsten carbide, mixed with cobalt (85%15%) 11107-01-0
Tungsten carbide, mixed with cobalt (92%8%) 12718-69-3
Tungsten carbide, mixed with cobalt and titanium(78%:14%:8%) 37329-49-0
Tungsten chloride, (OC-6-11)- 13283-01-7
1-alpha-H,5-alpha-H-Tropanium,8-(p-ethylbenzyl)-3-hydroxy-, bromide,alpha-phenylcyclohexaneacetate 102432-93-9

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